Search Results - "Cell Nucleus Structures"

Formation, function, and pathology of RNP granules.

Authors: Ripin N Parker R

Source: Cell [Cell] 2023 Oct 26; Vol. 186 (22), pp. 4737-4756.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH Terms: Cytoplasmic Granules*/metabolism , Cytoplasmic Granules*/pathology , Ribonucleoproteins*/metabolism , Cell Nucleus Structures*/metabolism , Cell Nucleus Structures*/pathology, Humans ; Cytoplasmic Ribonucleoprotein Granules ; Protein Processing, Post-Translational ; RNA/metabolism ; Cell Nucleolus/metabolism ; Animals

Interplay of cGAS with micronuclei: Regulation and diseases.

Authors: Guo X Hintzsche H Xu W et al.

Source: Mutation research. Reviews in mutation research [Mutat Res Rev Mutat Res] 2022 Jul-Dec; Vol. 790, pp. 108440. Date of Electronic Publication: 2022 Aug 12.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 101632211 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1388-2139 (Electronic) Linking ISSN: 13835742 NLM ISO Abbreviation: Mutat Res Rev Mutat Res Subsets: MEDLINE

MeSH Terms: Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Nucleotidyltransferases*/genetics , Nucleotidyltransferases*/metabolism , Cell Nucleus Structures*/genetics , Cell Nucleus Structures*/metabolism, Humans ; DNA/metabolism ; Immunity, Innate/genetics

RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination.

Authors: Gan T Wang Y Liu Y et al.

Source: Cell reports [Cell Rep] 2021 Oct 12; Vol. 37 (2), pp. 109824.

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: G1 Phase* , V(D)J Recombination*, Cell Nucleus Structures/*metabolism , DNA-Binding Proteins/*metabolism , Homeodomain Proteins/*metabolism , Lymphocytes/*metabolism , Nuclear Proteins/*metabolism, Cell Line, Tumor ; Cell Nucleus Structures/genetics ; DNA-Binding Proteins/genetics ; HEK293 Cells ; Homeodomain Proteins/genetics ; Humans ; Nuclear Proteins/genetics ; Protein Aggregates ; Species Specificity ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism

Superresolution light microscopy of the Drosophila histone locus body reveals a core-shell organization associated with expression of replication-dependent histone genes.

Authors: Kemp JP Jr Yang XC Dominski Z et al.

Source: Molecular biology of the cell [Mol Biol Cell] 2021 Apr 19; Vol. 32 (9), pp. 942-955. Date of Electronic Publication: 2021 Mar 31.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE

MeSH Terms: Cell Nucleus Structures/*metabolism , Histones/*metabolism , Microscopy/*methods, Animals ; Carrier Proteins/metabolism ; Cell Nucleus/metabolism ; Cell Nucleus Structures/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Mitosis ; RNA Precursors/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism ; Regulatory Elements, Transcriptional/genetics ; Ribonucleoprotein, U7 Small Nuclear/metabolism ; Tumor Suppressor Proteins/metabolism ; Zygote/metabolism

Cold shock induces novel nuclear bodies in Xenopus oocytes.

Authors: Liu JL Gall JG

Source: Experimental cell research [Exp Cell Res] 2021 Jan 01; Vol. 398 (1), pp. 112386. Date of Electronic Publication: 2020 Nov 18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

MeSH Terms: Cold-Shock Response*, Cell Nucleus/*ultrastructure , Cell Nucleus Structures/*ultrastructure , Chromosomes/*ultrastructure , Oocytes/*ultrastructure, Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus Structures/metabolism ; Chromosomes/genetics ; Female ; Oocytes/metabolism ; Xenopus laevis

Phase separated microenvironments inside the cell nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing.

