Výsledky vyhledávání - "Clinical Trials: Targeted Therapy"

First-in-Human Phase I/IIa Study of the First-in-Class CDK2/4/6 Inhibitor PF-06873600 Alone or with Endocrine Therapy in Patients with Breast Cancer

Autoři: Timothy A. Yap Jonathan W. Goldman Shaveta Vinayak a další

Zdroj: Clin Cancer Res

Témata: Clinical Trials: Targeted Therapy

Randomized Phase III Study of EGFR Tyrosine Kinase Inhibitor and Intercalated Platinum-Doublet Chemotherapy for Non–Small Cell Lung Cancer Harboring EGFR Mutation

Autoři: Shintaro Kanda Seiji Niho Takayasu Kurata a další

Zdroj: Clin Cancer Res

Témata: Clinical Trials: Targeted Therapy

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40162917

A Phase I Study of Nilotinib in Combination with Paclitaxel in Patients with Advanced Solid Tumors

Autoři: Sarah J. Shin Geraldine O’Sullivan Coyne Shivaani Kummar a další

Zdroj: Clin Cancer Res

Témata: Clinical Trials: Targeted Therapy

Longitudinal Genomic Analysis to Fine-tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients with BRAFV600-Mutant Metastatic Melanoma

Autoři: Reinhard Dummer Shahneen Sandhu Wilson H. Miller a další

Zdroj: Clin Cancer Res

Témata: Clinical Trials: Targeted Therapy

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40106536

A Phase I Dose-Escalation Study of the HIF-2 Alpha Inhibitor DFF332 in Patients with Advanced Clear-Cell Renal Cell Carcinoma

Autoři: Sumanta K. Pal Alice Bernard-Tessier Peter Grell a další

Přispěvatelé: Sumanta K. Pal Alice Bernard-Tessier Peter Grell a další

Zdroj: Clin Cancer Res
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname

Témata: Male, Adult, Maximum Tolerated Dose, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, Medicaments antineoplàstics - Ús terapèutic, Clinical Trials: Targeted Therapy, Antineoplastic Agents, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::carcinoma::adenocarcinoma::carcinoma de células renales, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias renales, DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Renal Cell, Basic Helix-Loop-Helix Transcription Factors, Humans, DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Kidney Neoplasms, Other subheadings::Other subheadings::Other subheadings::/administration & dosage, Carcinoma, Renal Cell, Aged, Aged, 80 and over, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Dose-Response Relationship, Drug, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome, PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug, Middle Aged, Posologia, Kidney Neoplasms, FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::relación dosis-respuesta de medicamentos, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento, Treatment Outcome, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos, Ronyons - Càncer - Tractament, Avaluació de resultats (Assistència sanitària), Otros calificadores::Otros calificadores::Otros calificadores::/administración & dosificación, Female, CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40043000
http://hdl.handle.net/11351/13354

Health-Related Quality of Life in Patients with HR+/HER2− Early Breast Cancer Treated with Ribociclib Plus a Nonsteroidal Aromatase Inhibitor: Results from the NATALEE Trial

Autoři: Peter A. Fasching Dennis Slamon Zbigniew Nowecki a další

Zdroj: Clin Cancer Res

Témata: Adult, Aromatase Inhibitors, Receptor, ErbB-2, Aminopyridines, Clinical Trials: Targeted Therapy, Breast Neoplasms, Middle Aged, Treatment Outcome, Receptors, Estrogen, Purines, Antineoplastic Combined Chemotherapy Protocols, Quality of Life, Humans, Female, Patient Reported Outcome Measures, Receptors, Progesterone, Aged, Neoplasm Staging

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40019493

177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study

Autoři: Hao Fu Jingxiong Huang Liang Zhao a další

Zdroj: Clin Cancer Res

Témata: Male, Adult, Radioisotopes, Aged, 80 and over, Membrane Proteins, Clinical Trials: Targeted Therapy, Middle Aged, Lutetium, Treatment Outcome, Neoplasms, Endopeptidases, Humans, Female, Neoplasm Metastasis, Radiopharmaceuticals, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40084923

A Phase II Study of Abemaciclib for Patients with Retinoblastoma-Positive, Metastatic Triple-Negative Breast Cancer

Autoři: Shom Goel Bojana Jovanović Xiangying Chu a další

Zdroj: Clin Cancer Res

Témata: Adult, Treatment Outcome, Biomarkers, Tumor, Humans, Aminopyridines, Clinical Trials: Targeted Therapy, Benzimidazoles, Female, Triple Negative Breast Neoplasms, Middle Aged, Neoplasm Metastasis, Retinoblastoma Protein, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39908010

Randomized Phase II Study of Bevacizumab with Weekly Anetumab Ravtansine or Weekly Paclitaxel in Platinum-Resistant/Refractory High-Grade Ovarian Cancer (NCI Trial)

Autoři: Husam A. Alqaisi David E. Cohn Jing-Yi Chern a další

Zdroj: Clin Cancer Res

Témata: Ovarian Neoplasms, Adult, Aged, 80 and over, Paclitaxel, Clinical Trials: Targeted Therapy, Middle Aged, GPI-Linked Proteins, Progression-Free Survival, Bevacizumab, Drug Resistance, Neoplasm, Mesothelin, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Neoplasm Grading, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39836408

