Search Results - "Cellular Reprogramming"

In Vitro Generation of Brown and Beige Adipocytes via Cellular Reprogramming.

Authors: Toshihiro K Harada Y Dai P

Source: Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 216-227. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE

MeSH Terms: Adipocytes, Beige*/cytology , Adipocytes, Beige*/metabolism , Cellular Reprogramming* , Adipocytes, Brown*/cytology , Adipocytes, Brown*/metabolism , Cellular Reprogramming Techniques*/methods, Humans ; Animals ; Thermogenesis

Cellular Reprogramming and Microfluidics Enable Large-Scale Blastoid Production from Aged Donors.

Authors: Moura MT; Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brasil.

Source: Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 213-215. Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article; News

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE

MeSH Terms: Microfluidics*/methods , Cellular Reprogramming* , Blastocyst*/cytology , Cellular Reprogramming Techniques*/methods , Aging*, Animals ; Macaca mulatta ; Humans

Establishment of human expanded potential stem cell lines via preimplantation embryo cultivation and somatic cell reprogramming.

Authors: Ruan D Chen ACH Tam TTKK et al.

Source: Nature protocols [Nat Protoc] 2025 Oct; Vol. 20 (10), pp. 2698-2734. Date of Electronic Publication: 2025 Apr 29.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

MeSH Terms: Blastocyst*/cytology , Cellular Reprogramming* , Cell Culture Techniques*/methods , Embryo Culture Techniques*/methods , Cellular Reprogramming Techniques*/methods, Humans ; Cell Line ; Cell Differentiation ; Fibroblasts/cytology ; Trophoblasts/cytology

Cellular reprogramming during anti-PD-1 and chemotherapy treatment in early-stage primary hormone receptor-positive breast cancer.

Authors: Fu J Waks AG Pimenta E et al.

Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10704. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Breast Neoplasms*/immunology , Cellular Reprogramming*/drug effects , Cellular Reprogramming*/genetics , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Female ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Paclitaxel/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Neoadjuvant Therapy ; Receptors, Estrogen/metabolism ; Macrophages/immunology ; Macrophages/drug effects ; Receptors, Progesterone/metabolism ; Middle Aged ; Gene Expression Regulation, Neoplastic/drug effects ; T-Lymphocytes/immunology ; Albumins

Light-Regulated Reprogramming in Moss: SHMT1 Mediates Blue Light Enhancement of Cell Regeneration.

Authors: Zhao M Huang X Lu W et al.

Source: Plant, cell & environment [Plant Cell Environ] 2025 Nov; Vol. 48 (11), pp. 7759-7774. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 9309004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3040 (Electronic) Linking ISSN: 01407791 NLM ISO Abbreviation: Plant Cell Environ Subsets: MEDLINE

MeSH Terms: Light* , Glycine Hydroxymethyltransferase*/metabolism , Glycine Hydroxymethyltransferase*/genetics , Glycine Hydroxymethyltransferase*/physiology , Cellular Reprogramming*/radiation effects , Cellular Reprogramming*/genetics , Plant Proteins*/metabolism , Plant Proteins*/genetics , Bryopsida*/radiation effects , Bryopsida*/physiology , Bryopsida*/genetics , Regeneration*/radiation effects, Protoplasts/radiation effects ; Protoplasts/metabolism ; Gene Expression Regulation, Plant/radiation effects ; Blue Light

Glioblastoma resistance to EGFR antibody-drug conjugate is driven by transcriptional reprogramming and TEK-induced EGFR suppression.

Authors: Blomquist MR Noviello TMR Sereduk C et al.

Source: Journal of translational medicine [J Transl Med] 2025 Oct 21; Vol. 23 (1), pp. 1153. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH Terms: Glioblastoma*/genetics , Glioblastoma*/drug therapy , Glioblastoma*/pathology , ErbB Receptors*/metabolism , ErbB Receptors*/antagonists & inhibitors , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Immunoconjugates*/therapeutic use , Immunoconjugates*/pharmacology , Brain Neoplasms*/genetics , Brain Neoplasms*/drug therapy , Transcription, Genetic*/drug effects , Cellular Reprogramming*/genetics , Cellular Reprogramming*/drug effects, Humans ; Animals ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Line, Tumor ; Mice ; Xenograft Model Antitumor Assays

Glial Cell Reprogramming in Ischemic Stroke: A Review of Recent Advancements and Translational Challenges.

Authors: Greșiță A Hermann DM Boboc IKS et al.

