Suchergebnisse - "CYTOTOXINS"

Treponema pallidum cytolytic toxin, Tp0649, induces apoptosis in THP-1 macrophages via the ERK MAPK, p38 MAPK, PI3K/AKT, and NF-κB signaling pathways.

Autoren: Sun P Li S Li W et al.

Quelle: Microbial pathogenesis [Microb Pathog] 2025 Nov; Vol. 208, pp. 107975. Date of Electronic Publication: 2025 Aug 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis*/drug effects , Treponema pallidum*/metabolism , Treponema pallidum*/pathogenicity , Treponema pallidum*/genetics , Signal Transduction*/drug effects , Macrophages*/drug effects , Macrophages*/metabolism , Macrophages*/microbiology , Bacterial Toxins*/metabolism , Bacterial Toxins*/genetics , Bacterial Toxins*/toxicity , Cytotoxins*, Humans ; NF-kappa B/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; THP-1 Cells ; Reactive Oxygen Species/metabolism ; Caspase 8/metabolism ; Syphilis/microbiology ; MAP Kinase Signaling System/drug effects ; Bacterial Proteins/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Recombinant Proteins

Complete deletion of the Chlamydia muridarum putative cytotoxin locus reveals contributions during invasion in tissue culture and oviduct pathology during murine genital tract infection.

Autoren: Berclaz LH Eicher G Wieselquist G et al.

Quelle: Infection and immunity [Infect Immun] 2025 Oct 14; Vol. 93 (10), pp. e0041925. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

MeSH-Schlagworte: Chlamydia muridarum*/genetics , Chlamydia muridarum*/pathogenicity , Chlamydia Infections*/microbiology , Chlamydia Infections*/pathology , Reproductive Tract Infections*/microbiology , Reproductive Tract Infections*/pathology , Oviducts*/pathology , Oviducts*/microbiology , Cytotoxins*/genetics , Cytotoxins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism, Animals ; Female ; Mice ; Gene Deletion ; Disease Models, Animal ; Humans

Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage.

Autoren: Kapitan M Niemiec MJ Millet N et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 18; Vol. 122 (46), pp. e2505310122. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Candida albicans*/pathogenicity , Candida albicans*/physiology , Candida albicans*/metabolism , Enterococcus faecalis*/pathogenicity , Enterococcus faecalis*/metabolism , Enterococcus faecalis*/physiology , Host-Pathogen Interactions* , Gram-Positive Bacterial Infections*/microbiology , Gram-Positive Bacterial Infections*/pathology , Cytotoxins*/metabolism, Animals ; Mice ; Humans ; Glucose/metabolism ; Candidiasis, Oral/microbiology ; Candidiasis, Oral/pathology ; Candidiasis/microbiology ; Mice, Inbred C57BL

Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation.

Autoren: Xiao N Kogishi A Radochonski L et al.

Quelle: Nature immunology [Nat Immunol] 2025 Oct; Vol. 26 (10), pp. 1673-1685. Date of Electronic Publication: 2025 Sep 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

MeSH-Schlagworte: Inflammasomes*/metabolism , Inflammasomes*/immunology , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , trans-Golgi Network*/metabolism , trans-Golgi Network*/immunology , Cholesterol*/metabolism , Cytotoxins*/metabolism, Animals ; Humans ; Mice ; Macrophages/immunology ; Macrophages/metabolism ; Mice, Inbred C57BL ; Protein Transport ; Mice, Knockout ; HEK293 Cells ; Potassium/metabolism

Annexin A2 is a potential membrane protein target of cobra venom cytotoxin.

Autoren: Yong Y Yap MKK

Quelle: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2025 Sep; Vol. 264, pp. 108452. Date of Electronic Publication: 2025 Jun 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE

MeSH-Schlagworte: Elapid Venoms*/toxicity , Elapid Venoms*/chemistry , Annexin A2*/metabolism , Cytotoxins*/toxicity , Cytotoxins*/chemistry , Membrane Proteins*/metabolism, Animals ; Humans ; Mass Spectrometry ; Protein Binding

Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes.

Autoren: Snoj T Lukan T Gruden K et al.

Quelle: The Journal of membrane biology [J Membr Biol] 2025 Aug; Vol. 258 (4), pp. 323-339. Date of Electronic Publication: 2024 Dec 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 0211301 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1424 (Electronic) Linking ISSN: 00222631 NLM ISO Abbreviation: J Membr Biol Subsets: MEDLINE

MeSH-Schlagworte: Cell Membrane*/metabolism , Plant Cells*/metabolism , Cytotoxins*/metabolism , Cytotoxins*/chemistry , Pythium*/metabolism, Protoplasts/metabolism ; Nicotiana/metabolism ; Unilamellar Liposomes/metabolism ; Unilamellar Liposomes/chemistry

Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity.

Autoren: Safriansyah W Juliansyah E Rustaman et al.

