Search Results - "Complement C3"

Complement C3 in panvascular disease: a central integrator of immune signaling and vascular remodeling.

Authors: Li Y Zeng H Zhong X

Source: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2025 Nov 04; Vol. 139 (21).

Publication Type: Journal Article; Review

Journal Info: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

MeSH Terms: Vascular Remodeling*/immunology , Signal Transduction* , Complement C3*/metabolism , Complement C3*/immunology , Vascular Diseases*/immunology , Vascular Diseases*/pathology , Vascular Diseases*/metabolism, Humans ; Animals

Low serum complement C3 levels are associated with adverse clinical outcomes in myelodysplastic syndromes.

Authors: Zou D Ying H Yong L et al.

Source: Leukemia research [Leuk Res] 2025 Nov; Vol. 158, pp. 108116. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7706787 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5835 (Electronic) Linking ISSN: 01452126 NLM ISO Abbreviation: Leuk Res Subsets: MEDLINE

MeSH Terms: Myelodysplastic Syndromes*/blood , Myelodysplastic Syndromes*/mortality , Complement C3*/metabolism , Complement C3*/analysis, Humans ; Male ; Female ; Aged ; Middle Aged ; Prognosis ; Aged, 80 and over ; Retrospective Studies ; Adult

Complement C3 predicting acute-on-chronic liver failure in cirrhotic patients with bacterial infection within 90 days: a cohort study.

Authors: Chen S Li R Liu H et al.

Source: European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2025 Oct 01; Vol. 37 (10), pp. 1147-1154. Date of Electronic Publication: 2025 Aug 27.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 9000874 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5687 (Electronic) Linking ISSN: 0954691X NLM ISO Abbreviation: Eur J Gastroenterol Hepatol Subsets: MEDLINE

MeSH Terms: Acute-On-Chronic Liver Failure*/mortality , Acute-On-Chronic Liver Failure*/blood , Acute-On-Chronic Liver Failure*/diagnosis , Acute-On-Chronic Liver Failure*/etiology , Liver Cirrhosis*/complications , Liver Cirrhosis*/mortality , Liver Cirrhosis*/blood , Complement C3*/analysis , Complement C3*/metabolism , Bacterial Infections*/complications , Bacterial Infections*/mortality , Bacterial Infections*/blood, Humans ; Male ; Middle Aged ; Female ; Aged ; Predictive Value of Tests ; Prospective Studies ; Biomarkers/blood ; Time Factors ; Prognosis ; Risk Factors ; Adult ; Risk Assessment ; ROC Curve ; China/epidemiology

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN.

Authors: Fakhouri F Bomback AS Ariceta G et al.

Corporate Authors: Fakhouri F Bomback AS Ariceta G et al.

Source: The New England journal of medicine [N Engl J Med] 2025 Dec 04; Vol. 393 (22), pp. 2210-2220.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

MeSH Terms: Complement C3*/analysis , Complement C3*/antagonists & inhibitors , Complement C3*/immunology , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/immunology , Glomerulonephritis, Membranoproliferative*/pathology , Glomerulonephritis, Membranoproliferative*/urine , Proteinuria*/drug therapy , Proteinuria*/immunology , Proteinuria*/pathology , Proteinuria*/urine , Peptides, Cyclic*/administration & dosage , Peptides, Cyclic*/adverse effects, Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Creatinine/urine ; Double-Blind Method ; Kidney Glomerulus/pathology ; Treatment Outcome

Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions.

Authors: Andersson LI Sandgren P Sjöström DJ et al.

Source: Platelets [Platelets] 2025 Dec; Vol. 36 (1), pp. 2513298. Date of Electronic Publication: 2025 Jun 25.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9208117 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1635 (Electronic) Linking ISSN: 09537104 NLM ISO Abbreviation: Platelets Subsets: MEDLINE

MeSH Terms: Blood Platelets*/metabolism , Blood Platelets*/drug effects , Complement C3*/antagonists & inhibitors , Complement C3*/metabolism , Complement Activation*/drug effects , Blood Preservation*/methods, Humans ; Platelet Activation/drug effects

Impact of complement C3 levels on the development of healthcare-associated infections in intensive care patients: a retrospective case-control study.

