Suchergebnisse - "DNA damage"

The Yeast HMGB Protein Hmo1 Is a Multifaceted Regulator of DNA Damage Tolerance.

Autoren: Huo J Wei A Guo N et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 01; Vol. 26 (7). Date of Electronic Publication: 2025 Apr 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage* , Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae Proteins*/chemistry , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , HMGB Proteins*/metabolism , HMGB Proteins*/genetics , High Mobility Group Proteins*/metabolism , High Mobility Group Proteins*/genetics, DNA Repair ; DNA Replication ; Methyl Methanesulfonate/pharmacology ; DNA Damage Tolerance

The DNA damage tolerance factor Rad5 and telomere replication.

Autoren: Mattarocci S; Université Paris-Saclay, Université Paris-Cité, CEA, Institut de biologie François Jacob, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, Inserm, France. stefano.mattarocci@inserm.fr.

Quelle: Current genetics [Curr Genet] 2025 May 26; Vol. 71 (1), pp. 11. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer International Country of Publication: United States NLM ID: 8004904 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0983 (Electronic) Linking ISSN: 01728083 NLM ISO Abbreviation: Curr Genet Subsets: MEDLINE

MeSH-Schlagworte: Telomere*/genetics , Telomere*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae Proteins*/metabolism , DNA Damage* , DNA Replication* , DNA Helicases*/genetics , DNA Helicases*/metabolism, Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; DNA Repair ; DNA Damage Tolerance

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.

Autoren: de Groot D Spanjaard A Shah R et al.

Quelle: Genome biology [Genome Biol] 2024 Dec 31; Vol. 25 (1), pp. 323. Date of Electronic Publication: 2024 Dec 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage* , DNA Replication* , Nucleotidyltransferases*/genetics , Nucleotidyltransferases*/metabolism , Proliferating Cell Nuclear Antigen*/metabolism, Animals ; Mice ; Humans ; Genomic Instability ; Sequence Deletion ; DNA Damage Tolerance ; DNA-Directed DNA Polymerase

Implications of DNA damage response and immunotherapy in tumor therapy.

Autoren: Li W Li B Cai C et al.

Quelle: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Dec 03; Vol. 23 (1), pp. 518. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

MeSH-Schlagworte: Immunotherapy* , DNA Damage* , Neoplasms*/therapy , Neoplasms*/immunology , Neoplasms*/genetics, Humans ; DNA Repair ; Animals

Targeting DNA damage response to enhance cancer immunotherapy efficacy: molecular mechanisms and clinical advances.

Autoren: Tang Z Chen P Xiang B et al.

Quelle: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Dec 03; Vol. 43 (1), pp. 33. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article; Review; Letter

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/immunology , Neoplasms*/therapy , Neoplasms*/genetics , Immunotherapy*/methods , DNA Damage*/drug effects, Humans ; Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Animals ; Molecular Targeted Therapy ; DNA Repair/drug effects

Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damage.

Autoren: Cyran A Ursu GM Krawic C et al.

Quelle: Toxicology [Toxicology] 2025 Dec; Vol. 518, pp. 154277. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH-Schlagworte: Ultraviolet Rays*/adverse effects , DNA Damage*/drug effects , DNA Damage*/radiation effects , DNA Repair*/drug effects , DNA Repair*/radiation effects , Mutagens*/toxicity , Methylmercury Compounds*/toxicity , Mercury Compounds*/toxicity, Humans ; Cricetulus ; Animals ; Keratinocytes/drug effects ; Keratinocytes/radiation effects ; Keratinocytes/metabolism ; CHO Cells ; Mutagenicity Tests ; Micronucleus Tests ; Cricetinae ; Pyrimidine Dimers

Investigation of radiation-induced DNA damage repair-related genes as diagnostic biomarkers for radiation.

Autoren: Zhang Q Yu Y

Quelle: Journal of radiation research [J Radiat Res] 2025 Nov 25; Vol. 66 (6), pp. 652-665.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376611 Publication Model: Print Cited Medium: Internet ISSN: 1349-9157 (Electronic) Linking ISSN: 04493060 NLM ISO Abbreviation: J Radiat Res Subsets: MEDLINE

MeSH-Schlagworte: DNA Repair*/genetics , DNA Repair*/radiation effects , DNA Damage*/radiation effects , DNA Damage*/genetics, Humans ; Gene Regulatory Networks/radiation effects ; Protein Interaction Maps/genetics ; Biomarkers/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Dose-Response Relationship, Radiation

Imaging the time course of DNA damage response at a nonrepetitive endogenous locus.

