Výsledky vyhľadávania - "CD1d"

DNA damage agents trigger iNKT cell-mediated elimination of AML cells through activation of NF-κB/HLA-DRB6/CD1d pathway.

Autori: Tu G Wu Q Yuan Y a ďalší

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117174. Date of Electronic Publication: 2025 Jul 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/metabolism , Antigens, CD1d*/genetics , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/immunology , Leukemia, Myeloid, Acute*/pathology , Natural Killer T-Cells*/drug effects , Natural Killer T-Cells*/metabolism , Natural Killer T-Cells*/immunology , DNA Damage*/drug effects , DNA Damage*/physiology , NF-kappa B*/metabolism, Humans ; Animals ; Mice ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Cell Line, Tumor ; Galactosylceramides/pharmacology ; RNA, Long Noncoding/metabolism ; RNA, Long Noncoding/genetics

B cell-expressed CD1d promotes MPL/TDCM lipid emulsion adjuvant effects in polysaccharide vaccines.

Autori: Jennings-Gee JE Daly CA Bray AS a ďalší

Zdroj: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Jul 01; Vol. 214 (7), pp. 1630-1642.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/immunology , Antigens, CD1d*/genetics , Antigens, CD1d*/metabolism , B-Lymphocytes*/immunology , Adjuvants, Immunologic* , Lipid A*/analogs & derivatives , Lipid A*/immunology , Lipid A*/administration & dosage , Adjuvants, Vaccine* , Pneumococcal Vaccines*/immunology, Animals ; Mice ; Immunoglobulin G/immunology ; Mice, Knockout ; Mice, Transgenic ; Mice, Inbred C57BL ; Emulsions ; Phosphorylcholine/immunology

CD1d-Restricted NKT Cells Promote Central Memory CD8 ⁺ T Cell Formation via an IL-15-pSTAT5-Eomes Axis in a Pathogen-Exposed Environment.

Autori: Qin Y Qian Y Zhang J a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 28; Vol. 26 (15). Date of Electronic Publication: 2025 Jul 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Antigens, CD1d*/genetics , Antigens, CD1d*/metabolism , Antigens, CD1d*/immunology , Interleukin-15*/metabolism , Interleukin-15*/immunology , Immunologic Memory* , STAT5 Transcription Factor*/metabolism , STAT5 Transcription Factor*/immunology , T-Box Domain Proteins*/metabolism , T-Box Domain Proteins*/immunology, Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction

Blocking the innate immune CD1d/NKT cell axis prevents the development of cortical hyperexcitability and posttraumatic epilepsy.

Autori: Ping X Xiong W Priya R a ďalší

Zdroj: Epilepsia [Epilepsia] 2025 Jun; Vol. 66 (6), pp. 2110-2123. Date of Electronic Publication: 2025 Feb 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/genetics , Antigens, CD1d*/immunology , Epilepsy, Post-Traumatic*/immunology , Epilepsy, Post-Traumatic*/prevention & control , Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/drug effects , Immunity, Innate*/drug effects , Immunity, Innate*/immunology , Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/immunology , Cerebral Cortex*/physiopathology , Cerebral Cortex*/immunology , Cerebral Cortex*/drug effects, Animals ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Male ; Electroencephalography ; Disease Models, Animal

HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function.

Autori: Qiu L Gao X Shao X a ďalší

Zdroj: Journal of virology [J Virol] 2025 Apr 15; Vol. 99 (4), pp. e0214024. Date of Electronic Publication: 2025 Mar 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/genetics , Antigens, CD1d*/metabolism , Antigens, CD1d*/immunology , Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , Herpesvirus 1, Human*/immunology , Herpesvirus 1, Human*/genetics , Herpesvirus 1, Human*/metabolism , Viral Proteins*/metabolism , Viral Proteins*/genetics , Viral Proteins*/immunology , Nedd4 Ubiquitin Protein Ligases*/metabolism , Nedd4 Ubiquitin Protein Ligases*/genetics, Animals ; Mice ; Humans ; Herpes Simplex/immunology ; Herpes Simplex/virology ; Mice, Inbred C57BL ; Ubiquitination ; Immune Evasion ; Down-Regulation

CD1d-iNKT Axis in Infectious Diseases: Lessons Learned From the Past.

Autori: Chatterjee P Brahma S Cresswell P a ďalší

Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2025 Apr; Vol. 101 (4), pp. e70024.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0323767 Publication Model: Print Cited Medium: Internet ISSN: 1365-3083 (Electronic) Linking ISSN: 03009475 NLM ISO Abbreviation: Scand J Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/immunology , Antigens, CD1d*/metabolism , Natural Killer T-Cells*/immunology , Communicable Diseases*/immunology, Humans ; Animals ; Glycolipids/immunology ; Antigen Presentation/immunology ; Cytokines/metabolism ; Cytokines/immunology ; Immunotherapy/methods ; Immunity, Innate

In silico identification and characterization of small molecule binding to the CD1d immunoreceptor.

