Suchergebnisse - "Carbonic Anhydrase Inhibitors"

Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death.

Autoren: Renzi G McDonald PC Awrey S et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118107. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Phospholipid Hydroperoxide Glutathione Peroxidase*/antagonists & inhibitors , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Carbonic Anhydrase IX*/antagonists & inhibitors , Carbonic Anhydrase IX*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis, Humans ; Animals ; Mice ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Female ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Cell Death/drug effects ; Mice, Nude

New Se-Compounds With Antileishmanial, Antitumor, and Carbonic Anhydrase Inhibitory Properties.

Autoren: Morán-Serradilla C Plano D Angelli A et al.

Quelle: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Dec; Vol. 358 (12), pp. e70145.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemical synthesis , Antiprotozoal Agents*/chemistry , Leishmania major*/drug effects , Organoselenium Compounds*/pharmacology , Organoselenium Compounds*/chemical synthesis , Organoselenium Compounds*/chemistry, Humans ; Structure-Activity Relationship ; Carbonic Anhydrases/metabolism ; Leishmania infantum/drug effects ; Molecular Structure ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Parasitic Sensitivity Tests ; Inhibitory Concentration 50

Synthesis, carbonic anhydrase inhibition and in silico insights of 4-formyl-2-nitrophenyl naphthalene-2-sulfonate hybrid thiosemicarbazones.

Autoren: Abbas K Islam M Tayyab M et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109243. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/pharmacology , Thiosemicarbazones*/chemical synthesis , Carbonic Anhydrase I*/metabolism , Carbonic Anhydrase I*/antagonists & inhibitors , Naphthalenes*/chemistry , Naphthalenes*/pharmacology , Naphthalenes*/chemical synthesis , Carbonic Anhydrase II*/metabolism , Carbonic Anhydrase II*/antagonists & inhibitors, Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Dose-Response Relationship, Drug

Computational and experimental investigations of novel 1,3-disubstituted thioureas as the dual inhibitor of b-TNAP and b-CAII enzyme for Cancer treatment.

Autoren: Bibi M Ejaz SA Saeed A et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109199. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Thiourea*/pharmacology , Thiourea*/chemistry , Thiourea*/chemical synthesis , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Carbonic Anhydrase II*/antagonists & inhibitors , Carbonic Anhydrase II*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects

Harnessing coumarin-thio(seleno)cyanate conjugates: potent In vivo antiproliferative agents targeting carbonic anhydrases.

Autoren: Meza-Ireta SA Romero-Hernández LL Begines P et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2578183. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrases*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Coumarins*/chemistry , Coumarins*/pharmacology , Coumarins*/chemical synthesis , Cyanates*/chemistry , Cyanates*/pharmacology , Cyanates*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Animals ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Caenorhabditis elegans/drug effects

Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors.

Autoren: Muayad J Alryalat SA Al Deyabat O et al.

Quelle: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society [J Neuroophthalmol] 2025 Dec 01; Vol. 45 (4), pp. 420-425. Date of Electronic Publication: 2024 Dec 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9431308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-5166 (Electronic) Linking ISSN: 10708022 NLM ISO Abbreviation: J Neuroophthalmol Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/adverse effects , Carbonic Anhydrase Inhibitors*/therapeutic use , Kidney Calculi*/epidemiology , Kidney Calculi*/chemically induced , Pseudotumor Cerebri*/drug therapy , Pseudotumor Cerebri*/complications, Humans ; Male ; Female ; Retrospective Studies ; Adult ; Middle Aged ; Incidence ; Risk Factors ; Risk Assessment/methods ; Acetazolamide/adverse effects ; Acetazolamide/therapeutic use ; Follow-Up Studies ; Young Adult ; Propensity Score

Hidden targets in dermatology: In vitro and In silico inhibitory effects of common 23 dermatologic drugs on human carbonic anhydrase isoenzymes I and II.

Autoren: Can İ Çıkrıkcı K Gençer N et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2540935. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase I*/antagonists & inhibitors , Carbonic Anhydrase I*/metabolism , Carbonic Anhydrase II*/antagonists & inhibitors , Carbonic Anhydrase II*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Computer Simulation

Exploration of New Pyrazole-Hydrazone-Benzenesulfonamide Conjugates as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation.

Autoren: Kumar P Singampalli A Bandela R et al.

Quelle: ChemMedChem [ChemMedChem] 2025 Nov 28; Vol. 20 (23), pp. e202500633. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry , Mycobacterium tuberculosis*/enzymology , Mycobacterium tuberculosis*/drug effects , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Sulfonamides*/chemistry , Sulfonamides*/pharmacology , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry , Drug Design* , Carbonic Anhydrases*/metabolism , Hydrazones*/chemistry , Hydrazones*/pharmacology, Microbial Sensitivity Tests ; Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug

Carbonic Anhydrase Targeting Polymer with Enhanced Intracellular Protein Delivery and Tumor Penetration for Cancer Therapy.

