Suchergebnisse - "Carbamates"

Microsynthesis, mass spectrometry data and acetylcholinesterase inhibition studies of carbamates related to the OPCW 1.A.16 Scheduled Chemicals.

Autoren: Voris DGR Jesus-Silva MC Carvalho-Silva T et al.

Quelle: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111698. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

MeSH-Schlagworte: Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/chemistry , Cholinesterase Inhibitors*/pharmacology , Carbamates*/chemical synthesis , Carbamates*/chemistry , Carbamates*/pharmacology , Acetylcholinesterase*/metabolism , Acetylcholinesterase*/chemistry , Chemical Warfare Agents*/chemistry , Chemical Warfare Agents*/chemical synthesis, Tandem Mass Spectrometry ; Humans ; Spectrometry, Mass, Electrospray Ionization

LC-MS/MS-based investigation of pharmacokinetic interactions between CYP3A4 substrates enzalutamide and repaglinide in rats.

Autoren: Navitha Reddy G Kumar Palepu MS Sonti R

Quelle: Analytical methods : advancing methods and applications [Anal Methods] 2025 Dec 04; Vol. 17 (47), pp. 9565-9574. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: RSC Pub Country of Publication: England NLM ID: 101519733 Publication Model: Electronic Cited Medium: Internet ISSN: 1759-9679 (Electronic) Linking ISSN: 17599660 NLM ISO Abbreviation: Anal Methods Subsets: MEDLINE

MeSH-Schlagworte: Phenylthiohydantoin*/pharmacokinetics , Phenylthiohydantoin*/analogs & derivatives , Phenylthiohydantoin*/blood , Tandem Mass Spectrometry*/methods , Carbamates*/pharmacokinetics , Carbamates*/blood , Piperidines*/pharmacokinetics , Piperidines*/blood , Cytochrome P-450 CYP3A*/metabolism, Animals ; Nitriles ; Benzamides ; Male ; Rats ; Drug Interactions ; Chromatography, Liquid/methods ; Rats, Sprague-Dawley ; Cytochrome P-450 CYP3A Inducers/pharmacokinetics ; Liquid Chromatography-Mass Spectrometry

Discovery of benzyl carbamate inhibitors of coronavirus M ^pro enzymes from a legacy collection of cysteine protease inhibitors.

Autoren: Sá Magalhães Serafim M Kronenberger T Francisco KR et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2585619. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Cysteine Proteinase Inhibitors*/pharmacology , Cysteine Proteinase Inhibitors*/chemistry , Cysteine Proteinase Inhibitors*/chemical synthesis , Carbamates*/chemistry , Carbamates*/pharmacology , Carbamates*/chemical synthesis , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , SARS-CoV-2*/enzymology , SARS-CoV-2*/drug effects , Drug Discovery* , Coronavirus 3C Proteases*/antagonists & inhibitors , Coronavirus 3C Proteases*/metabolism, Humans ; Structure-Activity Relationship ; Cathepsin L/antagonists & inhibitors ; Cathepsin L/metabolism ; Dose-Response Relationship, Drug ; Molecular Structure ; Molecular Docking Simulation

Cenobamate in pediatric epilepsy and developmental and epileptic encephalopathies: Efficacy, safety, and syndrome-specific considerations.

Autoren: Samanta D; Division of Child Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, 1 Children's Way, Little Rock, AR, 72202, USA. Electronic address: dsamanta@uams.edu.

Quelle: Epilepsy & behavior : E&B [Epilepsy Behav] 2025 Dec; Vol. 173, pp. 110787. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE

MeSH-Schlagworte: Anticonvulsants*/therapeutic use , Anticonvulsants*/adverse effects , Epilepsy*/drug therapy , Carbamates*/therapeutic use , Carbamates*/adverse effects , Chlorophenols*/therapeutic use , Chlorophenols*/adverse effects, Humans ; Child ; Adolescent ; Child, Preschool ; Treatment Outcome ; Infant ; Tetrazoles

Budget impact analysis of cenobamate, a novel adjunctive therapy for the treatment of drug resistant focal onset seizures, from the Belgian healthcare payer perspective.

Autoren: Vonck K Bodart O Weckhuysen S et al.

Quelle: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 990-1001. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

MeSH-Schlagworte: Anticonvulsants*/economics , Anticonvulsants*/therapeutic use , Carbamates*/economics , Carbamates*/therapeutic use , Chlorophenols*/economics , Chlorophenols*/therapeutic use , Drug Resistant Epilepsy*/drug therapy , Drug Resistant Epilepsy*/economics , Seizures*/drug therapy, Humans ; Belgium ; Budgets ; Adult ; Tetrazoles

Budget impact analysis of cenobamate for epilepsy patients with drug-resistant focal onset seizures in the Netherlands.

