Suchergebnisse - "Cholestasis"

GGT-normal cholestasis associated with LSR deficiency: A potential new subtype of PFIC.

Autoren: Cosar OS Ozturk H Kayhan G et al.

Quelle: Clinics and research in hepatology and gastroenterology [Clin Res Hepatol Gastroenterol] 2025 Sep-Oct; Vol. 49 (8), pp. 102674. Date of Electronic Publication: 2025 Aug 20.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Elsevier Masson Country of Publication: France NLM ID: 101553659 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2210-741X (Electronic) Linking ISSN: 22107401 NLM ISO Abbreviation: Clin Res Hepatol Gastroenterol Subsets: MEDLINE

MeSH-Schlagworte: gamma-Glutamyltransferase*/blood , Cholestasis, Intrahepatic*/genetics , Receptors, Lipoprotein*/genetics , Receptors, Lipoprotein*/deficiency, Humans ; Male ; Female ; Infant ; Cholestasis/genetics ; Mutation, Missense ; Child, Preschool

[Introduction to the recommendations of the EASL clinical practice guidelines for genetic cholestatic liver diseases].

Autoren: Hou W Zheng SJ

Quelle: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology [Zhonghua Gan Zang Bing Za Zhi] 2025 Jun 20; Vol. 33 (6), pp. 545-550.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo Country of Publication: China NLM ID: 9710009 Publication Model: Print Cited Medium: Print ISSN: 1007-3418 (Print) Linking ISSN: 10073418 NLM ISO Abbreviation: Zhonghua Gan Zang Bing Za Zhi Subsets: MEDLINE

MeSH-Schlagworte: Practice Guidelines as Topic* , Cholestasis*/genetics , Cholestasis*/therapy , Cholestasis*/diagnosis , Liver Diseases*/therapy , Liver Diseases*/genetics , Liver Diseases*/diagnosis, Humans ; Mutation ; Cholestasis, Intrahepatic/therapy ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/diagnosis

Yinzhihuang formula modulates the microbe‒gut‒liver axis and bile acid excretion to attenuate cholestatic liver injury.

Autoren: Luo X Cheng P Fang Y et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Apr; Vol. 139, pp. 156495. Date of Electronic Publication: 2025 Feb 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: Bile Acids and Salts*/metabolism , Drugs, Chinese Herbal*/pharmacology , Gastrointestinal Microbiome*/drug effects , Cholestasis, Intrahepatic*/drug therapy , Cholestasis, Intrahepatic*/chemically induced, Animals ; Male ; Mice ; Liver/drug effects ; Liver/pathology ; Liver/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal ; 1-Naphthylisothiocyanate ; Cholestasis/drug therapy ; Fecal Microbiota Transplantation

Novel PLEC variants associated with infantile cholestasis.

Autoren: Kor-Anantakul P Chen HL Chen YH et al.

Quelle: Clinical genetics [Clin Genet] 2024 Dec; Vol. 106 (6), pp. 769-775. Date of Electronic Publication: 2024 Aug 21.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 0253664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0004 (Electronic) Linking ISSN: 00099163 NLM ISO Abbreviation: Clin Genet Subsets: MEDLINE

MeSH-Schlagworte: Plectin*/genetics , Cholestasis*/genetics , Cholestasis*/pathology, Humans ; Infant ; Male ; Female ; Mutation ; Exome Sequencing ; Genetic Predisposition to Disease ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/pathology

Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations.

Autoren: Maddirevula S Shagrani M Ji AR et al.

Quelle: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2024 Nov; Vol. 26 (11), pp. 101231. Date of Electronic Publication: 2024 Aug 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE

MeSH-Schlagworte: Ciliopathies*/genetics , Ciliopathies*/pathology , Mutation*/genetics , Exome Sequencing* , Cholestasis*/genetics , Cholestasis*/pathology , Pedigree*, Humans ; Male ; Female ; Mice ; Animals ; Child ; Child, Preschool ; Infant ; Genomics/methods ; Homozygote ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/pathology ; Cholestasis, Intrahepatic/diagnosis ; Phenotype ; Cilia/pathology ; Cilia/genetics

Diagnostic approaches for infants with cholestatic liver diseases: Position paper and perspectives of the Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition.

Autoren: Chen HL Taylor SA Lee WS et al.

