Výsledky vyhľadávania - "CXCR4"

Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases.

Autori: Ruths L de Hesselle H Haußner F a ďalší

Zdroj: Arthritis research & therapy [Arthritis Res Ther] 2025 Dec 02; Vol. 27 (1), pp. 222. Date of Electronic Publication: 2025 Dec 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, CXCR4*/antagonists & inhibitors , Receptors, CXCR4*/metabolism , Chemokine CXCL12*/metabolism , Chemokine CXCL12*/antagonists & inhibitors , Chondrocytes*/drug effects , Chondrocytes*/metabolism, Humans ; Heterocyclic Compounds/pharmacology ; Benzylamines ; Cyclams ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Cells, Cultured ; Osteoarthritis/metabolism ; Osteoarthritis/drug therapy ; Osteoarthritis/pathology ; Cell Movement/drug effects ; Female ; Male ; Aged ; Middle Aged ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Receptors, CXCR

Development and characterization of AD-214, an anti-CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosis.

Autori: Lynch JP Organ L Tomusange K a ďalší

Zdroj: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2505090. Date of Electronic Publication: 2025 May 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

Výrazy zo slovníka MeSH: Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/immunology , Idiopathic Pulmonary Fibrosis*/pathology , Receptors, CXCR4*/immunology , Receptors, CXCR4*/antagonists & inhibitors , Recombinant Fusion Proteins*/pharmacology , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/immunology , Recombinant Fusion Proteins*/therapeutic use , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/immunology, Humans ; Animals ; Mice ; Cell Movement/drug effects

CXCR4 confers stemness and radioresistance in chordoma cells.

Autori: Jung CW Kim JY Park MJ

Zdroj: Cancer biology & therapy [Cancer Biol Ther] 2025 Dec; Vol. 26 (1), pp. 2471631. Date of Electronic Publication: 2025 Feb 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137842 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8576 (Electronic) Linking ISSN: 15384047 NLM ISO Abbreviation: Cancer Biol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Radiation Tolerance*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/radiation effects , Neoplastic Stem Cells*/pathology , Chordoma*/radiotherapy , Chordoma*/pathology , Chordoma*/metabolism , Chordoma*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; Xenograft Model Antitumor Assays ; Signal Transduction

Study on the regulation of Treg cell infiltration by EZH2 through CXCR4/CXCL12 in diffuse large B-cell lymphoma.

Autori: Wang H Liang D Qian Y a ďalší

Zdroj: Clinical and experimental medicine [Clin Exp Med] 2025 Nov 25; Vol. 26 (1), pp. 30. Date of Electronic Publication: 2025 Nov 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Enhancer of Zeste Homolog 2 Protein*/metabolism , Enhancer of Zeste Homolog 2 Protein*/genetics , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Chemokine CXCL12*/metabolism , Chemokine CXCL12*/genetics , Lymphoma, Large B-Cell, Diffuse*/immunology , Lymphoma, Large B-Cell, Diffuse*/pathology , Lymphoma, Large B-Cell, Diffuse*/genetics , T-Lymphocytes, Regulatory*/immunology, Humans ; Animals ; Male ; Mice ; Female ; Middle Aged ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Aged ; Adult

Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling.

Autori: Chen JY Jiang T Xu YT a ďalší

Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 15; Vol. 39 (21), pp. e71208.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Osteogenesis*/physiology , Cellular Senescence*/physiology , Proto-Oncogene Proteins c-akt*/metabolism , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Phosphatidylinositol 3-Kinases*/metabolism , Signal Transduction*/physiology , Stress, Mechanical*, Animals ; Cell Differentiation/physiology ; Humans ; Cells, Cultured ; Male

Rational design of a bispecific antibody for rapid and prolonged neutrophil mobilization and proliferation.

