Výsledky vyhledávání - "DENDRITIC spines"

Single Electrically Induced Epileptic Afterdischarge Triggers Synaptic Weakening, AMPA Receptor Endocytosis, and Shrinkage of Dendritic Spines in the Hippocampus.

Autoři: Crestani AP Zacharias LR Marques DB a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 15969-15977. Date of Electronic Publication: 2025 Jul 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/pathology , Dendritic Spines*/metabolism , Receptors, AMPA*/metabolism , Hippocampus*/pathology , Hippocampus*/physiopathology , Hippocampus*/metabolism , Endocytosis*/physiology , Synapses*/metabolism , Synapses*/pathology , Epilepsy*/physiopathology , Epilepsy*/pathology , Epilepsy*/metabolism, Animals ; Male ; Neuronal Plasticity/physiology ; Rats, Wistar ; Electric Stimulation ; Rats ; Long-Term Synaptic Depression/physiology

Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring.

Autoři: González-Madrid E Rangel-Ramírez MA Opazo MC a další

Zdroj: Scientific reports [Sci Rep] 2025 Nov 26; Vol. 15 (1), pp. 42160. Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/pathology , Dendritic Spines*/metabolism , Hippocampus*/pathology , Hippocampus*/metabolism , Hippocampus*/embryology , Inflammation*/pathology , Hypothyroidism*/pathology , Hypothyroidism*/complications , Thyroxine*/blood , Thyroxine*/deficiency , Prenatal Exposure Delayed Effects*/pathology , Brain*/embryology , Brain*/metabolism , Brain*/pathology , Pregnancy Complications*/pathology, Animals ; Pregnancy ; Female ; Mice ; Placenta/metabolism ; Placenta/pathology ; Interleukin-17/blood ; Interleukin-17/metabolism ; Interleukin-6/blood ; Interleukin-6/metabolism ; Disease Models, Animal ; Male ; Dendritic Cells ; Mice, Inbred C57BL

Perinatal Exposure to Bisphenol A Induces Depressive-Like Behaviors, ERβ Downregulation, and Dendritic Spine Loss in the Medial Amygdala.

Autoři: Jin Y Yu C

Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2025 Nov; Vol. 45 (11), pp. 2344-2352. Date of Electronic Publication: 2025 Jul 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Phenols*/toxicity , Benzhydryl Compounds*/toxicity , Estrogen Receptor beta*/metabolism , Estrogen Receptor beta*/genetics , Prenatal Exposure Delayed Effects*/chemically induced , Dendritic Spines*/drug effects , Dendritic Spines*/pathology , Behavior, Animal*/drug effects , Depression*/chemically induced , Endocrine Disruptors*/toxicity , Amygdala*/drug effects , Amygdala*/pathology , Corticomedial Nuclear Complex*/drug effects , Corticomedial Nuclear Complex*/pathology , Corticomedial Nuclear Complex*/metabolism, Animals ; Female ; Pregnancy ; Male ; Mice, Inbred C57BL ; Mice ; Down-Regulation/drug effects ; Sulfones/toxicity ; Bisphenol A Compounds ; Bisphenol S Compounds

Direct evidence for dendritic spine compensation and regeneration in Alzheimer's disease models.

Autoři: Bhembre N Boskovic Z Willshaw JL a další

Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70829.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/pathology , Dendritic Spines*/physiology , Alzheimer Disease*/pathology , Alzheimer Disease*/physiopathology, Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Amyloid beta-Peptides/metabolism ; Optogenetics ; Neuronal Plasticity/physiology ; Synapses/pathology ; Neurons

Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons.

Autoři: Curtis AJ Zhu J Studniarczyk D a další

Zdroj: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Dec 03; Vol. 45 (49). Date of Electronic Publication: 2025 Dec 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Calcium-Calmodulin-Dependent Protein Kinase Type 2*/genetics , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Dendritic Spines*/metabolism , Dendritic Spines*/physiology , Actinin*/metabolism , Actinin*/genetics , Mutation*/genetics , Neurons*/metabolism , Neurons*/cytology, Animals ; Rats ; Cells, Cultured ; Hippocampus/cytology ; Protein Binding/genetics ; Rats, Sprague-Dawley ; Long-Term Potentiation/physiology

Pathogenic KIF5C mutation disrupts dendritic spine maturation and mitochondrial trafficking in neurodevelopmental disorders.

Autoři: Wang X Ye L Banerjee S a další

Zdroj: Neurobiology of disease [Neurobiol Dis] 2025 Dec; Vol. 217, pp. 107196. Date of Electronic Publication: 2025 Nov 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

Výrazy ze slovníku MeSH: Kinesins*/genetics , Kinesins*/metabolism , Dendritic Spines*/metabolism , Dendritic Spines*/pathology , Mitochondria*/metabolism , Mitochondria*/pathology , Neurodevelopmental Disorders*/genetics , Neurodevelopmental Disorders*/metabolism , Neurodevelopmental Disorders*/pathology, Animals ; Mice ; Mutation ; Hippocampus/metabolism ; Axonal Transport ; Male ; Mice, Transgenic ; Neurons/metabolism ; Excitatory Postsynaptic Potentials/physiology ; Disease Models, Animal ; Female

Transient Photoactivation of Rac1 Induces Persistent Structural LTP Independent of CaMKII in Hippocampal Dendritic Spines.

