Suchergebnisse - "Cysteine/metabolism"

Cysteine Alkylation in Enzymes and Transcription Factors: A Therapeutic Strategy for Cancer.

Autoren: Andrés, Celia María Curieses Lobo, Fernando Pérez de la Lastra, José Manuel et al.

Quelle: Cancers. Jun2025, Vol. 17 Issue 11, p1876. 24p.

Schlagwörter: *CYSTEINE metabolism, *METHYLATION, *NF-kappa B, *COMPUTER simulation, *COMPUTER-assisted molecular modeling, *ANTINEOPLASTIC agents, *ENZYMES, *TRANSCRIPTION factors, *CYSTEINE, *TUMOR markers, *GENE expression, *CURCUMIN, *MOLECULAR structure, *TUMORS, *STAT proteins, *PHARMACODYNAMICS

Oncogenic mutant KRAS inhibition through oxidation at cysteine 118

Autoren: Kramer-Drauberg, Maximilian Petrini, Ettore Mira, Alessia et al.

Weitere Verfasser: Kramer-Drauberg, Maximilian Petrini, Ettore Mira, Alessia et al.

Quelle: Mol Oncol
Molecular Oncology, Vol 19, Iss 2, Pp 311-328 (2025)

Schlagwörter: Cancer Research, cysteine modification, KRAS protein, human, Oncologie, NSCLC, Sciences de la santé humaine, Proto-Oncogene Proteins p21(ras)/genetics, redox regulation, Proto-Oncogene Proteins p21(ras), Mice, Cysteine/metabolism, oncogene, Cell Line, Tumor, Genetics, Humans, Animals, Cysteine, Human health sciences, RC254-282, KRAS C118, ROS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, Mutation, Molecular Medicine, Proto-Oncogene Proteins p21(ras)/metabolism, Reactive Oxygen Species, Oxidation-Reduction, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39838816
https://doaj.org/article/84af2962b2cd4f30905eaf3ff2e7ea61
https://hdl.handle.net/2268/328671
https://doi.org/10.1002/1878-0261.13798
https://hdl.handle.net/2318/2049950
https://doi.org/10.1002/1878-0261.13798

Gastrointestinal challenges in nephropathic cystinosis: clinical perspectives.

Autoren: Joseph, Mark W. Stein, Deborah R. Stein, Adam C.

Quelle: Pediatric Nephrology. Oct2024, Vol. 39 Issue 10, p2845-2860. 16p.

Schlagwörter: *CYSTEINE metabolism, *DIARRHEA, *RISK assessment, *INBORN errors of metabolism, *ESOPHAGEAL motility disorders, *QUALITY of life, *AMINES, *VOMITING, *INFLAMMATION, *GASTROINTESTINAL diseases, *INTEGRATED health care delivery, *DEGLUTITION disorders, *IMMUNOSUPPRESSION, *DISEASE risk factors, *DISEASE complications, *SYMPTOMS

Extrarenal complications of cystinosis.

Autoren: Topaloglu, Rezan¹ rezantopaloglu@hacettepe.edu.tr

Quelle: Pediatric Nephrology. Aug2024, Vol. 39 Issue 8, p2283-2292. 10p.

Schlagwörter: *CYSTEINE metabolism, *BEHAVIOR disorders, *NEWBORN screening, *EARLY medical intervention, *CARDIOVASCULAR diseases, *SKIN diseases, *INBORN errors of metabolism, *MUSCULOSKELETAL system diseases, *CUTANEOUS manifestations of general diseases, *HUMAN growth, *EYE diseases, *RESPIRATORY diseases, *GENETIC counseling, *PRENATAL diagnosis, *FANCONI syndrome, *EARLY diagnosis, *ENDOCRINE diseases, *CENTRAL nervous system diseases, *BLOOD diseases, *GASTROINTESTINAL diseases, *BIOMARKERS, *DISEASE progression, *DISEASE risk factors, *DISEASE complications, INBORN errors of metabolism diagnosis

Injectable magnetic hydrogel induces multi-programmed cell death and deep tumor regression in magnetic hyperthermia therapy in hepatocellular carcinoma

Autoren: Linxue Zhang Xing He Hongyu Zhu et al.