Autori: Deng J Liu Y Zhang Y a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Nov 14; Vol. 165, pp. 115434. Date of Electronic Publication: 2025 Sep 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antibodies, Bispecific*/genetics , Antibodies, Bispecific*/pharmacology , Antibodies, Bispecific*/therapeutic use , Receptors, CXCR4*/immunology , Receptors, CXCR4*/antagonists & inhibitors , Neutrophils*/drug effects , Neutrophils*/immunology , Neutrophils*/physiology, Humans ; Cell Proliferation/drug effects ; Granulocyte Colony-Stimulating Factor/immunology ; Granulocyte Colony-Stimulating Factor/genetics ; Animals ; Receptors, Granulocyte Colony-Stimulating Factor/immunology ; Mice

CXCR4 expression serves as a promising candidate target in the treatment of breast cancer.

Autori: Liao F Huang J Zhang Y

Zdroj: Medicine [Medicine (Baltimore)] 2025 Nov 07; Vol. 104 (45), pp. e45356.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, CXCR4*/genetics , Receptors, CXCR4*/metabolism , Breast Neoplasms*/genetics , Breast Neoplasms*/mortality , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology, Humans ; Female ; Prognosis ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Kaplan-Meier Estimate

Modulation of HIF1α/CXCR4 by CDDP, acetazolamide, and salidroside in early lung injury caused by acute high-altitude hypoxia.

Autori: Wang F Zhang Y Liu B a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178174. Date of Electronic Publication: 2025 Sep 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Glucosides*/pharmacology , Glucosides*/therapeutic use , Phenols*/pharmacology , Phenols*/therapeutic use , Acute Lung Injury*/etiology , Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism , Acute Lung Injury*/pathology , Acetazolamide*/pharmacology , Acetazolamide*/therapeutic use , Hypoxia*/complications , Altitude Sickness*/complications , Altitude Sickness*/drug therapy , Altitude Sickness*/metabolism , Altitude*, Animals ; Mice ; Male ; Nitric Oxide Synthase Type III/metabolism ; Mice, Inbred C57BL ; Lung/drug effects ; Lung/pathology ; Lung/metabolism ; Disease Models, Animal

Nano-TiO2 inhibit cytotoxicity and osteogenic differentiation of CXCR4-transfected bone marrow mesenchymal stem cells.

Autori: Liu C Li Y Zhou Q a ďalší

Zdroj: Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2025 Nov-Dec; Vol. 38 (6), pp. 2353-2360.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Titanium*/toxicity , Titanium*/pharmacology , Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/metabolism , Receptors, CXCR4*/genetics , Receptors, CXCR4*/metabolism , Cell Differentiation*/drug effects , Osteogenesis*/drug effects , Bone Marrow Cells*/drug effects , Bone Marrow Cells*/metabolism , Nanoparticles*/toxicity, Animals ; Cell Survival/drug effects ; Transfection ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Core Binding Factor Alpha 1 Subunit/genetics ; Rats ; Osteocalcin/metabolism ; Osteocalcin/genetics ; Alkaline Phosphatase/metabolism

Extracellular Ubiquitin Drives M2 Macrophage Polarization in Multiple Myeloma Through JAK1/STAT3-mediated Transcriptional Activation of CXCR4.

Autori: Chen X Hou N Luo T a ďalší

Zdroj: Journal of cellular biochemistry [J Cell Biochem] 2025 Nov; Vol. 126 (11), pp. e70073.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print Cited Medium: Internet ISSN: 1097-4644 (Electronic) Linking ISSN: 07302312 NLM ISO Abbreviation: J Cell Biochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Multiple Myeloma*/pathology , Multiple Myeloma*/metabolism , Multiple Myeloma*/genetics , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/genetics , Macrophages*/metabolism , Macrophages*/pathology , Janus Kinase 1*/metabolism , Janus Kinase 1*/genetics , Ubiquitin*/metabolism, Humans ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Female ; Male ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Signal Transduction ; Tumor Microenvironment ; Transcriptional Activation ; Cell Line, Tumor ; Mice ; Macrophage Activation ; Animals

Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles.