Authors: Sawyer IA Bartek J Dundr M

Source: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2019 Jun; Vol. 90, pp. 94-103. Date of Electronic Publication: 2018 Jul 25.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9607332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3634 (Electronic) Linking ISSN: 10849521 NLM ISO Abbreviation: Semin Cell Dev Biol Subsets: MEDLINE

MeSH Terms: Cell Separation* , Liquid-Liquid Extraction*, Cell Nucleus/*chemistry , Cell Nucleus Structures/*metabolism , Epigenesis, Genetic/*genetics , Organelles/*metabolism , RNA/*metabolism, Cell Nucleus/metabolism ; Cell Nucleus Structures/chemistry ; Cell Nucleus Structures/genetics ; Humans ; Organelles/chemistry ; Organelles/genetics ; Particle Size ; RNA/genetics ; RNA/isolation & purification

Heterochromatin restricts the mobility of nuclear bodies.

Authors: Arifulin EA Sorokin DV Tvorogova AV et al.

Source: Chromosoma [Chromosoma] 2018 Dec; Vol. 127 (4), pp. 529-537. Date of Electronic Publication: 2018 Oct 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 2985138R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0886 (Electronic) Linking ISSN: 00095915 NLM ISO Abbreviation: Chromosoma Subsets: MEDLINE

MeSH Terms: Cell Nucleus Structures/*metabolism , Heterochromatin/*metabolism, Cell Nucleus Structures/genetics ; Chromatin/metabolism ; HeLa Cells ; Humans ; Interphase ; Time-Lapse Imaging

Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures.

Authors: Sarmento MJ Oneto M Pelicci S et al.

Source: Nature communications [Nat Commun] 2018 Aug 24; Vol. 9 (1), pp. 3415. Date of Electronic Publication: 2018 Aug 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Cell Nucleus Structures*, Microscopy, Fluorescence/*methods, Cell Nucleus/metabolism ; Humans

The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments.

Authors: Xu P Roizman B

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 May 09; Vol. 114 (19), pp. E3823-E3829. Date of Electronic Publication: 2017 Apr 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Antigens, Nuclear/*metabolism , Autoantigens/*metabolism , Cell Nucleus Structures/*metabolism , Promyelocytic Leukemia Protein/*metabolism , Simplexvirus/*physiology , Virus Assembly/*physiology, Animals ; Antigens, Nuclear/genetics ; Autoantigens/genetics ; Cell Nucleus Structures/genetics ; Cell Nucleus Structures/virology ; Chlorocebus aethiops ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Promyelocytic Leukemia Protein/genetics ; Vero Cells

Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture.

Authors: Jorgens DM Inman JL Wojcik M et al.

Source: Journal of cell science [J Cell Sci] 2017 Jan 01; Vol. 130 (1), pp. 177-189. Date of Electronic Publication: 2016 Aug 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

MeSH Terms: Imaging, Three-Dimensional*, Cell Culture Techniques/*methods , Cell Nucleus Structures/*metabolism , Cytoskeleton/*metabolism , Epithelial Cells/*cytology , Epithelial Cells/*metabolism, Actins/metabolism ; Biomimetics ; Breast/cytology ; Cell Adhesion ; Cell Communication ; Cell Cycle Checkpoints ; Cell Nucleus Structures/ultrastructure ; Cytoskeleton/ultrastructure ; Desmosomes/metabolism ; Desmosomes/ultrastructure ; Epithelial Cells/ultrastructure ; Extracellular Space/metabolism ; Female ; Humans ; Keratins/metabolism ; Microscopy, Fluorescence ; Nuclear Envelope/metabolism ; Nuclear Envelope/ultrastructure

Nuclear speckles are detention centers for transcripts containing expanded CAG repeats.

Authors: Urbanek MO Jazurek M Switonski PM et al.