Autoren: Rybczynski AT Cottle WT Chen PT et al.

Quelle: Cell reports methods [Cell Rep Methods] 2025 Nov 17; Vol. 5 (11), pp. 101219. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE

MeSH-Schlagworte: DNA Repair* , DNA Damage*, Humans ; DNA Breaks, Double-Stranded ; In Situ Hybridization, Fluorescence/methods ; Histones/metabolism ; Histones/genetics ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Tumor Suppressor p53-Binding Protein 1/genetics ; BRCA1 Protein/metabolism ; BRCA1 Protein/genetics ; Time Factors

Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair.

Autoren: Ayna A Caglayan C Taysi S

Quelle: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2025 Nov 11; Vol. 61 (11). Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage*/physiology , DNA Damage*/genetics , DNA Repair*/physiology , DNA Repair*/genetics , Oxidative Stress*/physiology , Oxidative Stress*/genetics, Humans

A novel PARP-ATR dual inhibitor exhibits anti-triple-negative breast cancer activity by inducing excessive DNA damage in the mitotic phase.

Autoren: Wang CC Duan J Mao ND et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117160. Date of Electronic Publication: 2025 Jul 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/pathology , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , Poly(ADP-ribose) Polymerase Inhibitors*/chemistry , Poly(ADP-ribose) Polymerase Inhibitors*/therapeutic use , DNA Damage*/drug effects , DNA Damage*/physiology , Mitosis*/drug effects , Mitosis*/physiology , Ataxia Telangiectasia Mutated Proteins*/antagonists & inhibitors , Ataxia Telangiectasia Mutated Proteins*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays/methods ; Mice, Nude ; Dose-Response Relationship, Drug

DNA damage agents trigger iNKT cell-mediated elimination of AML cells through activation of NF-κB/HLA-DRB6/CD1d pathway.

Autoren: Tu G Wu Q Yuan Y et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117174. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Antigens, CD1d*/metabolism , Antigens, CD1d*/genetics , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/immunology , Leukemia, Myeloid, Acute*/pathology , Natural Killer T-Cells*/drug effects , Natural Killer T-Cells*/metabolism , Natural Killer T-Cells*/immunology , DNA Damage*/drug effects , DNA Damage*/physiology , NF-kappa B*/metabolism, Humans ; Animals ; Mice ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Cell Line, Tumor ; Galactosylceramides/pharmacology ; RNA, Long Noncoding/metabolism ; RNA, Long Noncoding/genetics

Evaluation of DNA damage in long-term paint exposed workers by non-invasive buccal micronucleus assay.

Autoren: Bilinmiş İ Durna S Çetintepe SP et al.

Quelle: Toxicology and industrial health [Toxicol Ind Health] 2025 Oct-Nov; Vol. 41 (10-11), pp. 473-486. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 8602702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0393 (Electronic) Linking ISSN: 07482337 NLM ISO Abbreviation: Toxicol Ind Health Subsets: MEDLINE

MeSH-Schlagworte: Paint*/toxicity , Occupational Exposure*/adverse effects , Occupational Exposure*/analysis , DNA Damage* , Mouth Mucosa*/drug effects, Humans ; Micronucleus Tests ; Adult ; Male ; Middle Aged ; Female ; Case-Control Studies

Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC).

Autoren: Singhania M Sho S Fath MA et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 32-41. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Hydrogen Peroxide*/metabolism , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/genetics , DNA Damage*/drug effects , Ascorbic Acid*/pharmacology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , Ferric Compounds*/pharmacology , Nanoparticles*/chemistry , Ferrosoferric Oxide*/pharmacology, Humans ; Cell Line, Tumor ; Catalase/genetics ; Catalase/metabolism ; A549 Cells ; Oxidation-Reduction

Discovery of hydroxamate derivatives as potent anti-gastric cancer agents via inducing oxidative stress and DNA damage.

Autoren: Xu YC Zhang Y Xue YJ et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118396. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , DNA Damage*/drug effects , Oxidative Stress*/drug effects , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/chemistry , Hydroxamic Acids*/chemical synthesis , Drug Discovery*, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Molecular Structure ; Apoptosis/drug effects ; Animals ; Dose-Response Relationship, Drug ; Mice ; Molecular Docking Simulation ; Cell Line, Tumor

A dual PROTAC nanocarrier amplifies DNA damage and STING activation for cancer immunotherapy.

