Výsledky vyhľadávania - "Calcium Channel Agonists"

Small molecule agonist TPC2-A1-N increases intracellular Ca ²⁺ independent of two-pore channels.

Autori: Mallmann RT Gonzalez Mantuano MC Polomski K a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2025 Sep; Vol. 301 (9), pp. 110576. Date of Electronic Publication: 2025 Aug 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium*/metabolism , Calcium Channels*/metabolism , Calcium Channels*/genetics , Calcium Channel Agonists*/pharmacology , Calcium Release Activated Calcium Channels*/metabolism , Calcium Release Activated Calcium Channels*/genetics, Animals ; Humans ; Mice ; HeLa Cells ; Endoplasmic Reticulum/metabolism ; Sodium/metabolism ; NADP/analogs & derivatives ; NADP/pharmacology ; NADP/metabolism ; Fibroblasts/metabolism ; Fibroblasts/cytology ; Calcium Signaling/drug effects ; Two-Pore Channels

The calcium channel agonist (±)-BAY-K-8644 attenuates the ability of gabapentinoids to increase the potency of fentanyl and heroin and decrease the potency of cocaine and d-methamphetamine to elicit discriminative stimulus effects in rats.

Autori: Hiranita T Grisham AK Mijares AE a ďalší

Zdroj: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 May; Vol. 392 (5), pp. 103523. Date of Electronic Publication: 2025 Apr 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fentanyl*/pharmacology , Cocaine*/pharmacology , Heroin*/pharmacology , Calcium Channel Agonists*/pharmacology , 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester*/pharmacology , Methamphetamine*/pharmacology , Discrimination, Psychological*/drug effects, Animals ; Male ; Rats ; Gabapentin/pharmacology ; Rats, Sprague-Dawley ; Dose-Response Relationship, Drug ; Calcium Channel Blockers/pharmacology

Divergent Effects of Calcium Channel Modulators on H-Reflex Excitability in Fatigued Rat Muscle.

Autori: Maznychenko A Abramovych TI Bulgakova NV a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 05; Vol. 26 (21). Date of Electronic Publication: 2025 Nov 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Muscle Fatigue*/drug effects , Calcium Channel Blockers*/pharmacology , Muscle, Skeletal*/drug effects , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiology , H-Reflex*/drug effects , Calcium Channels*/metabolism, Animals ; Rats ; Male ; Nifedipine/pharmacology ; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Calcium/metabolism ; Calcium Channel Agonists/pharmacology ; Amiloride/pharmacology ; Motor Neurons/drug effects ; Motor Neurons/metabolism ; Muscle Contraction/drug effects

L-methionine and the L-type Ca ²⁺ channel agonist BAY K 8644 collaboratively contribute to the reduction of depressive-like behavior in mice.

Autori: He E Ma R Qu S a ďalší

Zdroj: Frontiers in neural circuits [Front Neural Circuits] 2024 Aug 29; Vol. 18, pp. 1435507. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477940 Publication Model: eCollection Cited Medium: Internet ISSN: 1662-5110 (Electronic) Linking ISSN: 16625110 NLM ISO Abbreviation: Front Neural Circuits Subsets: MEDLINE

Výrazy zo slovníka MeSH: DNA Methyltransferase 3A* , Calcium Channels, L-Type*/metabolism , Calcium Channels, L-Type*/drug effects , Methionine*/pharmacology , Depression*/drug therapy , Depression*/metabolism , Calcium Channel Agonists*/pharmacology , DNA Methylation*/drug effects , 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester*/pharmacology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Antidepressive Agents/pharmacology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Lipopolysaccharides/pharmacology ; Disease Models, Animal

Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives.

Autori: Lanzetti S Di Biase V

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 15; Vol. 27 (4). Date of Electronic Publication: 2022 Feb 15.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Calcium Channel Blockers/*pharmacology , Calcium Channels/*metabolism, Animals ; Calcium Channel Agonists/therapeutic use ; Calcium Channel Blockers/therapeutic use ; Calcium Channels/chemistry ; Calcium Channels/classification ; Calcium Channels/genetics ; Clinical Studies as Topic ; Disease Management ; Disease Susceptibility ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Ligands ; Nervous System Diseases/diagnosis ; Nervous System Diseases/drug therapy ; Nervous System Diseases/etiology ; Nervous System Diseases/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Treatment Outcome

Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity.

Autori: Saito T Shukla NM Sato-Kaneko F a ďalší

Zdroj: ACS chemical biology [ACS Chem Biol] 2022 Jan 21; Vol. 17 (1), pp. 217-229. Date of Electronic Publication: 2022 Jan 05.

