Suchergebnisse - "Cellular Reprogramming drug effects"

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

Autoren: Rahil Noorizadeh Barbara Sax Tahereh Javaheri et al.

Quelle: Cell Reports ; issn:1746-6148

Schlagwörter: Animals, Mesenchymal Stem Cells Metabolism, YAP-Signaling Proteins Metabolism, RNA-Binding Protein EWS Metabolism, RNA-Binding Protein EWS Genetics, Humans, Mice, Cell Transformation, Neoplastic Metabolism, Neoplastic Genetics, Proto-Oncogene Protein c-fli-1Metabolism, Proto-Oncogene Protein c-fli-1Genetics, Adaptor Proteins, Signal Transducing Metabolism, Insulin-Like Growth Factor I Metabolism, Transcription Factors Metabolism, Sarcoma, Ewing Metabolism, Ewing Pathology, Ewing Genetics, Cellular Reprogramming Drug Effects, Oncogene Proteins, Fusion Metabolism, Fusion Genetics, Receptor, IGF Type 1 Metabolism, Bone and Bones Metabolism, Bone and Bones Pathology

Dateibeschreibung: application/pdf

Relation: isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publikationen]; https://phaidra.vetmeduni.ac.at/o:4046

Verfügbarkeit: https://doi.org/10.1016/j.celrep.2025.115381
https://phaidra.vetmeduni.ac.at/o:4046

Functional Gene Restoration and Cancer Stem Cell Eradication in a Treatment-Resistant TNBC Case: A First-in-Human Paradigm Shift

Autoren: Malone, Marc orcid:0009-0004-8968- Greer, Erin et al.

Weitere Verfasser: Malone, Marc orcid:0009-0004-8968- Greer, Erin et al.

Schlagwörter: Epigenetics, Epigenetic Memory, Epigenetic Repression, Metabolic Reprogramming/drug effects, Cellular Reprogramming/drug effects, Cellular Reprogramming/genetics, Cellular Reprogramming Techniques/methods, Metabolic Reprogramming, Metabolic Reprogramming/genetics, Triple-Negative Breast Cancer, Breast cancer, Signal processing, Signal Transduction, Signal Transduction/genetics, cancer stem cells, metastatic, tumor reduction

Relation: https://zenodo.org/records/15278175; oai:zenodo.org:15278175; https://doi.org/10.5281/zenodo.15278175

Verfügbarkeit: https://doi.org/10.5281/zenodo.15278175
https://zenodo.org/records/15278175

First Human Epigenetic Reprogramming Case: ESR1/PGR Gene Restoration, Tumor Reduction, and CSC/CTC Suppression in Advanced TNBC

Autoren: Malone, Marc orcid:0009-0004-8968- Greer, Erin et al.

Weitere Verfasser: Malone, Marc orcid:0009-0004-8968- Greer, Erin et al.

Schlagwörter: Epigenetics, Epigenetic Memory, Epigenetic Repression, Metabolic Reprogramming/drug effects, Cellular Reprogramming/drug effects, Cellular Reprogramming/genetics, Cellular Reprogramming Techniques/methods, Metabolic Reprogramming, Metabolic Reprogramming/genetics, Triple-Negative Breast Cancer, Breast cancer, Signal processing, Signal Transduction, Signal Transduction/genetics

Relation: https://zenodo.org/records/15277781; oai:zenodo.org:15277781; https://doi.org/10.5281/zenodo.15277781

Verfügbarkeit: https://doi.org/10.5281/zenodo.15277781
https://zenodo.org/records/15277781

Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

Autoren: Sang Wook Lee Patrick Tae Joon Hwang Eric Shin et al.

Weitere Verfasser: Sang Wook Lee Patrick Tae Joon Hwang Eric Shin et al.

Quelle: Nature Biomedical Engineering. 5:880-896

Schlagwörter: 0301 basic medicine, Myocardium / metabolism, Myocytes, Smooth Muscle, Myocardial Infarction, Neovascularization, Physiologic, Ascorbic Acid, Bone Morphogenetic Protein 4, Myosin Heavy Chains / genetics, Gap Junctions / physiology, Inbred C57BL, Fibroblasts / metabolism, Mice, 03 medical and health sciences, Bone Morphogenetic Protein 4 / pharmacology, Animals, Regeneration, Smooth Muscle / transplantation, Physiologic, Neovascularization, Myocytes, 0303 health sciences, Endothelial Cells / transplantation, Myosin Heavy Chains, Endothelial Cells / metabolism, Myosin Heavy Chains / metabolism, Myocardium, Fibroblasts / cytology, Endothelial Cells, Gap Junctions, Heart, Smooth Muscle / cytology, Fibroblasts, Smooth Muscle / metabolism, Cellular Reprogramming, MicroRNAs / metabolism, Cellular Reprogramming / drug effects, Mice, Inbred C57BL, MicroRNAs, Ascorbic Acid / pharmacology, Myocardium / pathology, Heart / physiology, Myocardial Infarction / therapy, Myocardium / cytology, Transcriptome, Endothelial Cells / cytology