Autoři: Saneyoshi T Suematsu C Hayashi Y

Zdroj: ENeuro [eNeuro] 2025 Nov 26; Vol. 12 (11). Date of Electronic Publication: 2025 Nov 26 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/physiology , Dendritic Spines*/drug effects , Dendritic Spines*/metabolism , Long-Term Potentiation*/physiology , Long-Term Potentiation*/drug effects , rac1 GTP-Binding Protein*/metabolism , Hippocampus*/physiology , Hippocampus*/cytology , Hippocampus*/drug effects , Hippocampus*/metabolism , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/antagonists & inhibitors , Neuropeptides*/metabolism, Animals ; Male ; Female ; Rats, Sprague-Dawley ; Rats ; p21-Activated Kinases/metabolism ; p21-Activated Kinases/antagonists & inhibitors ; Actins/metabolism ; Animals, Newborn

CaMKII Drives Synaptic Maturation by Coordinating Spine Remodeling and Receptor Segregation via Liquid-Liquid Phase Separation.

Autoři: Kuo LMS Liu PW Arizono M a další

Zdroj: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Nov 26; Vol. 45 (48). Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/genetics , Dendritic Spines*/physiology , Dendritic Spines*/metabolism , Synapses*/physiology , Synapses*/metabolism , Receptors, AMPA*/metabolism , Receptors, N-Methyl-D-Aspartate*/metabolism, Animals ; Rats ; Hippocampus/cytology ; Hippocampus/metabolism ; Cells, Cultured ; Female ; Rats, Sprague-Dawley ; Male ; Phase Separation

Eye Opening Primes Synaptic Maturation by Enhancing AMPA Receptor-Mediated Transmission and Spinogenesis in the Developing Superior Colliculus.

Autoři: Wang J Yan Y Wang X a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 19; Vol. 63 (1), pp. 78. Date of Electronic Publication: 2025 Nov 19.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, AMPA*/metabolism , Superior Colliculi*/growth & development , Superior Colliculi*/metabolism , Superior Colliculi*/ultrastructure , Synaptic Transmission*/physiology , Synapses*/metabolism , Synapses*/ultrastructure , Dendritic Spines*/metabolism , Dendritic Spines*/ultrastructure , Eye*/growth & development, Animals ; Mice, Inbred C57BL ; Mice

Dendritic retraction contributes to spine density recovery following denervation in vitro.

Autoři: Greco D Drakew A Jungenitz T a další

Zdroj: Neurobiology of disease [Neurobiol Dis] 2025 Nov; Vol. 216, pp. 107136. Date of Electronic Publication: 2025 Oct 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/physiology , Dendritic Spines*/pathology , Entorhinal Cortex*/pathology , Dendrites*/physiology , Dendrites*/pathology , Recovery of Function*/physiology , Neurons*/pathology , Neurons*/physiology, Animals ; Mice ; Denervation ; Mice, Inbred C57BL ; Hippocampus/pathology ; Mice, Transgenic ; Organ Culture Techniques ; Neuronal Plasticity/physiology ; Dentate Gyrus

Protein kinase C gamma regulates Purkinje cell dendritic spine development in a mouse model of spinocerebellar ataxia.

Autoři: Sziber Z Torrents-Solé P Kovacevic A a další

Zdroj: Experimental neurology [Exp Neurol] 2025 Nov; Vol. 393, pp. 115377. Date of Electronic Publication: 2025 Jul 16.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Purkinje Cells*/pathology , Purkinje Cells*/enzymology , Dendritic Spines*/pathology , Dendritic Spines*/enzymology , Spinocerebellar Ataxias*/pathology , Spinocerebellar Ataxias*/genetics , Spinocerebellar Ataxias*/enzymology , Protein Kinase C*/genetics , Protein Kinase C*/metabolism , Protein Kinase C*/deficiency, Animals ; Mice ; Disease Models, Animal ; Mice, Knockout ; Mice, Inbred C57BL ; Organ Culture Techniques

SCR Disease Name: Spinocerebellar ataxia 14

A deep learning pipeline for accurate and automated restoration, segmentation, and quantification of dendritic spines.

Autoři: Bernal-Garcia S Schlotter AP Pereira DB a další

Zdroj: Cell reports methods [Cell Rep Methods] 2025 Oct 20; Vol. 5 (10), pp. 101179. Date of Electronic Publication: 2025 Sep 18.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/metabolism , Deep Learning* , Image Processing, Computer-Assisted*/methods, Animals ; Software ; Mice ; Reproducibility of Results

Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses.

Autoři: Kozlov A Blazquez-Llorca L Benavides-Piccione R a další

Zdroj: PLoS computational biology [PLoS Comput Biol] 2025 Oct 09; Vol. 21 (10), pp. e1013569. Date of Electronic Publication: 2025 Oct 09 (Print Publication: 2025).

