Výsledky vyhľadávania - "Cognitive Dysfunction/metabolism"

Hippocampal P2X7 and A2A purinoceptors mediate cognitive impairment caused by long-lasting epileptic seizures

Autori: Sun, Meng-Juan Ren, Wen-Jing Zhao, Ya-Fei a ďalší

Zdroj: Theranostics
Sun, M-J, Ren, W-J, Zhao, Y-F, Li, X, Khan, M T, Cheng, X-Y, Yin, H-Y, Verkhratsky, A, Engel, T, Rubini, P, Tang, Y & Illes, P 2025, 'Hippocampal P2X7 and A2A purinoceptors mediate cognitive impairment caused by long-lasting epileptic seizures', Theranostics, vol. 15, no. 7, pp. 3159-3184. https://doi.org/10.7150/thno.100365

Predmety: Male, Depression/metabolism, Hippocampus/metabolism, Cognitive Dysfunction/metabolism, Status Epilepticus/metabolism, Inbred C57BL, Hippocampus, Mice, Status Epilepticus, Seizures, Receptors, Animals, Cognitive Dysfunction, CA1 Region, Hippocampal/metabolism, Hippocampal/metabolism, CA1 Region, Hippocampal, Kainic Acid, Purinergic P2X7/metabolism, Animal, Depression, CA1 Region, Electroencephalography, Receptors, Purinergic P2X7/metabolism, Mice, Inbred C57BL, Disease Models, Animal, Kainic Acid/pharmacology, Disease Models, Seizures/metabolism, Receptors, Purinergic P2X7, Research Paper

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40083937
https://research.manchester.ac.uk/en/publications/322cd846-23cb-4ec0-8e4f-554884334b20
https://doi.org/10.7150/thno.100365

Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis

Autori: Yixun Su Hui Li Wenjie Zhang a ďalší

Zdroj: Nat Commun
Su, Y, Li, H, Zhang, W, Tao, S, Wang, Q, Zhang, X, Zhou, M, Huang, X, Wang, C, Tang, Y, Chen, H, Verkhratsky, A, Zha, Z, Niu, J & Yi, C 2025, 'Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis', Nature Communications, vol. 16, no. 1, pp. 5621. https://doi.org/10.1038/s41467-025-60746-w

Predmety: Mice, Knockout, Male, Animal, Knockout, Mice, Transgenic, Cognitive Dysfunction/metabolism, Transgenic, Neuroprotection, Presenilin-1/genetics, Article, Microglia/metabolism, Disease Models, Animal, Mice, Disease Models, Animals, Humans, Alzheimer Disease/metabolism, Female, Amyloidosis/metabolism, Plaque, Amyloid/pathology, Connexin 43/metabolism, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Peptides/metabolism, Plaque, Amyloid/pathology

Prístupová URL adresa: https://research.manchester.ac.uk/en/publications/bbd0c939-1f08-4aff-b3e9-497fcae15874
https://doi.org/10.1038/s41467-025-60746-w

Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease

Autori: Lasse S. Madsen Rola Ismail Peter Parbo a ďalší

Zdroj: Alzheimers Dement
Madsen, L S, Ismail, R, Parbo, P, Kjeldsen, P L, Schaldemose, J L, Hansen, K V, Gottrup, H, Aanerud, J, Eskildsen, S F & Brooks, D J 2024, 'Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease', Alzheimer's & Dementia, vol. 20, no. 11, pp. 8028-8037. https://doi.org/10.1002/alz.14298

Predmety: cognition, Male, Alzheimer Disease/diagnostic imaging, Aniline Compounds/pharmacology, Cognitive Dysfunction/metabolism, Neuropsychological Tests, Isoquinolines/pharmacology, position emission tomography, Microglia/metabolism, mild cognitive impairment, Cognition, Alzheimer Disease, Neuropsychological Tests/statistics & numerical data, Humans, Cognitive Dysfunction, Longitudinal Studies, Amyloid beta-Peptides/metabolism, Cognition/physiology, Aged, PK11195, Amyloid beta-Peptides, Aniline Compounds, translocator protein, Brain, Alzheimer's disease, Brain/diagnostic imaging, Isoquinolines, Magnetic Resonance Imaging, amyloid beta, Thiazoles, Positron-Emission Tomography, Female, Microglia, Research Article