Autoren: Li Y Feng J Wang H et al.

Quelle: Nano letters [Nano Lett] 2025 Nov 26; Vol. 25 (47), pp. 16747-16756. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE

MeSH-Schlagworte: Polymers*/chemistry , Melanoma, Experimental*/drug therapy , Melanoma, Experimental*/pathology , Carbonic Anhydrase IX*/antagonists & inhibitors , Carbonic Anhydrase IX*/metabolism , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/administration & dosage , Carbonic Anhydrase Inhibitors*/pharmacology, Animals ; Mice ; Humans ; Tumor Microenvironment/drug effects ; Cell Line, Tumor ; Drug Delivery Systems ; Sulfonamides/chemistry ; Mice, Inbred C57BL

Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore.

Autoren: Pala N Ladu F Szlasa W et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118043. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Carbonic Anhydrase IX*/antagonists & inhibitors , Carbonic Anhydrase IX*/metabolism , Drug Design* , Antigens, Neoplasm*/metabolism, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Molecular Structure ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Crystallography, X-Ray ; Pharmacophore

Design, synthesis, radiolabeling, and mechanistic insights of hydrazinyl imidazolones as broad spectrum antitumor agents with potential carbonic anhydrase inhibition: In vitro, in vivo, and in silico studies.

Autoren: Husseiny EM Sarg MT Sheta YS et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118049. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry , Drug Design* , Imidazoles*/pharmacology , Imidazoles*/chemistry , Imidazoles*/chemical synthesis , Carbonic Anhydrases*/metabolism , Hydrazines*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis, Humans ; Animals ; Structure-Activity Relationship ; Mice ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Molecular Docking Simulation ; Apoptosis/drug effects ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology

Intracellular Binding of Novel Fluorinated Compounds to Carbonic Anhydrase Isoforms Explored by In-Cell ¹⁹ F NMR.

Autoren: Costantino A Barbieri L Giovannuzzi S et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23363-23374. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/metabolism , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrases*/metabolism , Carbonic Anhydrases*/chemistry , Sulfonamides*/chemistry , Sulfonamides*/metabolism , Sulfonamides*/pharmacology , Sulfonamides*/chemical synthesis, Humans ; Halogenation ; Isoenzymes/metabolism ; Structure-Activity Relationship ; Fluorine ; Magnetic Resonance Spectroscopy ; Fluorine-19 Magnetic Resonance Imaging ; Ligands

Discovery of First-in-Class Carbonic Anhydrase/Histone Deacetylase Dual Inhibitors with Antiproliferative Activity in Cancer Cells.

Autoren: Bozdag M Mroweh N Raucci A et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 22874-22895. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Carbonic Anhydrases*/metabolism , Carbonic Anhydrases*/chemistry, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Histone Deacetylases/metabolism ; Histone Deacetylases/chemistry ; Cell Line, Tumor ; Models, Molecular ; Drug Screening Assays, Antitumor ; Crystallography, X-Ray ; Drug Discovery

Retrospective Assessment of Carbonic Anhydrase Inhibitors in Topical or Episcleral Implant Form for the Treatment of Equine Glaucoma.

Autoren: Tucker-Retter EK Yamagata M Gilger B et al.

Quelle: Veterinary ophthalmology [Vet Ophthalmol] 2025 Nov; Vol. 28 (6), pp. 977-982. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Science Country of Publication: England NLM ID: 100887377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-5224 (Electronic) Linking ISSN: 14635216 NLM ISO Abbreviation: Vet Ophthalmol Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/administration & dosage , Carbonic Anhydrase Inhibitors*/therapeutic use , Horse Diseases*/drug therapy , Glaucoma*/veterinary , Glaucoma*/drug therapy , Sulfonamides*/administration & dosage , Sulfonamides*/therapeutic use , Thiazines*/administration & dosage , Thiazines*/therapeutic use, Animals ; Horses ; Retrospective Studies ; Female ; Male ; Intraocular Pressure/drug effects ; Drug Implants ; Administration, Topical

Coumarin-Containing Aromatic Sulfonamides With Carbonic Anhydrase Inhibitory Properties Against Human and Fungal Isoforms.

Autoren: Angeli A Petrou A Kartsev V et al.