Quelle: Materials Today Bio, Vol 35, Iss , Pp 102341- (2025)

Schlagwörter: Hepatocellular carcinoma, Magnetic hyperthermia therapy, mPEG-b-PLV-Fe3O4, Cysteine metabolism, Redox homeostasis, Medicine (General), R5-920, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006425009123; https://doaj.org/toc/2590-0064

Zugangs-URL: https://doaj.org/article/cd59c5c5a0ad40449a7539f5168d1854

CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availability

Autoren: Xin Li Zhe Zhao Hongping Ye et al.

Quelle: Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-15 (2025)

Schlagwörter: CDO1, AKT, Cysteine metabolism, Tumorigenesis, Medicine, Cytology, QH573-671

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1478-811X

Zugangs-URL: https://doaj.org/article/6122bcde3fab4c71b08f390cf6613e60

Identification of sulfur metabolism-related gene signature in osteoarthritis and TM9SF2's sustenance effect on M2 macrophages' phagocytic activity.

Autoren: Zheng, Shuang Li, Yetian Yin, Li et al.

Quelle: Journal of Orthopaedic Surgery & Research. 1/13/2024, p1-13. 13p.

Schlagwörter: *CYSTEINE metabolism, *OSTEOARTHRITIS diagnosis, *TYROSINE metabolism, *SULFUR metabolism, *SYNOVIAL membranes, *PHAGOCYTOSIS, *LYSOSOMES, *MACROPHAGES, *SULFIDES, *REGRESSION analysis, *APOPTOSIS, *ORGANELLES, *GENE expression, *OSTEOARTHRITIS, *MEMBRANE transport proteins, *GENE expression profiling, *MESSENGER RNA, *RESEARCH funding, *T cells, *PROPORTIONAL hazards models

Is System x c − a Suitable Target for Tumour Detection and Response Assessment with Imaging?

Autoren: Sharkey, Amy R. Witney, Timothy H. Cook, Gary J. R.

Quelle: Cancers. Dec2023, Vol. 15 Issue 23, p5573. 15p.

Schlagwörter: *CYSTEINE metabolism, *GLUTAMIC acid metabolism, *TUMOR treatment, *BIOLOGICAL models, *RADIOISOTOPES, *POSITRON emission tomography computed tomography, *TREATMENT effectiveness, *MOLECULAR biology, *TUMORS, *TUMOR markers, *CELL lines, *PREDICTION models, *MOLECULAR structure, *CARRIER proteins, *DRUG resistance in cancer cells, *EVALUATION

Two disulfide-reducing pathways are required for the maturation of plastid c-type cytochromes in Chlamydomonas reinhardtii.

Autoren: Das, Ankita Subrahmanian, Nitya Gabilly, Stéphane T. et al.

Quelle: Genetics. Oct2023, Vol. 225 Issue 2, p1-13. 13p.

Schlagwörter: *CYSTEINE metabolism, *PROTOZOA, *BIOMARKERS, *ENERGY metabolism, *GENETIC mutation, *SEQUENCE analysis, *STAINS & staining (Microscopy), *SULFIDES, *METABOLISM, *DYNAMICS, *IMMUNOBLOTTING, *BIOINFORMATICS, *MITOCHONDRIA, *GENOMICS, *RESEARCH funding, *HEMOPROTEINS, *ENZYME inhibitors

NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells

Autoren: Laura Bottoni Alberto Minetti Giulia Realini et al.

Weitere Verfasser: Laura Bottoni Alberto Minetti Giulia Realini et al.