Zugangs-URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809198
https://pubmed.ncbi.nlm.nih.gov/34426676
https://www.nature.com/articles/s41551-021-00783-0
https://www.nature.com/articles/s41551-021-00783-0.pdf
https://pubmed.ncbi.nlm.nih.gov/34426676/
https://europepmc.org/article/MED/34426676

Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy

Autoren: Elodie Renaude Marie Kroemer Christophe Borg et al.

Weitere Verfasser: Elodie Renaude Marie Kroemer Christophe Borg et al.

Quelle: Front Immunol
Frontiers in Immunology, Vol 12 (2021)

Schlagwörter: 0301 basic medicine, Immunology, Antineoplastic Agents, Epigenesis, Genetic/drug effects, Biochimie, biophysique & biologie moléculaire, Immunotherapy, Adoptive, Epigenesis, Genetic, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Cellular Reprogramming/drug effects, Neoplasms, Tumor Microenvironment, tumor microenvironment, Animals, Humans, Lymphocytes, Tumor-Infiltrating/immunology, CD4+ helper T cells, 0303 health sciences, Lymphocytes, Tumor-Infiltrating/metabolism, epigenetics, Cell Differentiation, T-Lymphocytes, Helper-Inducer, RC581-607, Cellular Reprogramming, Life sciences, 3. Good health, Treatment Outcome, plasticity, Sciences du vivant, immunotherapy, Immunologic diseases. Allergy, Biochemistry, biophysics & molecular biology

Zugangs-URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.669992/pdf
https://pubmed.ncbi.nlm.nih.gov/34262562
https://doaj.org/article/291928e2de864f3b876293c40387eabb
https://pubmed.ncbi.nlm.nih.gov/34262562/
https://www.frontiersin.org/articles/10.3389/fimmu.2021.669992/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273698
https://europepmc.org/article/PMC/PMC8273698

DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells

Autoren: Bruyer, Angelique Maes, Ken Herviou, Laurie et al.

Weitere Verfasser: Bruyer, Angelique Maes, Ken Herviou, Laurie et al.

Quelle: Br J Cancer

Schlagwörter: 0301 basic medicine, mice, Plasma Cells, Multiple Myeloma/drug therapy, Epigenesis, Genetic/drug effects, Article, Epigenesis, Genetic, Mice, 03 medical and health sciences, Cellular Reprogramming/drug effects, Antineoplastic Combined Chemotherapy Protocols, Tumor Cells, Cultured, Animals, Humans, Molecular Targeted Therapy, 0303 health sciences, Histone Deacetylase Inhibitors/administration & dosage, Gene Expression Profiling, Cell Differentiation, Cellular Reprogramming, Microarray Analysis, 3. Good health, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, Plasma Cells/drug effects, Research Design, Cell Differentiation/drug effects, Gene Expression Regulation, Neoplastic/drug effects, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, microarray analysis, Multiple Myeloma, Transcriptome, Molecular Targeted Therapy/methods

Zugangs-URL: https://www.nature.com/articles/s41416-018-0025-x.pdf
https://pubmed.ncbi.nlm.nih.gov/29500406
https://europepmc.org/article/PMC/PMC5931098
https://www.nature.com/articles/s41416-018-0025-x
https://pubmed.ncbi.nlm.nih.gov/29500406/
https://paperity.org/p/136374428/dnmti-hdaci-combined-epigenetic-targeted-treatment-induces-reprogramming-of-myeloma-cells
https://www.ncbi.nlm.nih.gov/pubmed/29500406
https://researchportal.vub.be/en/publications/dnmtihdaci-combined-epigenetic-targeted-treatment-induces-reprogr
https://biblio.vub.ac.be/vubir/dnmtihdaci-combined-epigenetic-targeted-treatment-induces-reprogramming-of-myeloma-cells-in-the-direction-of-normal-plasma-cells(3bb55fec-a3b0-484c-83f0-895a06cb08d8).html

Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.

Autoren: Renaude, Elodie Kroemer, Marie Borg, Christophe et al.

