Výsledky vyhľadávania - "Cytochrome P-450 Enzyme System/metabolism"

Evaluating Drug–Drug Interaction Risk Associated with Peptide Analogs Using advanced In Vitro Systems

Autori: Rune Aa. Nørgaard Deepak K. Bhatt Erkka Järvinen a ďalší

Zdroj: Nørgaard, R A, Bhatt, D K, Järvinen, E, Stage, T B, Gabel-Jensen, C, Galetin, A & Säll, C 2024, 'Evaluating drug-drug interaction risk associated with peptide analogues using advanced in vitro systems', Drug Metabolism and Disposition, vol. 52, no. 9. https://doi.org/10.1124/dmd.123.001441

Predmety: Peptides/pharmacology, 0301 basic medicine, Cultured, Cytochrome P-450 Enzyme System/metabolism, Cells, Multidrug Resistance-Associated Protein 2, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Liver, Liver/drug effects, Spheroids, Cellular, Hepatocytes, Humans, Drug Interactions, Spheroids, Hepatocytes/drug effects, Peptides, Cells, Cultured, Cellular/drug effects

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38050097
https://research.manchester.ac.uk/en/publications/2b2ec7dc-5017-45c0-9c3d-735bae094941
https://doi.org/10.1124/dmd.123.001441

Effects of Chemicals in Reporter Gene Bioassays with Different Metabolic Activities Compared to Baseline Toxicity

Autori: Julia Huchthausen Jenny Braasch Beate I. Escher a ďalší

Zdroj: Chem Res Toxicol

Predmety: Genes, Reporter [MeSH], Article, Toxicity Tests [MeSH], Humans [MeSH], Cell Line [MeSH], Cell Survival/drug effects [MeSH], Biological Assay [MeSH], Animals [MeSH], Cytochrome P-450 Enzyme System/metabolism [MeSH], Cytochrome P-450 Enzyme System, Genes, Reporter, Cell Survival, Toxicity Tests, Humans, Animals, Biological Assay, Cell Line

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38652132
https://repository.publisso.de/resource/frl:6480717

The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice

Autori: Yntema, Tess Eijgenraam, Tim R Kloosterhuis, Niels J a ďalší

Zdroj: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Predmety: Liver/metabolism, Male, Hypercholesterolemia/genetics, Cytochrome P-450 Enzyme System/metabolism, Proprotein Convertase 9/genetics, Knockout, Science, Hypercholesterolemia, Bile Acids and Salts/metabolism, Cholesterol/blood, Article, Bile Acids and Salts, Mice, Cytochrome P-450 Enzyme System, Animals, Humans, Mice, Knockout, Western/adverse effects, Animal, Atherosclerosis, Diet, Disease Models, Animal, Atherosclerosis/genetics, Cholesterol, Liver, Diet, Western, Disease Models, Medicine, Proprotein Convertase 9

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39815082
https://doaj.org/article/04486e662d07451d8028e1be925691c4

Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells

Autori: Leonie T. D. Würger Jimmy Alarcan Albert Braeuning

Zdroj: Arch Toxicol

Predmety: Mammals, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Cytochrome P-450 Enzyme System, Liver, Okadaic Acid, Animals, Humans, Receptors, Cytoplasmic and Nuclear, Marine Toxins, Review Article, Receptors, Cytoplasmic and Nuclear [MeSH], Drug metabolism, Liver [MeSH], Humans [MeSH], Nuclear receptors, CYP, Mammals/metabolism [MeSH], Animals [MeSH], Marine Toxins/toxicity [MeSH], Cytochrome P-450 Enzyme System/metabolism [MeSH], Okadaic acid, Okadaic Acid [MeSH]

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38416141
https://repository.publisso.de/resource/frl:6492751

Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4

Autori: Matteo Rosellini Ejlal A. Omer Alicia Schulze a ďalší

Prispievatelia: Matteo Rosellini Ejlal A. Omer Alicia Schulze a ďalší

Zdroj: Arch Toxicol

Predmety: 0301 basic medicine, 0303 health sciences, Microplastics, Hep G2 Cells, Molecular Docking Simulation [MeSH], Female [MeSH], Ecotoxicity, Hepatotoxicity, Plastics/toxicity [MeSH], Environmental pollution, Humans [MeSH], In Vitro Systems, Microplastics [MeSH], Marine pollution, Hep G2 Cells [MeSH], RNA-sequencing, Cytochrome P-450 Enzyme System/metabolism [MeSH], Cytochrome P-450 Enzyme System/genetics [MeSH], Microplastic, Cresols [MeSH], Cytotoxicity, Transcriptome [MeSH], Pregnancy [MeSH], Cytochrome P-450 CYP3A/metabolism [MeSH], 570 Life sciences, 3. Good health, Molecular Docking Simulation, Cresols, 03 medical and health sciences, Cytochrome P-450 Enzyme System, Pregnancy, 13. Climate action, Humans, Cytochrome P-450 CYP3A, Female, ddc:570, Transcriptome, Plastics, 570 Biowissenschaften

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38160208
https://repository.publisso.de/resource/frl:6517484

Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers

Autori: Felicitas Stoll Antje Blank Gerd Mikus a ďalší

Zdroj: Eur J Drug Metab Pharmacokinet

Predmety: Area Under Curve [MeSH], Pharmaceutical Preparations [MeSH], Cytochrome P-450 CYP2D6/genetics [MeSH], Humans [MeSH], Midazolam [MeSH], Hydroxychloroquine/therapeutic use [MeSH], Yohimbine [MeSH], Cytochrome P-450 CYP2D6/metabolism [MeSH], Cytochrome P-450 Enzyme System/metabolism [MeSH], Hydroxychloroquine/pharmacology [MeSH], Medical and Health Sciences, Pantoprazole/pharmacology [MeSH], Drug Interactions [MeSH], Healthy Volunteers [MeSH], Original Research Article, Cytochrome P-450 CYP3A/metabolism [MeSH], Midazolam, Yohimbine, Healthy Volunteers, Cytochrome P-450 CYP2D6, Cytochrome P-450 Enzyme System, Pharmaceutical Preparations, Area Under Curve, Humans, Cytochrome P-450 CYP3A, Drug Interactions, Pantoprazole, Hydroxychloroquine

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38114885
https://repository.publisso.de/resource/frl:6484887

Integrative multi-omics data provide insights into the biosynthesis of furanocoumarins and mechanisms regulating their accumulation in Angelica dahurica

Autori: Ji, Jiaojiao Han, Xiaoxu Zang, Lanlan a ďalší

Predmety: Angelica - genetics, Angelica - growth & development, Angelica - metabolism, Biosynthetic Pathways, Cytochrome P-450 Enzyme System - genetics, Cytochrome P-450 Enzyme System - metabolism, Furocoumarins - biosynthesis, Furocoumarins - metabolism, Gene Expression Regulation, Plant, Multiomics, Plant Proteins - genetics, Plant Proteins - metabolism, Plant Roots - genetics, Plant Roots - growth & development, Plant Roots - metabolism

Popis súboru: pdf

Relation: ispartof: Communications biology issue 1 vol 8; WOS:001473841700005; 991005765128807891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12176899740007891/13176899730007891; alma:61MUN_INST/bibs/991005765128807891

Dostupnosť: https://doi.org/10.1038/s42003-025-08076-x
https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Integrative-multi-omics-data-provide-insights-into/991005765128807891
https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12176899740007891/13176899730007891

Differences in constitutive gene expression of cytochrome P450 enzymes and ATP-binding cassette transporter gene expression between a susceptible and a highly macrocyclic lactone-resistant Haemonchus contortus isolate in the absence of drug-inducible expression

Autori: Jakobs, Natalie Andreotti, Sandro Ramünke, Sabrina a ďalší

Zdroj: Parasit Vectors
Parasites & Vectors, Vol 17, Iss 1, Pp 1-19 (2024)