Spôsob vydávania: Journal Article; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Adjuvants, Immunologic*/pharmacology , Calcium Channel Agonists*/pharmacology, Animals ; Humans ; Mice ; Cell Line ; Cell Proliferation/drug effects ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation/drug effects ; Lipopolysaccharides/pharmacology ; Lymphocytes/drug effects ; Ovalbumin/immunology ; Receptors, Pattern Recognition/genetics ; Receptors, Pattern Recognition/metabolism

BK Ca Channel Activation Attenuates the Pathophysiological Progression of Monocrotaline-Induced Pulmonary Arterial Hypertension in Wistar Rats.

Autori: Ferraz AP Seara FAC Baptista EF a ďalší

Zdroj: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2021 Aug; Vol. 35 (4), pp. 719-732. Date of Electronic Publication: 2020 Nov 27.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists*/metabolism , Calcium Channel Agonists*/pharmacokinetics , Large-Conductance Calcium-Activated Potassium Channels*/agonists , Large-Conductance Calcium-Activated Potassium Channels*/metabolism , Pulmonary Arterial Hypertension*/drug therapy , Pulmonary Arterial Hypertension*/metabolism , Pulmonary Arterial Hypertension*/physiopathology, Quinolines/*pharmacology , Vascular Resistance/*drug effects , Vasoconstriction/*drug effects , Vasodilation/*drug effects, Animals ; Disease Models, Animal ; Rats ; Rats, Wistar ; Treatment Outcome ; Vascular Remodeling/drug effects ; Ventricular Function, Right/drug effects

Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice.

Autori: Yuan D Cheng A Kawahata I a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 13; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Calcium Channels, T-Type/*metabolism , Cognition/*drug effects , Imidazoles/*pharmacology , Olfactory Bulb/*drug effects , Olfactory Bulb/*metabolism , Oxidative Stress/*drug effects , Spiro Compounds/*pharmacology, Administration, Oral ; Alzheimer Disease/drug therapy ; Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Behavior, Animal/drug effects ; Calcium Channel Agonists/administration & dosage ; Calcium Channel Agonists/chemistry ; Disease Models, Animal ; Drug Administration Schedule ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Mice ; Microglia/metabolism ; Molecular Structure ; Olfactory Bulb/surgery ; Spatial Memory/drug effects ; Tyrosine/analogs & derivatives ; Tyrosine/metabolism

A Multichannel Ca ²⁺ Nanomodulator for Multilevel Mitochondrial Destruction-Mediated Cancer Therapy.

Autori: Zheng P Ding B Shi R a ďalší

Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2021 Apr; Vol. 33 (15), pp. e2007426. Date of Electronic Publication: 2021 Mar 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents/*chemistry , Calcium Channel Agonists/*chemistry , Cisplatin/*chemistry , Curcumin/*chemistry , Mitochondria/*drug effects , Nanocapsules/*chemistry, Animals ; Antineoplastic Agents/pharmacokinetics ; Calcium Carbonate/chemistry ; Calcium Channel Agonists/pharmacokinetics ; Cell Line, Tumor ; Cell Membrane Permeability ; Cisplatin/pharmacokinetics ; Curcumin/pharmacokinetics ; Drug Liberation ; Drug Therapy, Combination ; Humans ; Indoles/chemistry ; Mice, Nude ; Polymers/chemistry ; Signal Transduction ; Mice

Discovery of a polysubstituted phenyl containing novel N-phenylpyrazole scaffold as potent ryanodine receptor activator.

Autori: Liu J Li F Hao Z a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Dec 15; Vol. 28 (24), pp. 115829. Date of Electronic Publication: 2020 Oct 30.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*chemistry , Pyrazoles/*chemistry , Ryanodine Receptor Calcium Release Channel/*metabolism, Animals ; Binding Sites ; Calcium Channel Agonists/metabolism ; Calcium Channel Agonists/pharmacology ; Calcium Signaling/drug effects ; Drug Design ; Drug Evaluation, Preclinical ; Insecticides/chemistry ; Insecticides/metabolism ; Insecticides/pharmacology ; Larva/drug effects ; Molecular Docking Simulation ; Moths/drug effects ; Moths/growth & development ; Pyrazoles/metabolism ; Pyrazoles/pharmacology ; Ryanodine Receptor Calcium Release Channel/chemistry ; Structure-Activity Relationship

Synthesis, Insecticidal Evaluation, and 3D-QASR of Novel Anthranilic Diamide Derivatives Containing N -Arylpyrrole as Potential Ryanodine Receptor Activators.

