Suchergebnisse - "Chelating agents - chemical synthesis"

Antioxidant and cytotoxic activity of new di- and polyamine caffeine analogues

Autoren: Lucyna Mrówczyńska Krzysztof Bielawski Anna Bielawska et al.

Quelle: Free Radical Research. 52:724-736

Schlagwörter: Chelating agents - pharmacology, 0301 basic medicine, Caffeine - analogs & derivatives, Erythrocytes, Cell Survival, Hemolysis - drug effects, Iron, Antioxidants - chemical synthesis, Amidines, Caffeine - pharmacology, Chelating agents - chemical synthesis, Cytotoxins - chemical synthesis, Picrates - chemistry, Amidines - antagonists & inhibitors, Hemolysis, Antioxidants, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, Picrates, Erythrocytes - drug effects, Caffeine, Polyamines, Cell survival - drug effects, Humans, MCF-7 cells, Chelating Agents, Antioxidants - pharmacology, Oxidants - antagonists & inhibitors, Organ specificity, Cytotoxins, Biphenyl Compounds, Picrates - antagonists & inhibitors, Caffeine - chemical synthesis, Polyamines - chemistry, Biphenyl compounds - chemistry, Structure-activity relationship, Oxidants, Oxidation-reduction, 3. Good health, Oxidants - pharmacology, Organ Specificity, Inhibitory concentration 50, Iron - chemistry, MCF-7 Cells, Cytotoxins - pharmacology, Biphenyl compounds - antagonists & inhibitors, Amidines - pharmacology, Oxidation-Reduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/29669446
https://www.ncbi.nlm.nih.gov/pubmed/29669446
https://europepmc.org/article/MED/29669446
https://www.tandfonline.com/doi/abs/10.1080/10715762.2018.1467561

Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure

Autoren: Bordes, Alexandra Poveda, Ana Fontelle, Nathalie et al.

Weitere Verfasser: Bordes, Alexandra Poveda, Ana Fontelle, Nathalie et al.

Quelle: ISSN: 0008-6215.

Schlagwörter: iminosugar, ionophore, macrocycle, NMR analysis, MESH: Chelating Agents / chemical synthesis, MESH: Chelating Agents / chemistry, MESH: Crown Compounds / chemistry, MESH: Fluorescent Dyes / chemical synthesis, MESH: Fluorescent Dyes / chemistry, MESH: Glycopeptides / chemical synthesis, MESH: Glycopeptides / chemistry, MESH: Imino Sugars / chemistry, MESH: Molecular Conformation, [CHIM.COOR]Chemical Sciences/Coordination chemistry

Relation: info:eu-repo/semantics/altIdentifier/pmid/33618101; PUBMED: 33618101

Verfügbarkeit: https://hal.science/hal-04336072
https://hal.science/hal-04336072v1/document
https://hal.science/hal-04336072v1/file/CARB-S-20-00238.pdf
https://doi.org/10.1016/j.carres.2021.108258

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Autoren: Simoben, Conrad Robaa, Dina Chakrabarti, Alokta et al.

Weitere Verfasser: Simoben, Conrad Robaa, Dina Chakrabarti, Alokta et al.

Quelle: ISSN: 1420-3049 ; Molecules ; https://hal.science/hal-02391176 ; Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩.

Schlagwörter: virtual screening, schistosomiasis, histone deacetylase (HDAC) inhibitors, epigenetics, docking, crystal structure, MESH: Animals, MESH: Anthelmintics/pharmacology, MESH: Hydroxamic Acids/chemical synthesis, MESH: Hydroxamic Acids/pharmacology, MESH: Apoptosis/drug effects, MESH: Molecular Docking Simulation, MESH: Protein Binding, MESH: Protein Interaction Domains and Motifs, MESH: Protein Structure, Secondary, MESH: Pyrrolidines/chemical synthesis, MESH: Pyrrolidines/pharmacology, MESH: Schistosoma mansoni/drug effects, MESH: Helminth Proteins/chemistry, MESH: Schistosoma mansoni/enzymology, MESH: Schistosoma mansoni/genetics, MESH: Schistosoma mansoni/growth & development, MESH: Binding Sites, MESH: Structure-Activity Relationship, MESH: Zinc/chemistry, MESH: Zinc/metabolism, MESH: Chelating Agents/chemical synthesis, MESH: Anthelmintics/chemical synthesis, MESH: Chelating Agents/pharmacology

Relation: info:eu-repo/semantics/altIdentifier/pmid/29498707; PUBMED: 29498707; PUBMEDCENTRAL: PMC6017931

Verfügbarkeit: https://hal.science/hal-02391176
https://hal.science/hal-02391176v1/document
https://hal.science/hal-02391176v1/file/A_Novel_Class_of_Schistosoma_mansoni_Histone_Deacetylase_8_%28HDAC8%29_Inhibitors_Identified.pdf
https://doi.org/10.3390/molecules23030566

Design and Synthesis of Bis-Biotin-Containing Reagents for Applications Utilizing Monoclonal Antibody-Based Pretargeting Systems with Streptavidin Mutants

Autoren: Donald K. Hamlin Franz Buchegger Oliver W. Press et al.

