Search Results - "DECAY"

OsBBI1-targeted OsSUI1 negatively regulates rice immunity through modulating the nonsense-mediated mRNA decay pathway.

Authors: Wang H Yan Y Bi Y et al.

Source: The New phytologist [New Phytol] 2025 Oct; Vol. 248 (2), pp. 835-856. Date of Electronic Publication: 2025 Aug 09.

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

MeSH Terms: Oryza*/immunology , Oryza*/genetics , Oryza*/microbiology , Oryza*/drug effects , Nonsense Mediated mRNA Decay*/genetics , Nonsense Mediated mRNA Decay*/drug effects , Plant Proteins*/metabolism , Plant Proteins*/genetics , Plant Immunity*/genetics , Plant Immunity*/drug effects, Gene Expression Regulation, Plant/drug effects ; Plant Diseases/microbiology ; Plant Diseases/immunology ; Plant Diseases/genetics ; Disease Resistance/genetics ; Mutation/genetics ; Alternative Splicing/genetics ; Chitin/pharmacology ; Ubiquitination

ARID1A gene variants and fetal hydrocephalus: First evidence of mRNA decay escape.

Authors: Tanaka Y Yamada M Miya F et al.

Source: European journal of medical genetics [Eur J Med Genet] 2025 Dec; Vol. 78, pp. 105048. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101247089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0849 (Electronic) Linking ISSN: 17697212 NLM ISO Abbreviation: Eur J Med Genet Subsets: MEDLINE

MeSH Terms: Hydrocephalus*/genetics , Hydrocephalus*/pathology , Transcription Factors*/genetics , DNA-Binding Proteins*/genetics , RNA Stability* , Nonsense Mediated mRNA Decay*, Humans ; Female ; Pregnancy ; Adult ; Frameshift Mutation

Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay.

Authors: Embree CM Paul D Stephanou A et al.

Source: RNA biology [RNA Biol] 2025 Dec; Vol. 22 (1), pp. 1-26. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101235328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8584 (Electronic) Linking ISSN: 15476286 NLM ISO Abbreviation: RNA Biol Subsets: MEDLINE

MeSH Terms: Spliceosomes*/metabolism , Spliceosomes*/genetics , Nonsense Mediated mRNA Decay* , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Gene Expression Regulation*, Humans ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Hep G2 Cells ; Alternative Splicing ; RNA Splicing ; K562 Cells

The role of nonsense-mediated mRNA decay in restricting long noncoding RNA expression has been conserved in RNAi-capable budding yeast.

Authors: Wery M Szachnowski U Creux C et al.

Source: RNA (New York, N.Y.) [RNA] 2025 Nov 17; Vol. 31 (12), pp. 1886-1900. Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , RNA Interference* , Saccharomycetales*/genetics , Saccharomycetales*/metabolism, Gene Expression Regulation, Fungal ; Saccharomyces cerevisiae/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; Mutation ; RNA Helicases/genetics

Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer.

Authors: Pan H Wu X Hu B et al.

Source: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Nov 11; Vol. 23 (1), pp. 489. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/metabolism, Humans ; Animals ; RNA, Messenger/metabolism ; RNA, Messenger/genetics

Smg5 Enhances Oligodendrocyte Differentiation via Nonsense-Mediated mRNA Decay of Hnrnpl Variant Transcripts.

Authors: Jiang M Li C Xie B et al.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Oct 22; Vol. 45 (43). Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH Terms: Oligodendroglia*/metabolism , Oligodendroglia*/cytology , Oligodendroglia*/physiology , Nonsense Mediated mRNA Decay*/physiology , Cell Differentiation*/physiology , Cell Differentiation*/genetics, Animals ; Mice ; Male ; Female ; Mice, Knockout ; Myelin Sheath/metabolism ; Mice, Inbred C57BL

The dynamic interactions between virus infections and nonsense-mediated decay.

Authors: van der Klugt T van Gent M

Source: Human molecular genetics [Hum Mol Genet] 2025 Oct 07; Vol. 34 (R1), pp. R3-R10.

