Suchergebnisse - "Carcinoma, Squamous Cell genetics"

Metabolic heterogeneity in tumor cells impacts immunology in lung squamous cell carcinoma

Autoren: Wang, Qian Sun, Na Zhang, Chaoyang et al.

Quelle: Oncoimmunology
OncoImmunology, Vol 14, Iss 1 (2025)
Oncoimmunology, vol. 14, no. 1, pp. 2457797

Schlagwörter: Male, Lung Neoplasms, metabolic tumor subpopulation, FOS: Clinical medicine, Immunology, Humans, Lung Neoplasms/immunology, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Carcinoma, Squamous Cell/immunology, Carcinoma, Squamous Cell/pathology, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/genetics, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Female, Middle Aged, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Aged, Metabolomics/methods, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Spatial metabolomics, lung cancer, metabolic heterogeneity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, CD8-Positive T-Lymphocytes, Lymphocytes, Tumor-Infiltrating, Carcinoma, Squamous Cell, Metabolomics, Immunologic diseases. Allergy, RC254-282, Original Research

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39924768
https://doaj.org/article/b9d0c7215a0a49e9bcd00f346be6d77b
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D61DADE787A33
https://serval.unil.ch/notice/serval:BIB_D61DADE787A3
https://serval.unil.ch/resource/serval:BIB_D61DADE787A3.P001/REF.pdf

CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability

Autoren: Geyer, Maximilian Geyer, Fabian Reuning, Ute et al.

Quelle: Head Face Med
Head & Face Medicine, Vol 20, Iss 1, Pp 1-9 (2024)

Schlagwörter: 0301 basic medicine, Knock out, Integrin beta Chains, Specialties of internal medicine, Gene Knockout Techniques, 03 medical and health sciences, Cell Movement, Cell Line, Tumor, Humans, Neoplasm Invasiveness, CRISPR/Cas9, Cell Proliferation, Integrin beta 6, 0303 health sciences, Squamous Cell Carcinoma of Head and Neck, Research, Gene Expression Regulation, Neoplastic [MeSH], Cell Line, Tumor [MeSH], Mouth Neoplasms/pathology [MeSH], Cell Movement/genetics [MeSH], Squamous Cell Carcinoma of Head and Neck/pathology [MeSH], Humans [MeSH], Squamous Cell Carcinoma of Head and Neck/genetics [MeSH], Gene Knockout Techniques [MeSH], Oral squamous cell carcinoma, Cell Proliferation/genetics [MeSH], CRISPR-Cas Systems [MeSH], Neoplasm Invasiveness/genetics [MeSH], Carcinoma, Squamous Cell/genetics [MeSH], Carcinoma, Squamous Cell/pathology [MeSH], Integrin beta Chains/genetics [MeSH], Mouth Neoplasms/genetics [MeSH], ddc, 3. Good health, Gene Expression Regulation, Neoplastic, RC581-951, Carcinoma, Squamous Cell, Mouth Neoplasms, CRISPR-Cas Systems

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38890650
https://doaj.org/article/22953a201ecb4d18a0d66d3cb177183b
https://repository.publisso.de/resource/frl:6522274
https://mediatum.ub.tum.de/1770406

NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5

Autoren: Selina Gurri Beat Siegenthaler Michael Cangkrama et al.

Quelle: EMBO Mol Med
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-22 (2023)
EMBO molecular medicine, vol. 15, no. 11, pp. e17761
EMBO Molecular Medicine, 15 (11)

Schlagwörter: Medicine (General), Skin Neoplasms, skin carcinogenesis, Carcinogenesis, Malignancy, HSPA5, NRF3, Skin carcinogenesis, Unfolded protein response, unfolded protein response, Articles, QH426-470, 3. Good health, Mice, R5-920, Animals, Humans, Carcinoma, Squamous Cell/genetics, Endoplasmic Reticulum Chaperone BiP, Skin Neoplasms/genetics, Unfolded Protein Response, malignancy, Genetics, Carcinoma, Squamous Cell

Dateibeschreibung: application/pdf; application/application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37807968
https://doaj.org/article/70d51ab9fc7b4691a8599527533a94b1
https://serval.unil.ch/notice/serval:BIB_876B60FDD738
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_876B60FDD7385
https://serval.unil.ch/resource/serval:BIB_876B60FDD738.P001/REF.pdf
http://hdl.handle.net/20.500.11850/642075

Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles

Autoren: Stark, Leonhard Kasajima, Atsuko Stögbauer, Fabian et al.

