Suchergebnisse - "Circadian rhythm"

Suvorexant attenuates cognitive impairment associated with circadian rhythm sleep-wake disorders by modulating microglia activation via the BMAL1/NLRP3 pathway.

Autoren: Hu Y Yun T Hou D et al.

Quelle: Experimental neurology [Exp Neurol] 2025 Dec; Vol. 394, pp. 115464. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Microglia*/drug effects , Microglia*/metabolism , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/etiology , ARNTL Transcription Factors*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Triazoles*/pharmacology , Triazoles*/therapeutic use , Sleep Disorders, Circadian Rhythm*/drug therapy , Sleep Disorders, Circadian Rhythm*/metabolism , Sleep Disorders, Circadian Rhythm*/complications , Azepines*/pharmacology , Azepines*/therapeutic use , Sleep Aids, Pharmaceutical*/pharmacology , Sleep Aids, Pharmaceutical*/therapeutic use, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Circadian Rhythm/drug effects ; Circadian Rhythm/physiology

Neural correlates of shift work in nurses: Alterations in cortical gyrification and functional connectivity.

Autoren: Lu L Zhu L Jiang N et al.

Quelle: Sleep medicine [Sleep Med] 2025 Dec; Vol. 136, pp. 106836. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE

MeSH-Schlagworte: Nurses*/psychology , Shift Work Schedule*/adverse effects , Cerebral Cortex*/physiopathology , Cerebral Cortex*/diagnostic imaging , Sleep Disorders, Circadian Rhythm*/physiopathology, Humans ; Magnetic Resonance Imaging ; Adult ; Female ; Male ; Sleep Quality ; Middle Aged ; Brain/physiopathology ; Circadian Rhythm/physiology ; Anxiety/physiopathology

Prokaryotic Circadian Systems: Cyanobacteria and Beyond.

Autoren: Fang M Partch CL LiWang A et al.

Quelle: Annual review of microbiology [Annu Rev Microbiol] 2025 Oct; Vol. 79 (1), pp. 523-545. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Annual Reviews Country of Publication: United States NLM ID: 0372370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-3251 (Electronic) Linking ISSN: 00664227 NLM ISO Abbreviation: Annu Rev Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Synechococcus*/physiology , Synechococcus*/genetics , Circadian Rhythm*/physiology , Circadian Clocks* , Cyanobacteria*/physiology, Circadian Rhythm Signaling Peptides and Proteins/metabolism ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Circadian Rhythm Signaling Peptides and Proteins/chemistry ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/chemistry ; Gene Expression Regulation, Bacterial

SCR Organism: Synechococcus elongatus

Glymphatic dysfunction mediates altered regional neural abilities in night-shift nurses: A multimodal neuroimaging and transcriptomic study.

Autoren: Deng L Jiang N Yuan S et al.

Quelle: Journal of affective disorders [J Affect Disord] 2026 Feb 01; Vol. 394 (Pt A), pp. 120427. Date of Electronic Publication: 2025 Oct 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Glymphatic System*/physiopathology , Glymphatic System*/diagnostic imaging , Brain*/physiopathology , Brain*/diagnostic imaging , Transcriptome* , Shift Work Schedule*/adverse effects , Nurses* , Sleep Disorders, Circadian Rhythm*/physiopathology , Sleep Disorders, Circadian Rhythm*/diagnostic imaging, Humans ; Female ; Adult ; Diffusion Tensor Imaging ; Circadian Rhythm/physiology ; Neuroimaging ; Multimodal Imaging ; Middle Aged

Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases.

Autoren: Ning G Li BN Wu H et al.

Quelle: Asian journal of andrology [Asian J Androl] 2025 Sep 01; Vol. 27 (5), pp. 564-573. Date of Electronic Publication: 2025 Mar 18.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Shanghai Materia Medica Country of Publication: China NLM ID: 100942132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7262 (Electronic) Linking ISSN: 1008682X NLM ISO Abbreviation: Asian J Androl Subsets: MEDLINE

MeSH-Schlagworte: Testosterone*/biosynthesis , Testosterone*/metabolism , Circadian Clocks*/genetics , Circadian Rhythm Signaling Peptides and Proteins*/genetics , Circadian Rhythm Signaling Peptides and Proteins*/metabolism , Men's Health*, Humans ; Male ; Circadian Rhythm/physiology ; Hypogonadism/epidemiology ; Hypogonadism/genetics ; Hypogonadism/metabolism ; Erectile Dysfunction/epidemiology ; Erectile Dysfunction/genetics ; Erectile Dysfunction/metabolism ; Infertility, Male/epidemiology ; Infertility, Male/genetics ; Infertility, Male/metabolism ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism

Delayed sleep-wake phase disorder.