Source: Translational stroke research [Transl Stroke Res] 2025 Oct; Vol. 16 (5), pp. 1811-1835. Date of Electronic Publication: 2025 Feb 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE

MeSH Terms: Cellular Reprogramming*/physiology , Ischemic Stroke*/therapy , Ischemic Stroke*/pathology , Neuroglia*/physiology , Translational Research, Biomedical*, Humans ; Animals

Ascl1 in Retinal Regeneration: From Neuronal Fate Determination to Reprogramming Mechanisms.

Authors: Yan L Sun B Li N et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71261.

Publication Type: Journal Article; Review

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Basic Helix-Loop-Helix Transcription Factors*/metabolism , Basic Helix-Loop-Helix Transcription Factors*/genetics , Retina*/physiology , Retina*/metabolism , Cellular Reprogramming* , Nerve Regeneration* , Retinal Neurons*/metabolism , Regeneration*, Animals ; Humans ; Neurogenesis/physiology ; Zebrafish ; Ependymoglial Cells/metabolism

MicroRNA-mediated neuronal detargeting alters astrocyte cell fate conversion trajectories in vivo.

Authors: Ghazale H Parga Pazos M Jung S et al.

Source: Communications biology [Commun Biol] 2025 Dec 05; Vol. 8 (1), pp. 1750. Date of Electronic Publication: 2025 Dec 05.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: Astrocytes*/cytology , Astrocytes*/metabolism , Neurons*/metabolism , Neurons*/cytology , MicroRNAs*/genetics , MicroRNAs*/metabolism , Cellular Reprogramming*, Animals ; Mice ; Cell Lineage ; Cell Differentiation ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism

Injury-induced Clusterin ⁺ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages.

Authors: Fan L Tang Q Wang Y et al.

Source: Cell stem cell [Cell Stem Cell] 2025 Dec 04; Vol. 32 (12), pp. 1849-1868.e15. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

MeSH Terms: Clusterin*/metabolism , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Regeneration* , Inflammation*/pathology , Inflammation*/metabolism , Macrophages*/metabolism , Cellular Reprogramming* , Heart*/physiology, Animals ; Humans ; Mice ; Animals, Newborn ; Mice, Inbred C57BL ; Myocardial Infarction/pathology ; Myocardial Infarction/metabolism ; Toll-Like Receptor 4/metabolism ; Cell Proliferation

FOXO1-driven metabolic reprogramming of hematomal CD8 ⁺ T cells drives the expansion of perihematomal edema following intracerebral hemorrhage.

Authors: Lin J Ren H Wang Y et al.

Source: Cellular & molecular immunology [Cell Mol Immunol] 2025 Dec; Vol. 22 (12), pp. 1629-1641. Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article

Journal Info: Publisher: Chinese Society of Immunology;; _b Nature Pub. Group Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE

MeSH Terms: Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/immunology , Cerebral Hemorrhage*/pathology , Cerebral Hemorrhage*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Forkhead Box Protein O1*/metabolism , Hematoma*/immunology , Hematoma*/pathology , Hematoma*/metabolism , Brain Edema*/pathology , Brain Edema*/immunology , Brain Edema*/etiology , Brain Edema*/metabolism , Cellular Reprogramming*, Animals ; Humans ; Mice, Inbred C57BL ; Mice ; Male ; Interferon-gamma/metabolism ; Microglia/metabolism ; Female ; Metabolic Reprogramming

Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming.

Authors: Chu H Wu Q Xu Z et al.

Source: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 496-509. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH Terms: Hydrogen*/pharmacology , Hydrogen*/chemistry , Photothermal Therapy* , Apoptosis*/drug effects , Cellular Reprogramming*/drug effects, Animals ; Oxidation-Reduction/drug effects ; Tumor Microenvironment/drug effects ; Cell Line, Tumor ; Mice ; Humans ; Reactive Oxygen Species/metabolism ; Palladium/chemistry ; Palladium/pharmacology ; Rhodium/chemistry ; Rhodium/pharmacology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Macrophages

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility.

Authors: He C Cui Y Chen W et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e17491. Date of Electronic Publication: 2025 Oct 16.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Sertoli Cells*/metabolism , Sertoli Cells*/cytology , DNA Methylation*/genetics , Cellular Reprogramming*/genetics , Spermatogonia*/metabolism , Fertility*/genetics , Infertility, Male*/genetics , Infertility, Male*/metabolism , Adult Germline Stem Cells*/metabolism, Male ; Humans ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; Azoospermia/genetics

Reprogramming activated astrocytes into GABAergic neurons to treat trigeminal neuralgia.

Authors: Xia S Chen K Li X et al.

