Výsledky vyhledávání - "CARBOXYPEPTIDASES"

Real-time FRET assay for monitoring detyrosination by TMCP1 and VASH2.

Autoři: Simon M Espeut J Juge F a další

Zdroj: Protein science : a publication of the Protein Society [Protein Sci] 2025 Dec; Vol. 34 (12), pp. e70374.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Fluorescence Resonance Energy Transfer*/methods , Tyrosine*/analogs & derivatives , Tyrosine*/metabolism , Tyrosine*/chemistry , Tubulin*/metabolism , Tubulin*/chemistry , Carboxypeptidases*/metabolism , Carboxypeptidases*/chemistry , Cell Adhesion Molecules*/metabolism , Cell Adhesion Molecules*/chemistry , Enzyme Assays*/methods, Humans ; Kinetics

Stabilisation of PRCP by deubiquitinase-targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy.

Autoři: Zhou F Xia J Liu Y a další

Zdroj: British journal of pharmacology [Br J Pharmacol] 2025 Nov; Vol. 182 (21), pp. 5317-5339. Date of Electronic Publication: 2025 Jul 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Autophagy*/drug effects , Cardiomegaly*/drug therapy , Cardiomegaly*/pathology , Cardiomegaly*/metabolism , Carboxypeptidases*/metabolism , Carboxypeptidases*/genetics, Animals ; Mice, Knockout ; Mice ; Male ; Mice, Inbred C57BL ; Rats ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism

Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice.

Autoři: Demcsák A Sahin-Tóth M

Zdroj: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2025 Oct 01; Vol. 329 (4), pp. G546-G556.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/enzymology , Precancerous Conditions*/genetics , Precancerous Conditions*/pathology , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/enzymology , Carboxypeptidases A*/genetics , Carboxypeptidases A*/metabolism , Mutation* , Pancreas*/pathology , Pancreatitis, Chronic*/genetics , Pancreatitis, Chronic*/pathology, Animals ; Mice ; Proto-Oncogene Proteins p21(ras)/genetics ; Protein Folding ; Mice, Transgenic ; Genetic Predisposition to Disease ; Disease Models, Animal

Aminopeptidase and carboxypeptidase activity of DPP-4 on the example of peptides LPQNIPPL and LPβ ³ hQNIPPL.

Autoři: Turalić A Osmanović A Podlipnik Č a další

Zdroj: Journal of molecular graphics & modelling [J Mol Graph Model] 2026 Jan; Vol. 142, pp. 109173. Date of Electronic Publication: 2025 Sep 11.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science, Inc Country of Publication: United States NLM ID: 9716237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4243 (Electronic) Linking ISSN: 10933263 NLM ISO Abbreviation: J Mol Graph Model Subsets: MEDLINE

Výrazy ze slovníku MeSH: Dipeptidyl Peptidase 4*/chemistry , Dipeptidyl Peptidase 4*/metabolism , Carboxypeptidases*/chemistry , Carboxypeptidases*/metabolism , Aminopeptidases*/chemistry , Aminopeptidases*/metabolism , Peptides*/chemistry , Peptides*/metabolism, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Catalytic Domain ; Protein Binding ; Humans ; Binding Sites ; Substrate Specificity

Scpep1 inhibition attenuates myocardial infarction-induced dysfunction by improving mitochondrial bioenergetics.

Autoři: Chen G Gan J Wu F a další

Zdroj: European heart journal [Eur Heart J] 2025 Jul 07; Vol. 46 (26), pp. 2579-2594.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE

Výrazy ze slovníku MeSH: Myocardial Infarction*/metabolism , Myocardial Infarction*/physiopathology , Mitochondria, Heart*/metabolism , Carboxypeptidases*/metabolism , Carboxypeptidases*/antagonists & inhibitors , Carboxypeptidases*/genetics, Animals ; Mice ; Energy Metabolism/physiology ; Male ; Apoptosis/physiology ; Mice, Inbred C57BL ; Myocytes, Cardiac/metabolism ; Humans ; Disease Models, Animal

Multi-omics Mendelian randomization integrating RNA-seq, eQTL and pQTL data revealed CPXM1 as a potential drug target for osteoporosis.

