Suchergebnisse - "Chelating Agents"

Investigation of Ca ²⁺ signaling induced by the flavonoid diosmin in glioblastoma cells and its potential implications in the treatment using the Ca ²⁺ chelating agent BAPTA-AM.

Autoren: Hao LJ Chou CT Lin YH et al.

Quelle: Toxicology mechanisms and methods [Toxicol Mech Methods] 2025 Oct; Vol. 35 (8), pp. 982-992. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE

MeSH-Schlagworte: Diosmin*/pharmacology , Diosmin*/toxicity , Glioblastoma*/metabolism , Glioblastoma*/pathology , Glioblastoma*/drug therapy , Egtazic Acid*/analogs & derivatives , Egtazic Acid*/pharmacology , Calcium Signaling*/drug effects , Calcium Chelating Agents*/pharmacology , Calcium*/metabolism , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology , Brain Neoplasms*/drug therapy, Humans ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Type C Phospholipases/metabolism ; Chelating Agents/pharmacology

Preparation, structural characteristics and antioxidant activity of polysaccharide and its metal chelates from the peel of Dioscorea oppositifolia L.

Autoren: Liu Y Niu CF Wang Y et al.

Quelle: Natural product research [Nat Prod Res] 2025 Jan; Vol. 39 (1), pp. 119-126. Date of Electronic Publication: 2023 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

MeSH-Schlagworte: Dioscorea*/chemistry , Antioxidants*/chemistry , Antioxidants*/pharmacology , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Zinc*/chemistry , Chelating Agents*/chemistry, Iron/chemistry ; Spectroscopy, Fourier Transform Infrared ; Iron Chelating Agents/chemistry ; Iron Chelating Agents/pharmacology ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology

Citric acid is more effective than sodium thiosulfate in chelating calcium in a dissolution model of calcinosis.

Autoren: Burgess KA Winpenny REP Saiani A et al.

Quelle: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 30645. Date of Electronic Publication: 2024 Dec 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Thiosulfates*/chemistry , Thiosulfates*/pharmacology , Citric Acid*/chemistry , Calcinosis*/drug therapy , Calcinosis*/metabolism , Calcium Chelating Agents*/pharmacology, Humans ; Calcium/metabolism ; Edetic Acid/chemistry ; Edetic Acid/pharmacology ; Chelating Agents/chemistry ; Chelating Agents/pharmacology ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Solubility ; Durapatite/chemistry

Ethylenediaminetetraacetic acid conjugated with polyethylene glycol is a safe chelator for colonic epithelial denudation and intestinal epithelial replacement therapy.

Autoren: Matsumoto Y Murakami Y Suda K et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 20; Vol. 15 (1), pp. 41025. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Edetic Acid*/chemistry , Edetic Acid*/pharmacology , Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacology , Chelating Agents*/chemistry , Chelating Agents*/pharmacology , Colon*/drug effects , Colon*/cytology , Intestinal Mucosa*/drug effects, Animals ; Mice ; Organoids/transplantation ; Humans

Chelating mitochondrial iron and copper: Recipes, pitfalls and promise.

Autoren: Lamačová LJ Trnka J

Quelle: Mitochondrion [Mitochondrion] 2024 Sep; Vol. 78, pp. 101903. Date of Electronic Publication: 2024 May 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100968751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8278 (Electronic) Linking ISSN: 15677249 NLM ISO Abbreviation: Mitochondrion Subsets: MEDLINE

MeSH-Schlagworte: Copper*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects , Iron*/metabolism , Chelating Agents*/therapeutic use , Chelating Agents*/metabolism, Humans ; Iron Chelating Agents/pharmacology ; Animals ; Chelation Therapy/methods

The role, mechanisms and evaluation of natural chelating agents in food stability: a review.

Autoren: Mussio C Garcia-Perez P Moret E et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 1), pp. 146682. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Chelating Agents*/chemistry , Food Preservation*, Food Storage

Characterization and binding site profiling of zinc-chelated peptides from Takifugu rubripes bone with enhanced biological activity.

Autoren: Guo M Huang L Li Y et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 1), pp. 146627. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Zinc*/chemistry , Zinc*/pharmacology , Zinc*/metabolism , Peptides*/chemistry , Peptides*/pharmacology , Bone and Bones*/chemistry , Takifugu*/metabolism , Chelating Agents*/chemistry , Chelating Agents*/pharmacology , Fish Proteins*/chemistry , Fish Proteins*/pharmacology, Animals ; Binding Sites ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Molecular Docking Simulation ; Escherichia coli/drug effects ; Staphylococcus aureus/drug effects ; Antioxidants/chemistry ; Antioxidants/pharmacology

Characterization and bioaccessibility of Fe ²⁺ -oat bran peptide chelate.

