Suchergebnisse - "Cell Proliferation (mesh)"

Repurposing flavopiridol as an inhaled therapeutic for pulmonary fibrosis

Autoren: Chen, Ching-Hsien Chaudhary, Subash K Chang, Wen-Hsin et al.

Quelle: European Journal of Pharmacology. 1005

Schlagwörter: 3214 Pharmacology and Pharmaceutical Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Autoimmune Disease (rcdc), Orphan Drug (rcdc), Lung (rcdc), Rare Diseases (rcdc), 5.1 Pharmaceuticals (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Respiratory (hrcs-hc), Animals (mesh), Piperidines (mesh), Flavonoids (mesh), Mice (mesh), Humans (mesh), Idiopathic Pulmonary Fibrosis (mesh), Cyclin-Dependent Kinase 9 (mesh), Drug Repositioning (mesh), Administration, Inhalation (mesh), Male (mesh), Fibroblasts (mesh), Lung (mesh), Disease Models, Animal (mesh), Cell Proliferation (mesh), Mice, Inbred C57BL (mesh), Indoles (mesh), Bleomycin (mesh), Protein Kinase Inhibitors (mesh), CDK9, Flavopiridol, Inhaled drugs, Fibroblasts, Lung fibrosis, Lung (mesh), Fibroblasts (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Humans (mesh), Mice (mesh), Disease Models, Animal (mesh), Piperidines (mesh), Flavonoids (mesh), Indoles (mesh), Bleomycin (mesh), Protein Kinase Inhibitors (mesh), Administration, Inhalation (mesh), Cell Proliferation (mesh), Male (mesh), Cyclin-Dependent Kinase 9 (mesh), Idiopathic Pulmonary Fibrosis (mesh), Drug Repositioning (mesh), CDK9, Fibroblasts, Flavopiridol, Inhaled drugs, Lung fibrosis, Animals (mesh), Piperidines (mesh), Flavonoids (mesh), Mice (mesh), Humans (mesh), Idiopathic Pulmonary Fibrosis (mesh), Cyclin-Dependent Kinase 9 (mesh), Drug Repositioning (mesh), Administration, Inhalation (mesh), Male (mesh), Fibroblasts (mesh), Lung (mesh), Disease Models, Animal (mesh), Cell Proliferation (mesh), Mice, Inbred C57BL (mesh), Indoles (mesh), Bleomycin (mesh), Protein Kinase Inhibitors (mesh), 0801 Artificial Intelligence and Image Processing (for), 1115 Pharmacology and Pharmaceutical Sciences (for), 1701 Psychology (for), 1702 Cognitive Sciences (for), Behavioral Science & Comparative Psychology (science-metrix), Pharmacology & Pharmacy (science-metrix), 3109 Zoology (for-2020), 3214 Pharmacology and pharmaceutical sciences (for-2020), 5204 Cognitive and computational psychology (for-2020), 5205 Social and personality psychology (for-2020)

Zugangs-URL: https://escholarship.org/uc/item/2h70n9h3

Synthesis and Structure–Activity Relationships of CRBN-Recruiting ZBTB11 Molecular Glue Degraders

Autoren: Jiang, Jiewei Tran, Nathan L Svendsen, Emma et al.

Quelle: Journal of Medicinal Chemistry. 68(18)

Schlagwörter: 3404 Medicinal and Biomolecular Chemistry (for-2020), 34 Chemical Sciences (for-2020), Genetics (rcdc), Cancer (rcdc), Biotechnology (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Humans (mesh), Structure-Activity Relationship (mesh), Cell Line, Tumor (mesh), Cell Proliferation (mesh), Antineoplastic Agents (mesh), Proteolysis (mesh), Repressor Proteins (mesh), Ubiquitin-Protein Ligases (mesh), Cell Line, Tumor (mesh), Humans (mesh), Ubiquitin-Protein Ligases (mesh), Repressor Proteins (mesh), Antineoplastic Agents (mesh), Cell Proliferation (mesh), Structure-Activity Relationship (mesh), Proteolysis (mesh), Humans (mesh), Structure-Activity Relationship (mesh), Cell Line, Tumor (mesh), Cell Proliferation (mesh), Antineoplastic Agents (mesh), Proteolysis (mesh), Repressor Proteins (mesh), Ubiquitin-Protein Ligases (mesh), 0304 Medicinal and Biomolecular Chemistry (for), 0305 Organic Chemistry (for), 1115 Pharmacology and Pharmaceutical Sciences (for), Medicinal & Biomolecular Chemistry (science-metrix), 3214 Pharmacology and pharmaceutical sciences (for-2020), 3404 Medicinal and biomolecular chemistry (for-2020), 3405 Organic chemistry (for-2020)

Zugangs-URL: https://escholarship.org/uc/item/689030kw

RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer.

Autoren: Yamada-Hara, Miki Amaya, Lauren Wang, Zhihe et al.