Predmety: 0301 basic medicine, Landwirtschaft und verwandte Bereiche, Drug Resistance, Gene Expression, Cytochrome P450, Infectious and parasitic diseases, RC109-216, Lactones, 03 medical and health sciences, Cytochrome P-450 Enzyme System, Haemonchus contortus, ATP-binding cassette transporter, Animals, P-Glycoproteins, Phylogeny, Anthelmintic resistance, Anthelmintics, Macrocyclic lactones, 0303 health sciences, Ivermectin, Sheep, Research, Metabolism, Larva, Haemonchus, ATP-Binding Cassette Transporters, Macrolides, Gene expression, Lactones/pharmacology [MeSH], Larva/drug effects [MeSH], Gene Expression [MeSH], Sheep [MeSH], Ivermectin/pharmacology [MeSH], Cytochrome P-450 Enzyme System/metabolism [MeSH], ATP-Binding Cassette Transporters/metabolism [MeSH], Haemonchus/drug effects [MeSH], Haemonchiasis/parasitology [MeSH], Larva/genetics [MeSH], Anthelmintics/pharmacology [MeSH], Drug Resistance/genetics [MeSH], ATP-Binding Cassette Transporters/genetics [MeSH], Haemonchus/genetics [MeSH], Animals [MeSH], Phylogeny [MeSH], Haemonchiasis/veterinary [MeSH], Macrolides/pharmacology [MeSH], Cytochrome P-450 Enzyme System/genetics [MeSH], RNA sequencing, Haemonchus/enzymology [MeSH], Haemonchiasis

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39668355
https://doaj.org/article/8263fc4eb6e347e2aef187bb82a147e9
https://repository.publisso.de/resource/frl:6493053

Flucloxacillin Is a Weak Inducer of CYP3A4 in Healthy Adults and 3D Spheroid of Primary Human Hepatocytes

Autori: Ditte B. Iversen Ann‐Cathrine Dalgård Dunvald Daniel M. Jespersen a ďalší

Zdroj: Clinical Pharmacology & Therapeutics. 114:434-445

Predmety: Adult, Cytochrome P-450 Enzyme System/metabolism, Messenger, Hepatocytes/metabolism, Floxacillin, 3. Good health, Cytochrome P-450 CYP3A/genetics, Cytochrome P-450 Enzyme System, Floxacillin/pharmacology, Hepatocytes, RNA, Humans, Cytochrome P-450 CYP3A, Drug Interactions, RNA, Messenger

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37235733
https://portal.findresearcher.sdu.dk/da/publications/8aeb09bc-82ad-4863-bf5f-9b104a292877
https://doi.org/10.1002/cpt.2959

Evaluation of important human CYP450 isoforms and P‐glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after intensifying treatment regimen using Geneva cocktail

Autori: Neyshaburinezhad, Navid Shirzad, Nooshin Rouini, Mohammadreza a ďalší

Zdroj: Basic & Clinical Pharmacology & Toxicology. 132:485-497

Predmety: 0301 basic medicine, ATP Binding Cassette Transporter, Subfamily B, Genotype, Cytochrome P-450 CYP3A / genetics, Cytochrome P-450 Enzyme System / metabolism, Cytochrome P-450 CYP3A / metabolism, Cytochrome P-450 CYP2C9 / metabolism, 03 medical and health sciences, Cytochrome P-450 Enzyme System, ATP Binding Cassette Transporter, Subfamily B / genetics, Humans, Cytochrome P-450 CYP3A, Protein Isoforms, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cytochrome P-450 CYP2C9, Inflammation, 0303 health sciences, CYP450 phenotype and genotype, Protein Isoforms / metabolism, Type 2 diabetes, Personalized medicine, 3. Good health, Phenoconversion, Cytochrome P-450 Enzyme System / genetics, ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics, Phenotype, Diabetes Mellitus, Type 2, Protein Isoforms / genetics, Cytochrome P-450 CYP2C9 / genetics, Diabetes Mellitus, Type 2 / drug therapy

