Výsledky vyhľadávania - "Coenzyme A"

Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production.

Autori: Klass SH Wesselkamper M Cowan AE a ďalší

Zdroj: Nature chemical biology [Nat Chem Biol] 2025 Aug; Vol. 21 (8), pp. 1214-1225. Date of Electronic Publication: 2025 Jun 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Malonyl Coenzyme A*/metabolism , Malonyl Coenzyme A*/genetics , Malonyl Coenzyme A*/biosynthesis , Polyketides*/metabolism , Escherichia coli*/metabolism , Escherichia coli*/genetics , Metabolic Engineering*, Polyketide Synthases/metabolism ; Polyketide Synthases/genetics ; Coenzyme A Ligases/metabolism ; Coenzyme A Ligases/genetics ; Malonates/metabolism

Dual molecular genetic diagnosis with combined malonic and methylmalonic aciduria (CMAMMA): implications of coexisting genetic disorders on clinical presentation.

Autori: Ersoy M Abali ZY Papatya Cakir ED a ďalší

Zdroj: Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2025 Sep 11; Vol. 38 (12), pp. 1340-1349. Date of Electronic Publication: 2025 Sep 11 (Print Publication: 2025).

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9508900 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2191-0251 (Electronic) Linking ISSN: 0334018X NLM ISO Abbreviation: J Pediatr Endocrinol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Metabolism, Inborn Errors*/genetics , Metabolism, Inborn Errors*/diagnosis , Mutation* , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/deficiency , Amino Acid Metabolism, Inborn Errors*/genetics , Amino Acid Metabolism, Inborn Errors*/diagnosis, Humans ; Male ; Female ; Child ; Child, Preschool ; Infant ; Adolescent ; Adult ; Young Adult ; Infant, Newborn ; Pedigree ; Prognosis ; Exome Sequencing ; Follow-Up Studies ; Carboxy-Lyases/deficiency ; Malonyl Coenzyme A ; Methylmalonic Acid

SCR Disease Name: Methylmalonic acidemia; Malonic aciduria

Ketone body-supported respiration in murine isolated brain mitochondria is augmented by alpha-ketoglutarate and is optimized by neuronal SCOT expression.

Autori: Davis XC McCoin CS Morris EM a ďalší

Zdroj: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Jun 01; Vol. 328 (6), pp. E822-E832. Date of Electronic Publication: 2025 Apr 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ketone Bodies*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects , Brain*/metabolism , Brain*/drug effects , Neurons*/metabolism , Neurons*/drug effects , Coenzyme A-Transferases*/metabolism , Coenzyme A-Transferases*/genetics , Ketoglutaric Acids*/pharmacology , Ketoglutaric Acids*/metabolism, Animals ; Mice ; Mice, Knockout ; Male ; Acetyl Coenzyme A/metabolism ; Cell Respiration/drug effects ; Acetoacetates/metabolism ; Mice, Inbred C57BL ; Energy Metabolism/drug effects ; Acyl Coenzyme A/metabolism

p38 mediated ACSL4 phosphorylation drives stress-induced esophageal squamous cell carcinoma growth through Src myristoylation.

Autori: Yuan Q Shi Y Wang J a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Apr 07; Vol. 16 (1), pp. 3319. Date of Electronic Publication: 2025 Apr 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Esophageal Neoplasms*/metabolism , Esophageal Neoplasms*/pathology , Esophageal Neoplasms*/genetics , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/genetics , p38 Mitogen-Activated Protein Kinases*/metabolism , p38 Mitogen-Activated Protein Kinases*/genetics , src-Family Kinases*/metabolism , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/metabolism, Humans ; Phosphorylation ; Esophageal Squamous Cell Carcinoma/metabolism ; Cell Line, Tumor ; Long-Chain-Fatty-Acid-CoA Ligase ; Animals ; Cell Proliferation ; Mice ; Stress, Physiological ; MAP Kinase Signaling System ; Male ; Acyl Coenzyme A/metabolism

Structural and kinetic characterization of an acetoacetyl-Coenzyme A: acetate Coenzyme A transferase from the extreme thermophile Thermosipho melanesiensis.