Autori: Wu C Yu X Wang B a ďalší

Zdroj: Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Sep 02; Vol. 68 (35), pp. 9319-9328. Date of Electronic Publication: 2020 Aug 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*chemical synthesis , Calcium Channel Agonists/*pharmacology , Diamide/*chemistry , Insecticides/*chemical synthesis , Insecticides/*pharmacology , Isoxazoles/*chemistry, Animals ; Calcium Channel Agonists/chemistry ; Diamide/pharmacology ; Insect Proteins/agonists ; Insect Proteins/chemistry ; Insect Proteins/metabolism ; Insecticides/chemistry ; Isoxazoles/pharmacology ; Larva/chemistry ; Larva/drug effects ; Larva/metabolism ; Moths/chemistry ; Moths/drug effects ; Moths/metabolism ; Quantitative Structure-Activity Relationship ; Ryanodine Receptor Calcium Release Channel/chemistry ; Ryanodine Receptor Calcium Release Channel/metabolism

Discovery of Potential Species-Specific Green Insecticides Targeting the Lepidopteran Ryanodine Receptor.

Autori: Samurkas A Fan X Ma D a ďalší

Zdroj: Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Apr 15; Vol. 68 (15), pp. 4528-4537. Date of Electronic Publication: 2020 Apr 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Insect Proteins/*antagonists & inhibitors , Insecticides/*pharmacology , Moths/*drug effects, Amino Acid Sequence ; Animals ; Calcium Channel Agonists/chemistry ; HEK293 Cells ; Humans ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Insecticides/chemistry ; Moths/chemistry ; Moths/genetics ; Moths/metabolism ; Protein Domains ; Ryanodine Receptor Calcium Release Channel/chemistry ; Ryanodine Receptor Calcium Release Channel/metabolism ; Species Specificity

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.

Autori: Gerndt S Chen CC Chao YK a ďalší

Zdroj: ELife [Elife] 2020 Mar 16; Vol. 9. Date of Electronic Publication: 2020 Mar 16.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Calcium Channels/*metabolism , Macrophages/*metabolism , Raloxifene Hydrochloride/*pharmacology, Animals ; Benzylisoquinolines/pharmacology ; Calcium/metabolism ; Calcium Channel Agonists/chemistry ; Calcium Channels/genetics ; Fluphenazine/pharmacology ; Gene Expression Regulation/drug effects ; HEK293 Cells ; HeLa Cells ; Humans ; Ionomycin/pharmacology ; Macrophages/drug effects ; Mice ; NADP/analogs & derivatives ; NADP/metabolism ; Phosphatidylinositol Phosphates/pharmacology ; Single Molecule Imaging ; Sodium/metabolism

Hydroxysafflor yellow A actives BK Ca channels and inhibits L-type Ca channels to induce vascular relaxation.

Autori: Wang N He D Zhou Y a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2020 Mar 05; Vol. 870, pp. 172873. Date of Electronic Publication: 2019 Dec 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Calcium Channel Blockers/*pharmacology , Calcium Channels, L-Type/*metabolism , Chalcone/*analogs & derivatives , Potassium Channels, Voltage-Gated/*agonists , Quinones/*pharmacology, Animals ; Blood Pressure/drug effects ; Calcium Channel Agonists/metabolism ; Calcium Channel Blockers/metabolism ; Calcium Signaling ; Chalcone/metabolism ; Chalcone/pharmacology ; HEK293 Cells ; Humans ; Male ; Membrane Potentials/drug effects ; Mesenteric Arteries/drug effects ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Patch-Clamp Techniques ; Phenylephrine/metabolism ; Quinones/metabolism ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vasodilation/drug effects

Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca v 3.1 Low Voltage-Gated Ca ²⁺ Channel.

Autori: Ye YS Li WY Du SZ a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2020 Feb 27; Vol. 63 (4), pp. 1709-1716. Date of Electronic Publication: 2020 Feb 13.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Calcium Channels, T-Type/*metabolism , Monoterpenes/*pharmacology , Phloroglucinol/*analogs & derivatives , Phloroglucinol/*pharmacology, Animals ; Calcium Channel Agonists/isolation & purification ; Calcium Channels, T-Type/genetics ; HEK293 Cells ; Humans ; Hypericum/chemistry ; Ion Channel Gating/drug effects ; Membrane Potentials/drug effects ; Mice ; Monoterpenes/isolation & purification ; Mutation ; Phloroglucinol/isolation & purification

Synthesis and Biological Activity of a Bis-steroid-Methanocyclobutanaphthalene- dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation.