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36734157

Resistance of Anopheles gambiae s.s. against commonly used insecticides and implication of cytochrome P450 monooxygenase in resistance to pyrethroids in Lambaréné (Gabon)

Autori: Boussougou-Sambe, Stravensky Térence Djida, Ynous Doumba-Ndalembouly, Ange Gatien a ďalší

Zdroj: BMC Infect Dis
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-9 (2024)
BMC Infectious Diseases, 24, 1, pp. 1221

Predmety: Mosquito Vectors/genetics [MeSH], Nitriles/pharmacology [MeSH], Insecticide Resistance [MeSH], Larva/drug effects [MeSH], Gabon [MeSH], Cytochrome P-450 Enzyme System/metabolism [MeSH], Permethrin/pharmacology [MeSH], Resistance intensity, Larva/genetics [MeSH], Anopheles/genetics [MeSH], Voltage-Gated Sodium Channels/metabolism [MeSH], Anopheles/drug effects [MeSH], Female [MeSH], Pyrethroids, Voltage-Gated Sodium Channels/genetics [MeSH], Insecticides/pharmacology [MeSH], Anopheles/enzymology [MeSH], Acetylcholinesterase/genetics [MeSH], Animals [MeSH], Cytochrome P-450 Enzyme System/genetics [MeSH], Piperonyl Butoxide/pharmacology [MeSH], Research, Mosquito Vectors/drug effects [MeSH], Cytochrome p450, Acetylcholinesterase/metabolism [MeSH], Pyrethrins/pharmacology [MeSH], Mosquito Vectors/enzymology [MeSH], Gabon, Medical Microbiology - Radboud University Medical Center, A. gambiae s.s, Insecticides, Piperonyl Butoxide, Infectious and parasitic diseases, RC109-216, Mosquito Vectors, Voltage-Gated Sodium Channels, Insecticide Resistance, Cytochrome P-450 Enzyme System, Larva, Anopheles, Nitriles, Pyrethrins, Acetylcholinesterase, Animals, Female, Permethrin

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39478447
https://doaj.org/article/e268cf8364f5431ca8df0c984a9957db
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/313726
https://hdl.handle.net/2066/313726
https://repository.ubn.ru.nl//bitstream/handle/2066/313726/313726.pdf
https://repository.publisso.de/resource/frl:6521954

St. John's wort extract with a high hyperforin content does not induce P‐glycoprotein activity at the human blood–brain barrier

Autori: El Biali, Myriam Wölfl-Duchek, Michael Jackwerth, Matthias a ďalší

Zdroj: Clin Transl Sci
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)

Predmety: 301205 Pharmakokinetik, Male, Adult, Blood-Brain Barrier / metabolism, ATP Binding Cassette Transporter, Subfamily B, 301212 Clinical pharmacy, ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism, Cytochrome P-450 Enzyme System / metabolism, Hypericum / chemistry, 301205 Pharmacokinetics, RM1-950, Phloroglucinol, Young Adult, Bridged Bicyclo Compounds, Cytochrome P-450 Enzyme System, Humans, 301212 Klinische Pharmazie, ATP Binding Cassette Transporter, Subfamily B, Member 1, Positron-Emission Tomography / methods, Plant Extracts, Terpenes, Blood-Brain Barrier / drug effects, Articles, Healthy Volunteers, 301215 Drug safety, 3. Good health, Plant Extracts / pharmacology, ATP Binding Cassette Transporter, Subfamily B / metabolism, 301215 Arzneimittelsicherheit, Blood-Brain Barrier, Positron-Emission Tomography, Female, Therapeutics. Pharmacology, Terfenadine, Public aspects of medicine, RA1-1270, Hypericum

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38700454
https://doaj.org/article/bfdf145153d8476faf6df062d6d1d5d8
https://archive-ouverte.unige.ch/unige:178286
https://doi.org/10.1111/cts.13804

Drug metabolism and drug transport of the 100 most prescribed oral drugs

Autori: Ditte B. Iversen Nanna Elman Andersen Ann‐Cathrine Dalgård Dunvald a ďalší