Autoren: Jin W Wang L Ma Q et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 1), pp. 146323. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Iron Chelating Agents*/chemistry , Iron Chelating Agents*/metabolism , Peptides*/chemistry , Peptides*/metabolism , Iron*/chemistry , Iron*/metabolism , Ferrous Compounds*/chemistry , Ferrous Compounds*/metabolism , Dietary Fiber*/analysis, Biological Availability ; Digestion ; Antioxidants/chemistry ; Antioxidants/metabolism ; Humans

Control of pharmacokinetics of radioimmunoconjugates using chelating agents containing poly(ethylene glycol).

Autoren: Nakashima K Jinda H Shimohara H et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114293. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacokinetics , Chelating Agents*/chemistry , Chelating Agents*/pharmacokinetics , Chelating Agents*/administration & dosage , Immunoconjugates*/pharmacokinetics , Immunoconjugates*/administration & dosage , Immunoconjugates*/chemistry, Animals ; Humans ; Cell Line, Tumor ; Female ; Tissue Distribution ; Trastuzumab/pharmacokinetics ; Trastuzumab/administration & dosage ; Heterocyclic Compounds, 1-Ring/chemistry ; Heterocyclic Compounds, 1-Ring/pharmacokinetics ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Receptor, ErbB-2/metabolism ; Radioisotopes/pharmacokinetics ; Radioisotopes/administration & dosage ; Maleimides/chemistry

Deferoxamine improves intervertebral disc degeneration by activating HIF-1α/BNIP3-mediated mitophagy and inhibiting ferroptosis.

Autoren: Wang H Zhou Z Wu T et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115583. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Deferoxamine*/pharmacology , Deferoxamine*/therapeutic use , Intervertebral Disc Degeneration*/drug therapy , Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/pathology , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Membrane Proteins*/metabolism , Mitochondrial Proteins*/metabolism , Iron Chelating Agents*/pharmacology , Iron Chelating Agents*/therapeutic use, Animals ; Ferroptosis/drug effects ; Mice ; Mitophagy/drug effects ; Humans ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Oxidative Stress/drug effects ; Mitochondria/drug effects ; Signal Transduction/drug effects

Head-to-head evaluation of DFO and 3,4,3-LI(1,2-HOPO) chelators through site-specific conjugation of Anti-STEAP1 antibody V6-19-D11 for ⁸⁹ Zr-immuno-PET imaging.

Autoren: Shah SQ Shirin S

Quelle: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2025 Dec; Vol. 226, pp. 112168. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE

MeSH-Schlagworte: Zirconium*/chemistry , Radioisotopes*/chemistry , Positron-Emission Tomography*/methods , Chelating Agents*/chemistry , Chelating Agents*/pharmacokinetics , Prostatic Neoplasms*/diagnostic imaging , Prostatic Neoplasms*/metabolism , Immunoconjugates*/pharmacokinetics , Immunoconjugates*/chemistry , Deferoxamine*/chemistry , Deferoxamine*/pharmacokinetics , Antibodies, Monoclonal*/chemistry, Animals ; Humans ; Mice ; Tissue Distribution ; Mice, Nude ; Cell Line, Tumor ; Male ; Radiopharmaceuticals/pharmacokinetics ; Oxidoreductases/immunology ; Antigens, Neoplasm

Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.

Autoren: Burnett CL Bergfeld WF Belsito DV et al.

Quelle: International journal of toxicology [Int J Toxicol] 2025 Dec; Vol. 44 (4_suppl), pp. 82S-92S. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Cosmetics*/chemistry , Cosmetics*/toxicity , beta-Alanine*/toxicity , beta-Alanine*/pharmacokinetics , Chelating Agents*/toxicity , Chelating Agents*/pharmacokinetics, Humans ; Animals ; Consumer Product Safety ; Risk Assessment

Didox, a ribonucleotide reductase inhibitor with iron chelator properties, counteracts the in vitro and in vivo growth of rhabdomyosarcoma cells.

Autoren: Cantamessa L Asperti M Gryzik M et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117312. Date of Electronic Publication: 2025 Sep 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Iron Chelating Agents*/pharmacology , Iron Chelating Agents*/therapeutic use , Rhabdomyosarcoma*/drug therapy , Rhabdomyosarcoma*/pathology , Rhabdomyosarcoma*/metabolism , Rhabdomyosarcoma*/enzymology , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/therapeutic use , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use , Ribonucleotide Reductases*/antagonists & inhibitors, Animals ; Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Mice ; Cell Survival/drug effects ; Cell Survival/physiology ; Xenograft Model Antitumor Assays/methods ; Dose-Response Relationship, Drug

Iron-chelating and antioxidant synthetic peptides: Modulating salmon immunity and growth.

Autoren: Pombett Y Morales-Lange B Rocha SDC et al.

