Suchergebnisse - "DNA mismatch repair"

Response to PD-1 inhibition in MMRd/MSS pancreatic ductal adenocarcinoma: the relevance of parallel testing.

Autoren: Pahl HL Lassmann S Schultheis AM et al.

Körperschaften: Pahl HL Lassmann S Schultheis AM et al.

Quelle: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2025 Oct 21; Vol. 151 (12), pp. 302. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , DNA Mismatch Repair*/genetics , Immune Checkpoint Inhibitors*/therapeutic use , Microsatellite Instability* , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors, Humans

Deficient DNA mismatch repair and Nectin-4 expression in upper tract urothelial carcinoma (UTUC).

Autoren: Duan P Yu L Hao Y et al.

Quelle: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2025 Oct 07; Vol. 151 (11), pp. 280. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE

MeSH-Schlagworte: Cell Adhesion Molecules*/metabolism , Cell Adhesion Molecules*/biosynthesis , Cell Adhesion Molecules*/genetics , DNA Mismatch Repair* , Urologic Neoplasms*/genetics , Urologic Neoplasms*/pathology , Urologic Neoplasms*/metabolism , Carcinoma, Transitional Cell*/genetics , Carcinoma, Transitional Cell*/pathology , Carcinoma, Transitional Cell*/metabolism, Humans ; Female ; Male ; Aged ; Middle Aged ; Retrospective Studies ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Adult ; Nectins

DNA mutagenesis driven by transcription factor competition with mismatch repair.

Autoren: Zhu W Zhang Y Sahay H et al.

Quelle: Cell [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5735-5747.e15. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH-Schlagworte: DNA Mismatch Repair* , Transcription Factors*/metabolism , Mutagenesis*, Humans ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/genetics ; DNA-Binding Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; DNA Replication ; Binding Sites ; Saccharomyces cerevisiae Proteins/metabolism ; Mutation

Therapeutic targeting of mismatch repair-deficient cancers.

Autoren: Johannet P Rousseau B Aghajanian C et al.

Quelle: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2025 Oct; Vol. 22 (10), pp. 734-759. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500077 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4782 (Electronic) Linking ISSN: 17594774 NLM ISO Abbreviation: Nat Rev Clin Oncol Subsets: MEDLINE

MeSH-Schlagworte: DNA Mismatch Repair*/genetics , DNA Mismatch Repair*/drug effects , Neoplasms*/genetics , Neoplasms*/drug therapy , Neoplastic Syndromes, Hereditary*/genetics , Neoplastic Syndromes, Hereditary*/drug therapy, Humans ; Microsatellite Instability ; Immune Checkpoint Inhibitors/therapeutic use ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/drug therapy ; Molecular Targeted Therapy

The prognostic impact of lymph node yield in deficient and proficient mismatch repair colon cancers: A retrospective national cohort study.

Autoren: Bækgaard FW Iordache A Nordholm AH et al.

Quelle: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland [Colorectal Dis] 2025 Dec; Vol. 27 (12), pp. e70332.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 100883611 Publication Model: Print Cited Medium: Internet ISSN: 1463-1318 (Electronic) Linking ISSN: 14628910 NLM ISO Abbreviation: Colorectal Dis Subsets: MEDLINE

MeSH-Schlagworte: DNA Mismatch Repair*/genetics , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , Colonic Neoplasms*/surgery , Colonic Neoplasms*/mortality , Colonic Neoplasms*/immunology , Lymph Nodes*/pathology , Lymph Nodes*/surgery , Lymph Node Excision*/statistics & numerical data, Humans ; Male ; Female ; Retrospective Studies ; Aged ; Middle Aged ; Prognosis ; Denmark ; Lymphatic Metastasis/pathology ; Colectomy ; Aged, 80 and over ; Adult

Incidence of Mismatch Repair Deficiency in Rectal Cancer and Response to Neoadjuvant Treatment.

Autoren: Nieuwstraten JA van Geffen EGM Leenders MWH et al.

Quelle: Clinical colorectal cancer [Clin Colorectal Cancer] 2025 Dec; Vol. 24 (4), pp. 483-491. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 101120693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0674 (Electronic) Linking ISSN: 15330028 NLM ISO Abbreviation: Clin Colorectal Cancer Subsets: MEDLINE

MeSH-Schlagworte: Rectal Neoplasms*/therapy , Rectal Neoplasms*/genetics , Rectal Neoplasms*/pathology , Rectal Neoplasms*/epidemiology , Neoadjuvant Therapy*/methods , Neoadjuvant Therapy*/statistics & numerical data , DNA Mismatch Repair*, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Incidence ; Chemoradiotherapy, Adjuvant/methods ; Proctectomy ; Netherlands/epidemiology ; Adult ; Brain Neoplasms ; Neoplastic Syndromes, Hereditary ; Colorectal Neoplasms

SCR Disease Name: Turcot syndrome

Mismatch repair deficiency/microsatellite instability (dMMR/MSI-H) in rectal cancer patients treated with standard neoadjuvant therapy: a systematic review and meta-analysis.