Autoren: Zhou H Luo X Huang C et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114290. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage* , Membrane Proteins*/metabolism , Nanoparticles*/administration & dosage , Nanoparticles*/chemistry , Neoplasms*/therapy , Neoplasms*/immunology , Immune Checkpoint Inhibitors*/administration & dosage , Drug Carriers*/chemistry, Animals ; Humans ; Immunotherapy/methods ; Mice ; Female ; Cell Line, Tumor ; Liposomes ; Poly (ADP-Ribose) Polymerase-1 ; Transcription Factors ; Cell Cycle Proteins ; Bromodomain Containing Proteins

The insecticide chlorpyrifos leads to genotoxic effects by triggering oxidative stress and apoptosis in Sertoli cells.

Autoren: Aydin Y Kurtel H Cakir E et al.

Quelle: Toxicology and industrial health [Toxicol Ind Health] 2025 Dec; Vol. 41 (12), pp. 550-562. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 8602702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0393 (Electronic) Linking ISSN: 07482337 NLM ISO Abbreviation: Toxicol Ind Health Subsets: MEDLINE

MeSH-Schlagworte: Chlorpyrifos*/toxicity , Sertoli Cells*/drug effects , Sertoli Cells*/metabolism , Oxidative Stress*/drug effects , Apoptosis*/drug effects , Insecticides*/toxicity , DNA Damage*/drug effects, Male ; Animals ; Cell Survival/drug effects ; Cell Line ; Mice ; Malondialdehyde/metabolism

Transcription factor EB inhibition in response to genotoxic stress promotes apoptosis of glioblastoma cells.

Autoren: Park SH Jeong M Kong MJ et al.

Quelle: Neurochemistry international [Neurochem Int] 2025 Dec; Vol. 191, pp. 106087. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE

MeSH-Schlagworte: Glioblastoma*/metabolism , Glioblastoma*/pathology , Glioblastoma*/genetics , Glioblastoma*/drug therapy , Apoptosis*/drug effects , Apoptosis*/physiology , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/antagonists & inhibitors , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/genetics , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/drug therapy , DNA Damage*/physiology , DNA Damage*/drug effects, Humans ; Cell Line, Tumor ; Etoposide/pharmacology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cell Proliferation/drug effects ; Vorinostat

DNA damage in prepared semen is negatively associated with semen quality and fertilisation rate in assisted reproduction technology (ART) treatment.

Autoren: Altakroni B Hunter H Horne G et al.

Quelle: Human fertility (Cambridge, England) [Hum Fertil (Camb)] 2025 Dec; Vol. 28 (1), pp. 2442450. Date of Electronic Publication: 2024 Dec 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100888143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-8149 (Electronic) Linking ISSN: 14647273 NLM ISO Abbreviation: Hum Fertil (Camb) Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage* , Semen Analysis* , Reproductive Techniques, Assisted* , Spermatozoa*, Humans ; Male ; Adult ; Female ; Pregnancy ; Semen ; Fertilization in Vitro

Phosphorylation of RecA at the Loop 1 region modulates its activity in response to DNA damage.

Autoren: Hu J Cao Y Dai J et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 2), pp. 148652. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Rec A Recombinases*/metabolism , Rec A Recombinases*/chemistry , Rec A Recombinases*/genetics , Deinococcus*/metabolism , Deinococcus*/genetics , Deinococcus*/radiation effects , DNA Damage* , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics, Phosphorylation ; DNA, Single-Stranded/metabolism ; DNA Repair ; Protein Binding

Oxidative Stress in DNA Damage and Neurodegenerative Diseases: Unveiling The Mechanisms and Therapeutic Opportunities.

Autoren: Rahman MA Khatun MT Mim AK et al.

Quelle: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Dec; Vol. 83 (4), pp. 4233-4252. Date of Electronic Publication: 2025 Aug 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

MeSH-Schlagworte: Oxidative Stress*/drug effects , DNA Damage* , Neurodegenerative Diseases*/metabolism , Neurodegenerative Diseases*/pathology , Neurodegenerative Diseases*/therapy , Neurodegenerative Diseases*/genetics , Neurodegenerative Diseases*/drug therapy, Humans ; Reactive Oxygen Species/metabolism ; DNA Repair ; Animals ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Mitochondria/metabolism