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39392185
https://pure.au.dk/portal/en/publications/387f4b8c-3327-467d-b3fa-0a6de53d98c6
https://doi.org/10.1002/alz.14298
http://www.scopus.com/inward/record.url?scp=85205963623&partnerID=8YFLogxK

Biomarkers of cognitive and memory decline in psychotropic drug users

Autori: Monica Grigore Mihai Andrei Ruscu Dirk M. Hermann a ďalší

Prispievatelia: Monica Grigore Mihai Andrei Ruscu Dirk M. Hermann a ďalší

Zdroj: J Neural Transm (Vienna)

Predmety: Biomarkers, Memory Disorders/diagnosis [MeSH], Cognitive Dysfunction/metabolism [MeSH], Cognitive Dysfunction/diagnosis [MeSH], Psychotropic drugs, Humans [MeSH], Memory Disorders/chemically induced [MeSH], Psychotropic Drugs/adverse effects [MeSH], Mood disorders, Schizophrenia, Psychiatry and Preclinical Psychiatric Studies - Review Article, Recreational drugs, Memory, Cognitive Dysfunction/chemically induced [MeSH], Anxiety, Genetics, Athletic performance, Epigenetics, Biomarkers/metabolism [MeSH], Ageing, Memory Disorders/metabolism [MeSH], Cognition

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39377784
https://resolver.sub.uni-goettingen.de/purl?gro-2/146444
https://repository.publisso.de/resource/frl:6501867

Glucose metabolism in hyper-connected regions predicts neurodegeneration and speed of conversion in Alzheimer's disease.

Autori: Galli, Alice Inglese, Marianna Presotto, Luca a ďalší

Zdroj: European Journal of Nuclear Medicine and Molecular Imaging, 52 (12), 4639 - 4651 (2025-10)

Predmety: Glucose metabolism, Graph theory, Hyper-connectivity, Hypo-connectivity, Mild cognitive impairment, Prodromal, Glucose, Fluorodeoxyglucose F18, Humans, Male, Female, Aged, Positron-Emission Tomography, Disease Progression, Longitudinal Studies, Cognitive Dysfunction/metabolism, Cognitive Dysfunction/diagnostic imaging, Middle Aged, Aged, 80 and over, Alzheimer Disease/metabolism, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/pathology, Glucose/metabolism, Brain/metabolism, Brain/diagnostic imaging, Alzheimer, Clustering analysis, Cognitive impairment, Connected region, Neurodegeneration, Alzheimer Disease, Brain, Cognitive Dysfunction, Radiology, Nuclear Medicine and Imaging, Human health sciences, Radiology, nuclear medicine & imaging, Sciences de la santé humaine, Radiologie, médecine & imagerie nucléaire

Relation: https://link.springer.com/content/pdf/10.1007/s00259-025-07379-9.pdf; urn:issn:1619-7070; urn:issn:1619-7089

Prístupová URL adresa: https://orbi.uliege.be/handle/2268/337117

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

Autori: Camporesi, Sara Xin, Lijing Golay, Philippe a ďalší

Zdroj: Mol Psychiatry
Molecular psychiatry, vol. 29, no. 11, pp. 3669-3679
Camporesi, Sara; Xin, Lijing; Golay, Philippe; Eap, Chin Bin; Cleusix, Martine; Cuenod, Michel; Fournier, Margot; Hashimoto, Kenji; Jenni, Raoul; Ramain, Julie; Restellini, Romeo; Solida, Alessandra; Conus, Philippe; Do, Kim Q; Khadimallah, Ines (2024). Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study. (In Press). Molecular psychiatry Springer Nature 10.1038/s41380-024-02631-4 <http://dx.doi.org/10.1038/s41380-024-02631-4>
Camporesi, Sara; Xin, Lijing; Golay, Philippe; Eap, Chin Bin; Cleusix, Martine; Cuenod, Michel; Fournier, Margot; Hashimoto, Kenji; Jenni, Raoul; Ramain, Julie; Restellini, Romeo; Solida, Alessandra; Conus, Philippe; Do, Kim Q; Khadimallah, Ines (2024). Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study. Molecular psychiatry, 29(11), pp. 3669-3679. Springer Nature 10.1038/s41380-024-02631-4 <http://dx.doi.org/10.1038/s41380-024-02631-4>