Authors: Wang C Chen B Ying Z et al.

Source: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2487631. Date of Electronic Publication: 2025 Apr 07.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH Terms: Complement C3*/analysis , Cross Infection*/epidemiology , Cross Infection*/immunology , Cross Infection*/blood, Humans ; Male ; Female ; Aged ; Retrospective Studies ; Case-Control Studies ; Middle Aged ; Intensive Care Units/statistics & numerical data ; Biomarkers/blood ; Incidence ; Risk Factors ; Organ Dysfunction Scores ; Critical Care/statistics & numerical data ; Proportional Hazards Models ; Length of Stay/statistics & numerical data ; Aged, 80 and over ; Propensity Score

Neutrophil extracellular trap-borne C3-driven endothelial dysfunction in Klebsiella pneumoniae liver abscess.

Authors: Wang H Chen L Wang C et al.

Source: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2580104. Date of Electronic Publication: 2025 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH Terms: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Klebsiella pneumoniae*/pathogenicity , Klebsiella Infections*/microbiology , Klebsiella Infections*/immunology , Klebsiella Infections*/pathology , Liver Abscess*/microbiology , Liver Abscess*/immunology , Liver Abscess*/pathology , Complement C3*/metabolism , Complement C3*/immunology, Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Female ; Neutrophils/immunology ; Signal Transduction ; Liver/pathology ; Liver/microbiology ; Middle Aged

Serum complement C3 as a diagnostic biomarker for metabolic dysfunction -associated steatotic liver disease in middle-aged and elderly adults: a cross-sectional study.

Authors: Ye D Ma H Zhou J et al.

Source: BMC gastroenterology [BMC Gastroenterol] 2025 Nov 12; Vol. 25 (1), pp. 801. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

MeSH Terms: Complement C3*/analysis , Complement C3*/metabolism , Fatty Liver*/diagnosis , Fatty Liver*/blood, Humans ; Cross-Sectional Studies ; Male ; Female ; Middle Aged ; Biomarkers/blood ; Aged ; Case-Control Studies ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Complement C4/analysis ; ROC Curve ; Complement C1q/analysis

Complement C3 deficiency inhibits osteoclast differentiation and prevents ovariectomy-induced osteoporosis.

Authors: Guha A Prasad A Ashokkumar K et al.

Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Nov 01; Vol. 214 (11), pp. 3069-3082.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

MeSH Terms: Osteoclasts*/physiology , Osteoclasts*/immunology , Cell Differentiation* , Complement C3*/deficiency , Complement C3*/genetics , Osteoporosis*/immunology , Osteoporosis*/prevention & control , Osteoporosis*/etiology, Animals ; Mice ; Mice, Knockout ; Female ; Ovariectomy/adverse effects ; Mice, Inbred C57BL

Complement factor D of Paralichthys olivaceus in serum enhances C3 deposition to activate complement against bacterial infection.

Authors: Liu H Jin XY Han XP et al.

Source: Fish & shellfish immunology [Fish Shellfish Immunol] 2025 Nov; Vol. 166, pp. 110660. Date of Electronic Publication: 2025 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH Terms: Fish Diseases*/immunology , Fish Diseases*/microbiology , Complement C3*/immunology , Complement C3*/metabolism , Immunity, Innate*/genetics , Complement Factor D*/genetics , Complement Factor D*/immunology , Complement Factor D*/chemistry , Astacoidea*/immunology , Astacoidea*/genetics , Gene Expression Regulation*/immunology , Complement Activation*, Animals ; Fish Proteins/genetics ; Fish Proteins/immunology ; Fish Proteins/chemistry ; Vibrio/physiology ; Vibrio Infections/immunology ; Vibrio Infections/veterinary ; Amino Acid Sequence ; Sequence Alignment/veterinary ; Phylogeny ; Gene Expression Profiling/veterinary

SCR Organism: Vibrio harveyi

Improved immunocompatibility of active targeting liposomes by attenuating nucleophilic attack of cyclic RGD peptides on complement 3.