Autoren: Li N Majoie M Evers S et al.

Quelle: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 114-123. Date of Electronic Publication: 2025 Jan 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

MeSH-Schlagworte: Anticonvulsants*/therapeutic use , Anticonvulsants*/economics , Carbamates*/economics , Carbamates*/therapeutic use , Budgets* , Chlorophenols*/therapeutic use , Chlorophenols*/economics, Humans ; Netherlands ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/economics ; Cost-Benefit Analysis ; Male ; Female ; Benzyl Compounds/therapeutic use ; Benzyl Compounds/economics ; Models, Econometric ; Adult ; Epilepsies, Partial/drug therapy ; Epilepsies, Partial/economics ; Tetrazoles

Fabrication of montmorillonite composite alginate beads for micro-solid phase extraction of carbamate residues prior to their determination by ultra performance liquid chromatography-photodiode array detector.

Autoren: Maokam C Suwannasom P Chanthai S et al.

Quelle: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128452. Date of Electronic Publication: 2025 Jun 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH-Schlagworte: Carbamates*/analysis , Carbamates*/isolation & purification , Alginates*/chemistry , Bentonite*/chemistry , Solid Phase Microextraction*/methods , Pesticide Residues*/analysis , Pesticide Residues*/isolation & purification, Chromatography, High Pressure Liquid/methods ; Limit of Detection ; Solid Phase Extraction/methods

Osimertinib Cost Minimization in Non-Small Cell Lung Cancer (NSCLC) Treatment: Hypothesis Generation for a Population Pharmacokinetic Approach for Equivalent Dose Optimization of Osimertinib in Combination with Cobicistat.

Autoren: Westra N Kruithof PD Croes S et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1687-1698. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/economics , Acrylamides*/pharmacokinetics , Acrylamides*/administration & dosage , Acrylamides*/economics , Aniline Compounds*/pharmacokinetics , Aniline Compounds*/administration & dosage , Aniline Compounds*/economics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/economics , Carbamates*/administration & dosage , Carbamates*/pharmacokinetics , Carbamates*/economics , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/economics , Antineoplastic Combined Chemotherapy Protocols*/pharmacokinetics , Antineoplastic Combined Chemotherapy Protocols*/economics , Antineoplastic Combined Chemotherapy Protocols*/administration & dosage, Humans ; Male ; Models, Biological ; Female ; Middle Aged ; Aged ; Adult ; Dose-Response Relationship, Drug ; Indoles ; Pyrimidines

Simplified monitoring of sofosbuvir/velpatasvir in Japanese patients with chronic hepatitis C based on a retrospective analysis of a prospective multicenter cohort.

Autoren: Suda G Baba M Yamamoto Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 28; Vol. 15 (1), pp. 42628. Date of Electronic Publication: 2025 Nov 28.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Sofosbuvir*/therapeutic use , Sofosbuvir*/adverse effects , Sofosbuvir*/administration & dosage , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/adverse effects , Heterocyclic Compounds, 4 or More Rings*/administration & dosage , Hepatitis C, Chronic*/drug therapy , Hepatitis C, Chronic*/virology , Carbamates*/therapeutic use , Carbamates*/adverse effects , Carbamates*/administration & dosage , Antiviral Agents*/therapeutic use , Antiviral Agents*/adverse effects , Antiviral Agents*/administration & dosage, Humans ; Male ; Female ; Middle Aged ; Aged ; Japan ; Retrospective Studies ; Prospective Studies ; Sustained Virologic Response ; Hepacivirus/drug effects ; Adult ; Treatment Outcome ; East Asian People ; Benzimidazoles ; Benzopyrans ; Drug Combinations

Developing and validating a sensitive and fast UPLC-MS/MS method for estimating the in vitro metabolic stability of crenolanib in HLMs: identification of structural alarms related to the in silico toxicity and metabolic lability.

Autoren: Attwa MW Ali AM AlRabiah H et al.

Quelle: Analytical methods : advancing methods and applications [Anal Methods] 2025 Nov 27; Vol. 17 (46), pp. 9442-9453. Date of Electronic Publication: 2025 Nov 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: RSC Pub Country of Publication: England NLM ID: 101519733 Publication Model: Electronic Cited Medium: Internet ISSN: 1759-9679 (Electronic) Linking ISSN: 17599660 NLM ISO Abbreviation: Anal Methods Subsets: MEDLINE

MeSH-Schlagworte: Tandem Mass Spectrometry*/methods , Microsomes, Liver*/metabolism , Carbamates*/chemistry , Carbamates*/metabolism , Protein Kinase Inhibitors*/metabolism , Protein Kinase Inhibitors*/chemistry, Humans ; Chromatography, High Pressure Liquid/methods ; Drug Stability ; Reproducibility of Results ; Liquid Chromatography-Mass Spectrometry

Rare Case of Severe Pancreatitis Induced by Encorafenib and Cetuximab in BRAF V600E-Positive Colorectal Cancer.

