Výsledky vyhledávání - "Cell Proliferation/drug effects [MeSH]"

Antineoplastic therapy affects the in vitro phenotype and functionality of healthy human bone marrow-derived mesenchymal stromal cells

Autoři: Bo Scherer Lucienne Bogun Annemarie Koch a další

Zdroj: Arch Toxicol

Témata: 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor [MeSH], Genotoxicity and Carcinogenicity, MSC, Humans [MeSH], Cell Differentiation/drug effects [MeSH], Azacitidine/pharmacology [MeSH], Antineoplastic Agents/pharmacology [MeSH], Bridged Bicyclo Compounds, Heterocyclic/pharmacology [MeSH], Sulfonamides/pharmacology [MeSH], Mesenchymal Stem Cells/drug effects [MeSH], Azacitidine/toxicity [MeSH], Bone Marrow Cells/drug effects [MeSH], Antineoplastic therapy, Antineoplastic Agents/toxicity [MeSH], Etoposide/pharmacology [MeSH], Cellular Senescence/drug effects [MeSH], Phenotype [MeSH], Cells, Cultured [MeSH], Bone marrow microenvironment, Hematotoxicity, Cell Proliferation/drug effects [MeSH], Temozolomide/pharmacology [MeSH], Etoposide/toxicity [MeSH], Differentiation, Medizin

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39531065
https://repository.publisso.de/resource/frl:6517973

Potent combination benefit of the AKT inhibitor capivasertib and the BCL-2 inhibitor venetoclax in diffuse large B cell lymphoma

Autoři: Brandon S. Willis Kevin Mongeon Hannah Dry a další

Zdroj: Leukemia

Témata: Sulfonamides, PTEN Phosphohydrolase, Apoptosis, Mice, SCID, Bridged Bicyclo Compounds, Heterocyclic, Xenograft Model Antitumor Assays, Article, Mice, Pyrimidines, Proto-Oncogene Proteins c-bcl-2, Cell Line, Tumor, Proto-Oncogene Proteins c-bcl-2/antagonists, Rituximab/pharmacology [MeSH], Cell Line, Tumor [MeSH], Bridged Bicyclo Compounds, Heterocyclic/pharmacology [MeSH], Sulfonamides/therapeutic use [MeSH], Rituximab/therapeutic use [MeSH], Bridged Bicyclo Compounds, Heterocyclic/therapeutic use [MeSH], Xenograft Model Antitumor Assays [MeSH], Pyrroles/pharmacology [MeSH], Pyrimidines/pharmacology [MeSH], Lymphoma, Large B-Cell, Diffuse/drug therapy [MeSH], Humans [MeSH], Pyrroles/therapeutic use [MeSH], Apoptosis/drug effects [MeSH], Sulfonamides/pharmacology [MeSH], 692/308/2778, Animals [MeSH], 64/60, Mice, SCID [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Lymphoma, Large B-Cell, Diffuse/pathology [MeSH], PTEN Phosphohydrolase/metabolism [MeSH], 692/699/1541/1990, Mice [MeSH], Pyrimidines/therapeutic use [MeSH], Proto-Oncogene Proteins c-bcl-2/metabolism [MeSH], Antineoplastic Combined Chemotherapy Protocols/pharmacology [MeSH], Proto-Oncogene Proteins c-akt/metabolism [MeSH], 13/95, Cell Proliferation/drug effects [MeSH], article, Antineoplastic Combined Chemotherapy Protocols, Humans, Animals, Pyrroles, Lymphoma, Large B-Cell, Diffuse, Rituximab, Proto-Oncogene Proteins c-akt, Cell Proliferation

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39284898
https://repository.publisso.de/resource/frl:6495292

Effects of carvedilol on human prostate tissue contractility and stromal cell growth pointing to potential clinical implications

Autoři: Sheng Hu A. Elif Müderrisoglu Anna Ciotkowska a další

Zdroj: Pharmacol Rep

Témata: Male, 0301 basic medicine, 0303 health sciences, Dose-Response Relationship, Drug, Prostate, Prostatic Hyperplasia, Middle Aged, Article, Electric Stimulation, Methoxamine, Propanolamines, Norepinephrine, Phenylephrine, 03 medical and health sciences, Receptors, Adrenergic, alpha-1, Prostate/drug effects [MeSH], Aged [MeSH], Voiding symptoms, Adrenergic alpha-1 Receptor Agonists/pharmacology [MeSH], Carvedilol, Prostatic Hyperplasia/drug therapy [MeSH], Male [MeSH], Propanolamines/pharmacology [MeSH], Norepinephrine/pharmacology [MeSH], Prostatic Hyperplasia/pathology [MeSH], Adrenergic alpha-1 Receptor Antagonists/pharmacology [MeSH], Stromal Cells/drug effects [MeSH], Lower urinary tract symptoms (LUTS), Methoxamine/pharmacology [MeSH], Alpha1-blocker, Dose-Response Relationship, Drug [MeSH], Humans [MeSH], Phenylephrine/pharmacology [MeSH], Carvedilol/pharmacology [MeSH], Middle Aged [MeSH], Electric Stimulation [MeSH], Receptors, Adrenergic, alpha-1/drug effects [MeSH], Stromal Cells/metabolism [MeSH], Receptors, Adrenergic, alpha-1/metabolism [MeSH], Prostate smooth muscle contraction, Muscle Contraction/drug effects [MeSH], Cells, Cultured [MeSH], Cell Proliferation/drug effects [MeSH], Benign prostatic hyperplasia (BPH), Adrenergic alpha-1 Receptor Antagonists, Humans, Adrenergic alpha-1 Receptor Agonists, Stromal Cells, Cells, Cultured, Cell Proliferation, Muscle Contraction, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38858312
https://repository.publisso.de/resource/frl:6496536
https://epub.ub.uni-muenchen.de/125869/

Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer

Autoři: Alicia-Marie K. Beier Celina Ebersbach Tiziana Siciliano a další

Zdroj: Oncogene

Témata: Male, 0301 basic medicine, 0303 health sciences, Glutamine, Prostatic Neoplasms, Antineoplastic Agents, Docetaxel, Article, Oxidative Phosphorylation, 03 medical and health sciences, Glutaminase, Drug Resistance, Neoplasm, Cell Line, Tumor, 96/34, Cell Line, Tumor [MeSH], Prostatic Neoplasms/metabolism [MeSH], Prostatic Neoplasms/drug therapy [MeSH], Prostatic Neoplasms/pathology [MeSH], Antineoplastic Agents/pharmacology [MeSH], 96/109, 96/31, 13/51, Glutaminase/antagonists, Male [MeSH], 631/67/2327, Glutaminase/genetics [MeSH], 96/63, Drug Resistance, Neoplasm [MeSH], Docetaxel/pharmacology [MeSH], Humans [MeSH], Glutamine/metabolism [MeSH], 631/67/589/466, Oxidative Phosphorylation/drug effects [MeSH], Prostatic Neoplasms/genetics [MeSH], Glutaminase/metabolism [MeSH], Antineoplastic Agents/therapeutic use [MeSH], 38/89, 13/105, Cell Proliferation/drug effects [MeSH], article, Humans, Cell Proliferation

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38750263
https://repository.publisso.de/resource/frl:6504923

Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression

Autoři: Marilyn Kaul Ahmed Y. Sanin Wenjie Shi a další

Zdroj: Pharmacol Rep

Témata: 0301 basic medicine, 0303 health sciences, Dasatinib, Metal Nanoparticles, Antineoplastic Agents, Article, Pancreatic Neoplasms, 03 medical and health sciences, src-Family Kinases, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Gold, Pancreatic Neoplasms/genetics [MeSH], Cell Line, Tumor [MeSH], Dasatinib/pharmacology [MeSH], Gold/chemistry [MeSH], Drug Resistance, Neoplasm/drug effects [MeSH], Pancreatic Neoplasms/pathology [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], Humans [MeSH], Gold nanoparticles, Nanomedicine, Antineoplastic Agents/pharmacology [MeSH], LYN, Pancreatic Neoplasms/drug therapy [MeSH], Metal Nanoparticles/administration, Carcinoma, Pancreatic Ductal/drug therapy [MeSH], Metal Nanoparticles/chemistry [MeSH], Carcinoma, Pancreatic Ductal/pathology [MeSH], Dasatinib/administration, Cell Proliferation/drug effects [MeSH], src-Family Kinases/metabolism [MeSH], Pancreatic cancer, Protein Kinase Inhibitors, Carcinoma, Pancreatic Ductal, Cell Proliferation

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38739359
https://repository.publisso.de/resource/frl:6519233

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

Autoři: Kocher, Daniela Cao, Lei Guiho, Romain a další

Přispěvatelé: Kocher, Daniela Cao, Lei Guiho, Romain a další

Zdroj: J Neurooncol

Témata: Proto-Oncogene Proteins B-raf, 0301 basic medicine, Treatment withdrawal, MAP Kinase Signaling System, Mice, 03 medical and health sciences, Cell Line, Tumor, Humans, Animals, Child, Protein Kinase Inhibitors, MAPK inhibitor, Cell Proliferation, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Brain Neoplasms, Research, Rebound growth, Cell Line, Tumor [MeSH], Proto-Oncogene Proteins B-raf/genetics [MeSH], Microglia/drug effects [MeSH], Cytokines/metabolism [MeSH], Tumor microenvironment, Proto-Oncogene Proteins B-raf/metabolism [MeSH], Microglia/metabolism [MeSH], Glioma/drug therapy [MeSH], Glioma/pathology [MeSH], Xenograft Model Antitumor Assays [MeSH], Child [MeSH], Glioma/metabolism [MeSH], Mutation [MeSH], Brain Neoplasms/genetics [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], Humans [MeSH], MAP Kinase Signaling System/drug effects [MeSH], Animals [MeSH], Pediatric low-grade glioma, Cytokines, Mice [MeSH], Glioma/genetics [MeSH], Brain Neoplasms/drug therapy [MeSH], Cell Proliferation/drug effects [MeSH], Brain Neoplasms/metabolism [MeSH], Brain Neoplasms/pathology [MeSH], Glioma, Xenograft Model Antitumor Assays, Mutation, Microglia, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