Quelle: Frontiers in Immunology, 12, 669992 (2021)

Schlagwörter: CD4+ helper T cells, epigenetics, immunotherapy, plasticity, tumor microenvironment, Cellular Reprogramming/drug effects, Epigenesis, Genetic/drug effects, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Tumor Microenvironment, Cellular Reprogramming, Neoplasms, Immunology, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.669992/full; urn:issn:1664-3224

Zugangs-URL: https://orbi.uliege.be/handle/2268/330764

Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But not Angiogenesis of Human Pancreatic Duct Cells

Autoren: Ding, Lei Heremans, Yves Pipeleers, Daniel et al.

Weitere Verfasser: Ding, Lei Heremans, Yves Pipeleers, Daniel et al.

Quelle: Cell Transplantation, Vol 24 (2015)

Schlagwörter: Vascular Endothelial Growth Factor A, Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Chorioallantoic Membrane/blood supply, Apoptosis, Chick Embryo, Mice, SCID, Research & Experimental Medicine, Chorioallantoic Membrane, Cell Proliferation/drug effects, Mice, Mice, Inbred NOD, 10 Technology, Islet transplantation, Child, MYCOPHENOLATE-MOFETIL, 11 Medical and Health Sciences, Immunosuppressant, 0303 health sciences, Cytokines/genetics, Tacrolimus/pharmacology, Middle Aged, Cellular Reprogramming, 3. Good health, Interleukin-8/blood, Medicine, Research & Experimental, Human pancreatic duct cell, young adult, Medicine, Cytokines, Female, Dedifferentiation, Chemokines, Life Sciences & Biomedicine, Immunosuppressive Agents, HUMAN ISLET PREPARATIONS, Adult, mice, Adolescent, Neovascularization, Physiologic, Tacrolimus, Young Adult, 03 medical and health sciences, Chemokines/genetics, BETA-CELLS, Cellular Reprogramming/drug effects, Cell & Tissue Engineering, Animals, Humans, Cell Proliferation, Sirolimus, Transplantation, Science & Technology, Cytoldnes, Neurology & Neurosurgery, Immunosuppressive Agents/pharmacology, TRANSPLANTATION, Pancreatic Ducts/cytology, Vascular Endothelial Growth Factor A/blood, 31 Biological sciences, Apoptosis/drug effects, EDMONTON PROTOCOL, Interleukin-8, GRAFT, Pancreatic Ducts, Sirolimus/pharmacology, DIABETES-MELLITUS, Cell Biology, 06 Biological Sciences, ENDOTHELIAL GROWTH-FACTOR, RAT, Angiogenesis, RAPAMYCIN, Chickens

Zugangs-URL: https://lirias.kuleuven.be/bitstream/123456789/469022/3/Ding%20et%20al.%20Cell%20Transplant%202015.pdf
https://pubmed.ncbi.nlm.nih.gov/25198311
https://doaj.org/article/f61e82c0b6c84bf6bfd755feab98ab91
https://www.ncbi.nlm.nih.gov/pubmed/25198311
https://journals.sagepub.com/doi/10.3727/096368914X682819
https://journals.sagepub.com/doi/pdf/10.3727/096368914X682819
https://researchportal.vub.be/en/publications/clinical-immunosuppressants-inhibit-inflammatory-proliferative-an-2
http://journals.sagepub.com/doi/10.3727/096368914X682819
https://lirias.kuleuven.be/handle/123456789/469022
https://doi.org/10.3727/096368914x682819
https://biblio.vub.ac.be/vubir/clinical-immunosuppressants-inhibit-inflammatory-proliferative-and-reprogramming-potential-but-not-angiogenesis-of-human-pancreatic-duct-cells(838ca2d3-223f-4f44-87ef-270b152e1a7f).html
https://doi.org/10.3727/096368914x682819
https://biblio.vub.ac.be/vubir/clinical-immunosuppressants-inhibit-inflammatory-proliferative-and-reprogramming-potential-but-not-angiogenesis-of-human-pancreatic-duct-cells(5dc3b7c4-9bc4-4de6-a52d-79c2645a0a96).html
https://hdl.handle.net/20.500.14017/5dc3b7c4-9bc4-4de6-a52d-79c2645a0a96
https://doi.org/10.3727/096368914x682819

Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?

Autoren: Escoll, Pedro Buchrieser, Carmen Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria et al.

Weitere Verfasser: Escoll, Pedro Buchrieser, Carmen Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria et al.

Quelle: ISSN: 1742-464X.