Quelle: Journal of Asian natural products research [J Asian Nat Prod Res] 2025 Jul; Vol. 27 (7), pp. 1072-1079. Date of Electronic Publication: 2025 Jan 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

MeSH-Schlagworte: Triterpenes*/chemistry , Triterpenes*/isolation & purification , Triterpenes*/pharmacology , Aglaia*/chemistry , Cytotoxins*/chemistry , Cytotoxins*/isolation & purification , Cytotoxins*/pharmacology, Humans ; MCF-7 Cells/drug effects

Virulence gene profiling and cytotoxicity of Vibrio spp. isolated from treated wastewater effluent and receiving surface waters in Durban, South Africa.

Autoren: Ramessar K Olaniran AO

Quelle: Environmental science. Processes & impacts [Environ Sci Process Impacts] 2025 Aug 13; Vol. 27 (8), pp. 2262-2276. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101601576 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7895 (Electronic) Linking ISSN: 20507887 NLM ISO Abbreviation: Environ Sci Process Impacts Subsets: MEDLINE

MeSH-Schlagworte: Gene Expression Profiling* , Virulence*/genetics , Cytotoxins*/genetics , Vibrio*/genetics , Vibrio*/isolation & purification , Wastewater*/microbiology, South Africa ; Gram-Negative Bacterial Infections ; Water Purification ; Waste Disposal, Fluid ; Fresh Water/microbiology ; Environmental Monitoring

C-30 analogues of betulinic acid as potent cytotoxic agents: design, synthesis, biological evaluation and in-silico studies.

Autoren: Rath SK Nagar RK Das S et al.

Quelle: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Jun; Vol. 43 (9), pp. 4564-4577. Date of Electronic Publication: 2024 Feb 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH-Schlagworte: Triterpenes*/chemistry , Triterpenes*/pharmacology , Triterpenes*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Drug Design* , Cytotoxins*/pharmacology , Cytotoxins*/chemistry , Cytotoxins*/chemical synthesis, Betulinic Acid ; Humans ; Pentacyclic Triterpenes/chemistry ; Pentacyclic Triterpenes/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Molecular Structure ; A549 Cells

Vibrio cholerae cytolysin induces pro-inflammatory and death signals through novel TLR assembly.

Autoren: Gandhi S Puravankara S Mondal AK et al.

Quelle: PLoS pathogens [PLoS Pathog] 2025 Apr 04; Vol. 21 (4), pp. e1013033. Date of Electronic Publication: 2025 Apr 04 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

MeSH-Schlagworte: Vibrio cholerae*/immunology , Vibrio cholerae*/metabolism , Vibrio cholerae*/pathogenicity , Cholera*/immunology , Cholera*/metabolism , Perforin*/immunology , Perforin*/metabolism , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/immunology , Toll-Like Receptor 4*/genetics , Toll-Like Receptor 1*/metabolism , Toll-Like Receptor 1*/immunology , Toll-Like Receptor 1*/genetics , Cytotoxins*/immunology , Cytotoxins*/metabolism , Toll-Like Receptors*/metabolism , Toll-Like Receptors*/immunology, Animals ; Mice ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/microbiology ; Inflammation/immunology ; Inflammation/metabolism ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 2/immunology ; Signal Transduction/immunology ; Mice, Inbred C57BL ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/microbiology ; Myeloid Differentiation Factor 88/metabolism

Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression.

Autoren: Arnhold J; Institute of Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstr. 16-18, 04107 Leipzig, Germany.

Quelle: Biomolecules [Biomolecules] 2025 Apr 09; Vol. 15 (4). Date of Electronic Publication: 2025 Apr 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH-Schlagworte: Energy Metabolism*/drug effects , Aging*/metabolism , Aging*/pathology , Inflammation*/metabolism , Inflammation*/pathology , Oxidants*/metabolism , Cytotoxins*/metabolism, Humans ; Animals ; Disease Progression ; Chronic Disease ; Reactive Oxygen Species/metabolism ; Mitochondria/metabolism ; Oxidation-Reduction

Using simulation to improve pharmacy operators' handling of cytotoxic spills.

Autoren: Garnier A Bonnabry P Bouchoud L

Quelle: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2025 Apr; Vol. 31 (3), pp. 355-363. Date of Electronic Publication: 2024 Mar 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 9511372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-092X (Electronic) Linking ISSN: 10781552 NLM ISO Abbreviation: J Oncol Pharm Pract Subsets: MEDLINE

MeSH-Schlagworte: Simulation Training*/methods , Pharmacists*/standards , Cytotoxins*/adverse effects , Occupational Exposure*/prevention & control , Antineoplastic Agents*/adverse effects, Humans ; Surveys and Questionnaires ; Male ; Pharmacy Service, Hospital

High-throughput virtual screening, pharmacophore modelling and antagonist effects of small molecule inhibitors against cytotoxin-induced cytotoxicity.

Autoren: Lim EQ Ahemad N Yap MKK

Quelle: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Mar; Vol. 43 (4), pp. 2014-2028. Date of Electronic Publication: 2023 Dec 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH-Schlagworte: Cytotoxins*/chemistry , Cytotoxins*/toxicity , Cytotoxins*/antagonists & inhibitors , High-Throughput Screening Assays* , Small Molecule Libraries*/chemistry , Small Molecule Libraries*/pharmacology, Humans ; Binding Sites ; Cell Survival/drug effects ; Keratinocytes/drug effects ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pharmacophore ; Protein Binding ; Structure-Activity Relationship ; Elapid Venoms ; Animals ; Elapidae

Association of interstitial lung abnormalities with cytotoxic agent-induced pneumonitis in patients with malignancy.