Quelle: Clin Epigenetics
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)

Schlagwörter: 0301 basic medicine, DNA methylation, Research, QH426-470, DNA Methylation, Classifier, HNSCC, ddc, 3. Good health, Machine Learning, CUP, 03 medical and health sciences, 0302 clinical medicine, Head and Neck Neoplasms, Humans [MeSH], Neoplasms, Unknown Primary/diagnosis [MeSH], Head and Neck Neoplasms/genetics [MeSH], Neoplasms, Unknown Primary/genetics [MeSH], Head and Neck Neoplasms/diagnosis [MeSH], Carcinoma, Squamous Cell/diagnosis [MeSH], DNA Methylation [MeSH], Neoplasms, Unknown Primary/pathology [MeSH], Machine Learning [MeSH], Carcinoma, Squamous Cell/genetics [MeSH], Carcinoma, Squamous Cell/pathology [MeSH], Genetics, Carcinoma, Squamous Cell, Medicine, Humans, Neoplasms, Unknown Primary

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38528631
https://doaj.org/article/3924f13f9d754236b920773600a561fe
https://repository.publisso.de/resource/frl:6505733
https://mediatum.ub.tum.de/doc/1770348/document.pdf

Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome

Autoren: Broghammer, Felix Korovina, Irina Gouda, Mahesh et al.

Weitere Verfasser: Broghammer, Felix Korovina, Irina Gouda, Mahesh et al.

Quelle: Mol Cancer
Molecular Cancer, Vol 23, Iss 1, Pp 1-25 (2024)

Schlagwörter: 0301 basic medicine, Cancer Research, Squamous Cell/drug therapy, Integrin beta1/genetics, Radioprotection, Epithelial-Mesenchymal Transition, Adaptive resistance, Antineoplastic Agents, HNSCC, Cell Line, Tumor [MeSH], Epidermal growth factor receptor, Humans [MeSH], β1 integrin, Head and Neck Neoplasms/genetics [MeSH], Squamous Cell Carcinoma of Head and Neck/drug therapy [MeSH], Head and Neck Neoplasms/drug therapy [MeSH], Carcinoma, Squamous Cell/drug therapy [MeSH], Squamous Cell Carcinoma of Head and Neck/genetics [MeSH], Radiosensitization, Epithelial-Mesenchymal Transition/genetics [MeSH], ErbB Receptors/metabolism [MeSH], Epithelial-to-mesenchymal transition, Receptor Protein-Tyrosine Kinases/genetics [MeSH], Integrin beta1/genetics [MeSH], Research, Antineoplastic Agents/therapeutic use [MeSH], Carcinoma, Squamous Cell/genetics [MeSH], Carcinoma, Squamous Cell/pathology [MeSH], Phenotype [MeSH], Fibroblast growth factor receptor, Cell Line, 03 medical and health sciences, Epithelial-Mesenchymal Transition/genetics, Cell Line, Tumor, Squamous Cell Carcinoma of Head and Neck/drug therapy, Humans, RC254-282, ErbB Receptors/metabolism, 0303 health sciences, Tumor, Squamous Cell Carcinoma of Head and Neck, Receptor Protein-Tyrosine Kinases/genetics, Integrin beta1, Carcinoma, Antineoplastic Agents/therapeutic use, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Receptor Protein-Tyrosine Kinases, Head and Neck Neoplasms/drug therapy, 3. Good health, ErbB Receptors, Phenotype, Oncology, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Molecular Medicine

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38378518
https://doaj.org/article/ded1a485f83747baa803adfa3ea0b8c8
https://research.rug.nl/en/publications/f6b8bb0b-744d-4855-8200-f0540ffabd73
https://hdl.handle.net/11370/f6b8bb0b-744d-4855-8200-f0540ffabd73
https://doi.org/10.1186/s12943-024-01954-8
https://dspace.library.uu.nl/handle/1874/453825
https://repository.publisso.de/resource/frl:6523374

EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer

Autoren: Nadine T. Gaisa Edwin Herrmann Jochen Maurer et al.

Quelle: Oncogene
Oncogene : including Oncogene reviews 39(44), 6856-6870 (2020). doi:10.1038/s41388-020-01465-y

Schlagwörter: Male, Carcinoma, Transitional Cell, Receptor, ErbB-3, Receptor, ErbB-2, Drug Synergism, Gefitinib, Article, 3. Good health, Bladder cancer, Gene Expression Regulation, Neoplastic [MeSH], Urinary Bladder/pathology [MeSH], Cell Line, Tumor [MeSH], Aged [MeSH], Receptor, ErbB-2/metabolism [MeSH], Drug Synergism [MeSH], Urinary Bladder Neoplasms/drug therapy [MeSH], Cohort Studies [MeSH], Carcinoma, Transitional Cell/pathology [MeSH], ErbB Receptors/metabolism [MeSH], Carcinoma, Transitional Cell/genetics [MeSH], Male [MeSH], Carcinoma, Transitional Cell/drug therapy [MeSH], Receptor, ErbB-2/antagonists, Gefitinib/therapeutic use [MeSH], Signal Transduction/drug effects [MeSH], Urinary Bladder Neoplasms/genetics [MeSH], Receptor, ErbB-4/metabolism [MeSH], Carcinoma, Squamous Cell/pathology [MeSH], Female [MeSH], Drug Resistance, Neoplasm/drug effects [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], ErbB Receptors/antagonists, Humans [MeSH], Gene Knockdown Techniques [MeSH], ErbB Receptors/genetics [MeSH], Erlotinib Hydrochloride/therapeutic use [MeSH], Receptor, ErbB-3/metabolism [MeSH], Urinary Bladder Neoplasms/pathology [MeSH], Protein Kinase Inhibitors/therapeutic use [MeSH], Carcinoma, Squamous Cell/drug therapy [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Gefitinib/pharmacology [MeSH], Antineoplastic Combined Chemotherapy Protocols/pharmacology [MeSH], Receptor, ErbB-4/antagonists, Growth factor signalling, Carcinoma, Squamous Cell/genetics [MeSH], Receptor, ErbB-3/antagonists, RNA, Small Interfering/metabolism [MeSH], Erlotinib Hydrochloride/pharmacology [MeSH], Cohort Studies, ErbB Receptors, Gene Expression Regulation, Neoplastic, Erlotinib Hydrochloride, 03 medical and health sciences, 0302 clinical medicine, Drug Resistance, Neoplasm, Cell Line, Tumor, Gene Knockdown Techniques, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Humans, Female, RNA, Small Interfering, Protein Kinase Inhibitors, Aged

