Search Results - "Clinical trial"

Do prospective randomized controlled trials comply with filed protocols? Spin study of 206 trials from 2010 to 2023.

Authors: Erivan R Michon B Villatte G et al.

Source: Orthopaedics & traumatology, surgery & research : OTSR [Orthop Traumatol Surg Res] 2025 Dec; Vol. 111 (8), pp. 104013. Date of Electronic Publication: 2024 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101494830 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-0568 (Electronic) Linking ISSN: 18770568 NLM ISO Abbreviation: Orthop Traumatol Surg Res Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/standards , Research Design* , Clinical Trial Protocols as Topic* , Guideline Adherence*, Humans ; Retrospective Studies ; Prospective Studies ; Periodicals as Topic

Optimising adherence to inpatient rehabilitation trial protocols: A mixed-methods systematic review.

Authors: Logan A Marsden J Freeman J et al.

Source: Clinical trials (London, England) [Clin Trials] 2025 Dec; Vol. 22 (6), pp. 728-744. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article; Systematic Review; Review

Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 101197451 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-7753 (Electronic) Linking ISSN: 17407745 NLM ISO Abbreviation: Clin Trials Subsets: MEDLINE

MeSH Terms: Inpatients* , Randomized Controlled Trials as Topic* , Guideline Adherence* , Clinical Trial Protocols as Topic*, Humans ; Research Design

Developing a surgical trial intervention protocol: using qualitative methods in the operating theatre.

Authors: Twiddy M Jackson R Gordon K et al.

Source: Trials [Trials] 2025 Sep 26; Vol. 26 (1), pp. 368. Date of Electronic Publication: 2025 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

MeSH Terms: Operating Rooms* , Randomized Controlled Trials as Topic*/methods , Research Design* , Thyroidectomy*/adverse effects , Thyroidectomy*/methods , Clinical Trial Protocols as Topic*, Humans ; Hypoparathyroidism/prevention & control ; Hypoparathyroidism/etiology ; Interviews as Topic ; Qualitative Research ; Surgeons/psychology ; Treatment Outcome ; Video Recording

Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias.

Authors: Taji Heravi A Gryaznov D Busse JW et al.

Corporate Authors: Taji Heravi A Gryaznov D Busse JW et al.

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Sep; Vol. 185, pp. 111822. Date of Electronic Publication: 2025 May 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Patient Reported Outcome Measures* , Randomized Controlled Trials as Topic*/standards , Randomized Controlled Trials as Topic*/statistics & numerical data , Publication Bias*/statistics & numerical data , Clinical Trial Protocols as Topic*, Humans ; Germany ; Canada ; Switzerland ; Bias

Public availability of randomized clinical trial protocols: a repeated meta-research study.

Authors: Schönenberger CM Chiaborelli M Taji Heravi A et al.

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Sep; Vol. 185, pp. 111865. Date of Electronic Publication: 2025 Jul 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/statistics & numerical data , Clinical Trial Protocols as Topic*, Humans ; Registries/statistics & numerical data

SPIRIT 2025 Statement: Updated Guideline for Protocols of Randomized Trials.

Authors: Chan AW Boutron I Hopewell S et al.

Source: JAMA [JAMA] 2025 Aug 05; Vol. 334 (5), pp. 435-443.

Publication Type: Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE

MeSH Terms: Clinical Trial Protocols as Topic* , Randomized Controlled Trials as Topic*/standards , Research Design*/standards, Humans ; Checklist ; Scoping Review as Topic

Protocol Development for Investigator-Sponsored Clinical Studies.

Authors: Frumkin L; School of Medicine, SPARK at Stanford, Stanford University, Stanford, California, USA.

Source: Clinical and translational science [Clin Transl Sci] 2025 May; Vol. 18 (5), pp. e70237.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH Terms: Research Personnel* , Research Design*/standards , Clinical Trials as Topic*/economics , Clinical Trials as Topic*/methods , Clinical Trials as Topic*/standards , Clinical Trial Protocols as Topic*, Humans ; Research Support as Topic

Development and Testing of the Protocol Quality Rating Tool (PQRT) to Evaluate Clinical Trial Protocol Document Quality.

