Suchergebnisse - "Cross-Over Studies"

Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project.

Autoren: Hornero-Ramirez H Morisette A Marcotte B et al.

Quelle: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2438823. Date of Electronic Publication: 2024 Dec 22.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Microbiome* , Cross-Over Studies* , Inflammation*, Humans ; Male ; Female ; Middle Aged ; Adult ; Endotoxemia/diet therapy ; Cardiovascular Diseases/prevention & control ; Cardiometabolic Risk Factors ; Diet ; Polyphenols/administration & dosage ; Polyphenols/pharmacology ; Edible Grain ; Feces/microbiology ; Feces/chemistry ; Bacteria/classification ; Bacteria/isolation & purification ; Bacteria/metabolism ; Bacteria/genetics ; Fatty Acids, Omega-3/administration & dosage ; Dietary Fiber/administration & dosage ; Intestines/microbiology ; Intestines/pathology

Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.

Autoren: Kavcı Z Ozan M Buzdağlı Y et al.

Quelle: Journal of the International Society of Sports Nutrition [J Int Soc Sports Nutr] 2025 Dec; Vol. 22 (1), pp. 2445609. Date of Electronic Publication: 2024 Dec 23.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101234168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-2783 (Electronic) Linking ISSN: 15502783 NLM ISO Abbreviation: J Int Soc Sports Nutr Subsets: MEDLINE

MeSH-Schlagworte: Nitrates*/administration & dosage , Nitrates*/pharmacology , Cross-Over Studies* , Arginine*/administration & dosage , Arginine*/pharmacology , Dietary Supplements* , Martial Arts*/physiology , Athletic Performance*/physiology , Sports Nutritional Physiological Phenomena*, Humans ; Double-Blind Method ; Young Adult ; Male ; Postural Balance/drug effects ; Postural Balance/physiology ; Female ; Lactic Acid/blood ; Physical Endurance/drug effects ; Physical Endurance/physiology

Caffeine supplementation improved movement patterns and reactive agility in rugby sevens matches in male collegiate players.

Autoren: Hsueh CL Sun CY Chang CK

Quelle: Journal of the International Society of Sports Nutrition [J Int Soc Sports Nutr] 2025 Dec; Vol. 22 (1), pp. 2441763. Date of Electronic Publication: 2024 Dec 16.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101234168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-2783 (Electronic) Linking ISSN: 15502783 NLM ISO Abbreviation: J Int Soc Sports Nutr Subsets: MEDLINE

MeSH-Schlagworte: Caffeine*/administration & dosage , Caffeine*/pharmacology , Cross-Over Studies* , Athletic Performance*/physiology , Football*/physiology , Dietary Supplements*, Humans ; Male ; Young Adult ; Double-Blind Method ; Performance-Enhancing Substances/administration & dosage ; Performance-Enhancing Substances/pharmacology ; Acceleration

The impact of protocol designs for using massage guns on lower body flexibility: A randomised cross-over design study.

Autoren: Sams L Langdown BL Simons J et al.

Quelle: Journal of bodywork and movement therapies [J Bodyw Mov Ther] 2025 Mar; Vol. 41, pp. 85-93. Date of Electronic Publication: 2024 Nov 07.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 9700068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-9283 (Electronic) Linking ISSN: 13608592 NLM ISO Abbreviation: J Bodyw Mov Ther Subsets: MEDLINE

MeSH-Schlagworte: Cross-Over Studies* , Massage*/methods , Range of Motion, Articular*/physiology, Humans ; Adult ; Male ; Female ; Young Adult ; Lower Extremity/physiology ; Hip Joint/physiology ; Ankle Joint/physiology

The effectiveness of foam rolling with and without vibration and static stretching on range of motion, muscle strength and proprioception of the ankle joint in adults with chronic ankle instability.

Autoren: Chen CY Hsu HK Chang NJ

Quelle: Journal of bodywork and movement therapies [J Bodyw Mov Ther] 2025 Mar; Vol. 41, pp. 144-151. Date of Electronic Publication: 2024 Nov 20.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 9700068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-9283 (Electronic) Linking ISSN: 13608592 NLM ISO Abbreviation: J Bodyw Mov Ther Subsets: MEDLINE

MeSH-Schlagworte: Range of Motion, Articular*/physiology , Vibration*/therapeutic use , Joint Instability*/physiopathology , Joint Instability*/rehabilitation , Joint Instability*/therapy , Muscle Strength*/physiology , Ankle Joint*/physiopathology , Ankle Joint*/physiology , Cross-Over Studies* , Proprioception*/physiology , Muscle Stretching Exercises*/physiology, Humans ; Male ; Female ; Adult ; Young Adult ; Warm-Up Exercise/physiology

Acute dose-response effect of photobiomodulation therapy on muscle performance in female futsal players: A randomized, double-blind, placebo-controlled, crossover study.