Zugangs-URL: https://www.nature.com/articles/s41388-020-01465-y.pdf
https://pubmed.ncbi.nlm.nih.gov/32978523
https://pubmed.ncbi.nlm.nih.gov/32978523/
https://www.nature.com/articles/s41388-020-01465-y
https://epub.uni-regensburg.de/49663/
https://www.nature.com/articles/s41388-020-01465-y.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095268
https://publications.rwth-aachen.de/record/812741
https://repository.publisso.de/resource/frl:6471340
https://publications.rwth-aachen.de/record/812741

Attenuation of the pro-inflammatory signature of lung cancer-derived mesenchymal stromal cells by statins

Autoren: Sabine Galland Patricia Martin Giulia Fregni et al.

Quelle: Cancer letters, vol. 484, pp. 50-64

Schlagwörter: Aged, 80 and over, Male, 0301 basic medicine, Simvastatin, 0303 health sciences, Lung Neoplasms, Interleukin-6, Gene Expression, Mesenchymal Stem Cells, Middle Aged, Aged, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/pathology, Cells, Cultured, Chemokine CCL2/genetics, Chemokine CCL2/metabolism, Chemokine CCL3/genetics, Chemokine CCL3/metabolism, Cytokines/genetics, Cytokines/metabolism, Female, Gene Expression/drug effects, Humans, Inflammation Mediators/metabolism, Interleukin-6/genetics, Interleukin-6/metabolism, Lung Neoplasms/genetics, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Mesenchymal Stem Cells/cytology, Mesenchymal Stem Cells/drug effects, Mesenchymal Stem Cells/metabolism, Simvastatin/pharmacology, Tumor Cells, Cultured, Tumor Microenvironment/drug effects, Tumor Microenvironment/genetics, CCL2, CCL3, Lung cancer, Mesenchymal stromal cells, 3. Good health, 03 medical and health sciences, Carcinoma, Squamous Cell, Tumor Microenvironment, Cytokines, Inflammation Mediators, Chemokine CCL2, Chemokine CCL3

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/32418888
https://www.sciencedirect.com/science/article/pii/S0304383520302330
https://www.sciencedirect.com/science/article/abs/pii/S0304383520302330
https://pubmed.ncbi.nlm.nih.gov/32418888/
https://www.ncbi.nlm.nih.gov/pubmed/32418888
https://serval.unil.ch/notice/serval:BIB_2044EA0B5E7B
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_2044EA0B5E7B5
https://serval.unil.ch/resource/serval:BIB_2044EA0B5E7B.P001/REF.pdf

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma

Autoren: Stefan Knapp Susanne Müller Anais Lucas et al.

Quelle: Oncogene

Schlagwörter: 0301 basic medicine, 0303 health sciences, Oncogene Proteins, Fusion, Sialoglycoproteins, Tumor Suppressor Proteins, Medizin, Nuclear Proteins, Antineoplastic Agents, Brief Communication, Heterocyclic Compounds, 4 or More Rings, Peptide Fragments, 3. Good health, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Drug Delivery Systems, Protein Domains, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Proto-Oncogene Proteins c-myc/metabolism [MeSH], Target identification, Cell Line, Tumor [MeSH], Tumor Suppressor Proteins/genetics [MeSH], Peptide Fragments/metabolism [MeSH], Transcription Factors/genetics [MeSH], Heterocyclic Compounds, 4 or More Rings/pharmacology [MeSH], Sialoglycoproteins/metabolism [MeSH], Protein Domains [MeSH], Antineoplastic Agents/pharmacology [MeSH], Peptide Fragments/antagonists, Tumor Suppressor Proteins/metabolism [MeSH], Nuclear Proteins/metabolism [MeSH], Carcinoma, Squamous Cell/pathology [MeSH], Targeted therapies, Transcription Factors/metabolism [MeSH], Antineoplastic Agents/chemistry [MeSH], Peptide Fragments/genetics [MeSH], Humans [MeSH], Drug Delivery Systems [MeSH], Sialoglycoproteins/genetics [MeSH], Oncogene Proteins, Fusion/genetics [MeSH], Heterocyclic Compounds, 4 or More Rings/chemistry [MeSH], Carcinoma, Squamous Cell/drug therapy [MeSH], Nuclear Proteins/genetics [MeSH], Proto-Oncogene Proteins c-myc/genetics [MeSH], Sialoglycoproteins/antagonists, Carcinoma, Squamous Cell/genetics [MeSH], Oncogene Proteins, Fusion/metabolism [MeSH], Carcinoma, Squamous Cell/metabolism [MeSH], Transcription Factors