Autoren: Ricco G Gallio C Benhima N et al.

Quelle: Cancer treatment reviews [Cancer Treat Rev] 2025 Dec; Vol. 141, pp. 103039. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1967 (Electronic) Linking ISSN: 03057372 NLM ISO Abbreviation: Cancer Treat Rev Subsets: MEDLINE

MeSH-Schlagworte: Rectal Neoplasms*/genetics , Rectal Neoplasms*/therapy , Rectal Neoplasms*/pathology , Microsatellite Instability* , Neoadjuvant Therapy*/methods , DNA Mismatch Repair*, Humans ; Prognosis

The role of DNA mismatch repair mutS/mutL homolog genes in spermatogenesis and male infertility: a systematic review and cohort study.

Autoren: Podgrajsek R Hodzic A Maver A et al.

Quelle: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2025 Nov 19; Vol. 23 (1), pp. 149. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article; Systematic Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Spermatogenesis*/genetics , Infertility, Male*/genetics , DNA Mismatch Repair*/genetics , MutL Proteins*/genetics, Male ; Humans ; Cohort Studies ; DNA-Binding Proteins/genetics

Investigating somatic variants and pathways in mismatch repair-deficient (dMMR) colorectal carcinoma in South Africa.

Autoren: Aldera AP van der Westhuizen J Tsai WJ et al.

Quelle: Journal of clinical pathology [J Clin Pathol] 2025 Nov 19; Vol. 78 (12), pp. 848-854. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0376601 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-4146 (Electronic) Linking ISSN: 00219746 NLM ISO Abbreviation: J Clin Pathol Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , DNA Mismatch Repair*/genetics , Biomarkers, Tumor*/genetics, Humans ; Female ; South Africa ; Male ; Middle Aged ; Adult ; MutL Protein Homolog 1/genetics ; Mismatch Repair Endonuclease PMS2/genetics ; High-Throughput Nucleotide Sequencing ; Mutation ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; DNA-Binding Proteins/genetics ; Genetic Predisposition to Disease ; MutS Homolog 2 Protein/genetics ; DNA Polymerase III/genetics ; Young Adult

Mismatch Repair as a Dynamic and Clinically Actionable Vulnerability in Cancer.

Autoren: Piumatti E Vitiello PP Amodio V et al.

Quelle: Cancer research [Cancer Res] 2025 Nov 14; Vol. 85 (22), pp. 4299-4314.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: DNA Mismatch Repair* , Neoplasms*/genetics , Neoplasms*/immunology , Neoplasms*/therapy , Neoplasms*/drug therapy, Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Microsatellite Instability ; Animals ; Immunotherapy/methods

Mismatch repair disturbs meiotic crossover control in S. cerevisiae.

Autoren: Harper JA Cooper TJ Crawford MR et al.

Quelle: Nucleic acids research [Nucleic Acids Res] 2025 Nov 13; Vol. 53 (21).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH-Schlagworte: Crossing Over, Genetic* , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae*/genetics , DNA Mismatch Repair* , Meiosis*/genetics , MutS Homolog 2 Protein*/genetics , MutS Homolog 2 Protein*/metabolism, Ubiquitin-Protein Ligases

Cyclin D1 expression predicts mismatch repair deficiency and correlates significantly with overall survival and recurrence free survival in endometrial carcinoma.

Autoren: Saied AM ElSheikh SM Elshazly M et al.

Quelle: Journal of molecular histology [J Mol Histol] 2025 Nov 12; Vol. 56 (6), pp. 370. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE

MeSH-Schlagworte: Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/metabolism , Endometrial Neoplasms*/mortality , Endometrial Neoplasms*/genetics , DNA Mismatch Repair* , Cyclin D1*/metabolism , Cyclin D1*/genetics, Humans ; Female ; Aged ; Middle Aged ; Prognosis ; Aged, 80 and over ; Immunohistochemistry ; Disease-Free Survival ; Adult ; Biomarkers, Tumor/metabolism

Biology and evolving management of resectable dMMR/MSI-H cancers: current status and future perspectives.

Autoren: Tanegashima T Shiota M Toyosaki K et al.

Quelle: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Nov 06; Vol. 74 (12), pp. 364. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE

MeSH-Schlagworte: Microsatellite Instability* , DNA Mismatch Repair* , Neoplasms*/genetics , Neoplasms*/therapy , Neoplasms*/immunology , Immunotherapy*/methods, Humans ; Immune Checkpoint Inhibitors/therapeutic use

Increased CD103 ^- CD8 ⁺ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC.

Autoren: Liu J Zeng J Zhou T et al.