Autoren: Borim JM Borghi SM do Nascimento AP et al.

Quelle: Journal of bodywork and movement therapies [J Bodyw Mov Ther] 2025 Mar; Vol. 41, pp. 35-43. Date of Electronic Publication: 2024 Nov 07.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 9700068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-9283 (Electronic) Linking ISSN: 13608592 NLM ISO Abbreviation: J Bodyw Mov Ther Subsets: MEDLINE

MeSH-Schlagworte: Cross-Over Studies* , Low-Level Light Therapy*/methods , Muscle Strength*/physiology , Quadriceps Muscle*/physiology, Humans ; Female ; Young Adult ; Adult ; Double-Blind Method ; Adolescent ; Isometric Contraction/physiology ; Soccer/physiology ; Muscle Fatigue/physiology

Relationship between microaspiration and ventilator-associated events: A post-hoc analysis of a randomized controlled trial.

Autoren: Millot G Behal H Jaillette E et al.

Quelle: Intensive & critical care nursing [Intensive Crit Care Nurs] 2025 Feb; Vol. 86, pp. 103778. Date of Electronic Publication: 2024 Jul 27.

Publikationsart: Journal Article; Randomized Controlled Trial; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9211274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4036 (Electronic) Linking ISSN: 09643397 NLM ISO Abbreviation: Intensive Crit Care Nurs Subsets: MEDLINE

MeSH-Schlagworte: Cross-Over Studies*, Humans ; Male ; Female ; Middle Aged ; Aged ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Respiration, Artificial/statistics & numerical data ; Pneumonia, Ventilator-Associated/prevention & control ; Pneumonia, Ventilator-Associated/epidemiology ; Pneumonia, Ventilator-Associated/etiology ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Incidence ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/statistics & numerical data ; Oropharynx/physiopathology ; Adult

Evaluation of the extent of plaque removal and users' experience of alternative toothbrushes: A randomized single-blind crossover study.

Autoren: De Almeida Mello J Reynaert L Frites H et al.

Quelle: International journal of dental hygiene [Int J Dent Hyg] 2025 Feb; Vol. 23 (1), pp. 203-217. Date of Electronic Publication: 2024 May 26.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Blackwell Pub Country of Publication: England NLM ID: 101168070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-5037 (Electronic) Linking ISSN: 16015029 NLM ISO Abbreviation: Int J Dent Hyg Subsets: MEDLINE

MeSH-Schlagworte: Toothbrushing*/instrumentation , Cross-Over Studies* , Dental Plaque*/prevention & control , Equipment Design*, Humans ; Single-Blind Method ; Female ; Male ; Young Adult ; Dental Plaque Index ; Adult ; Time Factors ; Surveys and Questionnaires ; Dental Devices, Home Care

Impact of the Novel MRI Contrast Agent Gadopiclenol on Radiotherapy Decision Making in Patients With Brain Metastases.

Autoren: Sarria GR Fleckenstein J Eckl M et al.

Quelle: Investigative radiology [Invest Radiol] 2025 Feb 01; Vol. 60 (2), pp. 138-144. Date of Electronic Publication: 2024 Aug 20.

Publikationsart: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Comparative Study

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0045377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0210 (Electronic) Linking ISSN: 00209996 NLM ISO Abbreviation: Invest Radiol Subsets: MEDLINE

MeSH-Schlagworte: Contrast Media* , Brain Neoplasms*/secondary , Brain Neoplasms*/diagnostic imaging , Brain Neoplasms*/radiotherapy , Magnetic Resonance Imaging*/methods , Organometallic Compounds* , Cross-Over Studies* , Meglumine*/analogs & derivatives, Humans ; Female ; Male ; Middle Aged ; Aged ; Double-Blind Method ; Radiosurgery/methods ; Adult ; Gadolinium

Efficacy of toothpaste containing Brazilian green propolis extracts with an optimal kaempferide/betuletol ratio for improving oral microbiota: A randomized, controlled, paired crossover study.

Autoren: Amano S Matsumoto M Morimoto M et al.

Quelle: Journal of ethnopharmacology [J Ethnopharmacol] 2025 Jan 30; Vol. 337 (Pt 1), pp. 118762. Date of Electronic Publication: 2024 Aug 29.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Propolis*/pharmacology , Propolis*/administration & dosage , Toothpastes*/pharmacology , Cross-Over Studies* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/administration & dosage, Humans ; Female ; Male ; Young Adult ; Adult ; Adolescent ; Microbiota/drug effects ; Brazil ; Double-Blind Method ; Mouth/microbiology ; Dental Plaque Index ; Periodontal Index

Intermittent escitalopram treatment and reactive aggression in women with premenstrual irritability and anger: A crossover study.