Zugangs-URL: https://www.nature.com/articles/s41388-020-1301-9.pdf
https://pubmed.ncbi.nlm.nih.gov/32366905
https://pubmed.ncbi.nlm.nih.gov/32366905/
https://www.nature.com/articles/s41388-020-1301-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286816
https://europepmc.org/article/PMC/PMC7286816
https://www.nature.com/articles/s41388-020-1301-9.pdf
http://www.ncbi.nlm.nih.gov/pubmed/32366905
https://repository.publisso.de/resource/frl:6471366

Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

Autoren: Matthew Roberts Julia Ogden AS Mukarram Hossain et al.

Quelle: eLife
eLife, Vol 12 (2023)
Roberts, M, Ogden, J, Hossain, A S M, Chaturvedi, A, Kerr, A R W, Dive, C, Beane, J E & Lopez-Garcia, C 2023, 'Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE', eLife, vol. 12. https://doi.org/10.7554/eLife.77507

Schlagwörter: Lung Neoplasms, chromosomal instability, QH301-705.5, Science, Lung/pathology, transcriptomics, Carcinoma, Non-Small-Cell Lung/genetics, Precancerous Conditions/genetics, Carcinoma, Non-Small-Cell Lung, lung squamous cell carcinoma, Biomarkers, Tumor, Carcinoma, Squamous Cell/genetics, Lung Neoplasms/pathology, Humans, Biology (General), Squamous Cell/genetics, Lung, shiny app, Cancer Biology, Non-Small-Cell Lung/genetics, Neoplastic, Carcinoma, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Tumor/genetics, Carcinoma, Squamous Cell, Medicine, Biomarkers, Tumor/genetics, precancerous lesions, Precancerous Conditions, Biomarkers

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36892933
https://doaj.org/article/2b5e28916d8849bba8c6613fd630731c
https://research.manchester.ac.uk/en/publications/e53149e3-018f-40a7-9108-caa5650a2200
https://doi.org/10.7554/eLife.77507

Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

Autoren: Yilin Bao Jennis Gabrielpillai Jörn Dietrich et al.

Quelle: Clin Epigenetics

Schlagwörter: 0301 basic medicine, Research, Papillomavirus Infections, DNA Methylation/genetics [MeSH], Papillomavirus Infections/complications [MeSH], Head and neck squamous cell carcinoma (HNSCC), Fibroblast growth factor receptor (FGFR), Head and Neck Neoplasms/genetics [MeSH], Cyclin D1 (, Protein-Tyrosine Kinases/genetics [MeSH], Cohort Studies [MeSH], Statistics, Nonparametric [MeSH], Receptors, Fibroblast Growth Factor/genetics [MeSH], Cyclin D1/analysis [MeSH], Epigenetic Biomarkers, Head and Neck Neoplasms/physiopathology [MeSH], Tyrosine kinase inhibitor (TKI), DNA methylation, Carcinoma, Squamous Cell/physiopathology [MeSH], Head and Neck Neoplasms/epidemiology [MeSH], Fibroblast growth factor (FGF), Humans [MeSH], Papillomavirus Infections/epidemiology [MeSH], Predictive biomarker, Fibroblast Growth Factors/genetics [MeSH], Human papillomavirus (HPV), Carcinoma, Squamous Cell/epidemiology [MeSH], Cyclin D1/genetics [MeSH], Fibroblast Growth Factors/analysis [MeSH], Receptors, Fibroblast Growth Factor/drug effects [MeSH], Carcinoma, Squamous Cell/genetics [MeSH], Protein-Tyrosine Kinases/drug effects [MeSH], DNA Methylation, Protein-Tyrosine Kinases, Receptors, Fibroblast Growth Factor, Statistics, Nonparametric, 3. Good health, Cohort Studies, Fibroblast Growth Factors, 03 medical and health sciences, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Humans, Cyclin D1

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34933671
https://repository.publisso.de/resource/frl:6443344

Hereditary oral squamous cell carcinoma associated with CDKN2A germline mutation: A case report

Autoren: Jeong, Ah-Reum Forbes, Kimberly Orosco, Ryan K et al.