Autoren: Barnes KA; Keith A. Barnes practices urgent care at CareNow-Viscount in El Paso, Tex. and sleep medicine at Biorhythms by Dr. Omavi, also in El Paso, Tex. The author has disclosed no potential conflicts of interest, financial or otherwise.

Quelle: JAAPA : official journal of the American Academy of Physician Assistants [JAAPA] 2025 May 01; Vol. 38 (5), pp. e7-e11. Date of Electronic Publication: 2025 Apr 24.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 9513102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1547-1896 (Print) Linking ISSN: 08937400 NLM ISO Abbreviation: JAAPA Subsets: MEDLINE

MeSH-Schlagworte: Sleep Disorders, Circadian Rhythm*/diagnosis , Sleep Disorders, Circadian Rhythm*/therapy, Humans ; Melatonin/therapeutic use ; Adolescent ; Young Adult ; Phototherapy ; Adult ; Sleep ; Sleep Initiation and Maintenance Disorders/diagnosis ; Circadian Rhythm

Reconstruction of the ancient cyanobacterial proto-circadian clock system KaiABC.

Autoren: Li S Zhou Z Wan Y et al.

Quelle: The EMBO journal [EMBO J] 2025 May; Vol. 44 (10), pp. 3025-3046. Date of Electronic Publication: 2025 Apr 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

MeSH-Schlagworte: Circadian Clocks*/physiology , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Circadian Rhythm Signaling Peptides and Proteins*/metabolism , Circadian Rhythm Signaling Peptides and Proteins*/genetics , Synechococcus*/genetics , Synechococcus*/physiology , Synechococcus*/metabolism , Cyanobacteria*/physiology , Cyanobacteria*/genetics, Circadian Rhythm ; Photoperiod ; Phosphorylation

The nuclear transportation of CHRONO regulates the circadian rhythm.

Autoren: Zhou Q Su Y Wang R et al.

Quelle: The Journal of biological chemistry [J Biol Chem] 2024 Dec; Vol. 300 (12), pp. 107917. Date of Electronic Publication: 2024 Oct 24.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Active Transport, Cell Nucleus* , Circadian Rhythm*/physiology , Cell Nucleus*/metabolism , ARNTL Transcription Factors*/metabolism , ARNTL Transcription Factors*/genetics, Animals ; Humans ; Mice ; Nuclear Localization Signals/metabolism ; HEK293 Cells ; Circadian Rhythm Signaling Peptides and Proteins/metabolism ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Circadian Clocks/physiology

The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale.

Autoren: Wayment-Steele HK Otten R Pitsawong W et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 05; Vol. 121 (45), pp. e2412293121. Date of Electronic Publication: 2024 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Rhodobacter sphaeroides*/metabolism , Rhodobacter sphaeroides*/genetics , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Circadian Rhythm*/physiology , Protein Folding* , Protein Conformation*, Circadian Rhythm Signaling Peptides and Proteins/metabolism ; Circadian Rhythm Signaling Peptides and Proteins/chemistry ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Models, Molecular ; Magnetic Resonance Spectroscopy

Sleep quality and hours of nurses according to shift type and schedule: A cross-sectional study.

Autoren: Chang HE; Research Institute of Nursing Science, College of Nursing, Jeonbuk National University, Jeonju-si, Republic of Korea.