Quelle: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Nov 03; Vol. 74 (12), pp. 358. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , DNA Mismatch Repair*/immunology , Lymphocytes, Tumor-Infiltrating*/immunology , Lymphocytes, Tumor-Infiltrating*/metabolism , Antigens, CD*/metabolism , Antigens, CD*/immunology , Integrin alpha Chains*/metabolism , Integrin alpha Chains*/immunology, Humans ; Female ; Male ; Phenotype ; Prognosis ; Middle Aged ; Tumor Microenvironment/immunology ; Aged

Prevalence of Atypical and Subclonal p53 Immunohistochemistry Expression in Mismatch Repair Deficient and/or POLE-Mutant Endometrial Carcinomas with TP53 Mutation.

Autoren: Wang J Cai Y Fang J et al.

Quelle: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2025 Nov; Vol. 105 (11), pp. 104216. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0376617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0307 (Electronic) Linking ISSN: 00236837 NLM ISO Abbreviation: Lab Invest Subsets: MEDLINE

MeSH-Schlagworte: Endometrial Neoplasms*/genetics , Endometrial Neoplasms*/metabolism , Endometrial Neoplasms*/pathology , Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , DNA Mismatch Repair*/genetics , DNA Polymerase II*/genetics , Poly-ADP-Ribose Binding Proteins*/genetics, Humans ; Female ; Immunohistochemistry ; Middle Aged ; Mutation ; Aged ; Adult ; Aged, 80 and over ; Brain Neoplasms ; Neoplastic Syndromes, Hereditary ; Colorectal Neoplasms

SCR Disease Name: Turcot syndrome

Remarkable and Durable Tumor Response to Pembrolizumab in Locally Advanced dMMR/MSI-H Rectal Cancer.

Autoren: Hosokawa A Yamada R Otsuki Y et al.

Quelle: Anticancer research [Anticancer Res] 2025 Nov; Vol. 45 (11), pp. 5069-5076.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal, Humanized*/therapeutic use , Rectal Neoplasms*/drug therapy , Rectal Neoplasms*/genetics , Rectal Neoplasms*/pathology , Rectal Neoplasms*/immunology , Microsatellite Instability* , DNA Mismatch Repair* , Antineoplastic Agents, Immunological*/therapeutic use , Immune Checkpoint Inhibitors*/therapeutic use, Humans ; Aged ; Male ; Treatment Outcome ; Tumor Microenvironment/drug effects

Immune checkpoint inhibitors for dMMR/MSI localized rectal cancer: A systematic review of treatment strategies.

Autoren: Petrelli F Dottorini L Zaniboni A et al.

Quelle: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Nov; Vol. 215, pp. 104921. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article; Systematic Review; Review

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH-Schlagworte: Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/adverse effects , Immune Checkpoint Inhibitors*/pharmacology , Rectal Neoplasms*/drug therapy , Rectal Neoplasms*/genetics , Rectal Neoplasms*/pathology , Microsatellite Instability* , DNA Mismatch Repair*, Humans ; Neoadjuvant Therapy

Mismatch Repair System Gene Expression in FFPE Samples from Breast Cancer Patients.

Autoren: Quidute R Quidute P Perez MM et al.

Quelle: Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2025 Oct 31; Vol. 13 (4). Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629322 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-3271 (Electronic) Linking ISSN: 20763271 NLM ISO Abbreviation: Med Sci (Basel) Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , MutS Homolog 2 Protein*/genetics , MutS Homolog 2 Protein*/metabolism , DNA Mismatch Repair*/genetics , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Gene Expression Regulation, Neoplastic*, Humans ; Female ; Middle Aged ; Aged ; Adult ; Biomarkers, Tumor/genetics ; Paraffin Embedding ; Aged, 80 and over

Efficacy of immunotherapy in gastrointestinal (GI) tumors with mismatch repair deficient (MMRd) unusual phenotype: an AGEO real-world study.

Autoren: Alouani E Taieb J Tougeron D et al.

Quelle: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Oct 30; Vol. 13 (10). Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

MeSH-Schlagworte: DNA Mismatch Repair* , Immunotherapy*/methods , Gastrointestinal Neoplasms*/drug therapy , Gastrointestinal Neoplasms*/genetics , Gastrointestinal Neoplasms*/immunology, Humans ; Female ; Male ; Retrospective Studies ; Phenotype ; Middle Aged ; Aged ; Microsatellite Instability ; Adult ; Aged, 80 and over

Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations.

Autoren: Hawi G Kim PS Lee PP

Quelle: Journal of theoretical biology [J Theor Biol] 2025 Oct 07; Vol. 613, pp. 112231. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal, Humanized*/therapeutic use , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/immunology , Microsatellite Instability* , Neoadjuvant Therapy*/methods , DNA Mismatch Repair* , Models, Biological* , Antineoplastic Agents, Immunological*/therapeutic use, Humans