Autoren: Miyakawa Y Ishigaki Y Suzuki N et al.

Quelle: Internal medicine (Tokyo, Japan) [Intern Med] 2025 Nov 15; Vol. 64 (22), pp. 3252-3256. Date of Electronic Publication: 2025 Apr 26.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE

MeSH-Schlagworte: Proto-Oncogene Proteins B-raf*/genetics , Sulfonamides*/adverse effects , Sulfonamides*/administration & dosage , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Pancreatitis*/chemically induced , Pancreatitis*/diagnosis , Carbamates*/adverse effects , Carbamates*/administration & dosage , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/genetics , Rectal Neoplasms*/drug therapy , Rectal Neoplasms*/genetics, Humans ; Cetuximab/adverse effects ; Cetuximab/administration & dosage ; Male ; Mutation ; Fatal Outcome ; Middle Aged ; Aged

Multitarget-directed carbamate and carbamothioate derivatives: Cholinesterase and monoamine oxidase inhibition, anti-β-amyloid (Aβ) aggregation, antioxidant and blood-brain barrier permeation properties against Alzheimer's disease.

Autoren: Teke Tuncel S Erol Gunal S Demir İ et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117986. Date of Electronic Publication: 2025 Jul 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Amyloid beta-Peptides*/antagonists & inhibitors , Amyloid beta-Peptides*/metabolism , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/drug effects , Carbamates*/pharmacology , Carbamates*/chemistry , Carbamates*/chemical synthesis , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemistry , Cholinesterase Inhibitors*/chemical synthesis , Monoamine Oxidase Inhibitors*/pharmacology , Monoamine Oxidase Inhibitors*/chemistry , Monoamine Oxidase Inhibitors*/chemical synthesis, Animals ; Humans ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Molecular Structure ; Monoamine Oxidase/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/chemical synthesis ; Protein Aggregates/drug effects ; Structure-Activity Relationship ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/pharmacology

Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands.

Autoren: Ghosh AK Shaktah R Johnson ME et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117880. Date of Electronic Publication: 2025 Jun 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: HIV Protease Inhibitors*/chemical synthesis , HIV Protease Inhibitors*/pharmacology , HIV Protease Inhibitors*/chemistry , Drug Design* , HIV Protease*/metabolism , HIV Protease*/chemistry , Carbamates*/chemistry , Carbamates*/pharmacology , Carbamates*/chemical synthesis , HIV-1*/drug effects , HIV-1*/enzymology , Spiro Compounds*/chemistry , Spiro Compounds*/pharmacology , Spiro Compounds*/chemical synthesis, Crystallography, X-Ray ; Structure-Activity Relationship ; Ligands ; Molecular Structure ; Models, Molecular ; Humans ; Dose-Response Relationship, Drug

Human cytochrome P4502C8 metabolizes repaglinide to 4'-hydroxyrepaglinide, not 3'-hydroxyrepaglinide.

Autoren: Sharma R Balesano A Doran AC et al.

Quelle: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Nov; Vol. 53 (11), pp. 100177. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

MeSH-Schlagworte: Piperidines*/metabolism , Piperidines*/chemistry , Cytochrome P-450 CYP2C8*/metabolism , Carbamates*/metabolism , Carbamates*/chemistry , Hypoglycemic Agents*/metabolism, Humans ; Microsomes, Liver/metabolism ; Hydroxylation ; Recombinant Proteins/metabolism

Pregnenolone Carbamate Derivatives as Selective Cholinesterase Inhibitors: Multimodal Evaluation Including DNA and HSA Interactions.

Autoren: Akca S Ilkar Erdagi S Ozbagci DI

Quelle: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Nov; Vol. 358 (11), pp. e70140.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

MeSH-Schlagworte: Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/chemistry , DNA*/metabolism , DNA*/chemistry , Carbamates*/pharmacology , Carbamates*/chemistry , Carbamates*/chemical synthesis , Pregnenolone*/pharmacology , Pregnenolone*/chemistry , Pregnenolone*/chemical synthesis , Serum Albumin, Human*/metabolism , Serum Albumin, Human*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Butyrylcholinesterase/metabolism ; Molecular Structure ; Acetylcholinesterase/metabolism ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Animals ; Mice

Solvent-, enzyme-, and structural-dependence of phenyl-substituted methyl carbamate inhibition of acetylcholinesterase.