Quelle: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2025 Nov; Vol. 81 (5), pp. 1360-1377. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article; Practice Guideline

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis*/diagnosis , Cholestasis*/etiology , Cholestasis*/surgery, Humans ; Infant ; Infant, Newborn ; Biliary Atresia/diagnosis ; Biliary Atresia/surgery ; Biliary Atresia/complications ; Gastroenterology ; Liver Transplantation ; Neonatal Screening/methods ; Portoenterostomy, Hepatic ; Societies, Medical/standards ; Review Literature as Topic

Molecular Advances in Cholestatic Liver Diseases.

Autoren: Memon R Saxena R

Quelle: Advances in anatomic pathology [Adv Anat Pathol] 2025 Nov 01; Vol. 32 (6), pp. 375-386. Date of Electronic Publication: 2025 Jun 16.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9435676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4031 (Electronic) Linking ISSN: 10724109 NLM ISO Abbreviation: Adv Anat Pathol Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis, Intrahepatic*/genetics , Cholestasis*/genetics, Humans ; Mutation ; Genetic Predisposition to Disease

EASL Clinical Practice Guidelines on genetic cholestatic liver diseases.

Körperschaften: European Association for the Study of the Liver

Quelle: Journal of hepatology [J Hepatol] 2024 Aug; Vol. 81 (2), pp. 303-325. Date of Electronic Publication: 2024 Jun 08.

Publikationsart: Journal Article; Practice Guideline

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis, Intrahepatic*/genetics , Cholestasis, Intrahepatic*/diagnosis , Cholestasis, Intrahepatic*/therapy, Humans ; Europe ; Genetic Testing/methods ; Adult ; Cholestasis/genetics ; Cholestasis/diagnosis ; Cholestasis/therapy ; Gastroenterology/methods ; Gastroenterology/standards

Predictive efficacy of machine-learning algorithms on intrahepatic cholestasis of pregnancy based on clinical and laboratory indicators.

Autoren: He J Zhu X Yang X et al.

Quelle: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2025 Dec; Vol. 38 (1), pp. 2413854. Date of Electronic Publication: 2024 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis, Intrahepatic*/diagnosis , Cholestasis, Intrahepatic*/blood , Cholestasis, Intrahepatic*/therapy , Pregnancy Complications*/diagnosis , Pregnancy Complications*/therapy , Pregnancy Complications*/blood , Machine Learning*, Humans ; Female ; Pregnancy ; Retrospective Studies ; Adult ; Case-Control Studies ; Neural Networks, Computer ; Support Vector Machine ; Predictive Value of Tests ; Algorithms

SCR Disease Name: Intrahepatic Cholestasis of Pregnancy

The impact of gallbladder motility in intrahepatic cholestasis of pregnancy: a prospective observational study.

Autoren: Verma A Kumar I Kumari A et al.

Quelle: Abdominal radiology (New York) [Abdom Radiol (NY)] 2025 Dec; Vol. 50 (12), pp. 5810-5819. Date of Electronic Publication: 2025 Jun 02.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101674571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2366-0058 (Electronic) NLM ISO Abbreviation: Abdom Radiol (NY) Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis, Intrahepatic*/physiopathology , Cholestasis, Intrahepatic*/diagnostic imaging , Pregnancy Complications*/physiopathology , Pregnancy Complications*/diagnostic imaging , Gallbladder*/diagnostic imaging , Gallbladder*/physiopathology, Humans ; Female ; Pregnancy ; Prospective Studies ; Adult ; Ultrasonography/methods ; Case-Control Studies

SCR Disease Name: Intrahepatic Cholestasis of Pregnancy

Nodosin alleviates cholestatic liver injury by activation of SIRT1/FXR signaling pathway and inhibition of hepatic inflammation.

Autoren: Han M Cheng Y Wang W et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117200. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Diterpenes*/isolation & purification , Diterpenes*/pharmacology , Diterpenes*/therapeutic use , Cholestasis, Intrahepatic*/drug therapy , Cholestasis, Intrahepatic*/metabolism , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use, Isodon/chemistry ; Mice, Inbred C57BL ; Hep G2 Cells ; Humans ; Male ; Animals ; Mice ; Cholesterol 7-alpha-Hydroxylase/metabolism ; Sirtuin 1/metabolism ; NF-kappa B/metabolism ; Receptors, Cytoplasmic and Nuclear

Utility of Serum Matrix Metalloproteinase-7 as a Biomarker in Cholestatic Infants with Congenital Heart Disease.