Quelle: Cancer Immunology Research. 13(9)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), 3204 Immunology (for-2020), Cancer (rcdc), Lung Cancer (rcdc), Genetics (rcdc), Human Genome (rcdc), Lung (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), Cancer (hrcs-hc), Inflammatory and immune system (hrcs-hc), Nuclear Receptor Subfamily 1, Group F, Member 3 (mesh), Animals (mesh), Lung Neoplasms (mesh), Mice (mesh), Humans (mesh), Disease Models, Animal (mesh), Inflammation (mesh), Th17 Cells (mesh), Cell Line, Tumor (mesh), Cell Proliferation (mesh), Mice, Knockout (mesh), Mice, Inbred C57BL (mesh), Tumor Microenvironment (mesh), Cell Line, Tumor (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Mice, Knockout (mesh), Humans (mesh), Mice (mesh), Lung Neoplasms (mesh), Disease Models, Animal (mesh), Inflammation (mesh), Cell Proliferation (mesh), Nuclear Receptor Subfamily 1, Group F, Member 3 (mesh), Th17 Cells (mesh), Tumor Microenvironment (mesh), Nuclear Receptor Subfamily 1, Group F, Member 3 (mesh), Animals (mesh), Lung Neoplasms (mesh), Mice (mesh), Humans (mesh), Disease Models, Animal (mesh), Inflammation (mesh), Th17 Cells (mesh), Cell Line, Tumor (mesh), Cell Proliferation (mesh), Mice, Knockout (mesh), Mice, Inbred C57BL (mesh), Tumor Microenvironment (mesh), 1107 Immunology (for), 1112 Oncology and Carcinogenesis (for), 1115 Pharmacology and Pharmaceutical Sciences (for), 3204 Immunology (for-2020), 3211 Oncology and carcinogenesis (for-2020)

Zugangs-URL: https://escholarship.org/uc/item/2z26w555

An epithelial cell culture model for sturgeon integument responds sensitively to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure

Autoren: Nechat, Sumi Shadi, Melina Schreier, Andrea D et al.

Quelle: Scientific Reports. 15(1)

Schlagwörter: 31 Biological Sciences (for-2020), 41 Environmental Sciences (for-2020), 4105 Pollution and Contamination (for-2020), Agent Orange & Dioxin (rcdc), Biotechnology (rcdc), Endocrine Disruptors (rcdc), Genetics (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), 2.2 Factors relating to the physical environment (hrcs-rac), Generic health relevance (hrcs-hc), 15 Life on Land (sdg), Polychlorinated Dibenzodioxins (mesh), Animals (mesh), Epithelial Cells (mesh), Receptors, Aryl Hydrocarbon (mesh), Fishes (mesh), Cells, Cultured (mesh), Cell Proliferation (mesh), AHR ligand binding model, Epithelial histology, EROD induction, Keratin immunostaining and content, PacBio RNA sequencing, Cells, Cultured (mesh), Epithelial Cells (mesh), Animals (mesh), Fishes (mesh), Receptors, Aryl Hydrocarbon (mesh), Cell Proliferation (mesh), Polychlorinated Dibenzodioxins (mesh), AHR ligand binding model, EROD induction, Epithelial histology, Keratin immunostaining and content, PacBio RNA sequencing, Polychlorinated Dibenzodioxins (mesh), Animals (mesh), Epithelial Cells (mesh), Receptors, Aryl Hydrocarbon (mesh), Fishes (mesh), Cells, Cultured (mesh), Cell Proliferation (mesh)

Zugangs-URL: https://escholarship.org/uc/item/0k52r8mb

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors

Autoren: Pacaud, Romain Thomas, Scott Chaudhuri, Sibapriya et al.

Quelle: Breast Cancer Research. 27(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Rare Diseases (rcdc), Orphan Drug (rcdc), Cancer (rcdc), Genetics (rcdc), Women's Health (rcdc), Breast Cancer (rcdc), 5.1 Pharmaceuticals (hrcs-rac), 6.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Poly(ADP-ribose) Polymerase Inhibitors (mesh), Humans (mesh), Animals (mesh), Recombinational DNA Repair (mesh), Cell Line, Tumor (mesh), Mice (mesh), Xenograft Model Antitumor Assays (mesh), Female (mesh), BRCA2 Protein (mesh), BRCA1 Protein (mesh), DNA Damage (mesh), Triple Negative Breast Neoplasms (mesh), Drug Synergism (mesh), Antineoplastic Combined Chemotherapy Protocols (mesh), DNA Modification Methylases (mesh), Enzyme Inhibitors (mesh), Cell Proliferation (mesh), BRCA1, BRCA2, PARP inhibitor, DNMT inhibitor, Talazoparib, Decitabine, PARP1, DNMT1, Cell Line, Tumor (mesh), Animals (mesh), Humans (mesh), Mice (mesh), DNA Damage (mesh), DNA Modification Methylases (mesh), BRCA1 Protein (mesh), BRCA2 Protein (mesh), Antineoplastic Combined Chemotherapy Protocols (mesh), Enzyme Inhibitors (mesh), Xenograft Model Antitumor Assays (mesh), Cell Proliferation (mesh), Drug Synergism (mesh), Female (mesh), Recombinational DNA Repair (mesh), Triple Negative Breast Neoplasms (mesh), Poly(ADP-ribose) Polymerase Inhibitors (mesh), BRCA1, BRCA2, DNMT inhibitor, DNMT1, Decitabine, PARP inhibitor, PARP1, Talazoparib, Poly(ADP-ribose) Polymerase Inhibitors (mesh), Humans (mesh), Animals (mesh), Recombinational DNA Repair (mesh), Cell Line, Tumor (mesh), Mice (mesh), Xenograft Model Antitumor Assays (mesh), Female (mesh), BRCA2 Protein (mesh), BRCA1 Protein (mesh), DNA Damage (mesh), Triple Negative Breast Neoplasms (mesh), Drug Synergism (mesh), Antineoplastic Combined Chemotherapy Protocols (mesh), DNA Modification Methylases (mesh), Enzyme Inhibitors (mesh), Cell Proliferation (mesh), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3211 Oncology and carcinogenesis (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/09w791x1
https://escholarship.org/content/qt09w791x1/qt09w791x1.pdf