Predmety: Male, Adult, Adolescent, Psychotic Disorders / metabolism, Glutamic Acid, 610 Medicine & health, Schizophrenia, Treatment-Resistant / metabolism, Glutamic Acid / metabolism, Neuropsychological Tests, Humans, Female, Longitudinal Studies, Psychotic Disorders/drug therapy, Psychotic Disorders/metabolism, Receptors, N-Methyl-D-Aspartate/metabolism, Young Adult, Follow-Up Studies, Cognitive Dysfunction/drug therapy, Cognitive Dysfunction/metabolism, Antipsychotic Agents/therapeutic use, Antipsychotic Agents/pharmacology, Case-Control Studies, Cognition/physiology, Cognition/drug effects, Schizophrenia, Treatment-Resistant/drug therapy, Schizophrenia, Treatment-Resistant/metabolism, Glutamic Acid/metabolism, Schizophrenia/drug therapy, Schizophrenia/metabolism, Brain/metabolism, Receptors, N-Methyl-D-Aspartate, Receptors, N-Methyl-D-Aspartate / metabolism, Article, Cognition, Psychotic Disorders / drug therapy, Cognitive Dysfunction, Cognition / physiology, Cognitive Dysfunction / drug therapy, Schizophrenia / metabolism, Antipsychotic Agents / pharmacology, Schizophrenia, Treatment-Resistant / drug therapy, Schizophrenia / drug therapy, Brain, Cognitive Dysfunction / metabolism, Psychotic Disorders, Cognition / drug effects, 616.89, Schizophrenia, Brain / metabolism, Antipsychotic Agents / therapeutic use, Schizophrenia, Treatment-Resistant, Antipsychotic Agents

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38849515
https://archive-ouverte.unige.ch/unige:184121
https://doi.org/10.1038/s41380-024-02631-4
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_23EAC9CDB4DD2
https://serval.unil.ch/notice/serval:BIB_23EAC9CDB4DD
https://serval.unil.ch/resource/serval:BIB_23EAC9CDB4DD.P001/REF.pdf
https://boris.unibe.ch/197694/

Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease

Autori: Ercan, Huriye Reumiller, Christina Maria Mühlberger, Jacqueline a ďalší

Zdroj: Alzheimers Dement

Predmety: Blood Platelets, Male, Proteomics, Glutathione Transferase Metabolism, Alzheimer Disease Metabolism, Glutathione Peroxidase Metabolism, Alzheimer Disease Blood, Cognitive Dysfunction Blood, Superoxide Dismutase-1 Metabolism, Biomarkers Blood, Polymorphism, Single Nucleotide, Antioxidants, Superoxide Dismutase-1, Glutathione Peroxidase GPX1, Glutathione Peroxidase Blood, Alzheimer Disease, Polymorphism, Single Nucleotide Genetics, Humans, Cognitive Dysfunction, Aged, Glutathione Transferase, Aged, 80 and over, Glutathione Peroxidase, Superoxide Dismutase Metabolism, Blood Platelets Metabolism, Superoxide Dismutase, Cognitive Dysfunction Metabolism, Frontal Lobe Metabolism, Antioxidants Metabolism, Frontal Lobe, Alzheimer Disease Pathology, Female, Alzheimer Disease Genetics, Biomarkers, Research Article

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40189792
https://phaidra.vetmeduni.ac.at/o:4077
https://doi.org/10.1002/alz.70117

Microstructural assessment of the locus coeruleus–entorhinal cortex pathway and association with ATN markers in cognitive impairment

Autori: Aiello, M. Marizzoni, M. Borrelli, P. a ďalší

Zdroj: Alzheimers Dement
Alzheimer's & dementia, vol. 21, no. 4, pp. e70126

Predmety: Male, Amyloid beta-Peptides, Humans, Locus Coeruleus/diagnostic imaging, Locus Coeruleus/pathology, Locus Coeruleus/metabolism, Female, Cognitive Dysfunction/pathology, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/metabolism, Cross-Sectional Studies, Aged, Entorhinal Cortex/diagnostic imaging, Entorhinal Cortex/pathology, Entorhinal Cortex/metabolism, Biomarkers/metabolism, tau Proteins/metabolism, Positron-Emission Tomography, Magnetic Resonance Imaging, Neural Pathways/pathology, Neural Pathways/diagnostic imaging, Alzheimer Disease/pathology, Alzheimer Disease/diagnostic imaging, Amyloid beta-Peptides/metabolism, Middle Aged, amyloid/tau/neurodegeneration, dementia, diffusion‐weighted imaging, entorhinal cortex, locus coeruleus, magnetic resonance imaging, tau Proteins, Alzheimer Disease, Neural Pathways, Entorhinal Cortex, Locus Coeruleus, Cognitive Dysfunction, Biomarkers, Research Article

