Search Results - "Buffa, Francesca M"
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1
Authors: et al.
Source: 2024 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). :1-8
Subject Terms: Feature Importance, Feature Selection, Fuzzy Inference Systems, Interpretable AI, Interpretable Models, FEATURE IMPORTANCE, FEATURE SELECTION, FUZZY INFERENCE SYSTEMS, INTERPRETABLE AI, INTERPRETABLE MODELS
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2
Authors:
Source: 2024 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). :1-8
Subject Terms: BIOINFORMATICS, EVOLUTIONARY ALGORITHMS, GENE REGULATORY NETWORKS, GENETIC PROGRAMMING, OPTIMISATION
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3
Authors: et al.
Source: 2024 IEEE Congress on Evolutionary Computation (CEC). :01-08
Subject Terms: CEC 2017 COMPETITION, EVOLUTIONARY ALGORITHMS, GLOBAL OPTIMIZATION, LOCAL SEARCH, REAL-PARAMETER SINGLE OBJECTIVE OPTIMIZATION, CEC 2017 competition, Evolutionary Algorithms, Global Optimization, Local Search, Real-parameter single objective optimization
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4
Authors: et al.
Contributors: et al.
Source: Cancer Res Commun
Mahmood, U, Blake, A, Rathee, S, Samuel, L, Murray, G, Sebag-Montefiore, D, Gollins, S, West, N P, Begum, R, Bach, S P, Richman, S D, Quirke, P, Redmond, K L, Salto-Tellez, M, Koelzer, V H, Leedham, S J, Tomlinson, I, Dunne, P D, Buffa, F M, Maughan, T S, Domingo, E & S-CORT Consortium 2024, 'Stratification to neoadjuvant radiotherapy in rectal cancer by regimen and transcriptional signatures', Cancer Research Communications, vol. 4, no. 7, pp. 1765-1776. https://doi.org/10.1158/2767-9764.CRC-23-0502
Cancer Research CommunicationsSubject Terms: Male, 0301 basic medicine, Oxaliplatin/therapeutic use, Supplementary Data, MR/M016587/1, CRUK/08/032, R Medicine, Fluorouracil/therapeutic use, Neoplastic/drug effects, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Antineoplastic Combined Chemotherapy Protocols, Humans, name=SDG 3 - Good Health and Well-being, Response to neoadjuvant radiotherapy (RT) in rectal cancer has been associated with immune and stromal features that are captured by transcriptional signatures. However, how such associations perform across different chemoradiotherapy regimens and within individual consensus molecular subtypes (CMS) and how they affect survival remain unclear. In this study, gene expression and clinical data of pretreatment biopsies from nine cohorts of primary rectal tumors were combined (N = 826). Exploratory analyses were done with transcriptomic signatures for the endpoint of pathologic complete response (pCR), considering treatment regimen or CMS subtype. Relevant findings were tested for overall survival and recurrence-free survival. Immune and stromal signatures were strongly associated with pCR and lack of pCR, respectively, in RT and capecitabine (Cap)/5-fluorouracil (5FU)–treated patients (N = 387), in which the radiosensitivity signature (RSS) showed the strongest association. Upon addition of oxaliplatin (Ox, N = 123), stromal signatures switched direction and showed higher chances to achieve pCR than without Ox (p for interaction 0.02). Among Cap/5FU patients, most signatures performed similarly across CMS subtypes, except cytotoxic lymphocytes that were associated with pCR in CMS1 and CMS4 cases compared with other CMS subtypes (p for interaction 0.04). The only variables associated with survival were pCR and RSS. Although the frequency of pCR across different chemoradiation regimens is relatively similar, our data suggest that response rates may differ depending on the biological landscape of rectal cancer. Response to neoadjuvant RT in stroma-rich tumors may potentially be improved by the addition of Ox. RSS in preoperative biopsies provides predictive information for response specifically to neoadjuvant RT with 5FU, Capecitabine, Aged, 0303 health sciences, Capecitabine/therapeutic use, Rectal Neoplasms, Gene Expression Profiling, UK Research and Innovation (UKRI), Middle Aged, Neoadjuvant Therapy, 3. Good health, Oxaliplatin, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Gene Expression Regulation, Neoplastic/drug effects, Cancer Research UK, Female, Rectal Neoplasms/pathology, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Fluorouracil, Transcriptome, Research Article
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5
Authors: et al.
Source: 2023 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). :1-8
Subject Terms: Artificial Intelligence, Deep Learning, Consensus clustering, Bioinformatics, scRNA-seq data, ARTIFICIAL INTELLIGENCE, DEEP LEARNING, CONSENSUS CLUSTERING, BIOINFORMATICS, SCRNA-SEQ DATA
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6
Authors: et al.
Contributors: et al.
Source: Bioinformatics ; volume 41, issue 3 ; ISSN 1367-4811
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7
Authors: et al.
Contributors: et al.
Source: Cell Genomics ; volume 5, issue 2, page 100764 ; ISSN 2666-979X
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8
Authors: et al.
Source: Sci Adv
Science AdvancesSubject Terms: 0301 basic medicine, DNA REPAIR, BIOINFORMATICS, CANCER, 0303 health sciences, DNA End-Joining Repair, DNA Repair, Cell Cycle, Ubiquitination, 03 medical and health sciences, Exodeoxyribonucleases, DNA Repair Enzymes, Cyclins, Radiation, Ionizing, Humans, DNA Breaks, Double-Stranded, Biomedicine and Life Sciences
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9
Authors: et al.
Contributors: et al.