Source: Neurochemistry international [Neurochem Int] 2025 Dec; Vol. 191, pp. 106067. Date of Electronic Publication: 2025 Oct 08.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE

MeSH Terms: Trigeminal Neuralgia*/therapy , Trigeminal Neuralgia*/metabolism , Astrocytes*/metabolism , GABAergic Neurons*/metabolism , Cellular Reprogramming*/physiology, Animals ; Rats ; Rats, Sprague-Dawley ; Male ; Cell Transdifferentiation/physiology

N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.

Authors: Tang H Zhong Y Wang J et al.

Source: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112085. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , MicroRNAs*/metabolism , MicroRNAs*/genetics , Exosomes*/metabolism , Exosomes*/genetics , Neutrophils*/metabolism , Neutrophils*/pathology , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Cellular Reprogramming*, Humans ; Animals ; Disease Progression ; Cell Line, Tumor ; Mice ; Cell Proliferation ; PTEN Phosphohydrolase/metabolism ; PTEN Phosphohydrolase/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Forkhead Box Protein O3/metabolism ; Forkhead Box Protein O3/genetics ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Oxaliplatin/pharmacology ; Gene Expression Regulation, Neoplastic ; Male ; Mice, Nude

Regulated cell death environments drive fibroinflammatory reprogramming in surviving adipose-derived stem cells.

Authors: Oliva-Olivera W Ravnsborg T Le Boiteux E et al.

Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Dec; Vol. 30 (11-12), pp. 2800-2809. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

MeSH Terms: Adipose Tissue*/cytology , Stem Cells*/metabolism , Stem Cells*/cytology , Inflammation*/genetics , Inflammation*/metabolism , Cellular Reprogramming*, Humans ; Tumor Necrosis Factor-alpha/pharmacology ; Histones/metabolism ; Cell Death ; Cells, Cultured ; Cell Survival ; Protein Processing, Post-Translational

Role of macrophages reprogramming in pathogenesis of gestational diabetes mellitus.

Authors: Milan KL Shree RA Nandana N et al.

Source: Cytokine [Cytokine] 2025 Dec; Vol. 196, pp. 157041. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE

MeSH Terms: Diabetes, Gestational*/immunology , Diabetes, Gestational*/pathology , Diabetes, Gestational*/metabolism , Macrophages*/immunology , Macrophages*/metabolism , Macrophages*/pathology , Cellular Reprogramming*, Humans ; Pregnancy ; Female ; Animals ; Placenta/immunology ; Placenta/metabolism ; Insulin Resistance ; Macrophage Activation ; Inflammation

Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs.

Authors: Ward TR Qu PP Leung LC et al.

Source: European journal of human genetics : EJHG [Eur J Hum Genet] 2025 Dec; Vol. 33 (12), pp. 1698-1707. Date of Electronic Publication: 2025 May 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

MeSH Terms: DNA Copy Number Variations* , Neurons*/metabolism , Neurons*/cytology , Epigenome* , Transcriptome* , Cellular Reprogramming*, Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Chromosomes, Human, Pair 16/genetics ; DNA Methylation ; Intellectual Disability/genetics ; Autism Spectrum Disorder/genetics ; Chromosome Deletion ; Autistic Disorder ; Chromosome Disorders

SCR Disease Name: 16p11.2 Deletion Syndrome

Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration.

Authors: Tang LP Zhai LM Li J et al.

Source: Cell [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6923-6938.e18. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH Terms: Arabidopsis*/genetics , Arabidopsis*/cytology , Arabidopsis*/metabolism , Arabidopsis*/physiology , Cellular Reprogramming* , Regeneration*, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Indoleacetic Acids/metabolism ; Gene Expression Regulation, Plant ; Cotyledon/metabolism ; Cotyledon/cytology ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Oxygenases/metabolism ; Oxygenases/genetics ; Meristem/metabolism ; Meristem/cytology ; Mixed Function Oxygenases/metabolism ; Mixed Function Oxygenases/genetics ; Basic Helix-Loop-Helix Transcription Factors

TLR2 agonism suppresses myeloid leukemogenesis by reprogramming leukemia stem cells.

Authors: Lawler ME Romer-Seibert JS Bowman MS et al.

Source: Blood advances [Blood Adv] 2025 Nov 25; Vol. 9 (22), pp. 5888-5901.

Publication Type: Journal Article

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

MeSH Terms: Toll-Like Receptor 2*/agonists , Toll-Like Receptor 2*/metabolism , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/mortality , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Neoplastic Stem Cells*/drug effects , Cellular Reprogramming*, Animals ; Humans ; Mice ; Signal Transduction ; Disease Models, Animal