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40289861
https://serval.unil.ch/notice/serval:BIB_4C8321F17AD1
https://serval.unil.ch/resource/serval:BIB_4C8321F17AD1.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4C8321F17AD15

Dopaminergic deficits along the spectrum of Alzheimer's disease.

Autori: Pilotto, Andrea Galli, Alice Sala, Arianna a ďalší

Zdroj: Molecular Psychiatry, 30 (7), 3069 - 3076 (2025-07)

Predmety: Dopamine, Dopamine Plasma Membrane Transport Proteins, Tropanes, 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane, Humans, Male, Female, Aged, Brain/metabolism, Brain/diagnostic imaging, Tomography, Emission-Computed, Single-Photon/methods, Dopamine Plasma Membrane Transport Proteins/metabolism, Aged, 80 and over, Cognitive Dysfunction/metabolism, Middle Aged, Neural Pathways/metabolism, Alzheimer Disease/metabolism, Alzheimer Disease/diagnostic imaging, Dopamine/metabolism, Alzheimer Disease, Brain, Cognitive Dysfunction, Neural Pathways, Tomography, Emission-Computed, Single-Photon, Molecular Biology, Cellular and Molecular Neuroscience, Psychiatry and Mental Health, Human health sciences, Neurology, Sciences de la santé humaine, Neurologie

Relation: https://www.nature.com/articles/s41380-025-02913-5.pdf; urn:issn:1359-4184; urn:issn:1476-5578

Prístupová URL adresa: https://orbi.uliege.be/handle/2268/337116

Cortisol and 10‐Year Cognitive Decline in Older People From the General Population

Autori: Simone Amendola Sami Ouanes Leonardo Zullo a ďalší

Zdroj: Eur J Neurol
European journal of neurology, vol. 32, no. 3, pp. e70056

Predmety: Male, Aged, 80 and over, Humans, Hydrocortisone/metabolism, Female, Aged, Saliva/metabolism, Saliva/chemistry, Cognitive Dysfunction/metabolism, Cognitive Dysfunction/genetics, Apolipoprotein E4/genetics, Prospective Studies, Neuropsychological Tests, CoLaus|PsyCoLaus, HPA axis, cognition, cognitive decline, cortisol, dementia, Hydrocortisone, Apolipoprotein E4, Original Article, Cognitive Dysfunction, Saliva

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40022464
https://serval.unil.ch/notice/serval:BIB_6BA0D38C10BF
https://serval.unil.ch/resource/serval:BIB_6BA0D38C10BF.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6BA0D38C10BF8

Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study

Autori: Boccalini, Cecilia Peretti, Debora Elisa Scheffler, Max a ďalší

Zdroj: Alzheimers Res Ther
Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-11 (2025)
Alzheimer's research & therapy, vol. 17, no. 1, pp. 46
ALZHEIMERS RESEARCH & THERAPY, 17 (1)

Predmety: Male, tau-PET, Humans, Female, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/metabolism, Alzheimer Disease/psychology, Biomarkers/blood, Biomarkers/metabolism, Aged, tau Proteins/metabolism, Sex Characteristics, Cognition/physiology, Glial Fibrillary Acidic Protein/blood, Magnetic Resonance Imaging, Positron-Emission Tomography, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/metabolism, Aged, 80 and over, Amyloid beta-Peptides/metabolism, Middle Aged, Sex Factors, Alzheimer's disease, Biomarkers, Neuroimaging, Sex, Women, Neurosciences. Biological psychiatry. Neuropsychiatry, tau Proteins, Neuropsychological Tests, Cognition, Alzheimer Disease, Glial Fibrillary Acidic Protein, Cognitive Dysfunction, RC346-429, Amyloid beta-Peptides, Research, Neurology. Diseases of the nervous system, RC321-571