Autoři: Lian J Zhang X Shi S a další

Zdroj: Hereditas [Hereditas] 2025 Sep 30; Vol. 162 (1), pp. 200. Date of Electronic Publication: 2025 Sep 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 0374654 Publication Model: Electronic Cited Medium: Internet ISSN: 1601-5223 (Electronic) Linking ISSN: 00180661 NLM ISO Abbreviation: Hereditas Subsets: MEDLINE

Výrazy ze slovníku MeSH: Osteoporosis*/genetics , Osteoporosis*/drug therapy , Quantitative Trait Loci* , Carboxypeptidases*/genetics, Animals ; Humans ; Mice ; Mendelian Randomization Analysis ; RNA-Seq ; Bone Density ; Female ; Multiomics

The rice asura mutant exhibits abnormal stigma morphology caused by a T-DNA insertion in the gene for serine carboxypeptidase SCP5, a putative regulator of homeotic proteins.

Autoři: Shimada H Nishino Y Izumi S a další

Zdroj: Plant & cell physiology [Plant Cell Physiol] 2025 Sep 13; Vol. 66 (8), pp. 1205-1219.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: Japan NLM ID: 9430925 Publication Model: Print Cited Medium: Internet ISSN: 1471-9053 (Electronic) Linking ISSN: 00320781 NLM ISO Abbreviation: Plant Cell Physiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Oryza*/anatomy & histology , Oryza*/genetics , Flowers*/anatomy & histology , Carboxypeptidases*/genetics , Genes, Plant*, Mutagenesis, Insertional ; Codon, Terminator ; Amino Acid Sequence ; DNA, Bacterial

CPA1^S282P mutation leads to chronic pancreatitis in rabbits.

Autoři: Yang J Liu X Li CY a další

Zdroj: Zoological research [Zool Res] 2025 May 18; Vol. 46 (3), pp. 647-660.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Science Press Country of Publication: China NLM ID: 101697192 Publication Model: Print Cited Medium: Internet ISSN: 2095-8137 (Print) Linking ISSN: 20958137 NLM ISO Abbreviation: Zool Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pancreatitis, Chronic*/genetics , Pancreatitis, Chronic*/veterinary , Carboxypeptidases A*/genetics , Carboxypeptidases A*/metabolism, Animals ; Rabbits ; Humans ; Mutation ; HEK293 Cells ; Endoplasmic Reticulum Stress

AEBP1 or ACLP, which is the key factor in inflammation and fibrosis?

Autoři: Runtian Z Wenqiang H Zimeng S a další

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 May; Vol. 310 (Pt 4), pp. 143554. Date of Electronic Publication: 2025 Apr 26.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Inflammation*/metabolism , Inflammation*/pathology , Inflammation*/genetics , Carboxypeptidases*/metabolism , Carboxypeptidases*/genetics, Humans ; Fibrosis/metabolism ; Animals ; Signal Transduction ; Repressor Proteins

PRCP is a promising drug target for intracranial aneurysm rupture supported via multi-omics analysis.

Autoři: Wu J Mei Y Li X a další

Zdroj: Stroke and vascular neurology [Stroke Vasc Neurol] 2025 Apr 29; Vol. 10 (2). Date of Electronic Publication: 2025 Apr 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BMJ Country of Publication: England NLM ID: 101689996 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-8696 (Electronic) Linking ISSN: 20598688 NLM ISO Abbreviation: Stroke Vasc Neurol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Intracranial Aneurysm*/genetics , Intracranial Aneurysm*/enzymology , Intracranial Aneurysm*/drug therapy , Aneurysm, Ruptured*/genetics , Aneurysm, Ruptured*/enzymology , Aneurysm, Ruptured*/drug therapy , Aneurysm, Ruptured*/prevention & control , Proteomics*/methods , Carboxypeptidases*/genetics , Carboxypeptidases*/metabolism , Carboxypeptidases*/blood , Proteasome Endopeptidase Complex*/genetics , Proteasome Endopeptidase Complex*/metabolism , Proteasome Endopeptidase Complex*/blood , Subarachnoid Hemorrhage*/genetics , Subarachnoid Hemorrhage*/enzymology, Humans ; Genetic Predisposition to Disease ; Quantitative Trait Loci ; Phenotype ; Mendelian Randomization Analysis ; Risk Factors ; Molecular Targeted Therapy ; Gene Expression Profiling ; Gene Regulatory Networks ; Transcriptome ; Multiomics