Quelle: Fish & shellfish immunology [Fish Shellfish Immunol] 2025 Dec; Vol. 167, pp. 110910. Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH-Schlagworte: Antioxidants*/pharmacology , Antioxidants*/administration & dosage , Antioxidants*/metabolism , Salmo salar*/immunology , Salmo salar*/growth & development , Fish Diseases*/immunology , Iron Chelating Agents*/pharmacology , Iron Chelating Agents*/administration & dosage , Iron Chelating Agents*/metabolism , Peptides*/pharmacology , Peptides*/administration & dosage , Immunity, Innate*/drug effects , Oncorhynchus mykiss*/immunology , Oncorhynchus mykiss*/growth & development, Animals ; Piscirickettsia/physiology ; Diet/veterinary ; Animal Feed/analysis ; Piscirickettsiaceae Infections/immunology ; Piscirickettsiaceae Infections/veterinary ; Dietary Supplements/analysis ; Fish Proteins

SCR Organism: Piscirickettsia salmonis

Discovery of a dual-action compound for metallo-β-lactamase inhibition and biofilm clearance to reverse CRE resistance.

Autoren: Liu M Wu C Zhang X et al.

Quelle: Journal of inorganic biochemistry [J Inorg Biochem] 2025 Dec; Vol. 273, pp. 113028. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE

MeSH-Schlagworte: Biofilms*/drug effects , beta-Lactamase Inhibitors*/pharmacology , beta-Lactamase Inhibitors*/chemistry , beta-Lactamases*/metabolism , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Carbapenem-Resistant Enterobacteriaceae*/drug effects , Carbapenem-Resistant Enterobacteriaceae*/enzymology , Chelating Agents*/pharmacology , Chelating Agents*/chemistry, Microbial Sensitivity Tests ; Zinc/chemistry ; Humans

Preparation of oat metal ion chelating peptides via froth floatation: Efficacy, molecular characteristics, and their anti-browning effects.

Autoren: Guan X Gao X Yin X et al.

Quelle: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 2), pp. 145767. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article; Evaluation Study

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Chelating Agents*/chemistry , Chelating Agents*/pharmacology , Peptides*/chemistry , Peptides*/pharmacology, Fruit/chemistry ; Catechol Oxidase/chemistry ; Catechol Oxidase/antagonists & inhibitors ; Malus/chemistry ; Musa/chemistry ; Brassica/chemistry ; Peroxidase/chemistry ; Peroxidase/antagonists & inhibitors ; Maillard Reaction/drug effects ; Plant Proteins/chemistry ; Metals/chemistry ; Food Preservation/methods

Collagen-derived Fe ²⁺ -chelating peptide: Key amino acids for Fe ²⁺ chelating and mechanisms for enhancing cellular Fe ²⁺ bioavailability.

Autoren: Li J Lin S Chen S et al.

Quelle: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 2), pp. 145847. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Peptides*/chemistry , Peptides*/metabolism , Iron Chelating Agents*/chemistry , Iron Chelating Agents*/metabolism , Amino Acids*/chemistry , Iron*/chemistry , Iron*/metabolism, Biological Availability ; Humans ; Animals

Development and validation of combined in vitro and in vivo assays for evaluating the efficacy of strontium-chelating compounds.

Autoren: Varga N Pomozi V Kozák E et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 28; Vol. 15 (1), pp. 43006. Date of Electronic Publication: 2025 Nov 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Chelating Agents*/pharmacology , Chelating Agents*/chemistry , Strontium*/chemistry, Animals ; Mice ; Humans ; Strontium Radioisotopes/chemistry

Leveraging Vulnerabilities in Copper Trafficking for Synergistic Antifungal Activity.

Autoren: Denning-Jannace CA James KJ Monteagudo CR et al.

Quelle: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2659-2670. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Copper*/metabolism , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Candida albicans*/drug effects , Candida albicans*/metabolism , Candida albicans*/growth & development , Molybdenum*/pharmacology , Molybdenum*/chemistry , Chelating Agents*/pharmacology , Chelating Agents*/chemistry, Drug Synergism ; Microbial Sensitivity Tests ; Azoles/pharmacology ; Fungal Proteins/metabolism ; Oxidative Stress/drug effects

Investigation and preparation of a TREN-based bifunctional chelator for ⁸⁹ Zr.

Autoren: Lucero MY King AP Lee W et al.

Quelle: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2025 Nov 18; Vol. 54 (45), pp. 16772-16780. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9234 (Electronic) Linking ISSN: 14779226 NLM ISO Abbreviation: Dalton Trans Subsets: MEDLINE

MeSH-Schlagworte: Zirconium*/chemistry , Chelating Agents*/chemistry , Chelating Agents*/chemical synthesis , Chelating Agents*/pharmacokinetics , Radioisotopes*/chemistry , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/pharmacokinetics, Animals ; Mice ; Tissue Distribution ; Humans ; Positron-Emission Tomography ; Deferoxamine/chemistry