Popis souboru: application/pdf; pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38630384
https://hal.science/hal-04592464v1
https://hal.science/hal-04592464v1/document
https://doi.org/10.1007/s11060-024-04672-9
https://repository.publisso.de/resource/frl:6522340
https://discovery-pp.ucl.ac.uk/id/eprint/10191333/

Targeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer

Autoři: Guangfa Bao Ziqiang Wang Luoxia Liu a další

Zdroj: Eur J Nucl Med Mol Imaging

Témata: 0301 basic medicine, Receptors, CXCR4, Benzylamines, 0303 health sciences, Triple Negative Breast Neoplasms/drug therapy [MeSH], Cell Line, Tumor [MeSH], Receptors, CXCR4/antagonists, Triple-negative breast cancer (TNBC), Triple Negative Breast Neoplasms/radiotherapy [MeSH], Serine Endopeptidases/metabolism [MeSH], Radiopharmaceuticals/pharmacology [MeSH], Cyclams/pharmacology [MeSH], Original Article, Heterocyclic Compounds/pharmacology [MeSH], Membrane Proteins/metabolism [MeSH], CXCR4 antagonist, Cyclams/therapeutic use [MeSH], CXCR4/CXCL12, [, Chemokine CXCL12/metabolism [MeSH], Receptors, CXCR4/metabolism [MeSH], Lutetium [MeSH], Female [MeSH], Gelatinases/metabolism [MeSH], Humans [MeSH], Animals [MeSH], Triple Negative Breast Neoplasms/diagnostic imaging [MeSH], Heterocyclic Compounds/chemistry [MeSH], Endopeptidases [MeSH], Benzylamines/pharmacology [MeSH], Mice [MeSH], Cell Proliferation/drug effects [MeSH], Radiopharmaceuticals/therapeutic use [MeSH], Serine Endopeptidases, Membrane Proteins, Triple Negative Breast Neoplasms, Lutetium, Cyclams, Chemokine CXCL12, Mice, 03 medical and health sciences, Heterocyclic Compounds, Gelatinases, Cell Line, Tumor, Endopeptidases, Animals, Humans, Female, Radiopharmaceuticals, Cell Proliferation

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38587644
https://repository.publisso.de/resource/frl:6521149

Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer

Autoři: Finnegan, Ellen Ding, Wei Ude, Ziga a další

Zdroj: Cell Oncol (Dordr)

Témata: Sulfonamides, Research, Apoptosis, Antineoplastic Agents, Hydroxamic Acids, 3. Good health, Histone Deacetylase Inhibitors, Gene Expression Regulation, Neoplastic, Organoids, Cell Line, Tumor [MeSH], Epigenetic, Organoids/drug effects [MeSH], Microsomes, Liver/drug effects [MeSH], Antineoplastic Agents/pharmacology [MeSH], Copper/chemistry [MeSH], Histone Deacetylase Inhibitor, Copper Complex, Hydroxamic Acids/pharmacology [MeSH], Organoids/metabolism [MeSH], Colonic Neoplasms/pathology [MeSH], Colonic Neoplasms/metabolism [MeSH], Microsomes, Liver/metabolism [MeSH], Histone Deacetylase Inhibitors/pharmacology [MeSH], Humans [MeSH], Apoptosis/drug effects [MeSH], Colonic Neoplasms/genetics [MeSH], Sulfonamides/pharmacology [MeSH], Colon Cancer, Gene Expression Regulation, Neoplastic/drug effects [MeSH], Colonic Neoplasms/drug therapy [MeSH], Hydroxamic Acids/therapeutic use [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Cell Proliferation/drug effects [MeSH], Cell Line, Tumor, Colonic Neoplasms, Microsomes, Liver, Humans, Copper, Cell Proliferation

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37934338
https://repository.publisso.de/resource/frl:6524426

A spheroid whole mount drug testing pipeline with machine-learning based image analysis identifies cell-type specific differences in drug efficacy on a single-cell level

Autoři: Vitacolonna, Mario Bruch, Roman Schneider, Richard a další

Zdroj: BMC Cancer
BMC Cancer, Vol 24, Iss 1, Pp 1-23 (2024)
BMC Cancer, 24 (1), Art.-Nr.: 1542