Measuring the Carboxypeptidase and γ-Glutamyltranspeptidase Activities of Lager and Ale Yeasts to Assess Their Impact on the Release of Odorant Polyfunctional Thiols Through Fermentation.

Autoři: Calicis C Christiaens R Loquet N a další

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Jun 06; Vol. 30 (12). Date of Electronic Publication: 2025 Jun 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy ze slovníku MeSH: Fermentation* , Carboxypeptidases*/metabolism , gamma-Glutamyltransferase*/metabolism , Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Odorants*/analysis , Saccharomyces*/enzymology, Saccharomyces cerevisiae/enzymology

Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma.

Autoři: Allam VSRR Montpeyó D Beau F a další

Zdroj: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2025 May 24; Vol. 74 (1), pp. 80. Date of Electronic Publication: 2025 May 24.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9508160 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-908X (Electronic) Linking ISSN: 10233830 NLM ISO Abbreviation: Inflamm Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Asthma*/drug therapy , Asthma*/immunology , Asthma*/pathology , Anti-Asthmatic Agents*/therapeutic use , Anti-Asthmatic Agents*/pharmacology , Carboxypeptidases A*/antagonists & inhibitors, Animals ; Mice, Inbred BALB C ; Pyroglyphidae/immunology ; Disease Models, Animal ; Lung/pathology ; Lung/drug effects ; Lung/immunology ; Female ; Mice

Accessibility of Carboxypeptidase A-bound Zinc to Chelation Correlates with an Intermediate State in the Protein's Unfolding Pathway.

Autoři: Goulet DL Bignucolo MW Siemann S

Zdroj: Biochemistry [Biochemistry] 2025 Mar 18; Vol. 64 (6), pp. 1244-1256. Date of Electronic Publication: 2025 Mar 10.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Výrazy ze slovníku MeSH: Zinc*/chemistry , Zinc*/metabolism , Carboxypeptidases A*/chemistry , Carboxypeptidases A*/metabolism , Protein Unfolding* , Chelating Agents*/chemistry, Spectrometry, Fluorescence ; Protein Folding ; Resorcinols/chemistry ; Guanidine/chemistry

SCPL48 regulates the vessel cell programmed cell death during xylem development in Arabidopsis thaliana.

Autoři: Zhang C Shen M Xu Y a další

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Mar; Vol. 295, pp. 139495. Date of Electronic Publication: 2025 Jan 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Xylem*/growth & development , Xylem*/cytology , Xylem*/genetics , Xylem*/metabolism , Arabidopsis*/genetics , Arabidopsis*/growth & development , Arabidopsis*/cytology , Arabidopsis*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis Proteins*/metabolism , Apoptosis*/genetics , Carboxypeptidases*/genetics , Carboxypeptidases*/metabolism, Gene Expression Regulation, Plant ; Droughts ; Cell Differentiation/genetics ; Stress, Physiological/genetics ; Cell Wall/metabolism

A study on the molecular mechanism of cardiac protection of procarboxylpeptidase in MIRI rats based on the NLRP3 signaling pathway.