Autori: Lauro FV Francisco DC Marcela RN a ďalší

Zdroj: Anti-inflammatory & anti-allergy agents in medicinal chemistry [Antiinflamm Antiallergy Agents Med Chem] 2020; Vol. 19 (4), pp. 393-412.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101462262 Publication Model: Print Cited Medium: Internet ISSN: 1875-614X (Electronic) Linking ISSN: 18715230 NLM ISO Abbreviation: Antiinflamm Antiallergy Agents Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Cardiotonic Agents/*pharmacology , Myocardial Reperfusion Injury/*physiopathology , Naphthoquinones/*pharmacology, Animals ; Calcium Channel Agonists/chemistry ; Cardiotonic Agents/chemistry ; Male ; Myocardial Reperfusion Injury/drug therapy ; Naphthoquinones/chemistry ; Rats, Wistar ; Ventricular Function, Left/drug effects ; Ventricular Pressure/drug effects

Anti-schistosomal action of the calcium channel agonist FPL-64176.

Autori: McCusker P Chan JD

Zdroj: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2019 Dec; Vol. 11, pp. 30-38. Date of Electronic Publication: 2019 Sep 14.

Spôsob vydávania: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101576715 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3207 (Electronic) Linking ISSN: 22113207 NLM ISO Abbreviation: Int J Parasitol Drugs Drug Resist Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*pharmacology , Calcium Signaling/*drug effects , Pyrroles/*pharmacology , Schistosoma mansoni/*drug effects , Schistosomiasis mansoni/*drug therapy, Animals ; Biotinylation ; Calcium Channel Agonists/chemistry ; Calcium Channel Agonists/therapeutic use ; Female ; Helminth Proteins/metabolism ; Male ; Mice ; Microscopy, Electron, Transmission ; Pyrroles/chemistry ; Pyrroles/therapeutic use ; Real-Time Polymerase Chain Reaction ; Schistosoma mansoni/cytology ; Schistosoma mansoni/genetics ; Schistosoma mansoni/ultrastructure ; Schistosomiasis mansoni/parasitology

Synthesis, insecticidal evaluation and mode of action of novel anthranilic diamide derivatives containing sulfur moiety as potential ryanodine receptor activators.

Autori: Li FY Wang YH Liu JB a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Mar 01; Vol. 27 (5), pp. 769-776. Date of Electronic Publication: 2019 Jan 16.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amides/*pharmacology , Calcium Channel Agonists/*pharmacology , Insecticides/*pharmacology , Ryanodine Receptor Calcium Release Channel/*metabolism , ortho-Aminobenzoates/*pharmacology, Amides/chemical synthesis ; Amides/chemistry ; Animals ; Calcium/metabolism ; Calcium Channel Agonists/chemical synthesis ; Calcium Channel Agonists/chemistry ; Insecticides/chemical synthesis ; Insecticides/chemistry ; Larva/drug effects ; Molecular Structure ; Moths/drug effects ; Periplaneta/drug effects ; Structure-Activity Relationship ; Sulfones/chemical synthesis ; Sulfones/chemistry ; Sulfones/pharmacology ; ortho-Aminobenzoates/chemical synthesis ; ortho-Aminobenzoates/chemistry

Alteration in the phosphorylation status of NMDA receptor GluN2B subunit by activation of both NMDA receptor and L-type voltage gated calcium channel.

Autori: Kumar M John M Madhavan M a ďalší

Zdroj: Neuroscience letters [Neurosci Lett] 2019 Sep 14; Vol. 709, pp. 134343. Date of Electronic Publication: 2019 Jul 04.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcium Channel Agonists/*metabolism , Calcium Channels, L-Type/*metabolism , N-Methylaspartate/*metabolism , Receptors, N-Methyl-D-Aspartate/*metabolism, 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/metabolism ; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Animals ; Calcium Channel Agonists/pharmacology ; Male ; N-Methylaspartate/pharmacology ; Phosphorylation/drug effects ; Phosphorylation/physiology ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/agonists

Salpratlactones A and B: A Pair of cis - trans Tautomeric Abietanes as Ca v 3.1 T-Type Calcium Channel Agonists from Salvia prattii .

Autori: Xia F Li WY Yang XW a ďalší

Zdroj: Organic letters [Org Lett] 2019 Jul 19; Vol. 21 (14), pp. 5670-5674. Date of Electronic Publication: 2019 Jul 03.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Abietanes/*chemistry , Calcium Channel Agonists/*chemistry , Calcium Channels, T-Type/*metabolism , Salvia/*chemistry, Abietanes/pharmacology ; Calcium Channel Agonists/pharmacology ; Models, Molecular ; Molecular Conformation ; Stereoisomerism