Autoren: Gröndal M Näslund J Englund C et al.

Quelle: Journal of affective disorders [J Affect Disord] 2025 Jan 15; Vol. 369, pp. 599-607. Date of Electronic Publication: 2024 Oct 10.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Anger*/drug effects , Cross-Over Studies* , Aggression*/drug effects , Irritable Mood*/drug effects , Selective Serotonin Reuptake Inhibitors*/administration & dosage , Escitalopram*/administration & dosage, Humans ; Female ; Adult ; Single-Blind Method ; Young Adult ; Citalopram/therapeutic use ; Citalopram/administration & dosage ; Premenstrual Syndrome/drug therapy ; Premenstrual Syndrome/psychology ; Premenstrual Dysphoric Disorder/drug therapy ; Premenstrual Dysphoric Disorder/psychology ; Luteal Phase/drug effects ; Follicular Phase/drug effects

Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study.

Autoren: Mostofsky E Buring JE Come SE et al.

Quelle: Breast cancer research : BCR [Breast Cancer Res] 2025 Jan 09; Vol. 27 (1), pp. 5. Date of Electronic Publication: 2025 Jan 09.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Alcohol Drinking* , Aromatase Inhibitors*/therapeutic use , Breast Neoplasms*/drug therapy , Breast Neoplasms*/blood , Breast Neoplasms*/metabolism , Cancer Survivors*/statistics & numerical data , Cross-Over Studies* , Gonadal Steroid Hormones*/blood , Postmenopause*/blood, Aged ; Female ; Humans ; Middle Aged ; Estradiol/blood ; Pilot Projects ; Sex Hormone-Binding Globulin/metabolism ; Sex Hormone-Binding Globulin/analysis ; Wine

A novel technique of blindly positioning bronchial blockers for one-lung ventilation: a prospective, randomized, crossover study.

Autoren: Min S Yoon S Han J et al.

Quelle: Journal of cardiothoracic surgery [J Cardiothorac Surg] 2025 Jan 09; Vol. 20 (1), pp. 50. Date of Electronic Publication: 2025 Jan 09.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101265113 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-8090 (Electronic) Linking ISSN: 17498090 NLM ISO Abbreviation: J Cardiothorac Surg Subsets: MEDLINE

MeSH-Schlagworte: One-Lung Ventilation*/methods , Cross-Over Studies* , Bronchoscopy*/methods, Humans ; Prospective Studies ; Male ; Female ; Middle Aged ; Aged ; Bronchi/surgery ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/instrumentation

Augmenting Verb-Naming Therapy With Neuromodulation Decelerates Language Loss in Primary Progressive Aphasia.

Autoren: Sheppard SM Goldberg EB Sebastian R et al.

Quelle: American journal of speech-language pathology [Am J Speech Lang Pathol] 2025 Jan 07; Vol. 34 (1), pp. 155-173. Date of Electronic Publication: 2024 Dec 12.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: American Speech-Language-Hearing Association Country of Publication: United States NLM ID: 9114726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-9110 (Electronic) Linking ISSN: 10580360 NLM ISO Abbreviation: Am J Speech Lang Pathol Subsets: MEDLINE

MeSH-Schlagworte: Aphasia, Primary Progressive*/complications , Aphasia, Primary Progressive*/therapy , Cross-Over Studies* , Language Therapy*/methods , Transcranial Direct Current Stimulation*/methods , Language Disorders*/complications , Language Disorders*/therapy, Aged ; Female ; Humans ; Male ; Middle Aged ; Comprehension ; Double-Blind Method ; Treatment Outcome

Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3-Butanediol in Patients With Heart Failure With Reduced Ejection Fraction.

Autoren: Guldbrandsen H Gopalasingam N Christensen KH et al.

Quelle: Journal of the American Heart Association [J Am Heart Assoc] 2025 Jan 07; Vol. 14 (1), pp. e038461. Date of Electronic Publication: 2024 Dec 24.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

MeSH-Schlagworte: Heart Failure*/drug therapy , Heart Failure*/physiopathology , Heart Failure*/blood , Butylene Glycols*/administration & dosage , Stroke Volume*/drug effects , Stroke Volume*/physiology , Cross-Over Studies* , Ventricular Function, Left*/drug effects , 3-Hydroxybutyric Acid*/blood, Humans ; Male ; Female ; Middle Aged ; Aged ; Single-Blind Method ; Heart Rate/drug effects ; Treatment Outcome ; Ketone Bodies/blood ; Echocardiography ; Biomarkers/blood ; Administration, Oral ; Cardiac Output/drug effects ; Cardiac Output/physiology

Optimizing transcutaneous spinal stimulation: excitability of evoked spinal reflexes is dependent on electrode montage.