Autori: Bing RG Buhrman GK Ford KC a ďalší

Zdroj: The Biochemical journal [Biochem J] 2025 Feb 19; Vol. 482 (4), pp. 225-240.

Spôsob vydávania: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acyl Coenzyme A*/metabolism , Acyl Coenzyme A*/chemistry , Coenzyme A-Transferases*/chemistry , Coenzyme A-Transferases*/metabolism , Coenzyme A-Transferases*/genetics , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Firmicutes*/enzymology, Kinetics ; Crystallography, X-Ray ; Acetyl Coenzyme A/metabolism ; Acetyl Coenzyme A/chemistry ; Acetates/metabolism ; Substrate Specificity ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Recombinant Proteins/genetics

Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units.

Autori: Paulsel TQ Williams GJ

Zdroj: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Nov 04; Vol. 25 (21), pp. e202400532. Date of Electronic Publication: 2024 Sep 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polyketides*/metabolism , Polyketides*/chemistry , Halogenation* , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/genetics, Malonyl Coenzyme A/metabolism ; Protein Engineering ; Molecular Structure ; Bacterial Proteins

New-to-nature CO 2 -dependent acetyl-CoA assimilation enabled by an engineered B 12 -dependent acyl-CoA mutase.

Autori: Schulz-Mirbach H Wichmann P Satanowski A a ďalší

Zdroj: Nature communications [Nat Commun] 2024 Nov 26; Vol. 15 (1), pp. 10235. Date of Electronic Publication: 2024 Nov 26.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acetyl Coenzyme A*/metabolism , Carbon Dioxide*/metabolism , Cobamides*/metabolism, Metabolic Engineering/methods ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Bacillus/genetics ; Bacillus/enzymology ; Bacillus/metabolism ; Pyruvic Acid/metabolism ; Vitamin B 12/metabolism ; Intramolecular Transferases/metabolism ; Intramolecular Transferases/genetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Protein Engineering ; Acyl Coenzyme A/metabolism ; Lactic Acid/analogs & derivatives

A single Leishmania adenylate-forming enzyme of the ANL superfamily generates both acetyl- and acetoacetyl-CoA.

Autori: Jezewski AJ Esan TE Propp J a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2024 Nov; Vol. 300 (11), pp. 107879. Date of Electronic Publication: 2024 Oct 10.

Spôsob vydávania: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acyl Coenzyme A*/metabolism, Acetyl Coenzyme A/metabolism ; Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/chemistry ; Leishmania infantum/enzymology ; Substrate Specificity ; Acetate-CoA Ligase/metabolism ; Acetate-CoA Ligase/genetics ; Acetate-CoA Ligase/chemistry

Conformational switch upon substrate binding informs the rational design of CCoAOMT enzymes.

Autori: Cao Y Yue X Yu W a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Oct 21; Vol. 15 (1), pp. 36552. Date of Electronic Publication: 2025 Oct 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Methyltransferases*/chemistry , Methyltransferases*/metabolism , Methyltransferases*/genetics , Acyl Coenzyme A*/metabolism , Acyl Coenzyme A*/chemistry , Populus*/enzymology , Plant Proteins*/chemistry , Plant Proteins*/metabolism , Plant Proteins*/genetics, Molecular Dynamics Simulation ; Substrate Specificity ; Protein Conformation ; Protein Binding ; Binding Sites ; Lignin

Enzyme Catalyzed Formation of CoA Adducts of Fluorinated Hexanoic Acid Analogues using a Long-Chain acyl-CoA Synthetase from Gordonia sp. Strain NB4-1Y.

Autori: Mothersole RG Mothersole MK Goddard HG a ďalší

Zdroj: Biochemistry [Biochemistry] 2024 Sep 03; Vol. 63 (17), pp. 2153-2165. Date of Electronic Publication: 2024 Aug 17.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/chemistry , Caproates*/metabolism , Caproates*/chemistry, Gordonia Bacterium/metabolism ; Gordonia Bacterium/enzymology ; Gordonia Bacterium/genetics ; Halogenation ; Coenzyme A/metabolism ; Coenzyme A/chemistry ; Kinetics ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/chemistry ; Acyl Coenzyme A/metabolism ; Acyl Coenzyme A/chemistry ; Substrate Specificity ; Long-Chain-Fatty-Acid-CoA Ligase

Complete sequence randomness of lactate-based copolymers (LAHBs) with varied lactate monomer fractions employing a series of propionyl-CoA transferases.