Source: Cell Oncol (Dordr)
Subject Terms: Mitogen-Activated Protein Kinase Kinases, Proto-Oncogene Proteins B-raf, Vascular Endothelial Growth Factor A, 0301 basic medicine, 0303 health sciences, Receptor Tyrosine Kinase-like Orphan Receptors, Wnt-5a Protein, BRAF, 3. Good health, Bevacizumab, 03 medical and health sciences, Cell Line, Tumor, Mutation, Humans, Original Article, WNT5A, BRAF, MELANOMA, ROR2, WNT5A, Melanoma, ROR2
File Description: application/pdf; application/zip; text/xml
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10
Authors: et al.
Contributors: et al.
Subject Terms: ATOVAQUONE, ANTI-PD-L1 THERAPY, MOUSE CANCER MODELS, BIOINFORMATICS
File Description: PRINT + ONLINE
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001140990100001; volume:15; issue:1; firstpage:32; lastpage:-; journal:CELL DEATH & DISEASE; https://hdl.handle.net/11565/4064859
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11
Authors: et al.
Contributors: et al.
Subject Terms: GENES, IMMUNE RESPONSE, PRECISION MEDICINE, PREDICTION, RADIOTHERAPY, RECTAL NEOPLASMS, TGFΒ
File Description: PRINT + ONLINE
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001273258600001; volume:106; firstpage:105228; lastpage:-; journal:EBIOMEDICINE; https://hdl.handle.net/11565/4069886
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12
Authors:
Contributors:
Subject Terms: ROBUSTNESS, REPRODUCIBILITY, AI LEARNING, BIOMEDICAL SCIENCES
File Description: PRINT + ONLINE
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001148428500066; volume:14; issue:1; firstpage:1933; lastpage:-; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/11565/4064856
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13
Authors: et al.
Contributors: et al.
Subject Terms: BIOINFORMATICS, GENETICS, INHERITANCE, CANCER, OBESITY
File Description: PRINT + ONLINE
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001196356400118; volume:14; issue:1; firstpage:7270; lastpage:-; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/11565/4064876
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14
Authors: et al.
Contributors: et al.
Subject Terms: AGENT-BASED MODELLING, METABOLIC FLUX MODELLING, COMPUTATIONAL MODELLING, BOOLEAN NETWORKS, LOGIC GATES, SIMULATIONS, SYMBIOSIS
File Description: PRINT + ONLINE
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001192145200003; volume:20; issue:3; firstpage:e1011944; lastpage:-; journal:PLOS COMPUTATIONAL BIOLOGY; https://hdl.handle.net/11565/4064877; https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011944
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15
Authors: et al.
Source: Current Opinion in Oncology. 34:705-712
Subject Terms: 03 medical and health sciences, RNA, Untranslated, 0302 clinical medicine, circulating tumor cells, glioblastoma, glioma, liquid biopsy, non coding RNA, translational research, Biomarkers, Tumor, Liquid Biopsy, HEALTH RESEARCH, DATA SCIENCES, CANCER, GBM, OMICS, BIOMARKERS, BIOINFORMATICS, COMPUTATIONAL BIOLOGY, BIOMEDICAL DATA, STUDY DESIGN, Humans, Glioma, circulating tumor cells, DNA, glioblastoma, glioma, liquid biopsy, RNA, translational research, Neoplastic Cells, Circulating, Cell-Free Nucleic Acids, 3. Good health
File Description: application/pdf
Access URL: https://pubmed.ncbi.nlm.nih.gov/36093876
https://journals.lww.com/co-oncology/abstract/2022/11000/new_perspectives_in_liquid_biopsy_for_glioma.16.aspx
https://hdl.handle.net/20.500.14243/458700
https://doi.org/10.1097/CCO.0000000000000902
https://hdl.handle.net/11565/4052492
https://doi.org/10.1097/CCO.0000000000000902
https://journals.lww.com/co-oncology/Abstract/2022/11000/New_perspectives_in_liquid_biopsy_for_glioma.16.aspx -
16
Authors: et al.
Source: Cancer Metastasis Rev
Cancer and Metastasis ReviewsSubject Terms: 0301 basic medicine, 2. Zero hunger, 0303 health sciences, 03 medical and health sciences, Neovascularization, Pathologic, Carcinogenesis, Neoplasms, Humans, COMPUTATIONAL BIOLOGY, BIOINFORMATICS, GENOMICS, BIOMEDICAL RESEARCH, HEALTH RESEARCH, MEDICAL INFORMATICS, OBESITY, CANCER, BMI, ADIPOSITY, CARCINOGENESIS, HALLMARKS OF CANCER, Obesity, Article, Signal Transduction, 3. Good health
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17
Authors: et al.
Source: Diabetes; Nov2025, Vol. 74 Issue 11, p1929-1945, 17p
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18
Authors: et al.
Contributors: et al.
Subject Terms: BIOINFORMATICS, MARKER GENE SELECTION, MARKER PANELS, MULTI-OBJECTIVE OPTIMIZATION, SINGLE-CELL RNA-SEQ
File Description: ELETTRONICO
Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001099987300001; volume:147; firstpage:104510; lastpage:-; journal:JOURNAL OF BIOMEDICAL INFORMATICS; https://hdl.handle.net/11565/4060956
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19
Authors: et al.
Subject Terms: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Patient Safety, Cancer, Genetics, Prostate Cancer, Urologic Diseases, Aging, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Disease-Free Survival, Gene Expression Regulation, Neoplastic, Humans, Male, Neoplasm Metastasis, Prostatic Neoplasms, Survival Rate, Tumor Hypoxia, Gene expression signature, Hypoxia, Prognostic biomarker, Prostate cancer, Radiotherapy, Public Health and Health Services, Clinical sciences, Epidemiology
File Description: application/pdf
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20
Authors:
Source: 2025 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) ; page 1-8
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