Témata: ddc:004, 0301 basic medicine, Antineoplastic Agents, Apoptosis, Machine Learning, 03 medical and health sciences, Imaging, Three-Dimensional, 3D drug testing, Spheroids, Cellular, Cell Line, Tumor, Image Processing, Computer-Assisted, Humans, Cell Line, Tumor [MeSH], Microscopy, Confocal/methods [MeSH], Fibroblasts/drug effects [MeSH], Humans [MeSH], Apoptosis/drug effects [MeSH], Antineoplastic Agents/pharmacology [MeSH], Tumor microenvironment, Drug resistance, Spheroids, Cellular/drug effects [MeSH], 3D co-culture, Image Processing, Computer-Assisted/methods [MeSH], Drug Screening Assays, Antitumor/methods [MeSH], Single-cell analysis, Doxorubicin/pharmacology [MeSH], Single-Cell Analysis/methods [MeSH], Research, Machine Learning [MeSH], Coculture Techniques [MeSH], Imaging, Three-Dimensional/methods [MeSH], Deep-learning image analysis, Cell Proliferation/drug effects [MeSH], Fibroblasts/metabolism [MeSH], RC254-282, Cell Proliferation, 0303 health sciences, Microscopy, Confocal, DATA processing & computer science, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Fibroblasts, Coculture Techniques, Doxorubicin, Single-Cell Analysis, Drug Screening Assays, Antitumor

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39696122
https://doaj.org/article/94688b951250495fb6faafe8830e39c4
https://repository.publisso.de/resource/frl:6497322

Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

Autoři: Rath, Sandip K. Nyamsuren, Gunsmaa Tampe, Björn a další

Přispěvatelé: Rath, Sandip K. Nyamsuren, Gunsmaa Tampe, Björn a další

Zdroj: Clin Epigenetics
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-20 (2024)

Témata: Male, 0301 basic medicine, DNA Repair, QH426-470, Dioxygenases, Non-homologous end joining, Homologous recombination, Dioxygenases/genetics [MeSH], DNA-Binding Proteins/genetics [MeSH], DNA-Binding Proteins/metabolism [MeSH], DNA Damage/drug effects [MeSH], Male [MeSH], Cell Proliferation/genetics [MeSH], DNA Repair/drug effects [MeSH], TET3, Dioxygenases/metabolism [MeSH], Fibroblasts/metabolism [MeSH], Myocardium/metabolism [MeSH], TGF-ß, Clinical Epigenetics of Heart Failure, Fibroblasts/drug effects [MeSH], Humans [MeSH], Animals [MeSH], Fibrosis, Fibrosis/genetics [MeSH], Myocardium/pathology [MeSH], Mice [MeSH], Proto-Oncogene Proteins/metabolism [MeSH], Research, Proto-Oncogene Proteins/genetics [MeSH], Cell Proliferation/drug effects [MeSH], Mice, 03 medical and health sciences, Proto-Oncogene Proteins, Genetics, Animals, Humans, Cell Proliferation, 0303 health sciences, Myocardium, Fibroblasts, 3. Good health, DNA-Binding Proteins, Medicine, DNA Damage

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39192299
https://doaj.org/article/c9732583a636444882ccab2ad924f6f6
https://resolver.sub.uni-goettingen.de/purl?gro-2/144673
https://repository.publisso.de/resource/frl:6501404

Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition

Autoři: Nath, Kavindra Gupta, Pradeep K. Basappa, Johnvesly a další

Zdroj: J Transl Med
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)

Témata: 0301 basic medicine, Mantle cell lymphoma (MCL), Lymphoma, Mantle-Cell, Mice, 03 medical and health sciences, Cell Line, Tumor [MeSH], Lymphoma, Mantle-Cell/metabolism [MeSH], Xenograft Model Antitumor Assays [MeSH], Signal Transduction/drug effects [MeSH], Lymphoma, Mantle-Cell/pathology [MeSH], Signaling inhibition, Agammaglobulinaemia Tyrosine Kinase/metabolism [MeSH], Immunobiology and immunotherapy, Protein Kinase Inhibitors/pharmacology [MeSH], Humans [MeSH], ACP-196 (acalabrutinib), Proton magnetic resonance spectroscopy (, Animals [MeSH], Lymphoma, Mantle-Cell/drug therapy [MeSH], RNA Sequence analysis (RNA-Seq), Ibrutinib (IBR), Tricarboxylic or Citric acid cycle (TCA), Mice [MeSH], Biomarkers, Tumor/metabolism [MeSH], Magnetic resonance spectroscopy (MRS), Agammaglobulinaemia Tyrosine Kinase/antagonists, Research, Biomarkers/metabolism [MeSH], Bruton's tyrosine kinase (BTK), Cell Proliferation/drug effects [MeSH], Cell Line, Tumor, Agammaglobulinaemia Tyrosine Kinase, Biomarkers, Tumor, Humans, Animals, Protein Kinase Inhibitors, Cell Proliferation, Proton magnetic resonance spectroscopy (1H MRS), 0303 health sciences, Xenograft Model Antitumor Assays, 3. Good health, Medicine, Biomarkers, Signal Transduction