Autori: Koh S Endo R Kahar P a ďalší

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Aug; Vol. 274 (Pt 2), pp. 133055. Date of Electronic Publication: 2024 Jun 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lactic Acid*/chemistry , Coenzyme A-Transferases*/metabolism , Coenzyme A-Transferases*/genetics , Coenzyme A-Transferases*/chemistry, Polyesters/chemistry ; Acyl Coenzyme A/metabolism ; Acyl Coenzyme A/chemistry ; Polymers/chemistry ; Acetyl Coenzyme A/metabolism ; Acetyl Coenzyme A/chemistry

Asiatic acid inhibits endothelial-to-mesenchymal transition in diabetic kidney disease by reducing acetyl-CoA production via targeting ACSS2.

Autori: Lin RH Chen JC Xu SS a ďalší

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117311. Date of Electronic Publication: 2025 Sep 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/pathology , Acetyl Coenzyme A*/biosynthesis , Acetyl Coenzyme A*/antagonists & inhibitors , Acetyl Coenzyme A*/metabolism , Pentacyclic Triterpenes*/pharmacology , Pentacyclic Triterpenes*/therapeutic use , Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/antagonists & inhibitors , Coenzyme A Ligases*/genetics, Animals ; Mice ; Male ; Humans ; Mice, Inbred C57BL ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Molecular Docking Simulation/methods

Maize 4-coumarate coenzyme A ligase Zm4CL-like9 gene positively regulates drought stress response in Arabidopsis thaliana .

Autori: Fan J Luo Z Wang Y a ďalší

Zdroj: GM crops & food [GM Crops Food] 2025 Dec; Vol. 16 (1), pp. 199-215. Date of Electronic Publication: 2025 Feb 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572655 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-5701 (Electronic) Linking ISSN: 21645698 NLM ISO Abbreviation: GM Crops Food Subsets: MEDLINE

Výrazy zo slovníka MeSH: Arabidopsis*/genetics , Arabidopsis*/physiology , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism , Zea mays*/genetics , Zea mays*/enzymology , Zea mays*/physiology , Plant Proteins*/genetics , Plant Proteins*/metabolism, Droughts ; Plants, Genetically Modified/genetics ; Gene Expression Regulation, Plant ; Stress, Physiological/genetics

Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular carcinoma.

Autori: Wang Y Su K Wang C a ďalší

Zdroj: Cell death & disease [Cell Death Dis] 2024 Jul 31; Vol. 15 (7), pp. 545. Date of Electronic Publication: 2024 Jul 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Acetyl Coenzyme A*/metabolism , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Cell Nucleus*/metabolism, Humans ; Animals ; Acetylation ; Mice ; Cell Line, Tumor ; Mice, Nude ; Coenzyme A Ligases/metabolism ; Coenzyme A Ligases/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; N-Terminal Acetyltransferases/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Mice, Inbred BALB C ; Male ; Long-Chain-Fatty-Acid-CoA Ligase

Loss of ACSL1 fuels ferroptosis resistance in clear cell renal carcinoma.

Autori: Wang S Wang Y Liu B a ďalší

Zdroj: Cancer biology & therapy [Cancer Biol Ther] 2025 Dec 31; Vol. 26 (1), pp. 2567815. Date of Electronic Publication: 2025 Oct 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137842 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8576 (Electronic) Linking ISSN: 15384047 NLM ISO Abbreviation: Cancer Biol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/genetics , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/metabolism , Kidney Neoplasms*/pathology , Kidney Neoplasms*/genetics , Kidney Neoplasms*/metabolism , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism, Humans ; Animals ; Mice ; Reactive Oxygen Species/metabolism ; Tumor Suppressor Protein p53/metabolism ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Prognosis ; Long-Chain-Fatty-Acid-CoA Ligase ; Female ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Male ; Amino Acid Transport System y+

Targeted inhibition of METTL3 reprograms alveolar echinococcosis progression: attenuating ferroptosis by downregulating ACSL4 and reversing macrophage M2 polarization.