Popis súboru: application/pdf; application/application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39966925
https://doaj.org/article/ad1d015d9d584c47bfd2d0613b074491
https://serval.unil.ch/notice/serval:BIB_38E2DE99CC3C
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_38E2DE99CC3C9
https://serval.unil.ch/resource/serval:BIB_38E2DE99CC3C.P001/REF.pdf
http://hdl.handle.net/20.500.11850/724750

Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy

Autori: Jacopo Pasquini Hilmar P. Sigurdsson Michael Firbank a ďalší

Zdroj: J Neurol
Pasquini, J, Sigurdsson, H P, Firbank, M, Best, L, Foster, V, Galley, D, Maxwell, R, Silani, V, Ceravolo, R, Petrides, G, Brooks, D J & Pavese, N 2025, 'Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy', Journal of Neurology, vol. 272, no. 3, 195, pp. 195. https://doi.org/10.1007/s00415-025-12932-5

Predmety: Male, Cognitive decline, Cognitive Dysfunction/metabolism, Fluorodeoxyglucose F18, Locus coeruleus, Brain/metabolism, Glucose/metabolism, Humans, Cognitive Dysfunction, FDG-PET, Aged, Melanins, Original Communication, Melanins/metabolism, Brain, Locus Coeruleus/metabolism, Parkinson Disease, Multiple system atrophy, Multiple System Atrophy, Middle Aged, Parkinson Disease/metabolism, Magnetic Resonance Imaging, Glucose, Multiple System Atrophy/metabolism, Positron-Emission Tomography, Locus Coeruleus, Female

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39932591
https://link.springer.com/article/10.1007/s00415-025-12932-5
https://doi.org/10.1007/s00415-025-12932-5
https://hdl.handle.net/11568/1304948

Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner

Autori: Rubinski, Anna Dewenter, Anna Zheng, Lukai a ďalší

Zdroj: Eur J Nucl Med Mol Imaging
European journal of nuclear medicine and molecular imaging 51(4), 1035-1049 (2024). doi:10.1007/s00259-023-06530-8
European Journal of Nuclear Medicine and Molecular Imaging, vol 51, iss 4

Predmety: Florbetapir-PET, Aging, Apolipoprotein E4, Clinical sciences, genetics [Alzheimer Disease], Neurodegenerative, Alzheimer's Disease, metabolism [Cognitive Dysfunction], 2.1 Biological and endogenous factors, genetics [Apolipoprotein E4], Aniline Compounds, Original Article, Myelin, Tau, APOE, Medical and Health Sciences, Brain, 16. Peace & justice, ddc, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Neurological, Cognitive Dysfunction/metabolism [MeSH], Demyelinating Diseases/metabolism [MeSH], Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Aniline Compounds [MeSH], Alzheimer Disease/diagnostic imaging [MeSH], Brain/metabolism [MeSH], Ethylene Glycols [MeSH], Apolipoproteins E [MeSH], Positron-Emission Tomography [MeSH], Alzheimer Disease/genetics [MeSH], Apolipoprotein E4/genetics [MeSH], Alzheimer Disease/metabolism [MeSH], tau Proteins/metabolism [MeSH], Biomedical Imaging, metabolism [Demyelinating Diseases], florbetapir, Ethylene Glycols, metabolism [Alzheimer Disease], Clinical Sciences, metabolism [Amyloid beta-Peptides], tau Proteins, Apolipoproteins E, Clinical Research, Alzheimer Disease, Acquired Cognitive Impairment, Humans, Cognitive Dysfunction, ddc:610, Amyloid beta-Peptides, Biomedical and Clinical Sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Neuroimaging Initiative, metabolism [tau Proteins], Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, metabolism [Brain], Positron-Emission Tomography, Dementia, diagnostic imaging [Alzheimer Disease], Demyelinating Diseases

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38049659
https://pub.dzne.de/record/268319
https://repository.publisso.de/resource/frl:6502115
https://epub.ub.uni-muenchen.de/116314/
https://escholarship.org/uc/item/5r36q7bq
https://escholarship.org/content/qt5r36q7bq/qt5r36q7bq.pdf
https://mediatum.ub.tum.de/1764144

Impact of dementia and mild cognitive impairment on bone health in older people.