Authors: Lyden AK Kalpakjian CZ Spino C et al.

Source: Clinical and translational science [Clin Transl Sci] 2025 May; Vol. 18 (5), pp. e70240.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH Terms: Clinical Trials as Topic*/standards , Clinical Trial Protocols as Topic*, Humans ; Delphi Technique ; Checklist ; Quality Control

UK paediatric clinical trial protocols: A review of guidance for participant management and care in the event of premature termination.

Authors: Pluess-Hall H Smith P Menzies J

Source: Clinical trials (London, England) [Clin Trials] 2025 Apr; Vol. 22 (2), pp. 220-226. Date of Electronic Publication: 2024 Nov 19.

Publication Type: Journal Article; Review

Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 101197451 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-7753 (Electronic) Linking ISSN: 17407745 NLM ISO Abbreviation: Clin Trials Subsets: MEDLINE

MeSH Terms: Early Termination of Clinical Trials*/statistics & numerical data , Pediatrics* , Clinical Trials as Topic* , Clinical Trial Protocols as Topic*, Humans ; United Kingdom ; Child

Improving the completeness and transparency of protocols and reports of randomized trials: SPIRIT 2025 and CONSORT 2025.

Authors: Moher D Boutron I Chan AW et al.

Source: Journal of clinical epidemiology [J Clin Epidemiol] 2025 Jun; Vol. 182, pp. 111792. Date of Electronic Publication: 2025 Apr 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE

MeSH Terms: Randomized Controlled Trials as Topic*/standards , Guidelines as Topic* , Research Design*/standards , Research Report*/standards , Clinical Trial Protocols as Topic*, Humans ; Checklist ; Delphi Technique

Dissemination planning in exercise oncology trials-a systematic review of trial protocols.

Authors: Smyth E Politi L Guinan E et al.

Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2025 May 15; Vol. 33 (6), pp. 473. Date of Electronic Publication: 2025 May 15.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

MeSH Terms: Clinical Trial Protocols as Topic* , Exercise Therapy*/methods , Information Dissemination*/methods , Neoplasms*/rehabilitation, Humans ; Cancer Survivors

Sponsor- vs. FDA-Initiated Changes to Pediatric Clinical Trial Protocols: A Comparison of Associated Participant Burden.

Authors: Abdel-Rahman S Sund Z Alderman C et al.

Corporate Authors: Abdel-Rahman S Sund Z Alderman C et al.

Source: Therapeutic innovation & regulatory science [Ther Innov Regul Sci] 2025 May; Vol. 59 (3), pp. 558-565. Date of Electronic Publication: 2025 Feb 23.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101597411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-4804 (Electronic) Linking ISSN: 21684790 NLM ISO Abbreviation: Ther Innov Regul Sci Subsets: MEDLINE

MeSH Terms: Clinical Trials as Topic* , Clinical Trial Protocols as Topic*, Humans ; United States ; United States Food and Drug Administration ; Child ; Pediatrics

Supporting evidence in phase 2 cancer trial protocols: a content analysis.

Authors: Bicer S Nelson A Carayannis K et al.

Source: Journal of the National Cancer Institute [J Natl Cancer Inst] 2025 Apr 01; Vol. 117 (4), pp. 637-643.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7503089 Publication Model: Print Cited Medium: Internet ISSN: 1460-2105 (Electronic) Linking ISSN: 00278874 NLM ISO Abbreviation: J Natl Cancer Inst Subsets: MEDLINE

MeSH Terms: Neoplasms*/drug therapy , Clinical Trials, Phase II as Topic*/methods , Clinical Trials, Phase II as Topic*/standards , Research Design* , Antineoplastic Agents*/therapeutic use , Clinical Trial Protocols as Topic*, Humans

CPRS: a clinical protocol recommendation system based on LLMs.