Autori: Rathakrishnan P McShan AC

Zdroj: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Apr; Vol. 43 (6), pp. 2929-2947. Date of Electronic Publication: 2023 Dec 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/chemistry , Antigens, CD1d*/metabolism , Small Molecule Libraries*/chemistry , Small Molecule Libraries*/metabolism, Molecular Docking Simulation ; Protein Binding ; Molecular Dynamics Simulation ; Humans ; Ligands ; Binding Sites

Lipid structure-dependent CD1d functional stabilization and immunomodulation of endogenous glucosylceramides.

Autori: Ueki K Nozawa R Matsumaru T a ďalší

Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Mar 27; Vol. 61 (27), pp. 5154-5157. Date of Electronic Publication: 2025 Mar 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/immunology , Antigens, CD1d*/chemistry , Antigens, CD1d*/metabolism , Glucosylceramides*/chemistry , Glucosylceramides*/immunology , Glucosylceramides*/metabolism , Immunomodulation*, Animals ; Natural Killer T-Cells/immunology ; Mice ; Humans ; Glycolipids/chemistry

Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells.

Autori: Hosono Y Tomiyasu N Kasai H a ďalší

Zdroj: The Journal of experimental medicine [J Exp Med] 2025 Feb 03; Vol. 222 (2). Date of Electronic Publication: 2024 Dec 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Galactosylceramides*/immunology , Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , Antigens, CD1d*/metabolism , Antigens, CD1d*/immunology , Mice, Inbred C57BL* , Melanoma, Experimental*/immunology, Animals ; Mice ; Tandem Mass Spectrometry ; Antigens/immunology ; Cell Line, Tumor ; Lymphocyte Activation/immunology

The α glycolipid rules the NKT cell TCR.

Autori: Kronenberg M Ascui G

Zdroj: The Journal of experimental medicine [J Exp Med] 2025 Feb 03; Vol. 222 (2). Date of Electronic Publication: 2024 Dec 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Receptors, Antigen, T-Cell*/immunology , Receptors, Antigen, T-Cell*/metabolism , Glycolipids*/immunology , Glycolipids*/metabolism , Antigens, CD1d*/metabolism , Antigens, CD1d*/immunology, Animals ; Humans ; Mice

Highly Selective Cytokine Induction of Nitrated Lipid-Modified α-GalCer Derivatives Demonstrating High Binding Affinity to the Lipid Antigen Presenting Molecule CD1d.

Autori: Sueyoshi K Kishi J Inuki S a ďalší

Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2025 Jan 27; Vol. 31 (6), pp. e202403871. Date of Electronic Publication: 2025 Jan 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/chemistry , Antigens, CD1d*/metabolism , Antigens, CD1d*/immunology , Galactosylceramides*/chemistry , Galactosylceramides*/immunology , Galactosylceramides*/metabolism , Cytokines*/metabolism , Glycolipids*/chemistry , Lipids*/chemistry, Animals ; Mice ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Hydrogen Bonding ; Antigen Presentation ; Protein Binding ; Humans

α-GalCer sp ² -iminoglycolipid analogs as CD1d-dependent iNKT modulators: Evaluation of their immunotherapeutic potential in murine models of asthma and autoimmune hepatitis.

Autori: Lai AC González-Cuesta M Ho CH a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Jan 15; Vol. 282, pp. 117060. Date of Electronic Publication: 2024 Nov 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/drug effects , Natural Killer T-Cells*/immunology , Antigens, CD1d*/metabolism , Galactosylceramides*/chemistry , Galactosylceramides*/pharmacology , Galactosylceramides*/chemical synthesis , Asthma*/drug therapy , Asthma*/immunology , Hepatitis, Autoimmune*/drug therapy , Hepatitis, Autoimmune*/immunology, Animals ; Mice ; Disease Models, Animal ; Glycolipids/chemistry ; Glycolipids/pharmacology ; Glycolipids/chemical synthesis ; Structure-Activity Relationship ; Immunotherapy ; Molecular Structure ; Mice, Inbred C57BL ; Dose-Response Relationship, Drug ; Female ; Humans

Optimizing iNKT-driven immune responses against cancer by modulating CD1d in tumor and antigen presenting cells.

Autori: Shyanti RK Haque M Singh R a ďalší

Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Dec; Vol. 269, pp. 110402. Date of Electronic Publication: 2024 Nov 17.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antigens, CD1d*/immunology , Natural Killer T-Cells*/immunology , Neoplasms*/immunology , Neoplasms*/therapy , Antigen-Presenting Cells*/immunology, Humans ; Animals ; Immunotherapy/methods ; Antigen Presentation/immunology

Invariant TCR-triggered protein kinase D activation mediates NKT cell development.