Autoři: He L Qin Y Lu Q a další

Zdroj: Science progress [Sci Prog] 2025 Jan-Mar; Vol. 108 (1), pp. 368504251322085. Date of Electronic Publication: 2025 Mar 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: SAGE Publications Country of Publication: England NLM ID: 0411361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-7163 (Electronic) Linking ISSN: 00368504 NLM ISO Abbreviation: Sci Prog Subsets: MEDLINE

Výrazy ze slovníku MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/prevention & control , Signal Transduction* , Carboxypeptidases*/metabolism , Carboxypeptidases*/genetics, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Apoptosis ; Disease Models, Animal ; Myocardium/metabolism ; Myocardium/pathology ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism

Characterization of differentially regulated carboxypeptidase (metallopeptidase M32) protein in Miltefosine resistant Leishmania donovani parasites.

Autoři: Kumar K Banerjee S Sanivarapu H a další

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Feb; Vol. 289, pp. 138648. Date of Electronic Publication: 2024 Dec 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Leishmania donovani*/enzymology , Carboxypeptidases*/metabolism , Drug Resistance* , Antiprotozoal Agents*, Protein Interaction Maps ; Phosphorylcholine/analogs & derivatives

Mode of Metal Ligation Governs Inhibition of Carboxypeptidase A.

Autoři: Amador Balderas JA Beierlein F Horn AHC a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 23; Vol. 25 (24). Date of Electronic Publication: 2024 Dec 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Carboxypeptidases A*/chemistry , Carboxypeptidases A*/antagonists & inhibitors , Carboxypeptidases A*/metabolism , Zinc*/chemistry , Zinc*/metabolism , Molecular Dynamics Simulation*, Ligands ; Binding Sites ; Protein Binding ; Humans

Structural adaptations for carboxypeptidase activity in putative S9 acylaminoacyl peptidase from Bacillus subtilis.

Autoři: Chandravanshi K Singh R Kumar A a další

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec; Vol. 282 (Pt 1), pp. 136734. Date of Electronic Publication: 2024 Oct 19.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Bacillus subtilis*/enzymology , Carboxypeptidases*/metabolism , Carboxypeptidases*/chemistry, Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Amino Acid Sequence ; Substrate Specificity ; Models, Molecular ; Structure-Activity Relationship ; Protein Conformation ; Peptide Hydrolases

Phylogenomic and synteny analysis of BAHD and SCP/SCPL gene families reveal their evolutionary histories in plant specialized metabolism.

Autoři: Naake T D'Auria JC Fernie AR a další

Zdroj: Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2024 Nov 18; Vol. 379 (1914), pp. 20230349. Date of Electronic Publication: 2024 Sep 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Royal Society Country of Publication: England NLM ID: 7503623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2970 (Electronic) Linking ISSN: 09628436 NLM ISO Abbreviation: Philos Trans R Soc Lond B Biol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Phylogeny* , Synteny* , Evolution, Molecular* , Carboxypeptidases*/genetics , Carboxypeptidases*/metabolism , Multigene Family*, Plant Proteins/genetics ; Plant Proteins/metabolism ; Zea mays/genetics ; Solanum lycopersicum/genetics ; Arabidopsis/genetics ; Acyltransferases/genetics ; Acyltransferases/metabolism ; Genome, Plant

Genome-Wide Analysis of the Serine Carboxypeptidase-like (SCPL) Protein Family of Bitter Gourd and Functional Validation of McSCPL 22 in Fusarium oxysporum f. sp. Momordicae (FOM) Resistance.

Autoři: Guan F Yang X Shi B a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 03; Vol. 25 (21). Date of Electronic Publication: 2024 Nov 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Fusarium*/pathogenicity , Disease Resistance*/genetics , Gene Expression Regulation, Plant* , Plant Diseases*/microbiology , Plant Diseases*/genetics , Carboxypeptidases*/genetics , Carboxypeptidases*/metabolism , Plant Proteins*/genetics , Plant Proteins*/metabolism , Momordica charantia*/genetics, Phylogeny ; Multigene Family ; Cyclopentanes/metabolism ; Cyclopentanes/pharmacology ; Genome-Wide Association Study ; Oxylipins

SCR Organism: Fusarium oxysporum