Autori: Curtis, Elizabeth M Miguel, Mario McEvoy, Claire a ďalší

Zdroj: Aging Clinical and Experimental Research, 37 (1), 5 (2025)

Predmety: Bone mineral density, Cognitive impairment, Dementia, Epidemiology, Fracture, Osteoporosis, Aged, Humans, Aging/metabolism, Bone and Bones/metabolism, Bone Density, Risk Factors, Cognitive Dysfunction/epidemiology, Cognitive Dysfunction/metabolism, Dementia/epidemiology, Dementia/metabolism, Osteoporosis/epidemiology, Osteoporosis/metabolism, Aging, Bone and Bones, Cognitive Dysfunction, Geriatrics and Gerontology, Human health sciences, Public health, health care sciences & services, Sciences de la santé humaine, Santé publique, services médicaux & soins de santé

Relation: https://link.springer.com/content/pdf/10.1007/s40520-024-02871-y.pdf; urn:issn:1594-0667; urn:issn:1720-8319; https://orbi.uliege.be/handle/2268/334683; info:hdl:2268/334683; https://orbi.uliege.be/bitstream/2268/334683/1/Impact%20of%20dementia%20and%20mild%20cognitive%20impairment%20on%20bone%20health%20in%20older%20people%20%282%29.pdf; info:pmid:39725855

Dostupnosť: https://orbi.uliege.be/handle/2268/334683
https://orbi.uliege.be/bitstream/2268/334683/1/Impact%20of%20dementia%20and%20mild%20cognitive%20impairment%20on%20bone%20health%20in%20older%20people%20%282%29.pdf
https://doi.org/10.1007/s40520-024-02871-y

Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis

Autori: Pisani, Sara Velayudhan, Latha Aarsland, Dag a ďalší

Zdroj: Pisani, S, Velayudhan, L, Aarsland, D, Ray Chaudhuri, K, Ballard, C, Ffytche, D & Bhattacharyya, S 2025, 'Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis', BMJ mental health, vol. 28, no. 1, 301430. https://doi.org/10.1136/bmjment-2024-301430

Predmety: Humans, Parkinson Disease/metabolism, Male, Female, Aged, Psychotic Disorders/metabolism, Middle Aged, Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins/metabolism, Cognitive Dysfunction/metabolism, Corpus Striatum/metabolism, Neuropsychological Tests, Tropanes/pharmacokinetics, Disease Progression

Dostupnosť: https://kclpure.kcl.ac.uk/portal/en/publications/7ef20620-aacd-4a65-8bd8-77b71f826660
https://doi.org/10.1136/bmjment-2024-301430
http://www.scopus.com/inward/record.url?scp=105001717763&partnerID=8YFLogxK

The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline

Autori: Boccalini, Cécilia Ribaldi, Federica Hristovska, Ines a ďalší

Zdroj: Alzheimers Dement
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 20 (1)

Predmety: Positron emission tomography, Amyloid, positron emission tomography, Cognitive decline, Neuroimaging, tau Proteins, 618.97, Alzheimer's disease biomarkers, Biomarkers / metabolism, Alzheimer Disease, Fluorodeoxyglucose F18, Humans, Cognitive Dysfunction, Amyloid / metabolism, Fluorodeoxyglucose F18 / metabolism, Research Articles, Positron-Emission Tomography / methods, Amyloid beta-Peptides, neuroimaging, 616.0757, Alzheimer Disease / pathology, cognitive decline, 3. Good health, Cognitive Dysfunction / metabolism, Positron-Emission Tomography, Tau Proteins / metabolism, Biomarkers

Popis súboru: application/pdf; application/application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37555516
https://archive-ouverte.unige.ch/unige:177252
https://doi.org/10.1002/alz.13355
http://hdl.handle.net/20.500.11850/627372

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Autori: Zatcepin, Artem Gnörich, Johannes Rauchmann, Boris-Stephan a ďalší

Prispievatelia: Zatcepin, Artem Gnörich, Johannes Rauchmann, Boris-Stephan a ďalší

Zdroj: Mol Neurodegener
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Molecular neurodegeneration 19(1), 64 (2024). doi:10.1186/s13024-024-00752-6