Oncogenic HRAS Induces Metformin Resistance in Head and Neck Cancer by Promoting Glycolytic Metabolism.

Autoren: Wu, Xingyu Adame-Garcia, Sendi Rafael Koshizuka, Keiichi et al.

Quelle: Cancer Prevention Research. 17(12)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Digestive Diseases (rcdc), Prevention (rcdc), Orphan Drug (rcdc), Dental/Oral and Craniofacial Disease (rcdc), Genetics (rcdc), Rare Diseases (rcdc), Cancer (rcdc), 5.1 Pharmaceuticals (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), 2.2 Factors relating to the physical environment (hrcs-rac), Cancer (hrcs-hc), 3 Good Health and Well Being (sdg), Metformin (mesh), Humans (mesh), Head and Neck Neoplasms (mesh), Drug Resistance, Neoplasm (mesh), Glycolysis (mesh), Proto-Oncogene Proteins p21(ras) (mesh), Squamous Cell Carcinoma of Head and Neck (mesh), Mice (mesh), Animals (mesh), Mutation (mesh), Xenograft Model Antitumor Assays (mesh), Cell Line, Tumor (mesh), TOR Serine-Threonine Kinases (mesh), Cell Proliferation (mesh), Cell Line, Tumor (mesh), Animals (mesh), Humans (mesh), Mice (mesh), Head and Neck Neoplasms (mesh), Metformin (mesh), Xenograft Model Antitumor Assays (mesh), Cell Proliferation (mesh), Glycolysis (mesh), Drug Resistance, Neoplasm (mesh), Mutation (mesh), Proto-Oncogene Proteins p21(ras) (mesh), TOR Serine-Threonine Kinases (mesh), Squamous Cell Carcinoma of Head and Neck (mesh), Metformin (mesh), Humans (mesh), Head and Neck Neoplasms (mesh), Drug Resistance, Neoplasm (mesh), Glycolysis (mesh), Proto-Oncogene Proteins p21(ras) (mesh), Squamous Cell Carcinoma of Head and Neck (mesh), Mice (mesh), Animals (mesh), Mutation (mesh), Xenograft Model Antitumor Assays (mesh), Cell Line, Tumor (mesh), TOR Serine-Threonine Kinases (mesh), Cell Proliferation (mesh), 1103 Clinical Sciences (for), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3202 Clinical sciences (for-2020), 3211 Oncology and carcinogenesis (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/73s0b51w
https://escholarship.org/content/qt73s0b51w/qt73s0b51w.pdf

Optical microsensing reveals spatiotemporal oxygen dynamics in cornea wounds that affect healing via reactive oxygen species

Autoren: Ma, Li Ferreira, Fernando Reid, Brian et al.

Quelle: The FASEB Journal. 38(17)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Wound Healing and Care (rcdc), Physical Injury - Accidents and Adverse Effects (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Animals (mesh), Wound Healing (mesh), Reactive Oxygen Species (mesh), Mice (mesh), Oxygen (mesh), Corneal Injuries (mesh), Cornea (mesh), Mice, Inbred C57BL (mesh), Male (mesh), Cell Proliferation (mesh), Cell Movement (mesh), cornea, optrode, oxygen, ROS, wound healing, Cornea (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Mice (mesh), Oxygen (mesh), Reactive Oxygen Species (mesh), Wound Healing (mesh), Cell Proliferation (mesh), Cell Movement (mesh), Male (mesh), Corneal Injuries (mesh), ROS, cornea, optrode, oxygen, wound healing, Animals (mesh), Wound Healing (mesh), Reactive Oxygen Species (mesh), Mice (mesh), Oxygen (mesh), Corneal Injuries (mesh), Cornea (mesh), Mice, Inbred C57BL (mesh), Male (mesh), Cell Proliferation (mesh), Cell Movement (mesh), 0601 Biochemistry and Cell Biology (for), 0606 Physiology (for), 1116 Medical Physiology (for), Biochemistry & Molecular Biology (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3208 Medical physiology (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/6517p25h
https://escholarship.org/content/qt6517p25h/qt6517p25h.pdf

BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension

Autoren: Shen, Hui Gao, Ya Ge, Dedong et al.