Autoren: Pandurangi S Kim ME Noriega N et al.

Quelle: Pediatric cardiology [Pediatr Cardiol] 2025 Dec; Vol. 46 (8), pp. 2469-2474. Date of Electronic Publication: 2024 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: United States NLM ID: 8003849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1971 (Electronic) Linking ISSN: 01720643 NLM ISO Abbreviation: Pediatr Cardiol Subsets: MEDLINE

MeSH-Schlagworte: Matrix Metalloproteinase 7*/blood , Heart Defects, Congenital*/complications , Heart Defects, Congenital*/blood , Biliary Atresia*/blood , Biliary Atresia*/diagnosis , Biliary Atresia*/complications , Cholestasis*/blood , Cholestasis*/diagnosis , Cholestasis*/etiology , Cholestasis*/complications, Humans ; Biomarkers/blood ; Male ; Female ; Infant ; Cross-Sectional Studies ; Infant, Newborn

Yinchenhao decoction and its active compound rhein ameliorate intrahepatic cholestasis of pregnancy in mice via modulation of intestinal flora.

Autoren: Ren S Gao Y Wang J et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157397. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Microbiome*/drug effects , Drugs, Chinese Herbal*/pharmacology , Anthraquinones*/pharmacology , Cholestasis, Intrahepatic*/drug therapy , Cholestasis, Intrahepatic*/microbiology , Pregnancy Complications*/drug therapy , Pregnancy Complications*/microbiology, Animals ; Female ; Mice ; Pregnancy ; Disease Models, Animal ; RNA, Ribosomal, 16S

SCR Disease Name: Intrahepatic Cholestasis of Pregnancy

Forskolin alleviates cholestatic liver disease by inhibiting the Hippo/YAP-mediated ductular reaction and fibrosis progression.

Autoren: El-Maadawy WH Hafiz E Mostafa A et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178182. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis*/drug therapy , Cholestasis*/pathology , Cholestasis*/metabolism , Colforsin*/pharmacology , Colforsin*/therapeutic use , Protein Serine-Threonine Kinases*/metabolism , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism , Liver Diseases*/drug therapy , Liver Diseases*/pathology , Liver Diseases*/metabolism, Animals ; Male ; Rats ; YAP-Signaling Proteins ; Hippo Signaling Pathway ; Humans ; Signal Transduction/drug effects ; Bile Ducts/drug effects ; Bile Ducts/pathology ; Rats, Sprague-Dawley ; Disease Progression ; Liver/drug effects ; Liver/pathology ; Liver/metabolism ; Molecular Docking Simulation ; Cyclic AMP/metabolism

Semaphorin 7A Induces Liver Inflammation and Promotes Parenteral Nutrition-Associated Cholestasis via ITGβ1/NF-κB Pathway.

Autoren: Shen L Sun X Zheng R et al.

Quelle: Archives of medical research [Arch Med Res] 2025 Nov; Vol. 56 (7), pp. 103244. Date of Electronic Publication: 2025 Jun 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9312706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5487 (Electronic) Linking ISSN: 01884409 NLM ISO Abbreviation: Arch Med Res Subsets: MEDLINE

MeSH-Schlagworte: Semaphorins*/metabolism , Semaphorins*/genetics , Cholestasis*/etiology , Cholestasis*/pathology , Cholestasis*/metabolism , NF-kappa B*/metabolism , Integrin beta1*/metabolism , Integrin beta1*/genetics , Antigens, CD*/metabolism , Antigens, CD*/genetics, Animals ; Rats ; Signal Transduction ; Male ; Liver/pathology ; Liver/metabolism ; Rats, Sprague-Dawley ; Kupffer Cells/metabolism ; Animals, Newborn ; Disease Models, Animal ; Inflammation/pathology ; Humans

Novel SPTB Variations Cause Hereditary Spherocytosis With Cholangiolithiasis and Severe Intrahepatic Cholestasis.