Authors: Ruan J Su Q Chen Z et al.

Source: International journal of medical informatics [Int J Med Inform] 2025 Mar; Vol. 195, pp. 105746. Date of Electronic Publication: 2024 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 9711057 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8243 (Electronic) Linking ISSN: 13865056 NLM ISO Abbreviation: Int J Med Inform Subsets: MEDLINE

MeSH Terms: Clinical Protocols* , Programming Languages* , Clinical Trial Protocols as Topic* , Clinical Trials as Topic* , Natural Language Processing*, Humans ; Semantics

Scientific review of protocols to enhance informativeness of global health clinical trials.

Authors: Burford B Norman T Dolley S

Source: Trials [Trials] 2025 Mar 12; Vol. 26 (1), pp. 85. Date of Electronic Publication: 2025 Mar 12.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

MeSH Terms: Clinical Trials as Topic*/methods , Clinical Trials as Topic*/standards , Research Design* , Global Health* , Clinical Trial Protocols as Topic*, Humans ; Retrospective Studies

Considerations for master protocols using external controls.

Authors: Chen J Li XN Lu CC et al.

Source: Journal of biopharmaceutical statistics [J Biopharm Stat] 2025 Mar; Vol. 35 (2), pp. 297-319. Date of Electronic Publication: 2024 Feb 16.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9200436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5711 (Electronic) Linking ISSN: 10543406 NLM ISO Abbreviation: J Biopharm Stat Subsets: MEDLINE

MeSH Terms: Clinical Trial Protocols as Topic* , Control Groups* , Medical Oncology*/methods , Medical Oncology*/standards

Protocol publication rate and comparison between article, registry and protocol in RCTs.

Authors: Mathieu S Bouillon-Minois JB Renard Triché L et al.

Corporate Authors: Mathieu S Bouillon-Minois JB Renard Triché L et al.

Source: BMC medical research methodology [BMC Med Res Methodol] 2025 Feb 01; Vol. 25 (1), pp. 31. Date of Electronic Publication: 2025 Feb 01.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE

MeSH Terms: Registries*/statistics & numerical data , Randomized Controlled Trials as Topic*/statistics & numerical data , Randomized Controlled Trials as Topic*/standards , Publishing*/statistics & numerical data , Research Design*/standards , Clinical Trial Protocols as Topic*, Humans ; Sample Size ; Journal Impact Factor

Bayesian designs: scientific efficiency and regulatory acceptability in oncology drug developments.

Authors: García López-Rey, Borja

Thesis Advisors: Pontes García, Caridad, Torres Benítez, Ferran

Source: TDX (Tesis Doctorals en Xarxa)

Subject Terms: Bayes, Assaig clínic, Clinical trial, Ensayo clínico, Oncologia, Oncology, Oncología, Ciències de la Salut

File Description: application/pdf

Access URL: http://hdl.handle.net/10803/695773

Optimisation strategies for the first line treatment of tuberculosis

Authors: Espinosa Pereiro, Juan

Thesis Advisors: Sánchez Moltalvá, Adrián, Falcó Ferrer, Vicenç

Source: TDX (Tesis Doctorals en Xarxa)

Subject Terms: Tuberculosi, Tuberculosis, Assaig clínic, Clinical trial, Ensayo clínico, Rifampicina, Rifampicin, Ciències de la Salut

File Description: application/pdf

Access URL: http://hdl.handle.net/10803/694999

Reporting completeness of nutrition and diet-related randomised controlled trials protocols.

Authors: Silva FM Amorim Adegboye AR Curioni C et al.

Source: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2024 Jul; Vol. 43 (7), pp. 1626-1635. Date of Electronic Publication: 2024 May 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE

MeSH Terms: Diet* , Randomized Controlled Trials as Topic* , Clinical Trial Protocols as Topic*, Humans ; Checklist/standards ; Research Design/standards ; SARS-CoV-2 ; Editorial Policies ; Periodicals as Topic ; Guidelines as Topic