Publication Type: Journal Article; Review

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Virus Diseases*/genetics , Virus Diseases*/virology , Host-Pathogen Interactions*/genetics, Humans ; Virus Replication/genetics ; RNA, Viral/genetics ; Animals ; RNA Stability

Integrative and accurate annotations enhance current nonsense-mediated mRNA decay rules.

Authors: Iha H Kikutake C Suyama M

Source: Nucleic acids research [Nucleic Acids Res] 2025 Nov 26; Vol. 53 (22).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Codon, Nonsense*/genetics , Molecular Sequence Annotation*/methods , RNA, Messenger*/genetics , RNA, Messenger*/metabolism, Humans ; Genome, Human ; Transcriptome ; Protein Biosynthesis

Start Right to End Right: Authentic Open Reading Frame Selection Matters for Nonsense-Mediated Decay Target Identification.

Authors: Bagherian M Harris G Sathishkumar P et al.

Source: Genes [Genes (Basel)] 2025 Nov 01; Vol. 16 (11). Date of Electronic Publication: 2025 Nov 01.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Open Reading Frames*/genetics , Arabidopsis*/genetics , Codon, Initiator*/genetics, Molecular Sequence Annotation/methods ; Transcriptome/genetics ; Arabidopsis Proteins/genetics ; Codon, Nonsense/genetics

UPF1 inhibits cervical cancer cell migration and invasion by regulating nonsense-mediated decay of BMP6 and lncRNA WAKMAR2 .

Authors: Abudourexiti G Zhang J Abuduxikuer G

Source: Journal of gynecologic oncology [J Gynecol Oncol] 2025 Nov; Vol. 36 (6), pp. e127. Date of Electronic Publication: 2025 Jun 23.

Publication Type: Journal Article

Journal Info: Publisher: Asian Society of Gynecologic Oncology Country of Publication: Korea (South) NLM ID: 101483150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2005-0399 (Electronic) Linking ISSN: 20050380 NLM ISO Abbreviation: J Gynecol Oncol Subsets: MEDLINE

MeSH Terms: Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , RNA Helicases*/genetics , RNA Helicases*/metabolism , Trans-Activators*/genetics , Trans-Activators*/metabolism , Nonsense Mediated mRNA Decay*, Humans ; Female ; Cell Movement/genetics ; Animals ; Mice ; Neoplasm Invasiveness/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Mice, Nude ; Cell Proliferation/genetics ; Down-Regulation

Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders.

Authors: Montazaribarforoushi S Jolly LA

Source: Current opinion in genetics & development [Curr Opin Genet Dev] 2025 Oct; Vol. 94, pp. 102394. Date of Electronic Publication: 2025 Aug 06.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9111375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0380 (Electronic) Linking ISSN: 0959437X NLM ISO Abbreviation: Curr Opin Genet Dev Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Neurodevelopmental Disorders*/genetics , Neurodevelopmental Disorders*/pathology , RNA, Messenger*/genetics, Humans ; Animals ; Codon, Nonsense/genetics

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome.

Authors: Boehm V Wallmeroth D Wulf PO et al.

Source: Molecular cell [Mol Cell] 2025 Sep 18; Vol. 85 (18), pp. 3524-3546.e12. Date of Electronic Publication: 2025 Sep 10.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Trans-Activators*/genetics , Trans-Activators*/metabolism , RNA Helicases*/genetics , RNA Helicases*/metabolism , Transcriptome* , RNA, Messenger*/genetics , RNA, Messenger*/metabolism, Humans ; Alternative Splicing ; HEK293 Cells ; HeLa Cells ; Ribosomes/metabolism ; Ribosomes/genetics

Nonsense-Mediated mRNA Decay in Human Health and Diseases: Current Understanding, Regulatory Mechanisms and Future Perspectives.

Authors: Behera A Panigrahi GK Sahoo A

Source: Molecular biotechnology [Mol Biotechnol] 2025 Sep; Vol. 67 (9), pp. 3374-3390. Date of Electronic Publication: 2024 Sep 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Neoplasms*/genetics , RNA, Messenger*/genetics , RNA, Messenger*/metabolism, Humans ; Codon, Nonsense/genetics ; Alternative Splicing

Nonsense-Mediated mRNA Decay: Mechanisms and Recent Implications in Cardiovascular Diseases.