Predmety: Male, Cognitive Dysfunction/metabolism [MeSH], Neuroinflammation, Microglia desynchronization, PET, Alzheimer's disease, Mice, Transgenic [MeSH], Microglia/metabolism [MeSH], Male [MeSH], Positron-Emission Tomography [MeSH], Alzheimer Disease/metabolism [MeSH], Disease Models, Animal [MeSH], Research Article, Dementia, Female [MeSH], Brain/pathology [MeSH], Humans [MeSH], Microglia, TSPO, Connectome/methods [MeSH], Microglia synchronicity, Animals [MeSH], Brain connectivity, Mice [MeSH], Brain/metabolism [MeSH], Receptors, GABA/metabolism [MeSH], Alzheimer Disease/pathology [MeSH], Mice, Transgenic, metabolism [Microglia], pathology [Alzheimer Disease], metabolism [Cognitive Dysfunction], Mice, methods [Connectome], Receptors, GABA, pathology [Brain], Alzheimer Disease, ddc:570, Connectome, Animals, Humans, Cognitive Dysfunction, RC346-429, RC952-954.6, Brain, ddc, metabolism [Receptors, GABA], Disease Models, Animal, metabolism [Brain], Geriatrics, Positron-Emission Tomography, Female, Neurology. Diseases of the nervous system, metabolism [Alzheimer Disease]

Popis súboru: application/pdf; text/xml

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39238030
https://doaj.org/article/a5bbc5a0c7914c46ad9ff511752e6937
https://resolver.sub.uni-goettingen.de/purl?gro-2/145782
https://repository.publisso.de/resource/frl:6519401
https://epub.ub.uni-muenchen.de/123137/
https://mediatum.ub.tum.de/doc/1770432/document.pdf

CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility

Autori: Awad, Patricia Nora Zerbi, Valerio Johnson-Venkatesh, Erin M a ďalší

Zdroj: Mol Psychiatry
Molecular Psychiatry, 29 (6)
Molecular Psychiatry

Predmety: Neuroscience, Autism spectrum disorders, Magnetic Resonance Imaging / methods, Male, 0301 basic medicine, Neurodevelopmental Disorders / genetics, Corpus Callosum / metabolism, Protein Serine-Threonine Kinases, Cognitive Dysfunction / physiopathology, Epileptic Syndromes / physiopathology, Gyrus Cinguli, Article, Neurodevelopmental Disorders / metabolism, Corpus Callosum, Mice, 03 medical and health sciences, Cognition, 0302 clinical medicine, X-Linked Intellectual Disability, Synapses / physiology, Animals, Gyrus Cinguli / metabolism, Cognitive Dysfunction, Cognition / physiology, X-Linked Intellectual Disability / physiopathology, X-Linked Intellectual Disability / genetics, Mice, Knockout, Neurons, Neurons / metabolism, Brain, Protein Serine-Threonine Kinases / genetics, Synapses / metabolism, Magnetic Resonance Imaging, Spasms, Infantile / metabolism, Spasms, Infantile / physiopathology, Mice, Inbred C57BL, Disease Models, Animal, Cognitive Dysfunction / metabolism, Spasms, Infantile / genetics, Neurodevelopmental Disorders, Protein Serine-Threonine Kinases / metabolism, Cognitive Dysfunction / genetics, Epileptic Syndromes / genetics, Synapses, Brain / metabolism, Female, Epileptic Syndromes, Spasms, Infantile, Neurodevelopmental Disorders / physiopathology, CDKL5 Deficiency Disorder

Popis súboru: application/pdf; application/application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36737483
https://archive-ouverte.unige.ch/unige:185366
https://doi.org/10.1038/s41380-023-01962-y
http://hdl.handle.net/20.500.11850/601551

Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease

Autori: Fangda Leng Rainer Hinz Steve Gentleman a ďalší

Zdroj: Mol Psychiatry
Leng, F, Hinz, R, Gentleman, S, Hampshire, A, Dani, M, Brooks, D J & Edison, P 2023, 'Neuroinflammation is independently associated with brain network dysfunction in Alzheimer's disease', Molecular Psychiatry, vol. 28, no. 3, pp. 1303-1311. https://doi.org/10.1038/s41380-022-01878-z
Leng, F, Hinz, R, Gentleman, S, Hampshire, A, Dani, M, Brooks, D J & Edison, P 2022, 'Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease', Molecular psychiatry. https://doi.org/10.1038/s41380-022-01878-z