Quelle: Circulation. 150(2)

Schlagwörter: 3208 Medical Physiology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Rare Diseases (rcdc), Lung (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cardiovascular (hrcs-hc), Animals (mesh), Humans (mesh), Male (mesh), Mice (mesh), Activin Receptors, Type II (mesh), Bone Morphogenetic Protein Receptors, Type II (mesh), Cell Proliferation (mesh), Cells, Cultured (mesh), Disease Models, Animal (mesh), Hypertension, Pulmonary (mesh), Mice, Inbred C57BL (mesh), Mice, Knockout (mesh), Muscle, Smooth, Vascular (mesh), Myocytes, Smooth Muscle (mesh), PPAR gamma (mesh), Pulmonary Arterial Hypertension (mesh), Pulmonary Artery (mesh), Signal Transduction (mesh), Ubiquitination (mesh), Vascular Remodeling (mesh), activin receptor-like kinase-2, bone morphogenetic protein, BRCC3 protein, pulmonary arterial hypertension, Muscle, Smooth, Vascular (mesh), Pulmonary Artery (mesh), Cells, Cultured (mesh), Myocytes, Smooth Muscle (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Mice, Knockout (mesh), Humans (mesh), Mice (mesh), Hypertension, Pulmonary (mesh), Disease Models, Animal (mesh), Activin Receptors, Type II (mesh), PPAR gamma (mesh), Signal Transduction (mesh), Cell Proliferation (mesh), Male (mesh), Bone Morphogenetic Protein Receptors, Type II (mesh), Ubiquitination (mesh), Vascular Remodeling (mesh), Pulmonary Arterial Hypertension (mesh), BRCC3 protein, activin receptor-like kinase-2, bone morphogenetic protein, pulmonary arterial hypertension, Animals (mesh), Humans (mesh), Male (mesh), Mice (mesh), Activin Receptors, Type II (mesh), Bone Morphogenetic Protein Receptors, Type II (mesh), Cell Proliferation (mesh), Cells, Cultured (mesh), Disease Models, Animal (mesh), Hypertension, Pulmonary (mesh), Mice, Inbred C57BL (mesh), Mice, Knockout (mesh), Muscle, Smooth, Vascular (mesh), Myocytes, Smooth Muscle (mesh), PPAR gamma (mesh), Pulmonary Arterial Hypertension (mesh), Pulmonary Artery (mesh), Signal Transduction (mesh), Ubiquitination (mesh), Vascular Remodeling (mesh), 1102 Cardiorespiratory Medicine and Haematology (for), 1103 Clinical Sciences (for), 1117 Public Health and Health Services (for), Cardiovascular System & Hematology (science-metrix), 3201 Cardiovascular medicine and haematology (for-2020), 3202 Clinical sciences (for-2020), 4207 Sports science and exercise (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/1qc7b9zq
https://escholarship.org/content/qt1qc7b9zq/qt1qc7b9zq.pdf

Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution

Autoren: Lucas, Calixto-Hope G Mirchia, Kanish Seo, Kyounghee et al.

Quelle: Nature Genetics. 56(6)

Schlagwörter: 30 Agricultural, Veterinary and Food Sciences (for-2020), 31 Biological Sciences (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), 3105 Genetics (for-2020), 3001 Agricultural Biotechnology (for-2020), Rare Diseases (rcdc), Human Genome (rcdc), Cancer (rcdc), Genetics (rcdc), Brain Cancer (rcdc), Biotechnology (rcdc), Cancer Genomics (rcdc), Precision Medicine (rcdc), Brain Disorders (rcdc), Cancer (hrcs-hc), 3 Good Health and Well Being (sdg), Meningioma (mesh), Humans (mesh), Meningeal Neoplasms (mesh), Genetic Heterogeneity (mesh), DNA Copy Number Variations (mesh), Gene Expression Regulation, Neoplastic (mesh), Genomics (mesh), Single-Cell Analysis (mesh), Cell Proliferation (mesh), Neoplasm Recurrence, Local (mesh), Signal Transduction (mesh), Cell Line, Tumor (mesh), Transcriptome (mesh), Cell Line, Tumor (mesh), Humans (mesh), Meningioma (mesh), Meningeal Neoplasms (mesh), Neoplasm Recurrence, Local (mesh), Genomics (mesh), Signal Transduction (mesh), Cell Proliferation (mesh), Gene Expression Regulation, Neoplastic (mesh), Genetic Heterogeneity (mesh), DNA Copy Number Variations (mesh), Single-Cell Analysis (mesh), Transcriptome (mesh), Meningioma (mesh), Humans (mesh), Meningeal Neoplasms (mesh), Genetic Heterogeneity (mesh), DNA Copy Number Variations (mesh), Gene Expression Regulation, Neoplastic (mesh), Genomics (mesh), Single-Cell Analysis (mesh), Cell Proliferation (mesh), Neoplasm Recurrence, Local (mesh), Signal Transduction (mesh), Cell Line, Tumor (mesh), Transcriptome (mesh), 06 Biological Sciences (for), 11 Medical and Health Sciences (for), Developmental Biology (science-metrix), 3001 Agricultural biotechnology (for-2020), 3102 Bioinformatics and computational biology (for-2020), 3105 Genetics (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/3sx7d9gv
https://escholarship.org/content/qt3sx7d9gv/qt3sx7d9gv.pdf

Repurposing mebendazole against triple-negative breast cancer CNS metastasis

Autoren: Rodrigues, Adrian J Chernikova, Sophia B Wang, Yuelong et al.