Zdroj: Basic Clin Pharmacol Toxicol

Predmety: Member 2, 0301 basic medicine, drug transport, Cytochrome P-450 CYP2C8/metabolism, CYP3A4, Cytochrome P-450 Enzyme System/metabolism, ATP Binding Cassette Transporter, Subfamily G, Cytochrome P-450 CYP2C8, 03 medical and health sciences, 0302 clinical medicine, Membrane Transport Proteins/metabolism, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP1A2, Microsomes, Cytochrome P-450 CYP2C19/metabolism, Neoplasm Proteins/metabolism, ATP Binding Cassette Transporter, Subfamily G, Member 2, Cytochrome P-450 CYP3A, Member 1/metabolism, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP2D6/metabolism, MINI REVIEWS, Cytochrome P-450 CYP3A/metabolism, Membrane Transport Proteins, drug metabolism, Neoplasm Proteins, 3. Good health, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2C9/metabolism, Subfamily B, Liver, Cytochrome P-450 CYP2D6, ADME, Cytochrome P-450 CYP1A2/metabolism, Microsomes, Liver, P-gp

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35972991
https://portal.findresearcher.sdu.dk/da/publications/0a99b91e-219a-4880-a119-159162a84f34
https://doi.org/10.1111/bcpt.13780

Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis

Autori: Damoiseaux, David Schinkel, Alfred H Beijnen, Jos H a ďalší

Prispievatelia: Damoiseaux, David Schinkel, Alfred H Beijnen, Jos H a ďalší

Predmety: Animals, Cytochrome P-450 CYP3A/metabolism, Cytochrome P-450 Enzyme System/metabolism, Drug Interactions, Humans, Mice, Transgenic, Models, Animal, General Biochemistry,Genetics and Molecular Biology, General Neuroscience, Pharmacology, Toxicology and Pharmaceutics(all), Meta-Analysis, Journal Article, Review

Popis súboru: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/451806

Dostupnosť: https://dspace.library.uu.nl/handle/1874/451806

Organ-specific electrophile responsivity mapping in live C. elegans.

Autori: Liu, J. Kulkarni, A. Gao, Y.Q. a ďalší

Zdroj: Cell, vol. 187, no. 26, pp. 7450-7469.e29

Predmety: Caenorhabditis elegans/metabolism, Animals, Caenorhabditis elegans Proteins/metabolism, Cysteine/metabolism, Organ Specificity, Cytochrome P-450 Enzyme System/metabolism, Humans, Stress, Physiological, 4-hydroxynonenal, C. elegans, cytochrome P450, function-guided spatial mapping, organ-specific responsivity profiling, proximity labeling proteomics, reactive metabolite signaling, tissue-specific stress response

Popis súboru: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/39504959; info:eu-repo/semantics/altIdentifier/eissn/1097-4172; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_1CF6F7E9AF784; https://serval.unil.ch/notice/serval:BIB_1CF6F7E9AF78; https://serval.unil.ch/resource/serval:BIB_1CF6F7E9AF78.P001/REF.pdf

Dostupnosť: https://serval.unil.ch/notice/serval:BIB_1CF6F7E9AF78
https://doi.org/10.1016/j.cell.2024.10.014
https://serval.unil.ch/resource/serval:BIB_1CF6F7E9AF78.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_1CF6F7E9AF784

Impact of SARS-CoV-2 infection (COVID-19) on cytochromes P450 activity assessed by the Geneva cocktail

Autori: Youssef Daali Camille Lenoir François Curtin a ďalší

Zdroj: Clin Pharmacol Ther
Clinical Pharmacology & Therapeutics, 110 (5)