Elacestrant in Women with Estrogen Receptor–Positive and HER2-Negative Early Breast Cancer: Results from the Preoperative Window-of-Opportunity ELIPSE Trial

Autoři: Maria Vidal Claudette Falato Tomás Pascual a další

Zdroj: Clin Cancer Res

Témata: Treatment Outcome, Receptors, Estrogen, Receptor, ErbB-2, Biomarkers, Tumor, Humans, Clinical Trials: Targeted Therapy, Female, Breast Neoplasms, Middle Aged, Aged, Neoplasm Staging

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39820652

Phase I Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3, in Patients with Advanced Solid Tumors

Autoři: Apostolia M. Tsimberidou David J. Vining Sukeshi P. Arora a další

Zdroj: Clin Cancer Res

Témata: Male, STAT3 Transcription Factor, Adult, Aged, 80 and over, Treatment Outcome, Neoplasms, Humans, Administration, Oral, Clinical Trials: Targeted Therapy, Female, Antineoplastic Agents, Middle Aged, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39792482

Duvelisib with Docetaxel for Patients with Anti–PD-1 Refractory, Recurrent, or Metastatic Head and Neck Squamous Cell Carcinoma

Autoři: Glenn J. Hanna L. B. Oakley R. Shi a další

Zdroj: Clin Cancer Res

Témata: Male, Adult, Aged, 80 and over, Squamous Cell Carcinoma of Head and Neck, Programmed Cell Death 1 Receptor, Clinical Trials: Targeted Therapy, Docetaxel, Middle Aged, Head and Neck Neoplasms, Drug Resistance, Neoplasm, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Neoplasm Recurrence, Local, Neoplasm Metastasis, Immune Checkpoint Inhibitors, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39625478

A Phase III Randomized Trial of Integrated Genomics and Avatar Models for Personalized Treatment of Pancreatic Cancer: The AVATAR Trial

Autoři: Francesca Sarno Jair Tenorio Sofia Perea a další

Zdroj: Clin Cancer Res

Témata: Clinical Trials: Targeted Therapy, WCM Library Coordinated Deposit

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39540844

Circulating Chromogranin A as a Surveillance Biomarker in Patients with Carcinoids—The CASPAR Study

Autoři: Qing H. Meng Thorvardur R. Halfdanarson Joshua A. Bornhorst a další

Zdroj: Clin Cancer Res

Témata: Male, Adult, Aged, 80 and over, Clinical Trials: Targeted Therapy, Carcinoid Tumor, Middle Aged, Pancreatic Neoplasms, Neuroendocrine Tumors, Stomach Neoplasms, Intestinal Neoplasms, Biomarkers, Tumor, Disease Progression, Humans, Chromogranin A, Female, Prospective Studies, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39453770

First-in-Human Dose-Escalation Study of the First-in-Class PDE3A–SLFN12 Complex Inducer BAY 2666605 in Patients with Advanced Solid Tumors Coexpressing SLFN12 and PDE3A

Autoři: Kyriakos P. Papadopoulos Meredith McKean Silvia Goldoni a další

Zdroj: Clin Cancer Res

Témata: Male, Adult, Aged, 80 and over, Maximum Tolerated Dose, Dose-Response Relationship, Drug, Neoplasms, Humans, Clinical Trials: Targeted Therapy, Female, Antineoplastic Agents, Middle Aged, Cyclic Nucleotide Phosphodiesterases, Type 3, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39437010

Trastuzumab Deruxtecan with Nivolumab in HER2-Expressing Metastatic Breast or Urothelial Cancer: Analysis of the Phase Ib DS8201-A-U105 Study

Autoři: Erika Hamilton Matthew D. Galsky Sebastian Ochsenreither a další

Zdroj: Clin Cancer Res

Témata: Male, Adult, Aged, 80 and over, Urologic Neoplasms, Immunoconjugates, Receptor, ErbB-2, Clinical Trials: Targeted Therapy, Breast Neoplasms, Trastuzumab, Middle Aged, Nivolumab, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Camptothecin, Neoplasm Metastasis, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39405343

Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer

Autoři: Van Cutsem, Eric Collignon, Joëlle Eefsen, Rikke L a další

Zdroj: Clin Cancer Res

Témata: Male, Pancreatic Neoplasms/pathology, Oncologie, Carcinoma, Pancreatic Ductal/drug therapy, Deoxycytidine, ACTIVATION, Deoxycytidine/analogs & derivatives, Pancreatic Neoplasms/drug therapy, Antineoplastic Combined Chemotherapy Protocols, Paclitaxel/adverse effects, Human health sciences, Neoplasm Metastasis, Aged, 80 and over, CHEMORESISTANCE, Carcinoma, Pancreatic Ductal/immunology, Medicine (all), Middle Aged, Treatment Outcome, Oncology, Antibodies, Monoclonal, Humanized/adverse effects, Female, Pancreatic Neoplasms/immunology, Life Sciences & Biomedicine, Albumins/administration & dosage, Antibodies, Monoclonal, Humanized/administration & dosage, Carcinoma, Pancreatic Ductal, Adult, Paclitaxel, Clinical Trials: Targeted Therapy, Carcinoma, Pancreatic Ductal/pathology, Antibodies, Monoclonal, Humanized, Sciences de la santé humaine, POOR-PROGNOSIS, Paclitaxel/administration & dosage, 3211 Oncology and carcinogenesis, Albumins, Biomarkers, Tumor, Pancreatic Neoplasms/mortality, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Deoxycytidine/administration & dosage, Aged, Albumins/adverse effects, Science & Technology, Antineoplastic Combined Chemotherapy Protocols/adverse effects, IL1RAP protein, human, 3202 Clinical sciences, 130-nm albumin-bound paclitaxel, Gemcitabine, Pancreatic Neoplasms, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Interleukin-1 Receptor Accessory Protein, Deoxycytidine/therapeutic use

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39385434
https://lirias.kuleuven.be/handle/20.500.12942/769085
https://doi.org/10.1158/1078-0432.ccr-24-0645
https://hdl.handle.net/2268/333840
https://doi.org/10.1158/1078-0432.CCR-24-0645

A Preoperative Window-of-Opportunity Study of Oral SERD, Imlunestrant, in Newly Diagnosed ER-Positive, HER2-Negative Early Breast Cancer: Results from the EMBER-2 Study

Autoři: Patrick Neven Nicole Stahl Maria Vidal a další

Zdroj: Clin Cancer Res

Témata: Oral, Adult, Receptor, erbB-2, Receptor, ErbB-2, Administration, Oral, Clinical Trials: Targeted Therapy, Breast Neoplasms, ANASTROZOLE, ErbB-2, 3211 Oncology and carcinogenesis, Receptors, 80 and over, Medicine and Health Sciences, KI-67, Biomarkers, Tumor, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, TAMOXIFEN, KI67, Progesterone, Aged, Aged, 80 and over, Tumor, Science & Technology, ENDOCRINE THERAPY, Estradiol, ICTS (Institute of Clinical and Translational Sciences), 3202 Clinical sciences, Middle Aged, Estrogen, PROGNOSTIC VALUE, ESTROGEN-RECEPTOR, Treatment Outcome, Oncology, Receptors, Estrogen, NEOADJUVANT TREATMENT, FULVESTRANT, Administration, Female, Receptors, Progesterone, Life Sciences & Biomedicine, Biomarkers, Receptor

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39377773

A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6–Targeting Antibody–Drug Conjugate, in Patients with Small Cell Lung Cancer

Autoři: Daniel Morgensztern Neal Ready Melissa L. Johnson a další

Zdroj: Clin Cancer Res
Clinical Cancer Research, vol 30, iss 22

Témata: Male, Adult, Lung Neoplasms, Immunoconjugates, Maximum Tolerated Dose, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Clinical sciences, Clinical Trials: Targeted Therapy, Antibodies, Monoclonal, Humanized, Antibodies, Rare Diseases, Clinical Research, Monoclonal, Medicine and Health Sciences, 80 and over, Humans, Oncology & Carcinogenesis, Lung, 6.2 Cellular and gene therapies, Humanized, Cancer, Aged, Aged, 80 and over, Biomedical and Clinical Sciences, Lung Cancer, ICTS (Institute of Clinical and Translational Sciences), Oncology and carcinogenesis, Middle Aged, Small Cell Lung Carcinoma, Orphan Drug, 6.1 Pharmaceuticals, Female

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39287821
https://escholarship.org/uc/item/0188g55d
https://escholarship.org/content/qt0188g55d/qt0188g55d.pdf

A Phase 1 First-in-Human Study of the MCL-1 Inhibitor AZD5991 in Patients with Relapsed/Refractory Hematologic Malignancies

Autoři: Pinkal Desai Sagar Lonial Amanda Cashen a další

Zdroj: Clin Cancer Res
Clinical Cancer Research, vol 30, iss 21

Témata: Myeloid, Male, Adult, Indoles, Maximum Tolerated Dose, Drug Resistance, Clinical Trials: Targeted Therapy, Acute, Bridged Bicyclo Compounds, Antineoplastic Combined Chemotherapy Protocols, Medicine and Health Sciences, 80 and over, Humans, Aged, Aged, 80 and over, Sulfonamides, Acrylamides, Leukemia, Aniline Compounds, Heterocyclic, ICTS (Institute of Clinical and Translational Sciences), Middle Aged, Bridged Bicyclo Compounds, Heterocyclic, Leukemia, Myeloid, Acute, Neoplasm Recurrence, Pyrimidines, Treatment Outcome, Local, Drug Resistance, Neoplasm, Hematologic Neoplasms, Myelodysplastic Syndromes, Neoplasm, Myeloid Cell Leukemia Sequence 1 Protein, Female, Neoplasm Recurrence, Local

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39167622
https://escholarship.org/content/qt6mc9r760/qt6mc9r760.pdf
https://escholarship.org/uc/item/6mc9r760