Authors: Meng N Lu J Zhou J et al.

Source: Biomaterials [Biomaterials] 2025 Oct; Vol. 321, pp. 123350. Date of Electronic Publication: 2025 Apr 16.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

MeSH Terms: Liposomes*/chemistry , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/immunology , Complement C3*/metabolism , Complement C3*/immunology , Complement C3*/chemistry, Animals ; Humans ; Female ; Mice ; Cell Line, Tumor ; Integrin alphaVbeta3/metabolism ; Mice, Inbred BALB C

Targeting the alternative complement pathway by iptacopan abrogates C3 and strongly reduces C5b-9 deposition within glomeruli in IgA nephropathy recurrence after kidney transplantation.

Authors: Sanna E Nicassio SR Mella A et al.

Source: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2025 Dec; Vol. 25 (12), pp. 2651-2657. Date of Electronic Publication: 2025 Aug 23.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE

MeSH Terms: Glomerulonephritis, IGA*/drug therapy , Glomerulonephritis, IGA*/metabolism , Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/surgery , Kidney Transplantation*/adverse effects , Complement C3*/metabolism , Complement Pathway, Alternative*/drug effects , Complement Membrane Attack Complex*/metabolism , Kidney Glomerulus*/metabolism , Kidney Glomerulus*/pathology , Kidney Glomerulus*/drug effects , Graft Rejection*/etiology , Graft Rejection*/drug therapy, Humans ; Male ; Female ; Adult ; Recurrence ; Middle Aged ; Prognosis ; Follow-Up Studies ; Glomerular Filtration Rate ; Graft Survival/drug effects ; Kidney Function Tests ; Benzoates ; Indoles ; Piperidines

C3 glomerulopathy and acute kidney injury after mRNA-1273 (Moderna) COVID-19 vaccine and genetical analysis.

Authors: Chao MV Peng CH Chang FP et al.

Source: Clinical nephrology [Clin Nephrol] 2025 Dec; Vol. 104 (6), pp. 428-433.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Dustri-Verlag Dr. Karl Feistle Country of Publication: Germany NLM ID: 0364441 Publication Model: Print Cited Medium: Internet ISSN: 0301-0430 (Print) Linking ISSN: 03010430 NLM ISO Abbreviation: Clin Nephrol Subsets: MEDLINE

MeSH Terms: Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/genetics , COVID-19*/prevention & control , Complement C3* , COVID-19 Vaccines*/adverse effects, Humans ; Female ; Middle Aged ; 2019-nCoV Vaccine mRNA-1273/adverse effects ; Mutation, Missense ; SARS-CoV-2

Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis.

Authors: Novak L Hall SD Cutter G et al.

Source: Kidney international [Kidney Int] 2025 Dec; Vol. 108 (6), pp. 1158-1169. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

MeSH Terms: Glomerulonephritis, IGA*/immunology , Glomerulonephritis, IGA*/pathology , Complement C3*/analysis , Immunoglobulin A*/analysis , Immunoglobulin G*/analysis , Antigen-Antibody Complex*/analysis , Kidney Glomerulus*/immunology , Kidney Glomerulus*/pathology , IgA Vasculitis*/immunology , IgA Vasculitis*/pathology , Vasculitis*/immunology , Vasculitis*/pathology, Humans ; Male ; Female ; Adult ; Middle Aged ; Biopsy ; Young Adult ; Microscopy, Confocal ; Severity of Illness Index

Edwardsiella piscicida employs C3 derivative to mediate internalization and infection via the teleost-specific receptor.

Authors: Li MF Jin XY Liu H et al.

Source: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2526783. Date of Electronic Publication: 2025 Jul 03.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH Terms: Edwardsiella*/pathogenicity , Enterobacteriaceae Infections*/microbiology , Enterobacteriaceae Infections*/veterinary , Enterobacteriaceae Infections*/immunology , Fish Diseases*/microbiology , Fish Diseases*/immunology , Complement C3*/metabolism, Animals ; Host-Pathogen Interactions ; Signal Transduction ; Flatfishes/microbiology

SCR Organism: Edwardsiella piscicida

Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders.