Autoren: Thatcher KL Nielsen KE Sandler EB et al.

Quelle: Journal of neuroengineering and rehabilitation [J Neuroeng Rehabil] 2025 Jan 06; Vol. 22 (1), pp. 2. Date of Electronic Publication: 2025 Jan 06.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101232233 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-0003 (Electronic) Linking ISSN: 17430003 NLM ISO Abbreviation: J Neuroeng Rehabil Subsets: MEDLINE

MeSH-Schlagworte: Cross-Over Studies* , Transcutaneous Electric Nerve Stimulation*/methods , Transcutaneous Electric Nerve Stimulation*/instrumentation , Electrodes* , Reflex*/physiology, Humans ; Male ; Female ; Adult ; Middle Aged ; Spinal Cord Stimulation/methods ; Spinal Cord Stimulation/instrumentation ; Young Adult ; Electromyography ; Spinal Cord/physiology ; Muscle, Skeletal/physiology

Double dosing ulipristal acetate emergency contraception for individuals with obesity: a randomised crossover trial.

Autoren: Edelman A Hennebold JD Bond K et al.

Quelle: BMJ sexual & reproductive health [BMJ Sex Reprod Health] 2025 Jan 06; Vol. 51 (1), pp. 27-35. Date of Electronic Publication: 2025 Jan 06.

Publikationsart: Journal Article; Multicenter Study; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101715577 Publication Model: Electronic Cited Medium: Internet ISSN: 2515-2009 (Electronic) Linking ISSN: 25151991 NLM ISO Abbreviation: BMJ Sex Reprod Health Subsets: MEDLINE

MeSH-Schlagworte: Contraception, Postcoital*/methods , Contraception, Postcoital*/statistics & numerical data , Cross-Over Studies* , Norpregnadienes*/therapeutic use , Norpregnadienes*/administration & dosage , Obesity*/complications, Adult ; Female ; Humans ; Young Adult ; Body Mass Index ; Estradiol/blood ; Luteinizing Hormone/blood ; Progesterone/blood

Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administration.

Autoren: Murray F Yoo O Brophy-Williams S et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Jan 03; Vol. 80 (1), pp. 209-215.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Meropenem*/pharmacokinetics , Meropenem*/administration & dosage , Meropenem*/adverse effects , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/administration & dosage , Anti-Bacterial Agents*/adverse effects , Cross-Over Studies*, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Injections, Subcutaneous ; Adult ; Administration, Intravenous ; Aged ; Biological Availability ; Tandem Mass Spectrometry ; Thienamycins/pharmacokinetics ; Thienamycins/administration & dosage ; Thienamycins/adverse effects ; Young Adult ; Microbial Sensitivity Tests

Substituting animal protein with black soymilk reduces advanced glycation end product level and improves gut microbiota composition in obese prediabetic individuals: a randomized crossover intervention trial.

Autoren: Chang YH Lee PN Chen CH et al.

Quelle: Food & function [Food Funct] 2025 Jan 02; Vol. 16 (1), pp. 195-206. Date of Electronic Publication: 2025 Jan 02.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Microbiome* , Prediabetic State*/diet therapy , Prediabetic State*/metabolism , Obesity*/diet therapy , Obesity*/metabolism , Obesity*/microbiology , Glycation End Products, Advanced*/metabolism , Cross-Over Studies* , Soy Milk*, Humans ; Male ; Middle Aged ; Adult ; Female ; Animals ; Young Adult ; Swine ; Oxidative Stress

Performance on Activities of Daily Living and User Experience When Using Artificial Intelligence by Individuals With Vision Impairment.

Autoren: Seiple W van der Aa HPA Garcia-Piña F et al.

Quelle: Translational vision science & technology [Transl Vis Sci Technol] 2025 Jan 02; Vol. 14 (1), pp. 3.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association for Research in Vision and Ophthalmology Country of Publication: United States NLM ID: 101595919 Publication Model: Print Cited Medium: Internet ISSN: 2164-2591 (Electronic) Linking ISSN: 21642591 NLM ISO Abbreviation: Transl Vis Sci Technol Subsets: MEDLINE

MeSH-Schlagworte: Artificial Intelligence* , Activities of Daily Living*/psychology , Cross-Over Studies*, Humans ; Cross-Sectional Studies ; Male ; Female ; Middle Aged ; Adult ; Aged ; Smart Glasses ; Self-Help Devices ; Vision Disorders ; Mobile Applications