Autoren: Swale DR Carlier PR Totrov M et al.

Quelle: Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2025 Nov; Vol. 184, pp. 104385. Date of Electronic Publication: 2025 Aug 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9207282 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0240 (Electronic) Linking ISSN: 09651748 NLM ISO Abbreviation: Insect Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Cholinesterase Inhibitors*/chemistry , Cholinesterase Inhibitors*/pharmacology , Carbamates*/chemistry , Carbamates*/pharmacology , Anopheles*/enzymology , Acetylcholinesterase*/metabolism , Acetylcholinesterase*/chemistry , Insecticides*/pharmacology , Insecticides*/chemistry, Animals ; Solvents/chemistry ; Dimethyl Sulfoxide ; Structure-Activity Relationship

Efficacy, safety and tolerability of adjunctive cenobamate in pediatric and adult patients with Lennox Gastaut Syndrome.

Autoren: Pong AW Wehland M Klein P

Quelle: Epilepsy & behavior : E&B [Epilepsy Behav] 2025 Nov; Vol. 172, pp. 110660. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE

MeSH-Schlagworte: Lennox Gastaut Syndrome*/drug therapy , Anticonvulsants*/therapeutic use , Anticonvulsants*/adverse effects , Carbamates*/therapeutic use , Carbamates*/adverse effects, Humans ; Male ; Female ; Adolescent ; Young Adult ; Child ; Adult ; Treatment Outcome ; Electroencephalography ; Chlorophenols ; Tetrazoles

Solriamfetol improves daily fatigue symptoms in adults with myalgic encephalomyelitis/chronic fatigue syndrome after 8 weeks of treatment.

Autoren: Young JL Powell RN Powell A et al.

Quelle: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2025 Nov; Vol. 39 (11), pp. 1268-1276. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase IV

Info zur Zeitschrift: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Fatigue Syndrome, Chronic*/drug therapy , Fatigue*/drug therapy , Phenylalanine*/analogs & derivatives , Phenylalanine*/adverse effects , Phenylalanine*/therapeutic use , Phenylalanine*/administration & dosage , Phenylalanine*/pharmacology , Carbamates*/adverse effects , Carbamates*/therapeutic use , Carbamates*/administration & dosage, Humans ; Male ; Female ; Double-Blind Method ; Adult ; Middle Aged ; Treatment Outcome ; Executive Function/drug effects

Cost-effectiveness analysis of cenobamate for epilepsy patients with drug-resistant focal onset seizures in the Netherlands.

Autoren: Li N Majoie M Evers S et al.

Quelle: Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2025 Nov; Vol. 25 (9), pp. 1323-1335. Date of Electronic Publication: 2025 Aug 10.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101132257 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8379 (Electronic) Linking ISSN: 14737167 NLM ISO Abbreviation: Expert Rev Pharmacoecon Outcomes Res Subsets: MEDLINE

MeSH-Schlagworte: Anticonvulsants*/economics , Anticonvulsants*/adverse effects , Anticonvulsants*/administration & dosage , Anticonvulsants*/therapeutic use , Carbamates*/economics , Carbamates*/adverse effects , Carbamates*/administration & dosage , Carbamates*/therapeutic use , Drug Resistant Epilepsy*/drug therapy , Drug Resistant Epilepsy*/economics , Seizures*/drug therapy , Seizures*/economics , Epilepsies, Partial*/drug therapy , Epilepsies, Partial*/economics, Humans ; Cost-Benefit Analysis ; Netherlands ; Quality-Adjusted Life Years ; Markov Chains ; Randomized Controlled Trials as Topic ; Nitriles ; Male ; Cost-Effectiveness Analysis ; Chlorophenols ; Pyrrolidinones ; Tetrazoles

Long-Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons.

Autoren: McDonald CM Guglieri M Vučinić D et al.

Körperschaften: McDonald CM Guglieri M Vučinić D et al.

Quelle: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2025 Nov; Vol. 12 (11), pp. 2335-2348. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE

MeSH-Schlagworte: Muscular Dystrophy, Duchenne*/drug therapy , Carbamates*/pharmacology , Carbamates*/adverse effects , Carbamates*/administration & dosage , Histone Deacetylase Inhibitors*/adverse effects , Histone Deacetylase Inhibitors*/administration & dosage , Histone Deacetylase Inhibitors*/pharmacology, Humans ; Male ; Child ; Adolescent ; Young Adult ; Adult ; Child, Preschool ; Female ; Disease Progression