Authors: Wang JL Ye CH Teng ZF et al.

Source: Molecular psychiatry [Mol Psychiatry] 2025 Nov; Vol. 30 (11), pp. 5192-5202. Date of Electronic Publication: 2025 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE

MeSH Terms: Complement C3*/metabolism , Neurocognitive Disorders*/metabolism , Neurocognitive Disorders*/drug therapy , Platelet Factor 4*/metabolism , Receptors, Complement*/metabolism, Animals ; Mice ; Male ; Signal Transduction/drug effects ; Microglia/metabolism ; Humans ; Ceftriaxone/pharmacology ; Mice, Inbred C57BL ; Disease Models, Animal ; Aging ; Female ; Astrocytes/metabolism ; Aged ; Postoperative Cognitive Complications/metabolism ; Brain/metabolism

Activation of the C3 Complement Pathway in the Hippocampus Produces Anxiodepressive Effects in a Mouse Model of Inflammation Pain.

Authors: Zhang A Zhang X Tang X et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 14032-14049. Date of Electronic Publication: 2025 Jul 11.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Hippocampus*/metabolism , Hippocampus*/pathology , Inflammation*/complications , Inflammation*/metabolism , Inflammation*/pathology , Anxiety*/metabolism , Anxiety*/complications , Anxiety*/pathology , Pain*/metabolism , Pain*/complications , Pain*/pathology , Complement C3*/metabolism, Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction ; Freund's Adjuvant ; Glycogen Synthase Kinase 3 beta/metabolism ; Behavior, Animal

Early elevation of complement-related proteins in metabolic dysfunction-associated steatotic liver disease (MASLD) with normal liver enzymes.

Authors: Shao L Zhang B Liu J et al.

Source: BMC gastroenterology [BMC Gastroenterol] 2025 Oct 29; Vol. 25 (1), pp. 772. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

MeSH Terms: Fatty Liver*/blood , Fatty Liver*/enzymology , Complement C3*/metabolism , Complement System Proteins*/metabolism, Humans ; Male ; Animals ; Middle Aged ; Female ; Mice ; Proteomics ; Adult ; Liver/enzymology ; Alanine Transaminase/blood ; Case-Control Studies ; Diet, High-Fat ; Aspartate Aminotransferases/blood ; Complement Factor H/metabolism ; Disease Models, Animal ; C-Reactive Protein/metabolism ; Uric Acid/blood ; Aged

Ursolic acid improves cognitive impairment in type 2 diabetic mice by preventing complement 3 secretion and neuropathy.

Authors: Suo Y Fu Y Wang C et al.

Source: Brain research bulletin [Brain Res Bull] 2025 Oct 15; Vol. 231, pp. 111562. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

MeSH Terms: Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , Triterpenes*/pharmacology , Triterpenes*/therapeutic use , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/complications , Complement C3*/metabolism , Diabetic Neuropathies*/drug therapy , Diabetic Neuropathies*/metabolism, Animals ; Ursolic Acid ; Male ; Mice ; Mice, Inbred C57BL ; Neuroprotective Agents/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism

Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study.

Authors: Kavanagh D Bomback AS Vivarelli M et al.

Corporate Authors: Kavanagh D Bomback AS Vivarelli M et al.

Source: Lancet (London, England) [Lancet] 2025 Oct 11; Vol. 406 (10512), pp. 1587-1598. Date of Electronic Publication: 2025 Sep 25.

Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

MeSH Terms: Complement C3*/metabolism , Glomerulonephritis*/drug therapy , Complement Inactivating Agents*/administration & dosage , Complement Inactivating Agents*/therapeutic use, Humans ; Double-Blind Method ; Adult ; Male ; Female ; Middle Aged ; Administration, Oral ; Young Adult ; Adolescent ; Treatment Outcome ; Glomerular Filtration Rate ; Proteinuria ; Benzoates ; Indoles ; Piperidines