Schlagwörter: Bacterial infection, Glycolysis, Mitochondria, OXPHOS, Warburg-like metabolism, MESH: Animals, MESH: Bacteria/growth & development, MESH: Cell Differentiation, MESH: Cell Proliferation, MESH: Interleukin-1beta/immunology, MESH: Cellular Reprogramming/drug effects, MESH: Glycolysis/genetics, MESH: Host-Pathogen Interactions, MESH: Humans, MESH: Interleukin-1beta/biosynthesis, MESH: Lipopolysaccharides/pharmacology, MESH: Macrophages/drug effects, MESH: Mitochondria/metabolism, MESH: Macrophages/immunology, MESH: Macrophages/metabolism, MESH: Macrophages/microbiology, MESH: Mitochondria/drug effects, MESH: Mitochondria/immunology, MESH: Mitochondria/microbiology, MESH: Bacteria/pathogenicity, MESH: Oxidative Phosphorylation/drug effects, MESH: T-Lymphocytes/drug effects, MESH: T-Lymphocytes/immunology, MESH: T-Lymphocytes/metabolism, MESH: T-Lymphocytes/microbiology

Relation: info:eu-repo/semantics/altIdentifier/pmid/29603622; PUBMED: 29603622

Verfügbarkeit: https://pasteur.hal.science/pasteur-02437195
https://pasteur.hal.science/pasteur-02437195v1/document
https://pasteur.hal.science/pasteur-02437195v1/file/2018%20FEBS_Escoll.pdf
https://doi.org/10.1111/febs.14446

Temporal Perturbation of the Wnt Signaling Pathway in the Control of Cell Reprogramming Is Modulated by TCF1

Autoren: Aulicino, Francesco Theka, Ilda Ombrato, Luigi et al.

Quelle: Stem Cell Reports
Stem Cell Reports, Vol 2, Iss 5, Pp 707-720 (2014)

Schlagwörter: 0301 basic medicine, Medicine (General), Epithelial-Mesenchymal Transition, beta Catenin/genetics, Small Interfering/metabolism, QH301-705.5, Induced Pluripotent Stem Cells, Transcription Factors/genetics, Doxorubicin/pharmacology, Article, Cell Line, Mice, 03 medical and health sciences, R5-920, Cellular Reprogramming/drug effects, Induced Pluripotent Stem Cells/cytology, Antibiotics, Animals, Hepatocyte Nuclear Factor 1-alpha, Biology (General), RNA, Small Interfering, Wnt Signaling Pathway, Wnt Proteins/genetics, beta Catenin, Homeodomain Proteins, Antineoplastic/pharmacology, 0303 health sciences, Antibiotics, Antineoplastic, Cèl·lules mare embrionàries, Genètica animal, Hepatocyte Nuclear Factor 1-alpha/antagonists & inhibitors, Cellular Reprogramming, Wnt Proteins, Doxorubicin, RNA, RNA Interference, Homeodomain Proteins/genetics, Cèl·lules mare, Transcription Factors

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/24936456
https://doaj.org/article/0d2d95e62ca24034b60319aa17fcb1b8
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050487/
http://www.cell.com/stem-cell-reports/abstract/S2213-6711(14)00108-8
https://www.sciencedirect.com/science/article/pii/S2213671114001088
http://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2814%2900108-8
https://core.ac.uk/display/90932314
http://europepmc.org/articles/PMC4050487

Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.

Weitere Verfasser: College of Medicine Dept. of Neurosurgery Jinsoo Oh et al.

Schlagwörter: Animals, Cell Differentiation/drug effects, Cell Line, Tumor, Cell Proliferation/drug effects, Cellular Reprogramming/drug effects, Colforsin/administration & dosage, Cyclic AMP/antagonists & inhibitors, Cyclic AMP/genetics, Gene Expression Regulation, Neoplastic/drug effects, Glioma/drug therapy, Glioma/genetics, Glioma/pathology, Glycogen Synthase Kinase 3/antagonists & inhibitors, Glycogen Synthase Kinase 3/genetics, Humans, Mice, Neurons/drug effects, Neurons/metabolism, Optical Imaging, Pyridines/administration & dosage, Pyrimidines/administration & dosage, Rats, Signal Transduction/drug effects, Small Molecule Libraries/administration & dosage, Xenograft Model Antitumor Assays

Relation: PLOS ONE; J02540; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161495; T201704959; PLOS ONE, Vol.12(11) : e0178881, 2017; 61402

Verfügbarkeit: https://ir.ymlib.yonsei.ac.kr/handle/22282913/161495
https://doi.org/10.1371/journal.pone.0178881