Autori: Egorova A Freund S Krylova I a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 30; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endometriosis*/therapy , Endometriosis*/genetics , Endometriosis*/pathology , Endometriosis*/metabolism , Nanoparticles*/chemistry , RNA, Small Interfering*/genetics , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/antagonists & inhibitors , Receptors, CXCR4*/genetics , RNA Interference* , Peptides*/chemistry, Animals ; Female ; Rats ; Disease Models, Animal ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Humans ; RNAi Therapeutics/methods ; Endometrium/pathology ; Neovascularization, Pathologic/genetics ; Rats, Sprague-Dawley

Senkyunolide I targets CXCR4 to attenuate liver fibrosis via suppression of the NLRP3/GSDMD pathway.

Autori: Wang K Yang Y Yue B a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Oct 30; Vol. 164, pp. 115348. Date of Electronic Publication: 2025 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/antagonists & inhibitors , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/chemically induced , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism , Phosphate-Binding Proteins*/metabolism , Benzofurans*/pharmacology , Benzofurans*/therapeutic use , Antifibrotic Agents*/pharmacology , Antifibrotic Agents*/therapeutic use, Animals ; Mice ; Male ; Signal Transduction/drug effects ; Mice, Inbred C57BL ; Liver/drug effects ; Liver/pathology ; Hepatic Stellate Cells/drug effects ; Intracellular Signaling Peptides and Proteins/metabolism ; Carbon Tetrachloride ; Humans ; Pyroptosis/drug effects ; Cell Line ; Gasdermins

Disruption of the Nucleolin-CXCR4 interaction by the DNA aptamer HY-4 halts colorectal cancer metastasis.

Autori: Liu Y Wu Y Yuan C a ďalší

Zdroj: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Oct 01; Vol. 33 (10), pp. 4904-4922. Date of Electronic Publication: 2025 Jul 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Aptamers, Nucleotide*/pharmacology , Aptamers, Nucleotide*/chemistry , Aptamers, Nucleotide*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/drug therapy , Phosphoproteins*/metabolism , Phosphoproteins*/chemistry , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/chemistry , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/chemistry, Nucleolin ; Humans ; Cell Line, Tumor ; Molecular Docking Simulation ; Protein Binding/drug effects ; Cell Movement/drug effects ; SELEX Aptamer Technique ; G-Quadruplexes ; Neoplasm Metastasis ; Binding Sites

Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies.

Autori: Haq BU Sofi S Qayoom H a ďalší

Zdroj: PloS one [PLoS One] 2025 Dec 05; Vol. 20 (12), pp. e0323665. Date of Electronic Publication: 2025 Dec 05 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, CXCR4*/antagonists & inhibitors , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Receptors, CXCR4*/chemistry , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Transforming Growth Factor beta1*/antagonists & inhibitors , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta1*/chemistry, Humans ; Female ; Molecular Docking Simulation ; Computational Biology/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Protein Interaction Maps ; Signal Transduction/drug effects

NPM1 mediated up - regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma.

Autori: Shi Y Deng Y Ma J a ďalší

Zdroj: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2565956. Date of Electronic Publication: 2025 Oct 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, CXCR4*/genetics , Receptors, CXCR4*/biosynthesis , Receptors, CXCR4*/metabolism , Multiple Myeloma*/drug therapy , Multiple Myeloma*/genetics , Multiple Myeloma*/metabolism , Multiple Myeloma*/mortality , Drug Resistance, Neoplasm* , Bortezomib*/pharmacology , Bortezomib*/therapeutic use , Nuclear Proteins*/genetics , Nuclear Proteins*/metabolism , Up-Regulation* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Nucleophosmin ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects

Chlamydia pneumoniae invades into vascular smooth muscle cells through the CXCR4-β-arrestin 2 pathway via TLR2/CXCR4 crosstalk.