Quelle: Journal of Neuro-Oncology. 168(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Breast Cancer (rcdc), Women's Health (rcdc), Neurosciences (rcdc), Cancer (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Triple Negative Breast Neoplasms (mesh), Animals (mesh), Humans (mesh), Drug Repositioning (mesh), Female (mesh), Mebendazole (mesh), Mice (mesh), Mice, Nude (mesh), Mice, Inbred BALB C (mesh), Cell Movement (mesh), Xenograft Model Antitumor Assays (mesh), Cell Line, Tumor (mesh), Central Nervous System Neoplasms (mesh), Cell Proliferation (mesh), Breast cancer, Leptomeningeal disease, Drug repurposing, Mebendazole, Cell Line, Tumor (mesh), Animals (mesh), Mice, Inbred BALB C (mesh), Humans (mesh), Mice (mesh), Mice, Nude (mesh), Central Nervous System Neoplasms (mesh), Mebendazole (mesh), Xenograft Model Antitumor Assays (mesh), Cell Proliferation (mesh), Cell Movement (mesh), Female (mesh), Drug Repositioning (mesh), Triple Negative Breast Neoplasms (mesh), Breast cancer, Drug repurposing, Leptomeningeal disease, Mebendazole, Triple Negative Breast Neoplasms (mesh), Animals (mesh), Humans (mesh), Drug Repositioning (mesh), Female (mesh), Mebendazole (mesh), Mice (mesh), Mice, Nude (mesh), Mice, Inbred BALB C (mesh), Cell Movement (mesh), Xenograft Model Antitumor Assays (mesh), Cell Line, Tumor (mesh), Central Nervous System Neoplasms (mesh), Cell Proliferation (mesh), 1109 Neurosciences (for), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3209 Neurosciences (for-2020), 3211 Oncology and carcinogenesis (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/5kc28731
https://escholarship.org/content/qt5kc28731/qt5kc28731.pdf

Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis

Autoren: Ruan, Xianhui Yan, Wei Cao, Minghui et al.

Quelle: Nature Communications. 15(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Brain Disorders (rcdc), Cancer (rcdc), Women's Health (rcdc), Neurosciences (rcdc), Breast Cancer (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cancer (hrcs-hc), Neurological (hrcs-hc), Humans (mesh), MicroRNAs (mesh), Breast Neoplasms (mesh), Brain Neoplasms (mesh), Female (mesh), Animals (mesh), Cell Line, Tumor (mesh), Astrocytes (mesh), Neurons (mesh), Mice (mesh), Excitatory Amino Acid Transporter 2 (mesh), Extracellular Vesicles (mesh), Monocarboxylic Acid Transporters (mesh), Gene Expression Regulation, Neoplastic (mesh), Glutamic Acid (mesh), Glutamine (mesh), Brain (mesh), Lactic Acid (mesh), Cell Proliferation (mesh), Brain (mesh), Astrocytes (mesh), Neurons (mesh), Cell Line, Tumor (mesh), Animals (mesh), Humans (mesh), Mice (mesh), Breast Neoplasms (mesh), Brain Neoplasms (mesh), Lactic Acid (mesh), Glutamic Acid (mesh), Glutamine (mesh), Excitatory Amino Acid Transporter 2 (mesh), Monocarboxylic Acid Transporters (mesh), MicroRNAs (mesh), Cell Proliferation (mesh), Gene Expression Regulation, Neoplastic (mesh), Female (mesh), Extracellular Vesicles (mesh), Humans (mesh), MicroRNAs (mesh), Breast Neoplasms (mesh), Brain Neoplasms (mesh), Female (mesh), Animals (mesh), Cell Line, Tumor (mesh), Astrocytes (mesh), Neurons (mesh), Mice (mesh), Excitatory Amino Acid Transporter 2 (mesh), Extracellular Vesicles (mesh), Monocarboxylic Acid Transporters (mesh), Gene Expression Regulation, Neoplastic (mesh), Glutamic Acid (mesh), Glutamine (mesh), Brain (mesh), Lactic Acid (mesh), Cell Proliferation (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/5nb8x6bw
https://escholarship.org/content/qt5nb8x6bw/qt5nb8x6bw.pdf

Amiloride sensitizes prostate cancer cells to the reversible tyrosine kinase inhibitor lapatinib by modulating Erbb3 subcellular localization

Autoren: Jathal, Maitreyee K Mudryj, Maria Dall’Era, Marc A et al.