Source: Biochimica et biophysica acta [Biochim Biophys Acta] 2016 Sep; Vol. 1862 (9), pp. 1513-20. Date of Electronic Publication: 2016 May 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-3002 (Print) Linking ISSN: 00063002 NLM ISO Abbreviation: Biochim Biophys Acta Subsets: MEDLINE

MeSH Terms: Trinucleotide Repeat Expansion*, Cell Nucleus Structures/*genetics , Cell Nucleus Structures/*metabolism, Alternative Splicing ; Animals ; Cell Line ; Cell Nucleus Structures/pathology ; HeLa Cells ; Heredodegenerative Disorders, Nervous System/genetics ; Heredodegenerative Disorders, Nervous System/metabolism ; Heredodegenerative Disorders, Nervous System/pathology ; Humans ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; In Situ Hybridization, Fluorescence ; Mice ; Peptides/genetics ; Peptides/metabolism ; RNA/genetics ; RNA/metabolism ; RNA-Binding Proteins/metabolism ; Transcription, Genetic

Empirical Derivation of Correction Factors for Human Spiral Ganglion Cell Nucleus and Nucleolus Count Units.

Authors: Robert ME Linthicum FH Jr

Source: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2016 Jan; Vol. 154 (1), pp. 157-63. Date of Electronic Publication: 2015 Sep 16.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8508176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6817 (Electronic) Linking ISSN: 01945998 NLM ISO Abbreviation: Otolaryngol Head Neck Surg Subsets: MEDLINE

MeSH Terms: Cell Nucleus Structures*, Spiral Ganglion/*cytology, Cell Count ; Humans ; Middle Aged ; Spiral Ganglion/ultrastructure

Shigella infection interferes with SUMOylation and increases PML-NB number.

Authors: Sidik SM Salsman J Dellaire G et al.

Source: PloS one [PLoS One] 2015 Apr 07; Vol. 10 (4), pp. e0122585. Date of Electronic Publication: 2015 Apr 07 (Print Publication: 2015).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Sumoylation*, Cell Nucleus Structures/*metabolism , Cell Nucleus Structures/*microbiology , Shigella flexneri/*physiology, Cell Nucleus Structures/immunology ; HeLa Cells ; Humans ; Protein Transport ; SUMO-1 Protein/metabolism ; Signal Transduction

Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles.

Authors: Lee JH Jeong SA Khadka P et al.

Source: Nucleic acids research [Nucleic Acids Res] 2015 Sep 30; Vol. 43 (17), pp. 8435-51. Date of Electronic Publication: 2015 Aug 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH Terms: Cell Cycle*/genetics, Cell Nucleus Structures/*enzymology , Serine-Arginine Splicing Factors/*metabolism , Telomerase/*metabolism , Telomere/*enzymology, Cell Line, Tumor ; Cell Nucleus Structures/genetics ; HeLa Cells ; Humans ; Protein Interaction Domains and Motifs ; RNA/metabolism ; Serine-Arginine Splicing Factors/chemistry ; Telomerase/chemistry ; Telomere Homeostasis ; Telomeric Repeat Binding Protein 2/metabolism

An optimized fixation method containing glyoxal and paraformaldehyde for imaging nuclear bodies.

Authors: Yao RW Luan PF Chen LL

Source: RNA (New York, N.Y.) [RNA] 2021 Jun; Vol. 27 (6), pp. 725-733. Date of Electronic Publication: 2021 Apr 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

MeSH Terms: Cell Nucleus Structures/*ultrastructure , Fixatives/*chemistry , Formaldehyde/*chemistry , Glyoxal/*chemistry , In Situ Hybridization, Fluorescence/*methods , Polymers/*chemistry, HEK293 Cells ; HeLa Cells ; Humans

Identification of a chemical inhibitor for nuclear speckle formation: implications for the function of nuclear speckles in regulation of alternative pre-mRNA splicing.