Způsob vydávání: Journal Article; Comparative Study

Informace o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/physiology , Dendritic Spines*/ultrastructure , Corpus Striatum*/cytology , Corpus Striatum*/physiology , Dendrites*/physiology , Models, Neurological* , Neurons*/cytology , Neurons*/physiology, Humans ; Animals ; Mice ; Computer Simulation ; Computational Biology ; Male

Concussive injuries induce neuronal stress-dependent tau mislocalization to dendritic spines with acrolein and functional network alteration in TBI-on-a-chip.

Autoři: Rogers EA Diorio TC Beauclair T a další

Zdroj: Lab on a chip [Lab Chip] 2025 Oct 07; Vol. 25 (20), pp. 5203-5220. Date of Electronic Publication: 2025 Oct 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE

Výrazy ze slovníku MeSH: Acrolein*/metabolism , tau Proteins*/metabolism , Dendritic Spines*/metabolism , Dendritic Spines*/pathology , Lab-On-A-Chip Devices* , Brain Concussion*/metabolism , Brain Concussion*/pathology , Neurons*/metabolism , Neurons*/pathology, Animals ; Mice ; Oxidative Stress

Activity-induced conversion from dendritic filopodia to spines mediated by NMDA receptor-dependent calcium transients and vesicular exocytosis.

Autoři: Liu HJ Qi L Yin CY a další

Zdroj: The Journal of physiology [J Physiol] 2025 Oct; Vol. 603 (20), pp. 6345-6363. Date of Electronic Publication: 2025 Aug 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, N-Methyl-D-Aspartate*/metabolism , Receptors, N-Methyl-D-Aspartate*/physiology , Pseudopodia*/physiology , Pseudopodia*/metabolism , Exocytosis* , Dendritic Spines*/physiology , Dendritic Spines*/metabolism , Calcium*/metabolism, Animals ; Rats ; Cells, Cultured ; Hippocampus/physiology ; Hippocampus/cytology ; Hippocampus/metabolism ; Receptors, AMPA/metabolism ; Rats, Sprague-Dawley

Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model.

Autoři: Ouellette A O'Connell K Kaczorowski C

Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70728.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Výrazy ze slovníku MeSH: Hippocampus*/metabolism , Hippocampus*/pathology , Dendritic Spines*/pathology , Dendritic Spines*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Alzheimer Disease*/metabolism , Synapses*/pathology , Cognition*/physiology , GTPase-Activating Proteins*/metabolism , GTPase-Activating Proteins*/genetics, Animals ; Disease Models, Animal ; Mice, Transgenic ; Mice ; Neuronal Plasticity/physiology ; Male ; Humans

Retrograde and anterograde trans-synaptic viral tracing of neuronal connections reveals local and distant effects of ischemic stroke on dendritic spines.

Autoři: Van Sprengel M Butterworth J Reeson PL a další

Zdroj: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2025 Oct; Vol. 45 (10), pp. 1891-1904. Date of Electronic Publication: 2025 May 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/pathology , Ischemic Stroke*/pathology , Ischemic Stroke*/physiopathology , Neurons*/pathology , Synapses*/pathology , Stroke*/pathology, Animals ; Somatosensory Cortex/pathology ; Male ; Motor Cortex/pathology ; Dependovirus/genetics

Fisetin ameliorates neurobehavioral deficits in bile duct ligated rat model by restoring spine density and memory gene expression.

Autoři: Gupta S Rishi V Aggarwal A

Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2025 Dec; Vol. 146, pp. 110050. Date of Electronic Publication: 2025 Aug 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Flavonols*/pharmacology , Hepatic Encephalopathy*/drug therapy , Memory*/drug effects , Neuroprotective Agents*/pharmacology , Dendritic Spines*/drug effects, Animals ; Male ; Rats ; Disease Models, Animal ; Rats, Sprague-Dawley ; Ligation ; Maze Learning/drug effects ; Bile Ducts/surgery ; Behavior, Animal/drug effects ; Brain/metabolism ; Brain/drug effects

PKCγ-mediated Phosphorylation of Mtss1 Regulates the Dendritic Outgrowth and Spine Development of Cerebellar Purkinje Cells.

Autoři: Torrents-Solé P Sziber Z Shimobayashi E a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 25; Vol. 63 (1), pp. 168. Date of Electronic Publication: 2025 Nov 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Purkinje Cells*/metabolism , Protein Kinase C*/metabolism , Dendritic Spines*/metabolism , Microfilament Proteins*/metabolism , Cerebellum*/metabolism , Neuronal Outgrowth*/physiology, Animals ; Phosphorylation ; Mice ; Dendrites/metabolism ; Mice, Inbred C57BL

Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines.

Autoři: McCabe KJ Hernández Mesa M Rangamani P

Zdroj: Biophysical journal [Biophys J] 2025 Nov 04; Vol. 124 (21), pp. 3479-3488. Date of Electronic Publication: 2025 Sep 29.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dendritic Spines*/metabolism , Calcium*/metabolism , Models, Biological*, Animals ; Calcium Signaling ; Humans