Predmety: Amyloid beta-Peptides, Brain, Cognitive Dysfunction/metabolism, Positron-Emission Tomography/methods, 16. Peace & justice, Article, Cross-Sectional Studies, Alzheimer Disease, Positron-Emission Tomography, Neuroinflammatory Diseases, Brain/metabolism, Humans, Alzheimer Disease/metabolism, Cognitive Dysfunction, Amyloid beta-Peptides/metabolism

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36474000
https://pure.au.dk/portal/en/publications/b109dbde-8339-43cb-a68d-4ddb2ff27953

Amyloid-PET imaging predicts functional decline in clinically normal individuals

Autori: Quenon, Lisa Collij, Lyduine E den Braber, Anouk a ďalší

Prispievatelia: Quenon, Lisa Collij, Lyduine E den Braber, Anouk a ďalší

Zdroj: Alzheimers Res Ther
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
the AMYPAD Consortium 2024, 'Amyloid-PET imaging predicts functional decline in clinically normal individuals', Alzheimer's Research and Therapy, vol. 16, no. 1, 130. https://doi.org/10.1186/s13195-024-01494-9
Alzheimer's research & therapy 16(1), 130 (2024). doi:10.1186/s13195-024-01494-9
Alzheimer's research & therapy, Vol. 16, no. 1, p. 130 [1-13] (2024)

Predmety: Male, Clinical Neurology, diagnostic imaging [Cognitive Dysfunction], metabolism [Amyloid beta-Peptides], Neurosciences. Biological psychiatry. Neuropsychiatry, THRESHOLD, Female [MeSH], Aged, 80 and over [MeSH], Brain/diagnostic imaging [MeSH], Cognitive Dysfunction/metabolism [MeSH], Aged [MeSH], Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Longitudinal Studies [MeSH], Functional decline, Middle Aged [MeSH], Cross-Sectional Studies [MeSH], Preclinical Alzheimer, Positron-Emission Tomography/methods [MeSH], Male [MeSH], Brain/metabolism [MeSH], Instrumental activities of daily living, Research, Cognitive Dysfunction/diagnostic imaging [MeSH], Activities of Daily Living [MeSH], Centiloid, Amyloid-PET, metabolism [Cognitive Dysfunction], Activities of Daily Living, Humans, AMYPAD Consortium, Cognitive Dysfunction, ddc:610, Longitudinal Studies, RC346-429, diagnostic imaging [Brain], 11 Medical and Health Sciences, Aged, Aged, 80 and over, Science & Technology, 42 Health sciences, Amyloid beta-Peptides, DEMENTIA, methods [Positron-Emission Tomography], Neurosciences, Brain, 32 Biomedical and clinical sciences, IMPAIRMENT, Middle Aged, 16. Peace & justice, 3. Good health, Cross-Sectional Studies, metabolism [Brain], Positron-Emission Tomography, INSTRUMENTAL ACTIVITIES, COGNITIVE DECLINE, Female, Neurosciences & Neurology, Neurology. Diseases of the nervous system, Life Sciences & Biomedicine, RC321-571

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38886831
https://doaj.org/article/916789749e284220b7135dd30f36111c
https://hdl.handle.net/1871.1/54c58075-b99a-428d-98d4-1890d2935ff1
https://research.vu.nl/en/publications/54c58075-b99a-428d-98d4-1890d2935ff1
https://doi.org/10.1186/s13195-024-01494-9
https://cris.maastrichtuniversity.nl/en/publications/0af5d18d-00fb-499d-b18e-d52eb3a3f622
https://doi.org/10.1186/s13195-024-01494-9
https://research.vumc.nl/en/publications/f6445675-6cbd-46a9-ad67-6a03b8b854b4
https://pub.dzne.de/record/270307
https://lirias.kuleuven.be/handle/20.500.12942/749946
https://doi.org/10.1186/s13195-024-01494-9
https://hdl.handle.net/2078.1/296660
https://repository.publisso.de/resource/frl:6519631
https://discovery-pp.ucl.ac.uk/id/eprint/10194242/