Quelle: Oncogene

Schlagwörter: 0301 basic medicine, Epithelial-Mesenchymal Transition, Amino Acid Transport System y+, NF-E2-Related Factor 2, Cell Survival, Triple Negative Breast Neoplasms, Article, NRF2, 03 medical and health sciences, Breast cancer, computational biology, Cell Line, Tumor, oxidative stress, Humans, Cysteine, oncogenomics, cysteine, 0303 health sciences, Breast cancer, Triple-negative, NRF2, oxidative stress, cysteine, Kelch-Like ECH-Associated Protein 1, Gene Expression Regulation, Neoplastic [MeSH], Cell Line, Tumor [MeSH], Kelch-Like ECH-Associated Protein 1/metabolism [MeSH], 692/53/2422, Oxidative Stress [MeSH], NF-E2-Related Factor 2/metabolism [MeSH], 38/91, NF-E2-Related Factor 2/genetics [MeSH], 38/109, 38/39, 38/1, 82/58, 631/80/304, 631/67/1347, Female [MeSH], Kelch-Like ECH-Associated Protein 1/genetics [MeSH], Triple Negative Breast Neoplasms/pathology [MeSH], Amino Acid Transport System y /metabolism [MeSH], Humans [MeSH], Cysteine/metabolism [MeSH], 631/80/86/2366, Epithelial-Mesenchymal Transition/genetics [MeSH], 38/70, 631/337/572, 13/44, Amino Acid Transport System y /genetics [MeSH], Triple Negative Breast Neoplasms/genetics [MeSH], 38/89, Cell Survival/genetics [MeSH], Triple Negative Breast Neoplasms/metabolism [MeSH], article, 3. Good health, Gene Expression Regulation, Neoplastic, Oxidative Stress, Triple-negative, Female

Dateibeschreibung: application/pdf; ELETTRONICO

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38600165
https://repository.publisso.de/resource/frl:6508622

Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

Autoren: Yijia Hua Ningjun Duan Chunxiao Sun et al.

Quelle: eLife, Vol 14 (2025)

Schlagwörter: HER2-positive breast cancer, trastuzumab primary resistance, cysteine metabolism, epigenetic modifications, Medicine, Science, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: https://elifesciences.org/articles/103953; https://doaj.org/toc/2050-084X

Zugangs-URL: https://doaj.org/article/2f9783c65a014e958f1f45f3b0cdc96d

Oxidative stress-induced CDO1 glutathionylation regulates cysteine metabolism and sustains redox homeostasis under ionizing radiation

Autoren: Yumin He Dan Li Hongping Ye et al.

Quelle: Redox Biology, Vol 83, Iss , Pp 103656- (2025)

Schlagwörter: CDO1, Glutathionylation, Oxidative stress, Radiation damage, Cysteine metabolism, Medicine (General), R5-920, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231725001697; https://doaj.org/toc/2213-2317

Zugangs-URL: https://doaj.org/article/09a2b21a560e46b3af2d8e9b77d8ccf1

Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men.

Autoren: Papanikolaou, Konstantinos Jamurtas, Athanasios Z. Poulios, Athanasios et al.

Quelle: European Journal of Nutrition. Jun2023, Vol. 62 Issue 4, p1767-1782. 16p. 1 Diagram, 2 Charts, 3 Graphs.

Schlagwörter: *CYSTEINE metabolism, *ERYTHROCYTE metabolism, *BODY composition, *GLUTATHIONE, *SKELETAL muscle, *FOOD consumption, *CARDIOPULMONARY fitness, *MEN, *PHYSICAL fitness, *ANTIOXIDANTS, *DIET, *PHYSICAL activity, *MUSCLE strength, *EXERCISE intensity, *RESEARCH funding, *ATHLETIC ability, *SECONDARY analysis

Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant and pro-neoplastic activities

Autoren: Fiorella Faienza Claudio Laquatra Matteo Castelli et al.

Quelle: Redox Biol
Redox Biology, Vol 84, Iss, Pp 103677-(2025)

Schlagwörter: Medicine (General), Metabolism, R5-920, Oxidative stress, QH301-705.5, Tumorigenesis, Cysteine, Cysteine, Metabolism, Mitochondria,Oxidative stress,Tumorigenesis, mitochondrial chaperone trap1, metabolic switch , protects, phosphorylation, cells, Biology (General), Mitochondria, Research Paper

Dateibeschreibung: application/pdf

Zugangs-URL: https://doaj.org/article/971a14521ab2420cab8e3f0c199f80f4
https://www.sciencedirect.com/science/article/pii/S2213231725001909
https://hdl.handle.net/20.500.14243/547385
https://doi.org/10.1016/j.redox.2025.103677
https://hdl.handle.net/2108/423410
https://doi.org/10.1016/j.redox.2025.103677

Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT

Autoren: Tomoaki Yamauchi Yumi Okano Daishu Terada et al.