Autori: Ishikawa E Kosako H Motooka D a ďalší

Zdroj: The Journal of experimental medicine [J Exp Med] 2025 Dec 01; Vol. 222 (12). Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/cytology , Receptors, Antigen, T-Cell*/metabolism , Receptors, Antigen, T-Cell*/immunology , Protein Kinase C*/metabolism , Protein Kinase C*/genetics , Protein Kinase C*/immunology, Animals ; Promyelocytic Leukemia Zinc Finger Protein ; Mice ; Ikaros Transcription Factor/metabolism ; Ikaros Transcription Factor/genetics ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Mice, Inbred C57BL ; Enzyme Activation ; Cell Differentiation/immunology ; Phosphorylation ; Signal Transduction ; Mice, Knockout ; Antigens, CD1d/metabolism

Invariant and Diverse NKT Cells Regulate Bacterial Clearance and Pathology in Chlamydial Genital Tract Infection in Mice.

Autori: Ishii K Soejima T Ohnishi Y a ďalší

Zdroj: Pathogens (Basel, Switzerland) [Pathogens] 2025 Nov 15; Vol. 14 (11). Date of Electronic Publication: 2025 Nov 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Chlamydia Infections*/immunology , Chlamydia Infections*/microbiology , Chlamydia Infections*/pathology , Reproductive Tract Infections*/immunology , Reproductive Tract Infections*/microbiology , Reproductive Tract Infections*/pathology , Chlamydia muridarum*/immunology, Animals ; Female ; Mice ; Disease Models, Animal ; Mice, Knockout ; Cytokines/metabolism ; Mice, Inbred C57BL ; Antigens, CD1d/genetics ; Vagina/microbiology ; Vagina/immunology

Dual regulatory role of natural killer T cells during development of hepatocellular carcinoma.

Autori: Papanastasatou M Gioulbasani M Nakou E a ďalší

Zdroj: Communications biology [Commun Biol] 2025 Oct 20; Vol. 8 (1), pp. 1478. Date of Electronic Publication: 2025 Oct 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/chemically induced , Natural Killer T-Cells*/immunology , Liver Neoplasms*/immunology , Liver Neoplasms*/pathology , Liver Neoplasms*/chemically induced, Animals ; Mice ; Mice, Inbred C57BL ; Antigens, CD1d/genetics ; Diethylnitrosamine ; Mice, Knockout ; Male ; Apoptosis

Invariant Natural Killer T lymphocytes as natural sensors for microbes: a two-edged sword in liver diseases.

Autori: Gonzatti MB Keller AC

Zdroj: Frontiers in immunology [Front Immunol] 2025 Oct 06; Vol. 16, pp. 1662906. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , Liver Diseases*/immunology , Liver Diseases*/microbiology , Liver Diseases*/metabolism , Liver Diseases*/etiology , Gastrointestinal Microbiome*/immunology , Liver*/immunology , Liver*/microbiology , Liver*/pathology , Liver*/metabolism, Humans ; Animals ; Lymphocyte Activation ; Antigens, CD1d/immunology

TNF-expressing CD1d+ monocytes are associated with the activation of CD4- CD8- T cells in patients with Chagas cardiomyopathy.

Autori: Koh CC Velikkakam T Neves EGA a ďalší

Zdroj: Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2024 Nov 15; Vol. 57. Date of Electronic Publication: 2024 Nov 15 (Print Publication: 2024).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chagas Cardiomyopathy*/immunology , Monocytes*/immunology , Flow Cytometry* , Tumor Necrosis Factor-alpha* , Antigens, CD1d*/immunology, Humans ; Male ; Female ; Middle Aged ; Adult ; CD8-Positive T-Lymphocytes/immunology ; Lymphocyte Activation/immunology ; CD4-Positive T-Lymphocytes/immunology

CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms.

Autori: Zhou X Wang Y Dou Z a ďalší

Zdroj: Nature cancer [Nat Cancer] 2024 Nov; Vol. 5 (11), pp. 1607-1621. Date of Electronic Publication: 2024 Oct 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Receptors, Chimeric Antigen*/immunology , Immunotherapy, Adoptive*/methods , Antigens, CD1d*/immunology , Tumor Microenvironment*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology, Animals ; Mice ; Humans ; Cell Line, Tumor ; Hepatitis A Virus Cellular Receptor 2/immunology ; Macrophages/immunology ; Mice, Inbred C57BL ; Female

Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells.

Autori: Cheng TY Praveena T Govindarajan S a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 20; Vol. 121 (34), pp. e2321686121. Date of Electronic Publication: 2024 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , Antigens, CD1d*/immunology , Antigens, CD1d*/metabolism , Receptors, Antigen, T-Cell*/immunology , Receptors, Antigen, T-Cell*/metabolism , Lipidomics*/methods, Animals ; Mice ; Humans ; Autoantigens/immunology ; Autoantigens/metabolism ; Ceramides/metabolism ; Ceramides/immunology ; Lipids/chemistry ; Lipids/immunology ; Endoplasmic Reticulum Stress/immunology