Quelle: Chemical biology & drug design [Chem Biol Drug Des] 2025 Nov; Vol. 106 (5), pp. e70188.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/metabolism , Carbonic Anhydrases*/metabolism , Carbonic Anhydrases*/chemistry , Coumarins*/chemistry , Coumarins*/pharmacology , Sulfonamides*/chemistry , Sulfonamides*/pharmacology , Sulfonamides*/metabolism, Humans ; Carbonic Anhydrase I/metabolism ; Carbonic Anhydrase I/antagonists & inhibitors ; Carbonic Anhydrase II/metabolism ; Carbonic Anhydrase II/antagonists & inhibitors ; Catalytic Domain ; Isoenzymes/metabolism ; Isoenzymes/antagonists & inhibitors ; Malassezia/enzymology ; Malassezia/drug effects ; Molecular Docking Simulation ; Structure-Activity Relationship ; Fungal Proteins/chemistry

Identification of isatin-triazole-benzenesulfonamide hybrids as dual hCA IX/XII and c-met inhibitors with hypoxia-mediated chemo-sensitizing activity.

Autoren: Eldehna WM Elnagar MR Giovannuzzi S et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109071. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Proto-Oncogene Proteins c-met*/antagonists & inhibitors , Proto-Oncogene Proteins c-met*/metabolism , Isatin*/chemistry , Isatin*/pharmacology , Triazoles*/chemistry , Triazoles*/pharmacology , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Sulfonamides*/chemistry , Sulfonamides*/pharmacology , Carbonic Anhydrases*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; Carbonic Anhydrase IX/antagonists & inhibitors ; Carbonic Anhydrase IX/metabolism ; Structure-Activity Relationship ; Antigens, Neoplasm/metabolism ; Molecular Structure ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Benzenesulfonamides ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Hypoxia/drug effects

Innovative design and synthesis of dual-acting hCA IX/CDK-2 inhibitors through hetero ring fused pyrimidine utilization for cutting-edge anticancer therapy: Zein nanoparticles for in vivo lung cancer treatment.

Autoren: Abosalim HM El-Moselhy TF Sharafeldin N et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109057. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Zein*/chemistry , Zein*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Nanoparticles*/chemistry , Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Drug Design* , Carbonic Anhydrase IX*/antagonists & inhibitors , Carbonic Anhydrase IX*/metabolism , Cyclin-Dependent Kinase 2*/antagonists & inhibitors , Cyclin-Dependent Kinase 2*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry, Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Molecular Structure ; Animals ; Dose-Response Relationship, Drug ; Mice ; Apoptosis/drug effects ; A549 Cells ; Particle Size ; Antigens, Neoplasm

Comprehensive Elucidation of the Biochemical Activity and Phytochemical Content of an Uninvestigated Valuable Species: Anthemis tricornis Eig.

Autoren: Yilmaz MA Hasan A Cakir O

Quelle: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e00890. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH-Schlagworte: Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Antioxidants*/chemistry , Antioxidants*/pharmacology , Antioxidants*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Cholinesterase Inhibitors*/chemistry , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/isolation & purification , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/isolation & purification, Acetylcholinesterase/metabolism ; Tandem Mass Spectrometry ; alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Flavonoids/isolation & purification ; Carbonic Anhydrase II/metabolism ; Carbonic Anhydrase II/antagonists & inhibitors ; Humans ; Chromatography, Liquid ; Phenols/chemistry ; Phenols/isolation & purification ; Phenols/pharmacology ; Biphenyl Compounds/antagonists & inhibitors ; Picrates/antagonists & inhibitors

Discovery of novel thiourea benzenesulfonamides based 1,8-naphthalimide derivatives as carbonic anhydrase IX inhibitors that induce ferroptosis and inhibit triple-negative breast cancer metastasis.

Autoren: Liu J Wang Y Liang S et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118304. Date of Electronic Publication: 2025 Jul 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Carbonic Anhydrase IX*/antagonists & inhibitors , Carbonic Anhydrase IX*/metabolism , Naphthalimides*/chemistry , Naphthalimides*/pharmacology , Naphthalimides*/chemical synthesis , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Ferroptosis*/drug effects , Sulfonamides*/chemistry , Sulfonamides*/pharmacology , Sulfonamides*/chemical synthesis , Drug Discovery* , Thiourea*/chemistry , Thiourea*/pharmacology, Humans ; Animals ; Female ; Structure-Activity Relationship ; Mice ; Molecular Structure ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Molecular Docking Simulation ; Antigens, Neoplasm/metabolism ; Cell Movement/drug effects ; Mice, Nude ; Apoptosis/drug effects ; Neoplasm Metastasis

Synthesis of 6-ethoxyphenyl 4-fluorobenzenesulfonate-tagged thiosemicarbazones as carbonic anhydrase inhibitors: In-vitro and in silico approach.

Autoren: Munir I Aftab H Farooq AA et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118301. Date of Electronic Publication: 2025 Jul 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/chemical synthesis , Thiosemicarbazones*/pharmacology , Carbonic Anhydrase I*/metabolism , Carbonic Anhydrase I*/antagonists & inhibitors , Carbonic Anhydrase II*/metabolism , Carbonic Anhydrase II*/antagonists & inhibitors, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Molecular Dynamics Simulation ; Dose-Response Relationship, Drug ; Carbonic Anhydrases/metabolism