Quelle: J Otolaryngol Head Neck Surg
Journal of Otolaryngology-Head and Neck Surgery, Vol 51, Iss 1, Pp 1-9 (2022)
Journal of Otolaryngology, vol 51, iss 1

Schlagwörter: Adult, Skin Neoplasms, RD1-811, Oncology and Carcinogenesis, Clinical sciences, Oral squamous cell cancer, Case Report, 03 medical and health sciences, Rare Diseases, Cancer Genomics, 0302 clinical medicine, Clinical Research, CDKN2A germline mutation, Case report, Genetics, cancer, Humans, Head and neck squamous cell cancer, Genetic Testing, Dental/Oral and Craniofacial Disease, Cyclin-Dependent Kinase Inhibitor p16, Germ-Line Mutation, Cancer, Female [MeSH], Mutation [MeSH], Adult [MeSH], Skin Neoplasms [MeSH], Humans [MeSH], Cyclin-Dependent Kinase Inhibitor p16/genetics [MeSH], Squamous Cell Carcinoma of Head and Neck [MeSH], Germ-Line Mutation [MeSH], Head and Neck Neoplasms [MeSH], Mouth Neoplasms/diagnosis [MeSH], Carcinoma, Squamous Cell/genetics [MeSH], Neoplasm Recurrence, Local [MeSH], Familial atypical multiple moles melanoma, Mouth Neoplasms/genetics [MeSH], Biomedical and Clinical Sciences, Squamous Cell Carcinoma of Head and Neck, Prevention, Human Genome, Carcinoma, Health Services, 3. Good health, Orphan Drug, Good Health and Well Being, Neoplasm Recurrence, Squamous Cell, Local, Otorhinolaryngology, Head and Neck Neoplasms, Mutation, Carcinoma, Squamous Cell, Surgery, Female, Mouth Neoplasms, Neoplasm Recurrence, Local, Digestive Diseases, Head and neck squamous cell

Dateibeschreibung: application/pdf

Zugangs-URL: https://journalotohns.biomedcentral.com/track/pdf/10.1186/s40463-022-00556-y
https://pubmed.ncbi.nlm.nih.gov/35123577
https://doaj.org/article/f47f5889d62b4fcc8c2f4155a4e321ba
https://repository.publisso.de/resource/frl:6475822
https://escholarship.org/uc/item/3kv726ng
https://escholarship.org/content/qt3kv726ng/qt3kv726ng.pdf

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B

Autoren: Massimo Bongiovanni Dania Al Labban Renato G. Panizzon et al.

Quelle: The Journal of clinical investigation, vol. 128, no. 6, pp. 2581-2599
Journal of Clinical Investigation

Schlagwörter: Keratinocytes, 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, 0303 health sciences, Receptors, Notch, Mice, SCID, Neoplasms, Experimental, Neoplasm Proteins, 3. Good health, Mice, 03 medical and health sciences, Mice, Inbred NOD, Cell Line, Tumor, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Biomarkers, Tumor, Carcinoma, Squamous Cell, Animals, Humans, Biomarkers, Tumor/genetics, Biomarkers, Tumor/metabolism, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/pathology, Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics, Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism, Jumonji Domain-Containing Histone Demethylases/genetics, Jumonji Domain-Containing Histone Demethylases/metabolism, Keratinocytes/metabolism, Keratinocytes/pathology, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Neoplasms, Experimental/genetics, Neoplasms, Experimental/metabolism, Neoplasms, Experimental/pathology, Receptors, Notch/genetics, Receptors, Notch/metabolism, Signal Transduction, Cell Biology, Head & neck cancer, Lung cancer, Oncology, Skin cancer

Dateibeschreibung: application/pdf

Zugangs-URL: http://www.jci.org/articles/view/96915/files/pdf
https://pubmed.ncbi.nlm.nih.gov/29757189
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983322
http://www.jci.org/articles/view/96915/files/pdf
https://www.ncbi.nlm.nih.gov/pubmed/29757189
https://5320000.net.insight.mobile.jci.org/articles/view/96915
https://serval.unil.ch/resource/serval:BIB_64DFBBAE75C2.P001/REF.pdf
https://pubmed.ncbi.nlm.nih.gov/29757189/
https://serval.unil.ch/notice/serval:BIB_64DFBBAE75C2
https://serval.unil.ch/resource/serval:BIB_64DFBBAE75C2.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_64DFBBAE75C27

The Immune Heterogeneity Between Pulmonary Adenocarcinoma and Squamous Cell Carcinoma: A Comprehensive Analysis Based on lncRNA Model

Autoren: Tao Yan Guoyuan Ma Kai Wang et al.

Quelle: Front Immunol
Frontiers in Immunology, Vol 12 (2021)
Frontiers in immunology, 12:547333