Quelle: Cellular and Molecular Life Sciences. 82(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3202 Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Cancer (rcdc), Urologic Diseases (rcdc), Prostate Cancer (rcdc), Aging (rcdc), 6.1 Pharmaceuticals (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Lapatinib (mesh), Humans (mesh), Receptor, ErbB-3 (mesh), Male (mesh), Prostatic Neoplasms (mesh), Protein Kinase Inhibitors (mesh), Cell Line, Tumor (mesh), Amiloride (mesh), Receptor, ErbB-2 (mesh), Cell Nucleus (mesh), Antineoplastic Agents (mesh), Cell Proliferation (mesh), Receptors, Androgen (mesh), Tyrosine Kinase Inhibitors (mesh), Amiloride, Lapatinib, ErbB3, Subcellular localization, Heregulin-1 beta, Androgen receptor, Prostate cancer, Amiloride, Lapatinib, ErbB3, Subcellular localization, Heregulin-1 beta, Androgen receptor, Prostate cancer, Cell Line, Tumor (mesh), Cell Nucleus (mesh), Humans (mesh), Prostatic Neoplasms (mesh), Amiloride (mesh), Receptor, erbB-2 (mesh), Receptor, erbB-3 (mesh), Receptors, Androgen (mesh), Antineoplastic Agents (mesh), Protein Kinase Inhibitors (mesh), Cell Proliferation (mesh), Male (mesh), Lapatinib (mesh), Tyrosine Kinase Inhibitors (mesh), Amiloride, Androgen receptor, ErbB3, Heregulin-1β, Lapatinib, Prostate cancer, Subcellular localization, Lapatinib (mesh), Humans (mesh), Receptor, ErbB-3 (mesh), Male (mesh), Prostatic Neoplasms (mesh), Protein Kinase Inhibitors (mesh), Cell Line, Tumor (mesh), Amiloride (mesh), Receptor, ErbB-2 (mesh), Cell Nucleus (mesh), Antineoplastic Agents (mesh), Cell Proliferation (mesh), Receptors, Androgen (mesh), Tyrosine Kinase Inhibitors (mesh), 0601 Biochemistry and Cell Biology (for), 0606 Physiology (for), 1103 Clinical Sciences (for), Biochemistry & Molecular Biology (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3205 Medical biochemistry and metabolomics (for-2020), 3211 Oncology and carcinogenesis (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/8403v9p9
https://escholarship.org/content/qt8403v9p9/qt8403v9p9.pdf

Preclinical assessment of MAGMAS inhibitor as a potential therapy for pediatric medulloblastoma

Autoren: Motahari, Zahra Lepe, Javier J Bautista, Malia R et al.

Quelle: PLOS ONE. 19(10)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Pediatric (rcdc), Rare Diseases (rcdc), Brain Cancer (rcdc), Orphan Drug (rcdc), Brain Disorders (rcdc), Pediatric Cancer (rcdc), Cancer (rcdc), Neurosciences (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Medulloblastoma (mesh), Humans (mesh), Animals (mesh), Mice (mesh), Cell Proliferation (mesh), Cell Line, Tumor (mesh), Cell Movement (mesh), Xenograft Model Antitumor Assays (mesh), Cerebellar Neoplasms (mesh), Antineoplastic Agents (mesh), Child (mesh), Apoptosis (mesh), Cell Line, Tumor (mesh), Animals (mesh), Humans (mesh), Mice (mesh), Medulloblastoma (mesh), Cerebellar Neoplasms (mesh), Antineoplastic Agents (mesh), Xenograft Model Antitumor Assays (mesh), Apoptosis (mesh), Cell Proliferation (mesh), Cell Movement (mesh), Child (mesh), Medulloblastoma (mesh), Humans (mesh), Animals (mesh), Mice (mesh), Cell Proliferation (mesh), Cell Line, Tumor (mesh), Cell Movement (mesh), Xenograft Model Antitumor Assays (mesh), Cerebellar Neoplasms (mesh), Antineoplastic Agents (mesh), Child (mesh), Apoptosis (mesh), General Science & Technology (science-metrix)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/58m977dg
https://escholarship.org/content/qt58m977dg/qt58m977dg.pdf

