Suchergebnisse - "COVID-19 Drug Treatment"

Economic evaluation of oral Nirmatrelvir/ritonavir versus best supportive care in patients at high risk for progression to severe COVID-19 in Germany: a cost-effectiveness analysis.

Autoren: Schmalhofer C Otte Im Kampe E Eheberg D et al.

Quelle: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 1226-1240. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Comparative Study; Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/economics , Antiviral Agents*/therapeutic use , COVID-19*/economics , COVID-19*/epidemiology , COVID-19*/therapy , COVID-19 Drug Treatment*/economics , COVID-19 Drug Treatment*/methods , Palliative Care*/economics , Palliative Care*/statistics & numerical data, Germany/epidemiology ; Humans ; Male ; Female ; Middle Aged ; Aged ; Cost-Effectiveness Analysis ; Decision Trees ; Markov Chains ; Hospitalization/economics ; Hospitalization/statistics & numerical data ; Disease Progression ; Risk Factors ; Clinical Trials as Topic ; Sensitivity and Specificity ; Intensive Care Units/economics ; Intensive Care Units/statistics & numerical data ; SARS-CoV-2 ; Quality-Adjusted Life Years ; Cost-Benefit Analysis ; Lactams ; Ritonavir ; Drug Combinations ; Nitriles ; Proline ; Leucine

Developing New Drugs for the COVID-19 Emergency: Anatomy of the U.S. Response.

Autoren: Moore TJ Socal MP Anderson G

Quelle: Pharmacotherapy [Pharmacotherapy] 2025 Nov; Vol. 45 (11), pp. 780-790. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8111305 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9114 (Electronic) Linking ISSN: 02770008 NLM ISO Abbreviation: Pharmacotherapy Subsets: MEDLINE

MeSH-Schlagworte: COVID-19 Drug Treatment* , Antiviral Agents*/therapeutic use , Antiviral Agents*/economics , Drug Development*/organization & administration , Drug Development*/methods , Drugs, Investigational*/therapeutic use, Humans ; United States ; Drug Approval ; United States Food and Drug Administration ; COVID-19 ; SARS-CoV-2/drug effects

Data mining guided affinity ultrafiltration for rapid screening of SARS-CoV-2 3CL ^pro inhibitors in medicinal herbs.

Autoren: Wang L Chen M Wang H et al.

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117122. Date of Electronic Publication: 2025 Aug 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Data Mining*/methods , SARS-CoV-2*/drug effects , COVID-19 Drug Treatment* , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Coronavirus 3C Proteases*/antagonists & inhibitors , Coronavirus 3C Proteases*/metabolism , Plants, Medicinal*/chemistry, Animals ; Ultrafiltration/methods ; Mice ; Molecular Docking Simulation ; Humans ; COVID-19/virology ; Vero Cells

Interstitial drug delivery system: Physiological basis and (pre)clinical progress.

Autoren: Zhao A Tang Y Shi X et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114275. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Drug Delivery Systems*/methods , COVID-19 Vaccines*/administration & dosage , COVID-19 Drug Treatment* , Extracellular Fluid*, Humans ; Animals ; COVID-19 ; SARS-CoV-2

Prevalence of potentially inappropriate use of antiviral therapy with simnotrelvir-ritonavir versus nirmatrelvir-ritonavir in hospitalised patients: a retrospective study in Beijing, China.

Autoren: Zhu Y Zhang Y Yang H et al.

Quelle: BMJ open respiratory research [BMJ Open Respir Res] 2025 Dec 04; Vol. 12 (1). Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: BMJ Publishing Group Ltd & British Thoracic Society Country of Publication: England NLM ID: 101638061 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4439 (Electronic) Linking ISSN: 20524439 NLM ISO Abbreviation: BMJ Open Respir Res Subsets: MEDLINE

MeSH-Schlagworte: Ritonavir*/therapeutic use , Ritonavir*/administration & dosage , Antiviral Agents*/therapeutic use , Antiviral Agents*/administration & dosage , COVID-19 Drug Treatment* , Inappropriate Prescribing*/statistics & numerical data, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Hospitalization ; Beijing/epidemiology ; SARS-CoV-2 ; Drug Interactions ; Prevalence ; Drug Therapy, Combination ; COVID-19/epidemiology ; Adult

Moringa oleifera potential for the treatment and prevention of COVID-19 involving molecular interaction, antioxidant properties and kinetic mechanism.