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38965536
https://doaj.org/article/0e7806c50fd74e3da89b30454ab92a58
https://repository.publisso.de/resource/frl:6523258

Cytotoxic impact of nicotine products on periodontal ligament cells

Autoři: Wiesmann-Imilowski, Nadine Becker, Philipp Gielisch, Matthias W. a další

Přispěvatelé: Wiesmann-Imilowski, Nadine Becker, Philipp Gielisch, Matthias W. a další

Zdroj: Clin Oral Investig

Témata: Aerosols, Nicotine, Smoke/adverse effects [MeSH], Periodontal Ligament/cytology [MeSH], Nicotine/pharmacology [MeSH], Aerosols [MeSH], E-Cigarette Vapor/toxicity [MeSH], Flow Cytometry [MeSH], Humans [MeSH], Periodontal ligament cells, Apoptosis/drug effects [MeSH], Electronic Nicotine Delivery Systems [MeSH], In Vitro Techniques [MeSH], Nicotine/toxicity [MeSH], Periodontal Ligament/drug effects [MeSH], Periodontal health, Smoking, Electronic cigarette, Research, Tobacco Products/toxicity [MeSH], Heated tobacco product, Cells, Cultured [MeSH], Cell Proliferation/drug effects [MeSH], Periodontal Ligament, 610 Medizin, Apoptosis, Tobacco Products, Electronic Nicotine Delivery Systems, In Vitro Techniques, Flow Cytometry, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, E-Cigarette Vapor, 610 Medical sciences, Smoke, Humans, Cells, Cultured, Cell Proliferation, 0105 earth and related environmental sciences

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38922383
https://openscience.ub.uni-mainz.de/handle/20.500.12030/12335
https://doi.org/10.25358/openscience-12314
https://repository.publisso.de/resource/frl:6522613

Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization

Autoři: Viola K. DeTemple Antje Walter Sabine Bredemeier a další

Zdroj: Arch Dermatol Res

Témata: Keratinocytes, 0301 basic medicine, ddc:610, Original Paper, Skin Neoplasms, Pyridines [MeSH], Cell Line, Tumor [MeSH], Beta-tubulin-polymerization, Antineoplastic Agents/pharmacology [MeSH], Keratinocytes/drug effects [MeSH], Skin Neoplasms/drug therapy [MeSH], Cell Movement/drug effects [MeSH], Morpholines [MeSH], Keratinocytes/metabolism [MeSH], Tirbanibulin, Keratosis, Actinic/drug therapy [MeSH], Signal Transduction/drug effects [MeSH], Skin Neoplasms/metabolism [MeSH], Carcinoma, Squamous Cell/pathology [MeSH], Keratosis, Actinic/pathology [MeSH], Polymerization/drug effects [MeSH], Actinic keratosis (AK), Humans [MeSH], Apoptosis/drug effects [MeSH], Tubulin/metabolism [MeSH], Skin Neoplasms/pathology [MeSH], Carcinoma, Squamous Cell/drug therapy [MeSH], Cutaneous squamous cell carcinoma (cSCC), Acetamides [MeSH], Keratosis, Actinic/metabolism [MeSH], Cell Proliferation/drug effects [MeSH], Carcinoma, Squamous Cell/metabolism [MeSH], Pyridines, Morpholines, Apoptosis, Antineoplastic Agents, Polymerization, Keratosis, Actinic, 03 medical and health sciences, 0302 clinical medicine, Tubulin, Cell Movement, Cell Line, Tumor, Acetamides, Carcinoma, Squamous Cell, Humans, Cell Proliferation, Signal Transduction

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38847867
https://nbn-resolving.org/urn:nbn:de:hbz:294-114483
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/11448
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/11448/DeTempleViola07062024.pdf
https://repository.publisso.de/resource/frl:6500757

Cell survival after DNA damage in the comet assay

Autoři: Ezgi Eyluel Bankoglu Carolin Schuele Helga Stopper

Zdroj: Arch Toxicol

Témata: 0301 basic medicine, ddc:610, 0303 health sciences, Time Factors, DNA Repair, Dose-Response Relationship, Drug, Cell Survival, Apoptosis, Genotoxicity and Carcinogenicity, Hydrogen Peroxide, Methyl Methanesulfonate, Oxidants, Cell Line, 03 medical and health sciences, Humans, Topoisomerase II Inhibitors, Comet Assay, Antineoplastic Agents, Alkylating, Hydrogen Peroxide/administration, Methyl Methanesulfonate/administration, Methyl Methanesulfonate/toxicity [MeSH], Oxidants/administration, Topoisomerase II Inhibitors/toxicity [MeSH], Cell Line [MeSH], DNA Damage/drug effects [MeSH], Etoposide/administration, Hydrogen Peroxide/toxicity [MeSH], DNA Repair/drug effects [MeSH], DNA damage, Antineoplastic Agents, Alkylating/administration, Etoposide/toxicity [MeSH], DNA repair, Dose-Response Relationship, Drug [MeSH], Comet Assay [MeSH], Topoisomerase II Inhibitors/administration, Humans [MeSH], Apoptosis/drug effects [MeSH], Cell Survival/drug effects [MeSH], Oxidants/toxicity [MeSH], Time Factors [MeSH], Antineoplastic Agents, Alkylating/toxicity [MeSH], Cell Proliferation/drug effects [MeSH], Cell death and comet assay, Cell Proliferation, DNA Damage, Etoposide