Autoren: Li LL Ali S Bin Q

Quelle: Annals of human genetics [Ann Hum Genet] 2025 Nov; Vol. 89 (6), pp. 450-458. Date of Electronic Publication: 2025 Jun 23.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0416661 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-1809 (Electronic) Linking ISSN: 00034800 NLM ISO Abbreviation: Ann Hum Genet Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis, Intrahepatic*/genetics , Cholestasis, Intrahepatic*/pathology , Cholestasis, Intrahepatic*/complications , Spectrin*/genetics , Spherocytosis, Hereditary*/genetics , Spherocytosis, Hereditary*/complications , Spherocytosis, Hereditary*/pathology, Female ; Humans ; Male ; Mutation ; Pedigree ; Phenotype

Clinical Potential of HCMV-Encoded Serum miRNAs in Predicting Intrahepatic Cholestasis of Pregnancy: A Retrospective Analysis.

Autoren: Wang R Chen J Gao J et al.

Quelle: Journal of medical virology [J Med Virol] 2025 Nov; Vol. 97 (11), pp. e70679.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

MeSH-Schlagworte: Cholestasis, Intrahepatic*/diagnosis , Cholestasis, Intrahepatic*/blood , Cholestasis, Intrahepatic*/virology , MicroRNAs*/blood , MicroRNAs*/genetics , Cytomegalovirus*/genetics , Cytomegalovirus Infections*/virology , Cytomegalovirus Infections*/blood , Cytomegalovirus Infections*/diagnosis , Pregnancy Complications, Infectious*/diagnosis , Pregnancy Complications, Infectious*/virology , Pregnancy Complications*/diagnosis , Pregnancy Complications*/blood , Pregnancy Complications*/virology , RNA, Viral*/blood , RNA, Viral*/genetics, Humans ; Female ; Pregnancy ; Retrospective Studies ; Adult ; Biomarkers/blood ; ROC Curve ; Case-Control Studies ; DNA, Viral/blood ; Sensitivity and Specificity ; Immunoglobulin M/blood ; Antibodies, Viral/blood

SCR Disease Name: Intrahepatic Cholestasis of Pregnancy

First Report of Living Donor Liver Transplantation for NR1H4 Disease.

Autoren: Suresh L Menon J Shanmugam N et al.

Quelle: Pediatric transplantation [Pediatr Transplant] 2025 Nov; Vol. 29 (7), pp. e70175.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE

MeSH-Schlagworte: Liver Transplantation*/methods , Living Donors* , Receptors, Cytoplasmic and Nuclear*/genetics , Cholestasis*/genetics , Cholestasis*/surgery, Humans ; Male ; Infant

Selective agonism of liver and gut FXR prevents cholestasis and intestinal atrophy in parenterally fed neonatal pigs.

Autoren: Jiang Y Fang Z Guthrie G et al.

Quelle: Journal of lipid research [J Lipid Res] 2025 Nov; Vol. 66 (11), pp. 100919. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Cytoplasmic and Nuclear*/agonists , Receptors, Cytoplasmic and Nuclear*/metabolism , Cholestasis*/prevention & control , Cholestasis*/metabolism , Cholestasis*/pathology , Liver*/metabolism , Liver*/drug effects , Liver*/pathology , Intestines*/pathology , Intestines*/drug effects , Intestinal Mucosa*/metabolism , Intestinal Mucosa*/pathology , Parenteral Nutrition*, Animals ; Swine ; Animals, Newborn ; Chenodeoxycholic Acid/analogs & derivatives ; Chenodeoxycholic Acid/pharmacology ; Chenodeoxycholic Acid/administration & dosage ; Bile Acids and Salts/metabolism

Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGFβ1 expression.

Autoren: Olson KE Krishnan A Splinter P et al.

Quelle: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2025 Nov 01; Vol. 329 (5), pp. G597-G613. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE

MeSH-Schlagworte: Macrophages*/metabolism , Macrophages*/pathology , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Cholestasis*/metabolism , Cholestasis*/pathology , Cholestasis*/chemically induced , Bile Ducts*/metabolism , Bile Ducts*/pathology , Epithelial Cells*/metabolism, Animals ; Mice ; Disease Models, Animal ; CX3C Chemokine Receptor 1/metabolism ; CX3C Chemokine Receptor 1/genetics ; Male ; Mice, Inbred C57BL ; Signal Transduction ; Pyridines