Quelle: Chronobiology international [Chronobiol Int] 2024 Dec; Vol. 41 (12), pp. 1591-1599. Date of Electronic Publication: 2024 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8501362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6073 (Electronic) Linking ISSN: 07420528 NLM ISO Abbreviation: Chronobiol Int Subsets: MEDLINE

MeSH-Schlagworte: Work Schedule Tolerance*/physiology , Nurses* , Sleep*/physiology , Circadian Rhythm*/physiology , Sleep Quality*, Humans ; Cross-Sectional Studies ; Adult ; Female ; Male ; Republic of Korea ; Surveys and Questionnaires ; Time Factors ; Shift Work Schedule ; Young Adult ; Middle Aged ; Nursing Staff, Hospital ; Sleep Disorders, Circadian Rhythm/physiopathology

Markers of mitochondrial function and oxidative metabolism in skeletal muscle do not display intrinsic circadian regulation in female mice.

Autoren: Fitzgerald LS Reynoso Spurrier CS Lau NJ et al.

Quelle: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Dec 01; Vol. 329 (6), pp. E828-E838. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

MeSH-Schlagworte: Muscle, Skeletal*/metabolism , Circadian Rhythm*/physiology , Circadian Rhythm*/genetics , Mitochondria, Muscle*/metabolism, Animals ; Female ; Mice ; Mice, Inbred C57BL ; Biomarkers/metabolism ; Oxidation-Reduction ; Succinate Dehydrogenase/metabolism ; ARNTL Transcription Factors/metabolism ; ARNTL Transcription Factors/genetics ; Autophagy

Circadian disruption in astronauts: Causes, molecular mechanisms, and neurocognitive consequences.

Autoren: Tomaraei SN Ahmed M Nami M

Quelle: Chronobiology international [Chronobiol Int] 2025 Dec; Vol. 42 (12), pp. 1615-1632. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article; Systematic Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8501362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6073 (Electronic) Linking ISSN: 07420528 NLM ISO Abbreviation: Chronobiol Int Subsets: MEDLINE

MeSH-Schlagworte: Astronauts*/psychology , Circadian Rhythm*/physiology , Cognition*/physiology , Sleep Disorders, Circadian Rhythm*/physiopathology, Humans ; Circadian Clocks/physiology ; Sleep/physiology ; Sleep Wake Disorders/physiopathology ; Space Flight

The role of caffeine and probiotics in modulating biochemical alterations induced by constant light-mediated circadian rhythm disruption in a rat model.

Autoren: Shamandy AM Abdel-Rahman M El-Hennamy RE et al.

Quelle: Chronobiology international [Chronobiol Int] 2025 Dec; Vol. 42 (12), pp. 1653-1668. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8501362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6073 (Electronic) Linking ISSN: 07420528 NLM ISO Abbreviation: Chronobiol Int Subsets: MEDLINE

MeSH-Schlagworte: Caffeine*/pharmacology , Circadian Rhythm*/drug effects , Circadian Rhythm*/physiology , Light*/adverse effects , Probiotics*/pharmacology, Animals ; Melatonin/metabolism ; Melatonin/blood ; Male ; Corticosterone/blood ; Rats ; Glutathione/metabolism ; Malondialdehyde/metabolism ; Serotonin/metabolism ; Rats, Wistar

Circadian rhythm in gastrointestinal cancer: clinical applications and future perspectives.

Autoren: Han J Xiong Z Liu Y et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2529571. Date of Electronic Publication: 2025 Jul 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Neoplasms*/genetics , Gastrointestinal Neoplasms*/pathology , Gastrointestinal Neoplasms*/physiopathology , Gastrointestinal Neoplasms*/drug therapy , Gastrointestinal Neoplasms*/therapy , Circadian Rhythm*/genetics , Circadian Rhythm*/physiology, Humans ; Drug Resistance, Neoplasm/genetics ; Disease Progression ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Period Circadian Proteins/genetics ; Period Circadian Proteins/metabolism

Improvement in nocturnal blood pressure with bedtime antihypertensive administration in older adults aged 65 and above: a systematic review and meta-analysis.

Autoren: Saren J Lieten S Petrovic M et al.