Popis souboru: application/pdf

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00204-021-03164-3.pdf
https://pubmed.ncbi.nlm.nih.gov/34609522
https://link.springer.com/article/10.1007/s00204-021-03164-3
https://link.springer.com/content/pdf/10.1007/s00204-021-03164-3.pdf
https://repository.publisso.de/resource/frl:6451639
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/26533
https://doi.org/10.1007/s00204-021-03164-3
https://opus.bibliothek.uni-wuerzburg.de/files/26533/Bankoglu_Toxicology.pdf
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-265339

The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia

Autoři: Wellbrock, Jasmin Behrmann, Lena Muschhammer, Jana a další

Zdroj: Ann Hematol

Témata: 0301 basic medicine, Antineoplastic Agents, Cell Cycle Proteins, 3. Good health, Leukemia, Myeloid, Acute, 03 medical and health sciences, Cell Line, Tumor, Hedgehog Proteins/metabolism [MeSH], Cell Line, Tumor [MeSH], Humans [MeSH], Transcription Factors/antagonists, BET inhibitor, Antineoplastic Agents/pharmacology [MeSH], GLI, Leukemia, Myeloid, Acute/metabolism [MeSH], Cell Cycle Proteins/antagonists, Original Article, Acute myeloid leukemia, Hedgehog, ZEN-3365, Signal Transduction/drug effects [MeSH], Cell Cycle Proteins/metabolism [MeSH], Leukemia, Myeloid, Acute/drug therapy [MeSH], Transcription Factors/metabolism [MeSH], Cell Proliferation/drug effects [MeSH], GANT-61, Humans, Hedgehog Proteins, Cell Proliferation, Signal Transduction, Transcription Factors

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00277-021-04602-z.pdf
https://pubmed.ncbi.nlm.nih.gov/34333666
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592969
https://pubmed.ncbi.nlm.nih.gov/34333666/
https://link.springer.com/article/10.1007/s00277-021-04602-z
https://fis-uke.de/portal/en/publications/the-bet-bromodomain-inhibitor-zen3365-targets-the-hedgehog-signaling-pathway-in-acute-myeloid-leukemia(74f7f56e-c423-46e2-8236-d3c0609ff9d5).html
https://link.springer.com/content/pdf/10.1007/s00277-021-04602-z.pdf
https://repository.publisso.de/resource/frl:6447809

Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

Autoři: Reinhard Dummer Astrid Jullion Nelson Guerreiro a další

Přispěvatelé: Reinhard Dummer Astrid Jullion Nelson Guerreiro a další

Zdroj: Br J Cancer

Témata: Adult, Male, 0301 basic medicine, Cancer Research, Growth Differentiation Factor 15, Cell Survival, Medizin, Administration, Oral, 610 Medicine & health, Article, Drug Administration Schedule, Piperazines, Mice, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Biomarkers, Tumor, Animals, Humans, 1306 Cancer Research, Drug Dosage Calculations, Aged, Cell Proliferation, 0303 health sciences, 10177 Dermatology Clinic, Middle Aged, Isoquinolines, 3. Good health, Cell Line, Tumor [MeSH], Aged [MeSH], Cell Survival [MeSH], Piperazines/pharmacokinetics [MeSH], Administration, Oral [MeSH], Piperazines/administration, Male [MeSH], Xenograft Model Antitumor Assays [MeSH], Isoquinolines/pharmacokinetics [MeSH], Drug discovery, Piperazines/adverse effects [MeSH], Isoquinolines/administration, Female [MeSH], Adult [MeSH], Drug development, Humans [MeSH], Treatment Outcome [MeSH], Drug Administration Schedule [MeSH], Middle Aged [MeSH], Animals [MeSH], Growth Differentiation Factor 15/blood [MeSH], Drug Dosage Calculations [MeSH], Isoquinolines/adverse effects [MeSH], Mice [MeSH], Biomarkers, Tumor/blood [MeSH], Neoplasms/drug therapy [MeSH], Cell Proliferation/drug effects [MeSH], Neoplasms/blood [MeSH], Treatment Outcome, Oncology, 2730 Oncology, Female

Popis souboru: 918_Bauer_S._et_al._Pharmacokinetic-pharmacodynamic_guided_optimisation_of_dose_and_schedule_of_CGM097,_an_HDM2_inhibitor_Br_J_Cancer_2021.pdf - application/pdf