Quelle: Cancer & Metabolism, Vol 12, Iss 1, Pp 1-15 (2024)

Schlagwörter: Cysteine metabolism, xCT, de novo cysteine synthesis, Hepatocarcinoma, DNA methylation, NRF2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2049-3002

Zugangs-URL: https://doaj.org/article/35e7c01729b441ca91a5479265cb9b38

A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans

Autoren: Sonntag, Thomas Omi, Shizue Andreeva, Antonina et al.

Weitere Verfasser: Sonntag, Thomas Omi, Shizue Andreeva, Antonina et al.

Quelle: ISSN: 1553-7390.

Schlagwörter: PGENETICS-D-25-00256 C. elegans mig-21 distal tip cell cell migration Wnt signaling Netrin signaling gonad morphogenesis, PGENETICS-D-25-00256 C. elegans, mig-21, distal tip cell, cell migration, Wnt signaling, Netrin signaling, gonad, morphogenesis, MESH: Animals Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Caenorhabditis elegans* / genetics Cysteine / genetics Cysteine / metabolism Epidermis* / metabolism Extracellular Matrix / genetics Extracellular Matrix / metabolism Mutation Signal Transduction* Skin / metabolism Skin / pathology, MESH: Caenorhabditis elegans, MESH: extracellular matrix, [SDV]Life Sciences [q-bio]

Verfügbarkeit: https://hal.science/hal-05006245
https://hal.science/hal-05006245v1/document
https://hal.science/hal-05006245v1/file/Sontag25_PlosGen.pdf
https://doi.org/10.1371/journal.pgen.1011593

Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin

Autoren: Baptiste Dumont Laurent Terradot Eric Cascales et al.

Weitere Verfasser: Baptiste Dumont Laurent Terradot Eric Cascales et al.

Quelle: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Schlagwörter: Models, Molecular, 0301 basic medicine, Bacterial toxins, Molecular Chaperones -- metabolism -- chemistry -- genetics, Science, Bacterial Toxins, Bacterial Toxins -- metabolism -- chemistry, Article, Cysteine -- metabolism -- chemistry, 03 medical and health sciences, Thioredoxins, Models, Chaperones, Escherichia coli, Disulfides, Cysteine, ADP Ribose Transferases -- metabolism -- chemistry -- genetics, Disulfides -- metabolism -- chemistry, X-ray crystallography, ADP Ribose Transferases, 0303 health sciences, Binding Sites, Molecular, Thioredoxins -- metabolism -- chemistry -- genetics, Sciences bio-médicales et agricoles, [SDV] Life Sciences [q-bio], Escherichia coli -- metabolism -- genetics, Enzyme mechanisms, PolyADP-ribosylation, Oxidation-Reduction, Molecular Chaperones, Protein Binding

Dateibeschreibung: application/pdf; 1 full-text file(s): application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39613764
https://doaj.org/article/afead9ac7c6c4a9d9c7b7c15f4e0e4a6

Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

Autoren: Ningjun Duan Yijia Hua Chunxiao Sun et al.

Weitere Verfasser: Ningjun Duan Yijia Hua Chunxiao Sun et al.

Quelle: eLife
eLife, Vol 14 (2025)

Schlagwörter: trastuzumab primary resistance, epigenetic modifications, QH301-705.5, Science, Medicine, cysteine metabolism, Biology (General), HER2-positive breast cancer, Cancer Biology

Zugangs-URL: https://doaj.org/article/2f9783c65a014e958f1f45f3b0cdc96d
https://resolver.sub.uni-goettingen.de/purl?gro-2/150240

Emerging role of cysteinyl LTs in cancer.

Autoren: Saier, Lou Peyruchaud, Olivier

Quelle: British Journal of Pharmacology. Nov2022, Vol. 179 Issue 22, p5036-5055. 20p. 2 Diagrams, 3 Charts.

Schlagwörter: *CYSTEINE metabolism, *CARCINOGENESIS, *CELL physiology, *TUMORS, *LEUKOTRIENES

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Autoren: Wen Xu Bo Xie Dongfan Wei et al.

Quelle: Amino Acids, Vol 56, Iss 1, Pp 1-11 (2024)

Schlagwörter: Alopecia areata, Cysteine metabolism, Hair breakage, Exclamation mark hairs, Ferroptosis, Biochemistry, QD415-436, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1438-2199

Zugangs-URL: https://doaj.org/article/190d0b40c45c4aef92010909d58d57a2