Quelle: Clinical autonomic research : official journal of the Clinical Autonomic Research Society [Clin Auton Res] 2025 Dec; Vol. 35 (6), pp. 711-725. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis; Review

Info zur Zeitschrift: Publisher: Steinkopff Country of Publication: Germany NLM ID: 9106549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-1560 (Electronic) Linking ISSN: 09599851 NLM ISO Abbreviation: Clin Auton Res Subsets: MEDLINE

MeSH-Schlagworte: Antihypertensive Agents*/administration & dosage , Blood Pressure*/drug effects , Blood Pressure*/physiology , Circadian Rhythm*/physiology , Circadian Rhythm*/drug effects , Hypertension*/drug therapy , Hypertension*/physiopathology, Humans ; Aged ; Blood Pressure Monitoring, Ambulatory/methods ; Randomized Controlled Trials as Topic/methods ; Aged, 80 and over

Effects of exercise on mental health in mice with circadian rhythm disruption.

Autoren: He C Wakayama M Jiang H et al.

Quelle: Journal of affective disorders [J Affect Disord] 2025 Nov 15; Vol. 389, pp. 119936. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Circadian Rhythm*/physiology , Circadian Rhythm*/genetics , Physical Conditioning, Animal*/physiology , Physical Conditioning, Animal*/psychology , Anxiety* , Depression* , Chronobiology Disorders*, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Prefrontal Cortex/metabolism ; Dopamine/metabolism ; ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; CLOCK Proteins/genetics ; CLOCK Proteins/metabolism ; Behavior, Animal/physiology ; Disease Models, Animal

The crucial role of circadian synchronization in bone marrow adipose tissue mesenchymal stem cells: insights into pathogenesis in Fanconi anemia and acute myeloid leukemia.

Autoren: Muratoğlu B Özdemir C Eylem CC et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Nov 14; Vol. 53 (1), pp. 80. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/drug effects , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/pathology , Fanconi Anemia*/metabolism , Fanconi Anemia*/genetics , Fanconi Anemia*/pathology , Circadian Rhythm*/physiology , Circadian Rhythm*/genetics , Circadian Rhythm*/drug effects , Adipose Tissue*/metabolism , Adipose Tissue*/cytology, Humans ; Bone Marrow/metabolism ; Dexamethasone/pharmacology ; Bone Marrow Cells/metabolism ; Male

Diurnal regulation of urinary behavior and gene expression in aged mice.

Autoren: Taylor DS Allotey AA Fanelli RE et al.

Quelle: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2025 Nov 06; Vol. 80 (12).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE

MeSH-Schlagworte: Circadian Rhythm*/physiology , Circadian Rhythm*/genetics , Aging*/physiology , Aging*/genetics , Nocturia*/genetics , Nocturia*/physiopathology , Ion Channels*/genetics , Ion Channels*/metabolism , Urination*/physiology, Animals ; Mice ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Urinary Bladder/metabolism ; Kidney/metabolism ; Behavior, Animal/physiology ; Gene Expression ; Female

Changes in sleep timing and duration during and after rotating shifts can be explained without the assumptions of the shifts of the circadian phase of sleep and loss of its circadian control.

Autoren: Putilov AA Verevkin EG

Quelle: Sleep & breathing = Schlaf & Atmung [Sleep Breath] 2025 Nov 05; Vol. 29 (6), pp. 342. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 9804161 Publication Model: Electronic Cited Medium: Internet ISSN: 1522-1709 (Electronic) Linking ISSN: 15209512 NLM ISO Abbreviation: Sleep Breath Subsets: MEDLINE

MeSH-Schlagworte: Shift Work Schedule* , Sleep Disorders, Circadian Rhythm*/physiopathology , Sleep Disorders, Circadian Rhythm*/diagnosis , Circadian Rhythm*/physiology , Work Schedule Tolerance*/physiology, Humans ; Sleep Deprivation/physiopathology ; Wakefulness/physiology

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis.

Autoren: Zhang H Qin X Song H et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (43), pp. e01818. Date of Electronic Publication: 2025 Aug 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Period Circadian Proteins*/genetics , Period Circadian Proteins*/metabolism , Depression*/genetics , Depression*/metabolism , Gastrointestinal Microbiome*/physiology , Gastrointestinal Microbiome*/genetics , Circadian Rhythm*/genetics , Circadian Rhythm*/physiology , Dysbiosis*/metabolism , Dysbiosis*/genetics , Intestinal Mucosa*/metabolism, Animals ; Mice ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Tryptophan/metabolism