Autoren: Hamadou M Bakwo Bassogog CB Obadias FV et al.

Quelle: PloS one [PLoS One] 2025 Dec 03; Vol. 20 (12), pp. e0337904. Date of Electronic Publication: 2025 Dec 03 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Moringa oleifera*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , COVID-19 Drug Treatment* , SARS-CoV-2*/drug effects , SARS-CoV-2*/enzymology , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry, Molecular Docking Simulation ; Plant Leaves/chemistry ; Humans ; COVID-19/prevention & control ; COVID-19/virology ; Kinetics ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Coronavirus 3C Proteases/chemistry ; Papain/antagonists & inhibitors

Time to anti-cancer treatment resumption after SARS-CoV-2 infection in patients with active haematological diseases undergoing combined antiviral treatments.

Autoren: Matteini E Pinnetti C Frondizi F et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Dec 02; Vol. 80 (12), pp. 3236-3241.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: COVID-19*/complications , Hematologic Neoplasms*/drug therapy , Hematologic Neoplasms*/complications , Antiviral Agents*/therapeutic use , Antiviral Agents*/administration & dosage , COVID-19 Drug Treatment* , Antineoplastic Agents*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Aged ; SARS-CoV-2/drug effects ; Adult ; Cohort Studies ; Drug Therapy, Combination

Safety Profile of Using Tocilizumab in the Treatment of Severely Ill Patients with COVID-19.

Autoren: Schnaus MJ Schmidt TE Schmiechen K et al.

Quelle: Southern medical journal [South Med J] 2025 Dec; Vol. 118 (12), pp. 772-774.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Southern Medical Association Country of Publication: United States NLM ID: 0404522 Publication Model: Print Cited Medium: Internet ISSN: 1541-8243 (Electronic) Linking ISSN: 00384348 NLM ISO Abbreviation: South Med J Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal, Humanized*/adverse effects , Antibodies, Monoclonal, Humanized*/therapeutic use , COVID-19 Drug Treatment*, Humans ; Female ; Male ; Retrospective Studies ; Middle Aged ; COVID-19/mortality ; Aged ; Respiration, Artificial/statistics & numerical data ; Adult ; SARS-CoV-2 ; Length of Stay/statistics & numerical data ; Severity of Illness Index

Clinical Pharmacology Approaches to Predict Efficacy of Monoclonal Antibodies Against Emerging SARS-CoV-2 Variants.

Autoren: Wang Q Nader A Peppercorn A et al.

Quelle: Clinical and translational science [Clin Transl Sci] 2025 Dec; Vol. 18 (12), pp. e70421.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/drug effects , SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , Antibodies, Monoclonal*/pharmacology , Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/administration & dosage , COVID-19 Drug Treatment* , COVID-19*/virology , COVID-19*/immunology , Antibodies, Viral*/administration & dosage , Antibodies, Viral*/therapeutic use , Antibodies, Viral*/immunology , Antibodies, Viral*/pharmacology, Humans ; Pharmacology, Clinical/methods ; Antibodies, Neutralizing

SCR Organism: SARS-CoV-2 variants

Applying High-Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and COVID-19 Outcomes.

Autoren: Bokern M Tazare J Rentsch CT et al.

Quelle: Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2025 Dec; Vol. 34 (12), pp. e70248.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 9208369 Publication Model: Print Cited Medium: Internet ISSN: 1099-1557 (Electronic) Linking ISSN: 10538569 NLM ISO Abbreviation: Pharmacoepidemiol Drug Saf Subsets: MEDLINE

MeSH-Schlagworte: COVID-19*/mortality , COVID-19*/epidemiology , Adrenal Cortex Hormones*/administration & dosage , Adrenal Cortex Hormones*/adverse effects , Pulmonary Disease, Chronic Obstructive*/drug therapy , COVID-19 Drug Treatment*, Humans ; Propensity Score ; Administration, Inhalation ; Male ; Female ; Aged ; Middle Aged ; Hospitalization/statistics & numerical data ; Pharmacoepidemiology/methods ; Confounding Factors, Epidemiologic

Streamlined and accelerated nonclinical development of COVID-19 vaccines and therapeutics - an IQ consortium DruSafe survey.