Autoren: Oishi K Hozumi H Yoshizawa N et al.

Quelle: Respiratory medicine [Respir Med] 2025 Feb; Vol. 237, pp. 107924. Date of Electronic Publication: 2024 Dec 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE

MeSH-Schlagworte: Lung Diseases, Interstitial*/chemically induced , Lung Diseases, Interstitial*/epidemiology , Neoplasms*/drug therapy , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/therapeutic use , Pneumonia*/chemically induced , Pneumonia*/epidemiology , Cytotoxins*/adverse effects, Humans ; Male ; Female ; Aged ; Middle Aged ; Incidence ; Retrospective Studies ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Risk Factors

Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins.

Autoren: Dubovskii PV Utkin YN

Quelle: Toxins [Toxins (Basel)] 2024 Jun 04; Vol. 16 (6). Date of Electronic Publication: 2024 Jun 04.

Publikationsart: Journal Article; Review; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE

MeSH-Schlagworte: Cell Membrane*/drug effects , Cytotoxins*/chemistry , Cytotoxins*/toxicity, Animals ; Elapid Venoms/chemistry ; Elapid Venoms/toxicity ; Amino Acids/chemistry ; Amino Acid Sequence ; Humans

Comparative analysis of cyto-genotoxicity of zinc using the comet assay and chromosomal abnormality test.

Autoren: Üstündağ Ü Çavuşoğlu K Yalçın E

Quelle: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2024 Sep; Vol. 31 (44), pp. 56140-56152. Date of Electronic Publication: 2024 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE

MeSH-Schlagworte: Cytotoxins*/toxicity , Mutagens*/toxicity , Zinc*/toxicity, Comet Assay ; Onions/physiology ; Superoxide Dismutase/metabolism ; Chromosome Aberrations ; Catalase/metabolism ; Chlorophyll/metabolism ; Soil Pollutants/toxicity

Anti-Inflammatory, Cytotoxic, and Anti-Tuberculosis Properties of Selected Fabaceae Medicinal Plants through in vitro Studies.

Autoren: Khala MM van der Spoel van Dijk A Hildah Mfengwana PM

Quelle: Iranian biomedical journal [Iran Biomed J] 2024 Sep 01; Vol. 28 (5 & 6), pp. 265-72. Date of Electronic Publication: 2024 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pasteur Institute of Iran Country of Publication: Iran NLM ID: 9814853 Publication Model: Electronic Cited Medium: Internet ISSN: 2008-823X (Electronic) Linking ISSN: 1028852X NLM ISO Abbreviation: Iran Biomed J Subsets: MEDLINE

MeSH-Schlagworte: Anti-Inflammatory Agents*/pharmacology , Plants, Medicinal*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Antitubercular Agents*/pharmacology , Fabaceae*/chemistry , Cytotoxins*/pharmacology, Animals ; Chlorocebus aethiops ; Vero Cells ; Mycobacterium tuberculosis/drug effects ; Humans ; Mice

Structural investigation of interactions between halogenated flavonoids and the lipid membrane along with their role as cytotoxic agents.

Autoren: Dudek A Szulc N Pawlak A et al.

Quelle: Scientific reports [Sci Rep] 2024 May 08; Vol. 14 (1), pp. 10561. Date of Electronic Publication: 2024 May 08.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Cytotoxins*/chemistry , Cytotoxins*/pharmacology , Flavonoids*/chemistry , Flavonoids*/pharmacology , Halogenation* , Lipid Bilayers*/chemistry , Lipid Bilayers*/pharmacology , Erythrocytes*/drug effects, Fluorometry ; Dynamic Light Scattering ; Spectroscopy, Fourier Transform Infrared ; Humans ; Cell Line

Isolation, structural characterization and biological activity evaluation of melanoidins from thermally processed cocoa beans, carob kibbles and acorns as potential cytotoxic agents.

Autoren: Oracz J Lewandowska U Owczarek K et al.

Quelle: Food chemistry [Food Chem] 2024 Jun 01; Vol. 442, pp. 138423. Date of Electronic Publication: 2024 Jan 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Hot Temperature* , Cytotoxins* , Galactans* , Mannans* , Plant Gums*, Polymers

Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response.

Autoren: Sanford TC Tweten RK Abrahamsen HL

Quelle: Current opinion in infectious diseases [Curr Opin Infect Dis] 2024 Jun 01; Vol. 37 (3), pp. 164-169. Date of Electronic Publication: 2024 Mar 21.

Publikationsart: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8809878 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6527 (Electronic) Linking ISSN: 09517375 NLM ISO Abbreviation: Curr Opin Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Cholesterol*/metabolism , Cytotoxins*/immunology, Humans ; Host-Pathogen Interactions/immunology ; Bacteria/immunology ; Immune Evasion/immunology