Authors: Hassan FO Hoque MM Majid A et al.

Source: Cells [Cells] 2025 Aug 19; Vol. 14 (16). Date of Electronic Publication: 2025 Aug 19.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Cardiovascular Diseases*/genetics, Humans ; Animals ; Gene Expression Regulation ; Codon, Nonsense/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

Inhibiting UPF1 methylation enhances tumor immunotherapy sensitivity by reducing nonsense-mediated mRNA decay.

Authors: Zhu S Bai Y Zhang D et al.

Source: Cell reports [Cell Rep] 2025 Jul 22; Vol. 44 (7), pp. 115919. Date of Electronic Publication: 2025 Jun 25.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , RNA Helicases*/metabolism , RNA Helicases*/genetics , Immunotherapy*/methods , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/therapy , Colorectal Neoplasms*/pathology , Trans-Activators*/metabolism , Trans-Activators*/genetics, Animals ; Humans ; Mice ; Methylation ; Cell Line, Tumor ; Female ; Microsatellite Instability

Effects of heterozygous SMG1 mutations on nonsense-mediated mRNA decay in human pluripotent stem cell model.

Authors: Lee C Lee JS Kwon Y et al.

Source: Molecules and cells [Mol Cells] 2025 Jul; Vol. 48 (7), pp. 100225. Date of Electronic Publication: 2025 May 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9610936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0219-1032 (Electronic) Linking ISSN: 10168478 NLM ISO Abbreviation: Mol Cells Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Mutation*/genetics , Pluripotent Stem Cells*/metabolism , Protein Serine-Threonine Kinases*/genetics, Humans ; Heterozygote ; Male

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals.

Authors: Palou-Márquez G Supek F

Source: Genome biology [Genome Biol] 2025 Sep 29; Vol. 26 (1), pp. 316. Date of Electronic Publication: 2025 Sep 29.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay* , Neoplasms*/genetics, Humans ; Codon, Nonsense ; Transcriptome ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Organ Specificity ; DNA Copy Number Variations

Predicting nonsense-mediated mRNA decay from splicing events in sepsis using RNA-sequencing data.

Authors: Shin J Fredericks AM Armstead BE et al.

Source: Life science alliance [Life Sci Alliance] 2025 Sep 24; Vol. 8 (12). Date of Electronic Publication: 2025 Sep 24 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay*/genetics , Sepsis*/genetics , Alternative Splicing*/genetics , RNA Splicing*/genetics, Humans ; Sequence Analysis, RNA/methods ; Codon, Nonsense/genetics ; RNA, Messenger/genetics ; Male ; Female ; Critical Illness ; Gene Expression Profiling ; Middle Aged

LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells.

Authors: Yang Z Meng Z Liu S et al.

Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Sep 22; Vol. 13 (9). Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

MeSH Terms: Nonsense Mediated mRNA Decay* , Histocompatibility Antigens Class I*/genetics , Histocompatibility Antigens Class I*/metabolism , Neoplasms*/genetics , Neoplasms*/immunology , Nucleocytoplasmic Transport Proteins*/metabolism , Nucleocytoplasmic Transport Proteins*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor

A novel homozygous frameshift mutation likely causing nonsense-mediated mRNA decay in an Algerian kindred with CD19 complex deficiency.

Authors: Belaid B Chan KW Lamara Mahammed L et al.

Source: Frontiers in immunology [Front Immunol] 2025 Sep 05; Vol. 16, pp. 1634146. Date of Electronic Publication: 2025 Sep 05 (Print Publication: 2025).

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Antigens, CD19*/genetics , Antigens, CD19*/immunology , Frameshift Mutation* , Nonsense Mediated mRNA Decay*/genetics, Child ; Female ; Humans ; Male ; Algeria ; B-Lymphocytes/immunology ; Homozygote ; Pedigree ; Infant