A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state

Autoren: Caruso, Joseph A Chen-Tanyolac, Chira Tlsty, Thea D

Quelle: Breast Cancer Research. 26(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Cancer (rcdc), Breast Cancer (rcdc), Genetics (rcdc), Stem Cell Research (rcdc), Human Genome (rcdc), Women's Health (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cancer (hrcs-hc), Epithelial-Mesenchymal Transition (mesh), Humans (mesh), Breast Neoplasms (mesh), Female (mesh), Epithelial Cells (mesh), Transforming Growth Factor beta (mesh), Neoplastic Stem Cells (mesh), Cell Transformation, Neoplastic (mesh), Metaplasia (mesh), Epigenesis, Genetic (mesh), Cell Proliferation (mesh), Signal Transduction (mesh), Cell Differentiation (mesh), Human mammary epithelial cells, Basal, Myoepithelial, TGF-beta pathway, Epithelial-mesenchymal transition, Epigenetic regulation, Metaplastic breast cancer, Epithelial Cells (mesh), Humans (mesh), Breast Neoplasms (mesh), Cell Transformation, Neoplastic (mesh), Metaplasia (mesh), Transforming Growth Factor beta (mesh), Signal Transduction (mesh), Cell Differentiation (mesh), Cell Proliferation (mesh), Epigenesis, Genetic (mesh), Female (mesh), Neoplastic Stem Cells (mesh), Epithelial-Mesenchymal Transition (mesh), Basal, Epigenetic regulation, Epithelial-mesenchymal transition, Human mammary epithelial cells, Metaplastic breast cancer, Myoepithelial, TGF-β pathway, Epithelial-Mesenchymal Transition (mesh), Humans (mesh), Breast Neoplasms (mesh), Female (mesh), Epithelial Cells (mesh), Transforming Growth Factor beta (mesh), Neoplastic Stem Cells (mesh), Cell Transformation, Neoplastic (mesh), Metaplasia (mesh), Epigenesis, Genetic (mesh), Cell Proliferation (mesh), Signal Transduction (mesh), Cell Differentiation (mesh), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3211 Oncology and carcinogenesis (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/38d7x6n2
https://escholarship.org/content/qt38d7x6n2/qt38d7x6n2.pdf

Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation

Autoren: Roychowdhury, Tanaya McNutt, Seth W Pasala, Chiranjeevi et al.

Quelle: Nature Communications. 15(1)

Schlagwörter: 3101 Biochemistry and Cell Biology (for-2020), 3102 Bioinformatics and Computational Biology (for-2020), 31 Biological Sciences (for-2020), 1.1 Normal biological development and functioning (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Generic health relevance (hrcs-hc), Cancer (hrcs-hc), Humans (mesh), Cell Proliferation (mesh), Phosphorylation (mesh), HSP90 Heat-Shock Proteins (mesh), Molecular Chaperones (mesh), Protein Processing, Post-Translational (mesh), Animals (mesh), Protein Interaction Maps (mesh), Mice (mesh), Serine (mesh), Cell Line, Tumor (mesh), Cell Line, Tumor (mesh), Animals (mesh), Humans (mesh), Mice (mesh), Serine (mesh), Molecular Chaperones (mesh), Cell Proliferation (mesh), Protein Processing, Post-Translational (mesh), Phosphorylation (mesh), HSP90 Heat-Shock Proteins (mesh), Protein Interaction Maps (mesh), Humans (mesh), Cell Proliferation (mesh), Phosphorylation (mesh), HSP90 Heat-Shock Proteins (mesh), Molecular Chaperones (mesh), Protein Processing, Post-Translational (mesh), Animals (mesh), Protein Interaction Maps (mesh), Mice (mesh), Serine (mesh), Cell Line, Tumor (mesh)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/95k8w9xz
https://escholarship.org/content/qt95k8w9xz/qt95k8w9xz.pdf

CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells

Autoren: Yan Wang Ursula Rambold Petra Fiedler et al.

Quelle: Cell Mol Immunol

Schlagwörter: 631/250/2152/2153/1982, Cell Proliferation [MeSH], Mice, Inbred C57BL [MeSH], B-Lymphocytes/immunology [MeSH], Plasma Cells/immunology [MeSH], T Follicular Helper Cells/immunology [MeSH], CD30L, Cell Differentiation [MeSH], Animals [MeSH], Germinal Center/immunology [MeSH], Lymphocyte Activation [MeSH], Senescence associated T cells (SAT cells), Immunoglobulin G/immunology [MeSH], Mice [MeSH], Article, B lymphocytes, Ki-1 Antigen/metabolism [MeSH], CD30, Germinal center reaction, 631/250/1619/40, Conditional mice, Immunoglobulin Class Switching [MeSH], Receptors, CXCR4/metabolism [MeSH], article, B-Lymphocytes, Receptors, CXCR4, T Follicular Helper Cells, Plasma Cells, Ki-1 Antigen, Cell Differentiation, Germinal Center, Lymphocyte Activation, Immunoglobulin Class Switching, Mice, Inbred C57BL, Mice, Immunoglobulin G, Animals, Cell Proliferation

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39420111
https://repository.publisso.de/resource/frl:6492539

Association of endothelial function and lower extremity perfusion in peripheral artery disease

Autoren: Kangbo Li Mengjun Dai Mesud Sacirovic et al.