Autoren: Liu MM Ralston SL

Quelle: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2025 Dec; Vol. 163, pp. 105928. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: COVID-19 Vaccines* , COVID-19*/prevention & control , Drug Development*/methods , COVID-19 Drug Treatment* , Antiviral Agents*/therapeutic use, Humans ; Surveys and Questionnaires ; Drug Industry ; SARS-CoV-2 ; Animals

Effectiveness of Colchicine for the Treatment of Long COVID: A Randomized Clinical Trial.

Autoren: Bassi A Devasenapathy N Thankachen SS et al.

Quelle: JAMA internal medicine [JAMA Intern Med] 2025 Dec 01; Vol. 185 (12), pp. 1462-1470.

Publikationsart: Journal Article; Randomized Controlled Trial; Multicenter Study

Info zur Zeitschrift: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE

MeSH-Schlagworte: Colchicine*/therapeutic use , Colchicine*/administration & dosage , COVID-19*/complications , COVID-19*/physiopathology , COVID-19 Drug Treatment* , Anti-Inflammatory Agents*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Double-Blind Method ; Adult ; SARS-CoV-2 ; Treatment Outcome ; Quality of Life

Nirmatrelvir/ritonavir treatment for COVID-19: an economic value systematic literature review.

Autoren: Mugwagwa T Marcano Belisario J Hartley L et al.

Quelle: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 1933-1954. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article; Systematic Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

MeSH-Schlagworte: Ritonavir*/economics , Ritonavir*/therapeutic use , COVID-19 Drug Treatment* , Antiviral Agents*/economics , Antiviral Agents*/therapeutic use, Humans ; Cost-Benefit Analysis ; COVID-19 ; Drug Combinations ; SARS-CoV-2

Pharmacoinformatics-based screening and construction of a neutralizing anti-SARS-CoV-2 camelidae nanobody drug conjugate.

Autoren: Kalita E Panda M Dhar S et al.

Quelle: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 5835-5853. Date of Electronic Publication: 2025 Jan 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/immunology , SARS-CoV-2*/drug effects , Single-Domain Antibodies*/chemistry , Single-Domain Antibodies*/immunology , Single-Domain Antibodies*/genetics , Single-Domain Antibodies*/pharmacology , Antibodies, Neutralizing*/chemistry , Antibodies, Neutralizing*/immunology , COVID-19 Drug Treatment*, Molecular Docking Simulation ; Animals ; Camelidae/immunology ; Humans ; Molecular Dynamics Simulation ; COVID-19 ; Mutagenesis, Site-Directed

Real-world efficacy of oral azvudine in hospitalized patients with COVID-19: A multicenter retrospective cohort study.

Autoren: Han R Guan Y Li P et al.

Quelle: Journal of infection and public health [J Infect Public Health] 2025 Dec; Vol. 18 (12), pp. 102987. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE

MeSH-Schlagworte: COVID-19 Drug Treatment* , COVID-19*/mortality , Antiviral Agents*/therapeutic use , Antiviral Agents*/administration & dosage, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; China/epidemiology ; Aged ; Hospitalization ; SARS-CoV-2 ; Intensive Care Units/statistics & numerical data ; Administration, Oral ; Treatment Outcome ; Respiration, Artificial/statistics & numerical data ; Adult

Durations of fever and other symptoms among COVID-19 outpatients administered ensitrelvir during the 2023 Japanese XBB epidemic period.

Autoren: Kawai N Bando T Goto T et al.