Predmety: Male, COVID-19 / blood, Cytochrome P-450 Enzyme System / metabolism, Interleukin-6 / blood, 03 medical and health sciences, Tumor Necrosis Factor-alpha / blood, 0302 clinical medicine, Cytochrome P-450 Enzyme System, COVID-19 / enzymology, Humans, Prospective Studies, Aged, Aged, 80 and over, Interleukin-6, Tumor Necrosis Factor-alpha, Research, COVID-19, Genetic Variation, Middle Aged, Models, Theoretical, Cytochrome P-450 Enzyme System / genetics, 3. Good health, C-Reactive Protein / metabolism, C-Reactive Protein, Linear Models, Female

Popis súboru: application/pdf; application/application/pdf

Prístupová URL adresa: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpt.2412
https://pubmed.ncbi.nlm.nih.gov/34473836
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2412
https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/es/covidwho-1384149
https://www.research-collection.ethz.ch/handle/20.500.11850/507677
https://pubmed.ncbi.nlm.nih.gov/34473836/
https://archive-ouverte.unige.ch/unige:161947
https://doi.org/10.1002/cpt.2412
http://hdl.handle.net/20.500.11850/507677

Cytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state-of-the-art review

Autori: Ann-Kathrin Loerracher Thomas Braunbeck

Zdroj: Arch Toxicol

Predmety: Mammals, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Embryo, Nonmammalian, Cytochrome P-450 Enzyme System, 13. Climate action, Xenobiotic metabolism, Zebrafish Proteins/genetics [MeSH], Biotransformation, Biotransformation [MeSH], Zebrafish, Review Article, Embryo, Nonmammalian/metabolism [MeSH], Ecotoxicology, Mammals/metabolism [MeSH], Animals [MeSH], Cytochrome P-450 Enzyme System/metabolism [MeSH], Cytochrome P-450 Enzyme System/genetics [MeSH], Zebrafish [MeSH], Embryo, Toxicology, Cytochrome P450, Animals, Zebrafish Proteins

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00204-021-03071-7.pdf
https://pubmed.ncbi.nlm.nih.gov/34148099
https://link.springer.com/article/10.1007/s00204-021-03071-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241672/
https://link.springer.com/content/pdf/10.1007/s00204-021-03071-7.pdf
https://pubmed.ncbi.nlm.nih.gov/34148099/
https://europepmc.org/article/MED/34148099
https://repository.publisso.de/resource/frl:6451681

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

Autori: Katariya, Mona M Snee, Matthew Tunnicliffe, Richard B a ďalší

Prispievatelia: Katariya, Mona M Snee, Matthew Tunnicliffe, Richard B a ďalší

Zdroj: Chemistry
Katariya, M M, Snee, M, Tunnicliffe, R B, Kavanagh, M E, Boshoff, H I M, Amadi, C N, Levy, C W, Munro, A W, Abell, C, Leys, D, Coyne, A G & McLean, K J 2023, 'Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis', Chemistry: A European Journal, vol. 29, no. 29, e202203868. https://doi.org/10.1002/chem.202203868

Predmety: cytochrome P450 enzymes, Cytochrome P-450 Enzyme System/metabolism, drug design, Inhibitors, structure-activity relationships, Antitubercular Agents, Mycobacterium tuberculosis, 01 natural sciences, Drug design, 0104 chemical sciences, 3. Good health, Cholesterol, Cytochrome P-450 Enzyme System, tuberculosis, Cholesterol/chemistry, inhibitors, Drug Discovery, Cytochrome P450 Enzymes, Research Articles, Antitubercular Agents/pharmacology

Popis súboru: application/pdf; text/xml

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36912255
http://www.scopus.com/inward/record.url?scp=85152365252&partnerID=8YFLogxK
https://www.mendeley.com/catalogue/a6acba9e-a4a9-3748-a562-6fb2a73fe5fe/
https://doi.org/10.1002/chem.202203868
https://research.manchester.ac.uk/en/publications/5882106e-b17e-4b0b-bbea-f13794652dee
https://www.repository.cam.ac.uk/handle/1810/348581
https://doi.org/10.1002/chem.202203868
https://doi.org/10.17863/cam.96009
https://www.repository.cam.ac.uk/handle/1810/347549
https://doi.org/10.1002/chem.202203868
https://doi.org/10.17863/cam.94964