Přístupová URL adresa: https://www.nature.com/articles/s41416-021-01444-4.pdf
https://pubmed.ncbi.nlm.nih.gov/34140638
https://www.nature.com/articles/s41416-021-01444-4.pdf
https://www.zora.uzh.ch/id/eprint/209201/
https://www.nature.com/articles/s41416-021-01444-4
https://europepmc.org/articles/PMC8405607/
https://pubmed.ncbi.nlm.nih.gov/34140638/
https://www.zora.uzh.ch/id/eprint/209201/1/918_Bauer_S._et_al._Pharmacokinetic-pharmacodynamic_guided_optimisation_of_dose_and_schedule_of_CGM097%2C_an_HDM2_inhibitor_Br_J_Cancer_2021.pdf
https://repository.publisso.de/resource/frl:6442878
https://www.zora.uzh.ch/id/eprint/209201/
https://doi.org/10.5167/uzh-209201

The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells

Autoři: Gerst F. Kemter E. Lorza-Gil E. a další

Zdroj: Diabetologia
Diabetologia 64, 1358–1374 (2021)

Témata: 0301 basic medicine, Swine, alpha-2-HS-Glycoprotein, Smad Proteins, Pancreatic beta cells, Article, Islets of Langerhans, 03 medical and health sciences, Phosphorylation/drug effects [MeSH], Islets of Langerhans/drug effects [MeSH], Swine [MeSH], Humans [MeSH], Insulin Secretion/drug effects [MeSH], Adaptive proliferation, FOXM1, Functional maturity, Glucose Intolerance/metabolism [MeSH], Animals [MeSH], Fetuin-A, Islets of Langerhans/metabolism [MeSH], TGFBR–SMAD2/3, Signal Transduction/drug effects [MeSH], Smad Proteins/metabolism [MeSH], Gene Expression Profiling [MeSH], Diabetes Mellitus, Type 2/metabolism [MeSH], Cell Proliferation/drug effects [MeSH], alpha-2-HS-Glycoprotein/pharmacology [MeSH], Insulin/metabolism [MeSH], Glucose Intolerance, Insulin Secretion, Animals, Humans, Insulin, Phosphorylation, Cell Proliferation, 0303 health sciences, Gene Expression Profiling, Adaptive Proliferation, Foxm1, Fetuin-a, Functional Maturity, Pancreatic Beta Cells, Tgfbr–smad2/3, Diabetes Mellitus, Type 2, Signal Transduction

Popis souboru: application/pdf

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00125-021-05435-1.pdf
https://pubmed.ncbi.nlm.nih.gov/33765181
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099843
https://pubmed.ncbi.nlm.nih.gov/33765181/
http://pubmed.ncbi.nlm.nih.gov/33765181/
https://link.springer.com/article/10.1007/s00125-021-05435-1
https://link.springer.com/content/pdf/10.1007/s00125-021-05435-1.pdf
https://europepmc.org/article/PMC/PMC8099843
https://hdl.handle.net/20.500.11768/115647
https://doi.org/10.1007/s00125-021-05435-1
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61684
https://repository.publisso.de/resource/frl:6451918

Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells

Autoři: Yuru Shang Lili Lu Dietmar Zechner a další

Zdroj: Br J Cancer

Témata: Male, Cell Survival, Immunoglobulins, Intravenous, Middle Aged, Xenograft Model Antitumor Assays, Article, 3. Good health, Gene Expression Regulation, Neoplastic, Oxaliplatin, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Colonic Neoplasms, Cell Line, Tumor [MeSH], Aged [MeSH], Humans [MeSH], Molecular medicine, Cell Survival/drug effects [MeSH], Middle Aged [MeSH], Gene Expression Regulation, Neoplastic/drug effects [MeSH], Preclinical research, Oxaliplatin/pharmacology [MeSH], Male [MeSH], Colonic Neoplasms/drug therapy [MeSH], Immunoglobulins, Intravenous/pharmacology [MeSH], Xenograft Model Antitumor Assays [MeSH], Drug Interactions [MeSH], Colonic Neoplasms/metabolism [MeSH], Immunoglobulins, Intravenous/administration, Cell Proliferation/drug effects [MeSH], Extracellular Signal-Regulated MAP Kinases/drug effects [MeSH], Colon cancer, Humans, Drug Interactions, Extracellular Signal-Regulated MAP Kinases, Aged, Cell Proliferation

Přístupová URL adresa: https://www.nature.com/articles/s41416-021-01272-6.pdf
https://pubmed.ncbi.nlm.nih.gov/33558709
https://europepmc.org/article/PMC/PMC8039037
https://www.nature.com/articles/s41416-021-01272-6.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039037
http://www-nature-com-443.webvpn.bjmu.tsg211.com/articles/s41416-021-01272-6
https://pubmed.ncbi.nlm.nih.gov/33558709/
https://www.ncbi.nlm.nih.gov/pubmed/33558709
https://repository.publisso.de/resource/frl:6442896

Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard

Autoři: Simone Rothmiller Niklas Jäger Nicole Meier a další

Zdroj: Arch Toxicol

Témata: 0301 basic medicine, Alkylating Agents, Wound Healing, Apoptosis, Mesenchymal Stem Cells, Hydrogen Peroxide, Biologics, 3. Good health, 03 medical and health sciences, Cell Movement, 13. Climate action, Chemokines/metabolism [MeSH], Chemical Warfare Agents/toxicity [MeSH], Senescence, Skin/injuries [MeSH], Skin/drug effects [MeSH], Wound Healing/drug effects [MeSH], Cell Movement/drug effects [MeSH], Cytokines/metabolism [MeSH], Alkylating Agents/toxicity [MeSH], Mesenchymal Stem Cells/drug effects [MeSH], Sulfur mustard, Chemical warfare agents, Mesenchymal Stem Cells/cytology [MeSH], Hydrogen Peroxide/toxicity [MeSH], Mustard Gas/toxicity [MeSH], Cellular Senescence/drug effects [MeSH], Wound healing disorder, Humans [MeSH], Apoptosis/drug effects [MeSH], Mesenchymal Stem Cells/metabolism [MeSH], Biomarkers/metabolism [MeSH], Cells, Cultured [MeSH], Cytokines/genetics [MeSH], Cell Proliferation/drug effects [MeSH], Mesenchymal stem cells, Chemokines/genetics [MeSH], Mustard Gas, Cytokines, Humans, Chemical Warfare Agents, Chemokines, Biomarkers, Cells, Cultured, Cellular Senescence, Cell Proliferation, Skin

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00204-020-02946-5.pdf
https://pubmed.ncbi.nlm.nih.gov/33491125
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870771
https://kops.uni-konstanz.de/handle/123456789/52592
https://europepmc.org/article/MED/33491125
https://link.springer.com/article/10.1007/s00204-020-02946-5?error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&error=cookies_not_supported&code=4acdcd1c-07dc-4688-98dc-7a7d15fa8a7f&code=df09e271-8065-4d4b-b05c-34949581065b&code=47eae568-eea7-4b42-a913-584eb4f9b0ad&code=9344f33e-3871-43aa-b40f-642603f8f690
https://www.scilit.net/article/516e8cd09414d7681f2a6136e2e99cc2
https://link.springer.com/content/pdf/10.1007/s00204-020-02946-5.pdf
https://repository.publisso.de/resource/frl:6451719

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling

Autoři: Nina N. Seel Nina A. Hering Verena Liu a další

Zdroj: Cell Oncol (Dordr)

Témata: Male, STAT3 Transcription Factor, 0301 basic medicine, Time Factors, Mice, Nude, Adenocarcinoma, STAT3, Mice, gp130, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Cytokine Receptor gp130, Animals, Estrogen Receptor beta, Humans, Estrogen receptor, ERβ, Neoplasm Metastasis, Cell Proliferation, IL-6, Interleukin-6, Pancreatic cancer, Xenograft Model Antitumor Assays, SERM, 3. Good health, Pancreatic Neoplasms, Cell Line, Tumor [MeSH], STAT3 Transcription Factor/metabolism [MeSH], Pancreatic Neoplasms/pathology [MeSH], Raloxifene Hydrochloride/pharmacology [MeSH], Raloxifene, Adenocarcinoma/metabolism [MeSH], Original Article, Male [MeSH], Adenocarcinoma/pathology [MeSH], Xenograft Model Antitumor Assays [MeSH], Signal Transduction/drug effects [MeSH], Interleukin-6/metabolism [MeSH], Humans [MeSH], Neoplasm Metastasis [MeSH], Animals [MeSH], Time Factors [MeSH], Mice, Nude [MeSH], Estrogen Receptor beta/metabolism [MeSH], Cytokine Receptor gp130/metabolism [MeSH], Pancreatic Neoplasms/metabolism [MeSH], Cell Proliferation/drug effects [MeSH], Raloxifene Hydrochloride, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Signal Transduction

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s13402-020-00559-9.pdf
https://pubmed.ncbi.nlm.nih.gov/32940862
https://pubmed.ncbi.nlm.nih.gov/32940862/
https://europepmc.org/article/PMC/PMC7906944
https://link.springer.com/content/pdf/10.1007/s13402-020-00559-9.pdf
https://link.springer.com/article/10.1007/s13402-020-00559-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906944/
http://www.ncbi.nlm.nih.gov/pubmed/32940862
https://repository.publisso.de/resource/frl:6471286
https://refubium.fu-berlin.de/handle/fub188/35646
https://doi.org/10.17169/refubium-35360
https://doi.org/10.1007/s13402-020-00559-9