Quelle: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2025 Dec; Vol. 31 (12), pp. 102852. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9608375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7780 (Electronic) Linking ISSN: 1341321X NLM ISO Abbreviation: J Infect Chemother Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/therapeutic use , COVID-19*/epidemiology , COVID-19*/prevention & control , COVID-19 Drug Treatment* , Fever*/epidemiology , Fever*/drug therapy , Fever*/virology, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Japan/epidemiology ; Outpatients/statistics & numerical data ; Retrospective Studies ; Time Factors ; East Asian People ; Indazoles ; Triazines ; Triazoles

In Silico and in vitro evaluation of Cucurbitaceae seed lectins as promising prophylactic and therapeutic agents against SARS-CoV-2.

Autoren: Ahmad R Akhter Y Varsha et al.

Quelle: Glycoconjugate journal [Glycoconj J] 2025 Dec; Vol. 42 (5-6), pp. 307-337. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 8603310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4986 (Electronic) Linking ISSN: 02820080 NLM ISO Abbreviation: Glycoconj J Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/drug effects , SARS-CoV-2*/metabolism , Spike Glycoprotein, Coronavirus*/chemistry , Spike Glycoprotein, Coronavirus*/metabolism , Seeds*/chemistry , Plant Lectins*/pharmacology , Plant Lectins*/chemistry , Cucurbitaceae*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , COVID-19 Drug Treatment* , Lectins*/pharmacology , Lectins*/chemistry, Humans ; Molecular Docking Simulation ; COVID-19/prevention & control ; COVID-19/virology ; Polysaccharides/metabolism ; Polysaccharides/chemistry ; Protein Binding ; Binding Sites

Peginterferon λ for the treatment of patients admitted to hospital with COVID-19: a phase 2, placebo-controlled randomized trial.

Autoren: Kandel C Biondi MJ Gillrie M et al.

Quelle: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2025 Dec; Vol. 31 (12), pp. 2048-2055. Date of Electronic Publication: 2025 Aug 14.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE

MeSH-Schlagworte: COVID-19 Drug Treatment* , Antiviral Agents*/therapeutic use , Polyethylene Glycols*/therapeutic use , Interferons*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; COVID-19 ; Brazil ; SARS-CoV-2/drug effects ; Hospitalization ; Treatment Outcome ; Canada ; Severity of Illness Index ; Interferon Lambda ; Interleukins

Safety and tolerability of molnupiravir and nirmatrelvir/ritonavir in patients with advanced chronic kidney disease and kidney failure; a cohort study.

Autoren: Sawtell R Ouyang T Moreno D et al.

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2466823. Date of Electronic Publication: 2025 Feb 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: Ritonavir*/adverse effects , Ritonavir*/therapeutic use , Ritonavir*/administration & dosage , COVID-19 Drug Treatment* , Antiviral Agents*/adverse effects , Antiviral Agents*/therapeutic use , Hydroxylamines*/adverse effects , Hydroxylamines*/therapeutic use , Hydroxylamines*/administration & dosage , Cytidine*/analogs & derivatives , Cytidine*/adverse effects , Cytidine*/therapeutic use , Renal Insufficiency, Chronic*/complications , Kidney Failure, Chronic*/complications, Humans ; Male ; Female ; Middle Aged ; Aged ; Drug Combinations ; SARS-CoV-2 ; COVID-19/complications ; Cohort Studies ; Morpholines/adverse effects ; Aged, 80 and over

Efficacy and safety of obeldesivir in low-risk, non-hospitalised patients with COVID-19 (OAKTREE): a phase 3, randomised, double-blind, placebo-controlled study.

Autoren: Ogbuagu O Goldman JD Gottlieb RL et al.

Körperschaften: Ogbuagu O Goldman JD Gottlieb RL et al.

Quelle: The Lancet. Infectious diseases [Lancet Infect Dis] 2025 Dec; Vol. 25 (12), pp. 1282-1292. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/therapeutic use , Antiviral Agents*/adverse effects , Antiviral Agents*/administration & dosage , COVID-19 Drug Treatment* , COVID-19*/virology, Humans ; Double-Blind Method ; Male ; Female ; Middle Aged ; Adult ; SARS-CoV-2/drug effects ; Adolescent ; Aged ; Treatment Outcome ; Young Adult ; Viral Load ; Japan