Autori: Zhang Y Zhang L Li Y a ďalší

Zdroj: Microbial pathogenesis [Microb Pathog] 2025 Dec; Vol. 209, pp. 108067. Date of Electronic Publication: 2025 Sep 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

Výrazy zo slovníka MeSH: Toll-Like Receptor 2*/metabolism , Toll-Like Receptor 2*/genetics , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Chlamydophila pneumoniae*/pathogenicity , Chlamydophila pneumoniae*/growth & development , beta-Arrestin 2*/metabolism , beta-Arrestin 2*/genetics , Muscle, Smooth, Vascular*/microbiology , Muscle, Smooth, Vascular*/metabolism , Myocytes, Smooth Muscle*/microbiology , Myocytes, Smooth Muscle*/metabolism, Signal Transduction ; Animals ; Phosphorylation ; Humans ; Cells, Cultured ; Rats

A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages.

Autori: Bever KM Shin SM Durham JN a ďalší

Zdroj: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2543614. Date of Electronic Publication: 2025 Aug 15.

Spôsob vydávania: Journal Article; Clinical Trial, Phase II

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/pathology , Receptors, CXCR4*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/immunology , Carcinoma, Pancreatic Ductal*/pathology , Macrophages*/immunology , Macrophages*/drug effects , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , T-Lymphocytes*/immunology , T-Lymphocytes*/drug effects, Animals ; Mice ; Humans ; Female ; Male ; Middle Aged ; Benzylamines ; Cyclams ; Aged ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Heterocyclic Compounds/administration & dosage ; Immune Checkpoint Inhibitors/therapeutic use

Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration.

Autori: Cohen JN Kolluri G Clancy S a ďalší

Zdroj: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116467. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hair Follicle*/physiology , Hair Follicle*/metabolism , T-Lymphocytes, Regulatory*/metabolism , T-Lymphocytes, Regulatory*/immunology , Chemokine CXCL12*/metabolism , Receptors, CXCR4*/metabolism , Regeneration* , Skin*/metabolism, Animals ; Humans ; Mice ; Keratinocytes/metabolism ; Signal Transduction ; Mice, Inbred C57BL ; Receptors, Glucocorticoid/metabolism

Precision targeting of CXCR4 ⁺ leukemia cells by a humanized MMAE-nanoconjugate in an AML mouse model.

Autori: Garcia-León A Mendoza JI Rueda A a ďalší

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Nov; Vol. 192, pp. 118573. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, CXCR4*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/metabolism , Nanoconjugates*/chemistry , Nanoconjugates*/administration & dosage , Oligopeptides*/pharmacology , Oligopeptides*/administration & dosage , Oligopeptides*/chemistry , Antineoplastic Agents*/pharmacology, Animals ; Humans ; Mice ; Cell Line, Tumor ; Apoptosis/drug effects ; Xenograft Model Antitumor Assays ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Female ; Disease Models, Animal

Human cytomegalovirus interleukin 10 (cmvIL-10) orchestrates crosstalk between the cellular IL-10 receptor and CXCR4.

Autori: Satani KH Spencer JV

Zdroj: Virology [Virology] 2025 Nov; Vol. 612, pp. 110693. Date of Electronic Publication: 2025 Sep 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cytomegalovirus*/immunology , Cytomegalovirus*/genetics , Cytomegalovirus*/metabolism , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Interleukin-10*/metabolism , Interleukin-10*/genetics , Receptors, Interleukin-10*/metabolism , Receptors, Interleukin-10*/genetics , Viral Proteins*/metabolism , Viral Proteins*/genetics , Cytomegalovirus Infections*/virology , Cytomegalovirus Infections*/metabolism , Cytomegalovirus Infections*/genetics , Cytomegalovirus Infections*/immunology, Humans ; Signal Transduction ; Cell Movement ; Cell Proliferation