Autori: Chen J Ma Y Fan B a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115660. Date of Electronic Publication: 2025 Oct 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/drug effects , Ferroptosis*/genetics , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism , Macrophages*/drug effects , Macrophages*/immunology , Echinococcosis, Hepatic*/drug therapy , Echinococcosis, Hepatic*/immunology , Echinococcosis, Hepatic*/pathology, Animals ; Humans ; Mice ; Long-Chain-Fatty-Acid-CoA Ligase ; Down-Regulation ; RAW 264.7 Cells ; Echinococcus multilocularis ; Disease Models, Animal ; Male ; Disease Progression ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Female ; Echinococcosis

SCR Disease Name: Alveolar echinococcosis

Down-regulation of ACSM3 Promotes Tumorigenesis in Breast Cancer.

Autori: Kim HB Kim SH Lee HJ a ďalší

Zdroj: Anticancer research [Anticancer Res] 2025 Dec; Vol. 45 (12), pp. 5435-5443.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism , Carcinogenesis*/genetics, Humans ; Female ; Animals ; Mice ; Cell Movement/genetics ; Down-Regulation ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Wnt Signaling Pathway ; Proto-Oncogene Proteins c-akt/metabolism ; Xenograft Model Antitumor Assays ; Neoplasm Invasiveness ; Mice, Nude ; Mice, Inbred BALB C

HNRNPC aggravates the symptoms of preeclampsia by regulating m6A-dependent alternative splicing of ACSL3.

Autori: Liu K Tao T Li R a ďalší

Zdroj: Journal of hypertension [J Hypertens] 2025 Dec 01; Vol. 43 (12), pp. 2057-2071. Date of Electronic Publication: 2025 Sep 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wolters Kluwer Health, Inc Country of Publication: Netherlands NLM ID: 8306882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5598 (Electronic) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pre-Eclampsia*/genetics , Pre-Eclampsia*/metabolism , Alternative Splicing* , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism, Female ; Pregnancy ; Humans ; Animals ; Mice ; Long-Chain-Fatty-Acid-CoA Ligase ; Placenta/metabolism ; Disease Models, Animal ; Cell Line ; Cell Proliferation ; Cell Movement

A machine learning-based glycolysis and fatty acid metabolism-related prognostic signature is constructed and identified ACSL5 as a novel marker inhibiting the proliferation of breast cancer.

Autori: Liang MZ Huang XF Zhu JC a ďalší

Zdroj: Computational biology and chemistry [Comput Biol Chem] 2025 Dec; Vol. 119, pp. 108507. Date of Electronic Publication: 2025 May 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Breast Neoplasms*/metabolism , Breast Neoplasms*/diagnosis , Breast Neoplasms*/pathology , Glycolysis* , Fatty Acids*/metabolism , Machine Learning* , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/genetics, Humans ; Female ; Prognosis ; Cell Proliferation ; Long-Chain-Fatty-Acid-CoA Ligase

Neonatal liver-derived FTH1-enriched extracellular vesicles attenuate ferroptosis and ameliorate MASLD pathogenesis.

Autori: Zeng X Jiang W Wu T a ďalší

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 693-703. Date of Electronic Publication: 2025 Sep 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis* , Extracellular Vesicles*/metabolism , Extracellular Vesicles*/transplantation , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/genetics , Liver*/metabolism , Liver*/pathology , Fatty Liver*/pathology , Fatty Liver*/metabolism , Fatty Liver*/therapy, Animals ; Humans ; Mice ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Iron/metabolism ; Lipid Peroxidation ; Long-Chain-Fatty-Acid-CoA Ligase ; Oxidative Stress ; Male ; Disease Models, Animal ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Mice, Inbred C57BL ; Animals, Newborn ; Ferritins ; Oxidoreductases