Quelle: Bioconjugate Chemistry, Vol. 21, No 7 (2010) pp. 1225-1238

Schlagwörter: 0301 basic medicine, Acetylgalactosamine/chemical synthesis/chemistry/*therapeutic use, Acetylgalactosamine, Lymphoma, B-Cell, Recombinant Fusion Proteins, Biotin, Lymphoma, B-Cell/*drug therapy/genetics/immunology, ddc:616.0757, Heterocyclic Compounds, 1-Ring, Mice, 03 medical and health sciences, Recombinant Fusion Proteins/chemistry/genetics/immunology, Streptavidin/chemistry/*genetics/immunology, Cell Line, Tumor, Animals, Humans, Chelating Agents, 0303 health sciences, 616.0757, Molecular Structure, Chelating Agents/chemical synthesis/chemistry/*therapeutic use, Heterocyclic Compounds, 1-Ring/chemistry, Biotin/*chemistry/immunology, Antigens, CD20, Xenograft Model Antitumor Assays, 3. Good health, Drug Design, Mutation, Single-Chain Antibodies/chemistry/immunology/*therapeutic use, Streptavidin, Antigens, CD20/immunology, Single-Chain Antibodies

Dateibeschreibung: application/pdf

Zugangs-URL: https://europepmc.org/articles/pmc2912428?pdf=render
https://pubmed.ncbi.nlm.nih.gov/20597486
https://www.ncbi.nlm.nih.gov/pubmed/20597486
https://archive-ouverte.unige.ch/unige:20667
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912428/figure/F7/
https://pubs.acs.org/doi/abs/10.1021/bc100030q
https://archive-ouverte.unige.ch/unige:20667/ATTACHMENT01
http://europepmc.org/articles/PMC2912428
https://archive-ouverte.unige.ch/unige:20667
https://archive-ouverte.unige.ch/unige:20667
https://doi.org/10.1021/bc100030q

Design and synthesis of bis-biotin-containing reagents for applications utilizing monoclonal antibody-based pretargeting systems with streptavidin mutants

Autoren: Wilbur, D Scott Park, Steven I. Chyan, Ming-Kuan et al.

Quelle: ISSN: 1043-1802 ; Bioconjugate chemistry, vol. 21, no. 7 (2010) p. 1225-1238.

Schlagwörter: info:eu-repo/classification/ddc/616.0757, Acetylgalactosamine/chemical synthesis/chemistry/*therapeutic use, Animals, Antigens, CD20/immunology, Biotin/*chemistry/immunology, Cell Line, Tumor, Chelating Agents/chemical synthesis/chemistry/*therapeutic use, Drug Design, Heterocyclic Compounds, 1-Ring/chemistry, Humans, Lymphoma, B-Cell/*drug therapy/genetics/immunology, Mice, Molecular Structure, Mutation, Recombinant Fusion Proteins/chemistry/genetics/immunology, Single-Chain Antibodies/chemistry/immunology/*therapeutic use, Streptavidin/chemistry/*genetics/immunology, Xenograft Model Antitumor Assays

Relation: info:eu-repo/semantics/altIdentifier/pmid/20597486; unige:20667

Verfügbarkeit: https://archive-ouverte.unige.ch/unige:20667

Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds.

Autoren: Charton, Julie Charruault, Lise Déprez-Poulain, Rebecca et al.

Weitere Verfasser: Charton, Julie Charruault, Lise Déprez-Poulain, Rebecca et al.

Quelle: ISSN: 1386-2073 ; Combinatorial Chemistry and High Throughput Screening ; https://inserm.hal.science/inserm-00281198 ; Combinatorial Chemistry and High Throughput Screening, 2008, 11 (4), pp.294-303. ⟨10.2174/138620708784246013⟩.

Schlagwörter: MESH: Amines/chemical synthesis, MESH: Amines/chemistry, MESH: Chelating Agents/chemical synthesis, MESH: Chelating Agents/chemistry, MESH: Chemistry, Pharmaceutical/methods, MESH: Combinatorial Chemistry Techniques/methods, MESH: Cyclobutanes/chemistry, MESH: Enzyme Inhibitors/chemical synthesis, MESH: Enzyme Inhibitors/chemistry, MESH: Esters/chemistry, MESH: Hydroxamic Acids/chemistry, MESH: Molecular Structure, MESH: Pharmaceutical Preparations/chemical synthesis, MESH: Pharmaceutical Preparations/chemistry, MESH: Piperidines/chemistry, MESH: Small Molecule Libraries/chemical synthesis, MESH: Small Molecule Libraries/chemistry, MESH: Zinc/chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences

Relation: info:eu-repo/semantics/altIdentifier/pmid/18473739; PUBMED: 18473739

Verfügbarkeit: https://inserm.hal.science/inserm-00281198
https://inserm.hal.science/inserm-00281198v1/document
https://inserm.hal.science/inserm-00281198v1/file/CCHTS-Charton_et_al.pdf
https://doi.org/10.2174/138620708784246013