Authors: Kurogi Y Matsuo Y Mihara Y et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2014 Mar 28; Vol. 446 (1), pp. 119-24. Date of Electronic Publication: 2014 Feb 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Alternative Splicing*/drug effects , Alternative Splicing*/genetics, Cell Nucleus Structures/*drug effects , Cell Nucleus Structures/*metabolism , RNA Precursors/*metabolism, Actinobacteria/chemistry ; Cell Nucleus Structures/genetics ; Drug Evaluation, Preclinical ; Exons ; HeLa Cells ; Humans ; Models, Biological ; Nuclear Proteins/metabolism ; Primed In Situ Labeling ; Protein Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; RNA Precursors/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA-Binding Proteins/metabolism ; Serine-Arginine Splicing Factors ; Tubercidin/isolation & purification ; Tubercidin/pharmacology

Phenolic promiscuity in the cell nucleus--epigallocatechingallate (EGCG) and theaflavin-3,3'-digallate from green and black tea bind to model cell nuclear structures including histone proteins, double stranded DNA and telomeric quadruplex DNA.

Authors: Mikutis G Karaköse H Jaiswal R et al.

Source: Food & function [Food Funct] 2013 Feb; Vol. 4 (2), pp. 328-37.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE

MeSH Terms: Biflavonoids/*pharmacology , Camellia sinensis/*chemistry , Catechin/*analogs & derivatives , Cell Nucleus Structures/*drug effects , DNA/*chemistry , Gallic Acid/*analogs & derivatives , Histones/*chemistry , Plant Extracts/*pharmacology , Telomere/*chemistry, Catechin/pharmacology ; Cell Nucleus Structures/chemistry ; Cell Nucleus Structures/metabolism ; Circular Dichroism ; DNA/metabolism ; G-Quadruplexes/drug effects ; Gallic Acid/pharmacology ; Histones/metabolism ; Humans ; Kinetics ; Mass Spectrometry ; Polyphenols/pharmacology ; Tea/chemistry ; Telomere/metabolism

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation.

Authors: Hands KJ Cuchet-Lourenco D Everett RD et al.

Source: Journal of cell science [J Cell Sci] 2014 Jan 15; Vol. 127 (Pt 2), pp. 365-75. Date of Electronic Publication: 2013 Nov 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

MeSH Terms: Arsenic/*pharmacology , Cell Nucleus Structures/*metabolism , Oncogene Proteins, Fusion/*metabolism , Proteolysis/*drug effects, Blotting, Western ; Cell Nucleus Structures/drug effects ; Fluorescent Antibody Technique ; Humans ; Nuclear Proteins/metabolism ; Protein Isoforms/metabolism ; Protein Processing, Post-Translational/drug effects ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Subcellular Fractions/drug effects ; Subcellular Fractions/metabolism ; Transcription Factors/metabolism ; Ubiquitin/metabolism

Structural basis of polycomb bodies.

Authors: Smigová J Juda P Krejčí J et al.

Source: Folia biologica [Folia Biol (Praha)] 2014; Vol. 60 Suppl 1, pp. 13-20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Univerzita Karlova v Praze - 1. lékařská fakulta Country of Publication: Czech Republic NLM ID: 0234640 Publication Model: Print Cited Medium: Internet ISSN: 0015-5500 (Print) Linking ISSN: 00155500 NLM ISO Abbreviation: Folia Biol (Praha) Subsets: MEDLINE

MeSH Terms: Cell Nucleus Structures/*metabolism , Polycomb-Group Proteins/*chemistry, Animals ; Cell Nucleus Structures/ultrastructure ; Gene Silencing ; Humans ; Subcellular Fractions/metabolism

Biogenesis of nuclear bodies.

Authors: Dundr M Misteli T

Source: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2010 Dec; Vol. 2 (12), pp. a000711. Date of Electronic Publication: 2010 Nov 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101513680 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-0264 (Electronic) Linking ISSN: 19430264 NLM ISO Abbreviation: Cold Spring Harb Perspect Biol Subsets: MEDLINE

MeSH Terms: Biosynthetic Pathways/*physiology , Cell Nucleus Structures/*metabolism , Cell Nucleus Structures/*physiology , Inheritance Patterns/*genetics , RNA/*metabolism, Cell Nucleus Structures/classification ; Mitosis/genetics ; Mitosis/physiology