Schlagwörter: squamous cell carcinoma, Risk, 0301 basic medicine, Lung Neoplasms, T-Lymphocytes, Immunology, Adenocarcinoma, Cohort Studies, long non-coding RNAs, 03 medical and health sciences, Tumor Microenvironment, Humans, Molecular Targeted Therapy, Carcinoma, Squamous Cell/mortality [MeSH], Models, Immunological [MeSH], Lung Neoplasms/genetics [MeSH], immune, RNA, Long Noncoding/genetics [MeSH], Risk [MeSH], Cohort Studies [MeSH], Adenocarcinoma/immunology [MeSH], Lung Neoplasms/immunology [MeSH], Carcinoma, Squamous Cell/immunology [MeSH], Cellular Senescence/genetics [MeSH], Immunity/genetics [MeSH], A549 Cells [MeSH], Lung Neoplasms/mortality [MeSH], RNA, Long Noncoding/immunology [MeSH], T-Lymphocytes/immunology [MeSH], Humans [MeSH], Survival Analysis [MeSH], Molecular Targeted Therapy [MeSH], adenocarcinoma, Adenocarcinoma/genetics [MeSH], non-small cell lung cancer, Carcinoma, Squamous Cell/genetics [MeSH], Adenocarcinoma/mortality [MeSH], Tumor Microenvironment [MeSH], Cellular Senescence, 0303 health sciences, Immunity, Models, Immunological, RC581-607, Survival Analysis, 3. Good health, A549 Cells, Carcinoma, Squamous Cell, RNA, Long Noncoding, Immunologic diseases. Allergy

Zugangs-URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.547333/pdf
https://pubmed.ncbi.nlm.nih.gov/34394068
https://doaj.org/article/c9c81c4d3af64cec8d37e9daa0eec5b2
https://www.frontiersin.org/articles/10.3389/fimmu.2021.547333/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358782/
https://pubmed.ncbi.nlm.nih.gov/34394068/
https://repository.publisso.de/resource/frl:6478835

PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation

Autoren: Jo, Seung-Hee Kim, Dong Eun Dotto, G. Paolo et al.

Quelle: Oncotarget
Oncotarget, vol. 7, no. 37, pp. 58717-58727

Schlagwörter: 0301 basic medicine, Skin Neoplasms, Transcription, Genetic, Down-Regulation, Mice, SCID, squamous cancer, Mice, 03 medical and health sciences, Animals, Apoptosis Regulatory Proteins/genetics, Apoptosis Regulatory Proteins/metabolism, Cancer-Associated Fibroblasts/immunology, Cancer-Associated Fibroblasts/metabolism, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/metabolism, Cell Line, Tumor, Cellular Senescence, HEK293 Cells, HeLa Cells, Humans, Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism, Keratosis, Actinic/genetics, Keratosis, Actinic/metabolism, Protein Binding, RNA, Small Interfering/genetics, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism, Signal Transduction, Skin Neoplasms/genetics, Skin Neoplasms/metabolism, Xenograft Model Antitumor Assays, CAFs, Notch/CSL signaling, PDCD4, transcription repression, Cancer-Associated Fibroblasts, RNA, Small Interfering, 0303 health sciences, RNA-Binding Proteins, 3. Good health, Keratosis, Actinic, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Carcinoma, Squamous Cell, Apoptosis Regulatory Proteins, Priority Research Paper

Dateibeschreibung: application/pdf

Zugangs-URL: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11227&path%5B%5D=35538
https://pubmed.ncbi.nlm.nih.gov/27542230
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=11227&path%5B%5D=35539
https://serval.unil.ch/resource/serval:BIB_7C3981655C04.P001/REF.pdf
https://dash.harvard.edu/handle/1/32072034
https://khepri-node.dev.meta-infra.org/papers/pdcd4-is-a-csl-associated-protein-with-a/27542230
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312270
https://serval.unil.ch/en/notice/serval:BIB_7C3981655C04
https://serval.unil.ch/resource/serval:BIB_7C3981655C04.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_7C3981655C044
https://serval.unil.ch/notice/serval:BIB_7C3981655C04

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

Autoren: Mamunur Rashid Marc J Williams Inês Sequeira et al.

Weitere Verfasser: Mamunur Rashid Marc J Williams Inês Sequeira et al.

Quelle: Nat Commun
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Sequeira, I, Rashid, M, Tomás, I M, Williams, M J, Graham, T A, Adams, D J, Vigilante, A & Watt, F M 2020, ' Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology ', Nature Communications, vol. 11, no. 1, 5671 . https://doi.org/10.1038/s41467-020-19401-9

Schlagwörter: p53, Exome/genetics, 0301 basic medicine, Carcinogenesis, Inbred C57BL, Mice, Exome, p53/genetics, Receptor, Notch1, 0303 health sciences, Genomics, Cadherins, 4-Nitroquinoline-1-oxide, Gene Expression Regulation, Neoplastic, Carcinoma, Squamous Cell, Disease Progression, Mouth Neoplasms/genetics, Mouth Neoplasms, Receptor, Carcinogenesis/chemically induced, Science, Article, 03 medical and health sciences, Carcinoma, Squamous Cell/genetics, Animals, Neoplasm Invasiveness, Squamous Cell/genetics, Notch1, Neoplastic, Receptor, Notch1/genetics, Animal, Cadherins/genetics, Carcinoma, Genes, p53, Notch1/genetics, Mice, Inbred C57BL, Genes, p53/genetics, Disease Models, Animal, Squamous Cell, Gene Expression Regulation, Genes, 4-Nitroquinoline-1-oxide/adverse effects, Disease Models, Mutation, Neoplasm, Genes, Neoplasm