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Autori: Al-Majdoub, Zubida Couto, Narciso Achour, Brahim a ďalší

Zdroj: Clin Pharmacol Ther
Al-Majdoub, Z, Couto, N, Achour, B, Harwood, M D, Carlson, G, Warhurst, G, Barber, J & Rostami-Hodjegan, A 2021, 'Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics', Clinical Pharmacology & Therapeutics, vol. 109, no. 4, pp. 1136-1146. https://doi.org/10.1002/cpt.2097

Predmety: Proteomics, 0301 basic medicine, Cytochrome P-450 Enzyme System/metabolism, Transferases/metabolism, Models, Biological, Xenobiotics, 03 medical and health sciences, Ileum/metabolism, Thioredoxins, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Models, Ileum, Transferases, Xenobiotics/pharmacokinetics, Humans, Intestinal Mucosa, Tight Junction Proteins, Research, Proteins, Thioredoxins/metabolism, Biological, Alkaline Phosphatase, Enzymes/metabolism, Enzymes, Jejunum, Alkaline Phosphatase/metabolism, Oxygenases, Proteins/metabolism, Tight Junction Proteins/metabolism, Oxygenases/metabolism, Jejunum/metabolism, Intestinal Mucosa/metabolism

Prístupová URL adresa: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpt.2097
https://pubmed.ncbi.nlm.nih.gov/33113152
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048492
https://www.research.manchester.ac.uk/portal/en/publications/quantification-of-proteins-involved-in-intestinal-epithelial-handling-of-xenobiotics(0c296352-0be7-45cb-bc4e-6ea13e7cb3ee).html
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2097
https://europepmc.org/article/PMC/PMC8048492

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

Autori: Agnieszka Grybos‐Gajniak Amin Rostami-Hodjegan Jeoffrey Schageman a ďalší

Zdroj: Clin Pharmacol Ther
Achour, B, Al-Majdoub, Z, Grybos-Gajniak, A, Lea, K, Kilford, P, Zhang, M, Knight, D, Barber, J, Schageman, J & Rostami-Hodjegan, A 2021, 'Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters', Clinical Pharmacology & Therapeutics, vol. 109, no. 1, pp. 222-232. https://doi.org/10.1002/cpt.2102

Predmety: Liver/metabolism, Adult, Male, 0301 basic medicine, Cytochrome P-450 Enzyme System/metabolism, Metabolic Clearance Rate, Exosomes, Inactivation, Metabolic Clearance Rate/physiology, Young Adult, 03 medical and health sciences, Inactivation, Metabolic/physiology, Membrane Transport Proteins/metabolism, Cytochrome P-450 Enzyme System, 80 and over, Humans, Biological Transport/physiology, Aged, Aged, 80 and over, 0303 health sciences, Research, Metabolic/physiology, Liquid Biopsy, Membrane Transport Proteins, Biological Transport, Liquid Biopsy/methods, Middle Aged, 3. Good health, Exosomes/metabolism, Liver, Inactivation, Metabolic, Female

Popis súboru: application/pdf

Prístupová URL adresa: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpt.2102
https://pubmed.ncbi.nlm.nih.gov/33141922
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/cpt.2102
https://www.research.manchester.ac.uk/portal/en/publications/liquid-biopsy-enables-quantification-of-the-abundance-and-interindividual-variability-of-hepatic-enzymes-and-transporters(b9fd9968-9b26-4bbd-86d5-02a543c2b98d).html
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202102281185586586
https://pubmed.ncbi.nlm.nih.gov/33141922/
https://europepmc.org/article/MED/33141922
https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2102
http://www.scopus.com/inward/record.url?scp=85096758140&partnerID=8YFLogxK
https://pure.manchester.ac.uk/ws/files/178476774/Achour_etal_2020_cpt.2102.pdf
https://doi.org/10.1002/cpt.2102
https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/cpt.2102
https://research.manchester.ac.uk/en/publications/b9fd9968-9b26-4bbd-86d5-02a543c2b98d