Quelle: Vasa. 53:333-340

Schlagwörter: Male, 0301 basic medicine, Endothelial Cells, Middle Aged, Pulse Wave Analysis, Carotid Intima-Media Thickness, Severity of Illness Index, Vasodilation, Peripheral Arterial Disease, 03 medical and health sciences, Cross-Sectional Studies, 0302 clinical medicine, Lower Extremity, Regional Blood Flow, Predictive Value of Tests, Risk Factors, Oscillometry, Ankle Brachial Index [MeSH], Aged [MeSH], Peripheral Arterial Disease/physiopathology [MeSH], Risk Factors [MeSH], Rutherford stage, Lower Extremity/blood supply [MeSH], atherosclerosis, Original communication, Male [MeSH], Regional Blood Flow [MeSH], Peripheral Arterial Disease/diagnostic imaging [MeSH], Peripheral Arterial Disease/diagnosis [MeSH], Endothelial function, Female [MeSH], Cell Proliferation [MeSH], Carotid Intima-Media Thickness [MeSH], Humans [MeSH], Severity of Illness Index [MeSH], Endothelium, Vascular/physiopathology [MeSH], Predictive Value of Tests [MeSH], Middle Aged [MeSH], Cross-Sectional Studies [MeSH], peripheral artery disease, Oscillometry [MeSH], Endothelial Cells [MeSH], Pulse Wave Analysis [MeSH], Vasodilation [MeSH], lower extremity perfusion, Humans, Female, Ankle Brachial Index, Endothelium, Vascular, Aged, Cell Proliferation

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38979892
https://repository.publisso.de/resource/frl:6484569

Disrupting glioblastoma networks with tumor treating fields (TTFields) in in vitro models

Autoren: Schlieper-Scherf, Steffen Hebach, Nils Hausmann, David et al.

Quelle: J Neurooncol

Schlagwörter: 0301 basic medicine, 0303 health sciences, Brain Neoplasms, Research, Electric Stimulation Therapy, Organoids, 03 medical and health sciences, Cell Line, Tumor, Tumor Cells, Cultured, Humans, Calcium, Glioma, Calcium/metabolism [MeSH], Cell Line, Tumor [MeSH], Cell Proliferation [MeSH], Organoids [MeSH], Humans [MeSH], Cancer cell network, Electric Stimulation Therapy/methods [MeSH], Glioblastoma/metabolism [MeSH], Glioblastoma/pathology [MeSH], Glioblastoma/therapy [MeSH], TTFields, Tumor Cells, Cultured [MeSH], Tumor microtubes, Cancer neuroscience, Brain Neoplasms/pathology [MeSH], Brain Neoplasms/therapy [MeSH], Glioblastoma, Cell Proliferation

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39088157
https://repository.publisso.de/resource/frl:6512352

In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

Autoren: Ngoc Tung Tran Robin Graf Ernesto Acevedo-Ochoa et al.

Weitere Verfasser: Ngoc Tung Tran Robin Graf Ernesto Acevedo-Ochoa et al.

Quelle: Leukemia

Schlagwörter: 0301 basic medicine, Cancer Research, E2F4 Transcription Factor, Article, Transcription factor DP1, Mice, 03 medical and health sciences, Cell differentiation, Animals, Humans, Cell proliferation, Cell Proliferation, 0303 health sciences, Cell Cycle, 631/532/1542, 631/136/232, Hematopoietic Stem Cells/metabolism [MeSH], Mice, Inbred C57BL [MeSH], 42/41, 42, 38/91, Cell Cycle/genetics [MeSH], 38/39, 13/100, CRISPR-Cas Systems [MeSH], 13/31, 38/1, Hematopoietic Stem Cells/cytology [MeSH], E2F4 Transcription Factor/genetics [MeSH], Transcription Factor DP1/metabolism [MeSH], 13/2, Cell Proliferation [MeSH], Humans [MeSH], Transcription Factor DP1/genetics [MeSH], Cell Differentiation/genetics [MeSH], 13/106, Animals [MeSH], 64/60, 38/70, 13/44, Hematopoiesis/genetics [MeSH], Mice [MeSH], E2F4 Transcription Factor/metabolism [MeSH], 38, article, Cell Differentiation, Hematopoietic Stem Cells, Hematopoiesis, Mice, Inbred C57BL, Integrative Biomedicine [Topic 3], Technology Platforms, CRISPR-Cas Systems, Transcription Factor DP1, Hematopoietic stem cells

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39043964
https://edoc.mdc-berlin.de/id/eprint/24553/2/24553suppl.zip
https://repository.publisso.de/resource/frl:6491352

Potential of animal-welfare compliant and sustainably sourced serum from pig slaughter blood

Autoren: Olga Hahn Kirsten Peters Alexander Hartmann et al.

Quelle: Cell Tissue Res

Schlagwörter: Serum, 0301 basic medicine, 0303 health sciences, Swine, Short Communication, Stem Cells, Cell Differentiation, FBS replace, Cell Proliferation [MeSH], Swine [MeSH], Humans [MeSH], Adult stem cells, Cell Differentiation [MeSH], Animals [MeSH], Human, Serum [MeSH], Abattoirs [MeSH], Proliferation, Cells, Cultured [MeSH], Stem Cells/cytology [MeSH], Differentiation, 03 medical and health sciences, Animals, Humans, Abattoirs, Cells, Cultured, Cell Proliferation

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38990342
https://repository.publisso.de/resource/frl:6506508