Dateibeschreibung: application/pdf; Electronic

Zugangs-URL: https://www.nature.com/articles/s41467-020-19401-9.pdf
https://pubmed.ncbi.nlm.nih.gov/33168804
https://doaj.org/article/13283850aaeb488c9ff3f4816f9ef00d
https://qmro.qmul.ac.uk/xmlui/handle/123456789/68823
http://ui.adsabs.harvard.edu/abs/2020NatCo..11.5671S/abstract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652942
https://www.nature.com/articles/s41467-020-19401-9
https://pubmed.ncbi.nlm.nih.gov/33168804/
https://www.ncbi.nlm.nih.gov/pubmed/33168804
https://kclpure.kcl.ac.uk/en/publications/634e6354-5651-4d7c-9bea-1677e534f8b3
https://kclpure.kcl.ac.uk/portal/en/publications/634e6354-5651-4d7c-9bea-1677e534f8b3

Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer

Autoren: Winther, Mette Alsner, Jan Tramm, Trine et al.

Quelle: Winther, M, Alsner, J, Tramm, T, Holtved, E, Baeksgaard, L & Nordsmark, M 2016, ' Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer ', Acta Oncologica, vol. 55, no. 5, pp. 652-655 . https://doi.org/10.3109/0284186X.2015.1114680
Winther, M, Alsner, J, Tramm, T, Holtved, E, Baeksgaard, L & Nordsmark, M 2016, 'Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer', Acta Oncologica, vol. 55, no. 5, pp. 652-5. https://doi.org/10.3109/0284186X.2015.1114680

Schlagwörter: Adult, Male, 0301 basic medicine, Esophageal Neoplasms, Biopsy, Stomach Neoplasms/genetics, Adenocarcinoma, Esophageal Neoplasms/genetics, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Stomach Neoplasms, Hypoxia/metabolism, 80 and over, Adenocarcinoma/genetics, Carcinoma, Squamous Cell/genetics, Humans, Squamous Cell/genetics, Hypoxia, Aged, Aged, 80 and over, Neoplastic, Gene Expression Profiling, Carcinoma, Middle Aged, Prognosis, 3. Good health, Gene Expression Regulation, Neoplastic, Survival Rate, Gene Expression Regulation, Carcinoma, Squamous Cell, Female, Follow-Up Studies

Zugangs-URL: https://www.tandfonline.com/doi/pdf/10.3109/0284186X.2015.1114680?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/26623712
https://www.tandfonline.com/doi/full/10.3109/0284186X.2015.1114680
https://www.ncbi.nlm.nih.gov/pubmed/26623712
https://portal.findresearcher.sdu.dk/da/publications/732be34b-cd56-4c45-9b78-c58db1080a35
https://portal.findresearcher.sdu.dk/da/publications/732be34b-cd56-4c45-9b78-c58db1080a35
https://doi.org/10.3109/0284186X.2015.1114680
https://pure.au.dk/portal/en/publications/c832eb0f-96a3-4d1b-a3de-4c12f48882c8
http://www.scopus.com/inward/record.url?scp=84948738024&partnerID=8YFLogxK
https://doi.org/10.3109/0284186X.2015.1114680

Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma

Autoren: Jun Jing Qiao Fang Fang Li Yan Ru Qin et al.

Weitere Verfasser: Jun Jing Qiao Fang Fang Li Yan Ru Qin et al.

Quelle: Cancer Research. 74:840-851

Schlagwörter: 0301 basic medicine, Adenosine, Esophageal Neoplasms, Adenosine Deaminase, Esophageal Neoplasms - genetics - metabolism - mortality, Gene Expression, Cohort Studies, 03 medical and health sciences, Cell Line, Tumor, Adenosine Deaminase - genetics - metabolism, Humans, Squamous Cell - genetics - metabolism - mortality, Oncogene Proteins, 0303 health sciences, Carcinoma, RNA-Binding Proteins, Inosine, 3. Good health, Gene Expression Regulation, Neoplastic, Carcinoma, Squamous Cell - genetics - metabolism - mortality, Carcinoma, Squamous Cell, Disease Progression, Esophageal Squamous Cell Carcinoma, RNA Editing, Carrier Proteins

Zugangs-URL: https://cancerres.aacrjournals.org/content/canres/74/3/840.full.pdf
https://pubmed.ncbi.nlm.nih.gov/24302582
https://cancerres.aacrjournals.org/content/canres/74/3/840.full.pdf
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-5472.CAN-13-2545
http://hub.hku.hk/handle/10722/198471
https://cancerres.aacrjournals.org/content/74/3/840
https://mdanderson.influuent.utsystem.edu/en/publications/adenosine-to-inosine-rna-editing-mediated-by-adars-in-esophageal-
https://pubmed.ncbi.nlm.nih.gov/24302582/
http://hdl.handle.net/10722/198471

Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization

Autoren: Sun, L Fong, Y Sham, JST et al.

Quelle: Genes, Chromosomes and Cancer. 30:254-260

Schlagwörter: Adult, Male, Squamous Cell - genetics, Chromosome Disorders, 03 medical and health sciences, 0302 clinical medicine, Neoplasm - analysis, Humans, genetics, Biology, Nucleic Acid Hybridization - methods, Aged, Nasopharyngeal Neoplasms - genetics, Chromosome Aberrations, Carcinoma, Nucleic Acid Hybridization, Nasopharyngeal Neoplasms, DNA, DNA, Neoplasm, Middle Aged, DNA, Neoplasm - analysis, 3. Good health, Carcinoma, Squamous Cell, Chromosome Aberrations - genetics, Carcinoma, Squamous Cell - genetics, Female, Chromosome Deletion

Dateibeschreibung: 1048742 bytes; 257990 bytes; application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/11170282
https://onlinelibrary.wiley.com/doi/10.1002/1098-2264%282000%299999%3A9999%3C%3A%3AAID-GCC1086%3E3.0.CO%3B2-D
http://hub.hku.hk/handle/10722/44634
https://mdanderson.elsevierpure.com/en/publications/analysis-of-genetic-alterations-in-primary-nasopharyngeal-carcino
https://pubmed.ncbi.nlm.nih.gov/11170282/
https://jhu.pure.elsevier.com/en/publications/analysis-of-genetic-alterations-in-primary-nasopharyngeal-carcino-5
https://www.ncbi.nlm.nih.gov/pubmed/11170282
http://hdl.handle.net/10722/57224
http://hdl.handle.net/10722/44634
http://hdl.handle.net/10722/71940

Establishment and Characterization of HKESC-1, a New Cancer Cell Line from Human Esophageal Squamous Cell Carcinoma

Autoren: Hu, YC Lam, KY Wan, TSK et al.

Quelle: Cancer Genetics and Cytogenetics. 118:112-120

Schlagwörter: Male, 0301 basic medicine, Esophageal Neoplasms, Nude, Transplantation, Heterologous, Mice, Nude, Squamous Cell - genetics - pathology, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Neoplasm - analysis, Animals, Humans, Telomerase, Carcinoma, Squamous Cell - genetics - pathology, Chromosome Aberrations, Transplantation, Heterologous, Carcinoma, Oncology and carcinogenesis, DNA, DNA, Neoplasm, Middle Aged, Flow Cytometry, DNA, Neoplasm - analysis, 3. Good health, Esophageal Neoplasms - genetics - pathology, Karyotyping, Carcinoma, Squamous Cell, Telomerase - analysis, Neoplasm Transplantation

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/10748291
http://hub.hku.hk/handle/10722/88321
https://research-repository.griffith.edu.au/handle/10072/58000
https://pubmed.ncbi.nlm.nih.gov/10748291/
https://www.sciencedirect.com/science/article/pii/S0165460899001934
http://www.sciencedirect.com/science/article/pii/S0165460899001934
https://www.ncbi.nlm.nih.gov/pubmed/10748291
http://hdl.handle.net/10722/88321
http://hdl.handle.net/10722/104857

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Autoren: Jin Hee Kim Takashi Kohno In-Jae Oh et al.

Weitere Verfasser: Jin Hee Kim Takashi Kohno In-Jae Oh et al.

Quelle: Nature Genetics. 44:1330-1335

Schlagwörter: Adenocarcinoma - Genetics, Adult, Lung Neoplasms, Adenocarcinoma of Lung, Lung Neoplasms - Genetics, Adenocarcinoma, Squamous Cell - Genetics, Polymorphism, Single Nucleotide, Chromosomes, Asian Continental Ancestry Group - Genetics, Pair 15 - Genetics, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Asian People, Pair 10 - Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Aged, Chromosomes, Human, Pair 15, Pair 6 - Genetics, Chromosomes, Human, Pair 5 - Genetics, Chromosomes, Human, Pair 10, Pair 17, Carcinoma, Smoking, Single Nucleotide, Middle Aged, Genetic Predisposition To Disease, 3. Good health, Pair 5 - Genetics, Chromosomes, Human, Pair 15 - Genetics, Genetic Loci, Chromosomes, Human, Pair 10 - Genetics, Carcinoma, Squamous Cell, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 6, Female, Chromosomes, Human, Pair 6 - Genetics, Human, Carcinoma, Squamous Cell - Genetics, Chromosomes, Human, Pair 17, Genome-Wide Association Study

Zugangs-URL: https://europepmc.org/articles/pmc4169232?pdf=render
https://pubmed.ncbi.nlm.nih.gov/23143601
https://research-portal.uu.nl/en/publications/261d8eaf-ec28-4c39-9146-10944c20a422
https://doi.org/10.1038/ng.2456
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23143601/
https://pubmed.ncbi.nlm.nih.gov/23143601/
http://europepmc.org/abstract/MED/23143601
https://tmu.pure.elsevier.com/en/publications/genome-wide-association-analysis-identifies-new-lung-cancer-susce
http://hub.hku.hk/handle/10722/184313
https://www.nature.com/articles/ng.2456
http://hdl.handle.net/10722/184313