Search Results - "Brain Neoplasms/genetics [MeSH]"

A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4: implications for prognosis and clinical trial design

Authors: Wetzel, Ethan A. Nohman, Amin I. Hsieh, Annie L. et al.

Source: J Neurooncol

Subject Terms: Male, Adult, Clinical Trials as Topic, Brain Neoplasms, Research, Glioma, Neoplasm Grading [MeSH], Aged [MeSH], Research Design [MeSH], Glioma/mortality [MeSH], Glioma/pathology [MeSH], Male [MeSH], Astrocytoma/genetics [MeSH], Brain Neoplasms/mortality [MeSH], Cyclin-Dependent Kinase Inhibitor p15/genetics [MeSH], Astrocytoma, Astrocytoma/mortality [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Mutation [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Astrocytoma/pathology [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Isocitrate dehydrogenase (IDH), Cyclin-Dependent Kinase Inhibitor p16/genetics [MeSH], Survival Rate [MeSH], Glioma/diagnosis [MeSH], Clinical Trials as Topic [MeSH], Biomarkers, Tumor/genetics [MeSH], Glioma/genetics [MeSH], Prognosis [MeSH], Young Adult [MeSH], WHO grade 4, Isocitrate Dehydrogenase/genetics [MeSH], Brain Neoplasms/pathology [MeSH], Middle Aged, Prognosis, Isocitrate Dehydrogenase, Survival Rate, Research Design, Mutation, Humans, Female, Neoplasm Grading, Cyclin-Dependent Kinase Inhibitor p16, Retrospective Studies, Aged, Cyclin-Dependent Kinase Inhibitor p15, Follow-Up Studies

Access URL: https://pubmed.ncbi.nlm.nih.gov/39432026
https://repository.publisso.de/resource/frl:6495852

ERN GENTURIS guidelines on constitutional mismatch repair deficiency diagnosis, genetic counselling, surveillance, quality of life, and clinical management

Authors: Colas, Chrystelle Guerrini-Rousseau, Léa Suerink, Manon et al.

Contributors: Colas, Chrystelle Guerrini-Rousseau, Léa Suerink, Manon et al.

Source: Eur J Hum Genet
European Journal of Human Genetics, 32, 12, pp. 1526-1541

Subject Terms: Neoplastic Syndromes, Hereditary, Brain Neoplasms, Genetics, Quality of Life, Humans, Genetics(clinical), Genetic Counseling, Brain Neoplasms/genetics [MeSH], Colorectal Neoplasms/diagnosis [MeSH], Humans [MeSH], Review Article, 692/700/459/1748, Neoplastic Syndromes, Hereditary/genetics [MeSH], 631/67/2332, Neoplastic Syndromes, Hereditary/diagnosis [MeSH], Genetic Testing/standards [MeSH], Neoplastic Syndromes, Hereditary/therapy [MeSH], Quality of Life [MeSH], review-article, Brain Neoplasms/diagnosis [MeSH], Colorectal Neoplasms/genetics [MeSH], Genetic Counseling/standards [MeSH], Genetic Testing/methods [MeSH], Brain Neoplasms/therapy [MeSH], Genetic Testing, Gastroenterology - Radboud University Medical Center, Colorectal Neoplasms

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39420201
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/315171
https://dspace.library.uu.nl/handle/1874/458673
https://repository.ubn.ru.nl//bitstream/handle/2066/315171/315171.pdf
https://hdl.handle.net/2066/315171
https://repository.publisso.de/resource/frl:6499539

Determinants of long-term survival in patients with IDH-mutant gliomas

Authors: Katzendobler, Sophie Niedermeyer, Sebastian Blobner, Jens et al.

Contributors: Katzendobler, Sophie Niedermeyer, Sebastian Blobner, Jens et al.

Source: J Neurooncol

Subject Terms: Male, Adult, Adolescent, Oligodendroglioma, 610 Medicine & health, Aged [MeSH], Glioma/mortality [MeSH], Glioma/pathology [MeSH], Male [MeSH], Astrocytoma/genetics [MeSH], Brain Neoplasms/mortality [MeSH], Case-Control Studies [MeSH], Astrocytoma, Astrocytoma/mortality [MeSH], Adolescent [MeSH], Female [MeSH], Oligodendroglioma/mortality [MeSH], Follow-Up Studies [MeSH], Mutation [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Astrocytoma/pathology [MeSH], Oligodendroglioma/pathology [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], IDH-mutation, Oligodendroglioma/genetics [MeSH], Survival Rate [MeSH], Lower grade glioma, Research, Glioma/genetics [MeSH], Prognosis [MeSH], Young Adult [MeSH], Chemotherapy, Temozolomide, Radiotherapy, Isocitrate Dehydrogenase/genetics [MeSH], Brain Neoplasms/pathology [MeSH], Young Adult, Humans, 1306 Cancer Research, Retrospective Studies, Aged, Brain Neoplasms, Glioma, Middle Aged, Prognosis, Isocitrate Dehydrogenase, 10040 Clinic for Neurology, Survival Rate, 2728 Neurology (clinical), 2808 Neurology, Case-Control Studies, Mutation, 2730 Oncology, Female, Follow-Up Studies

File Description: s11060_024_04826_9.pdf - application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39316316
https://repository.publisso.de/resource/frl:6490810
https://epub.ub.uni-muenchen.de/126248/

Report of the sixth meeting of the European Consortium ‘Care for CMMRD’ (C4CMMRD), Paris, France, November 16th 2022

Authors: Guerrini-Rousseau, Léa Gallon, Richard Pineda, Marta et al.

Contributors: Guerrini-Rousseau, Léa Gallon, Richard Pineda, Marta et al.

Source: Fam Cancer
Familial Cancer, 23, 4, pp. 447-457

Subject Terms: 0301 basic medicine, Cancer Research, 0303 health sciences, Meeting report, Review, Europe [MeSH], C, European C, Brain Neoplasms/genetics [MeSH], Humans [MeSH], Neoplastic Syndromes, Hereditary/genetics [MeSH], DNA-Binding Proteins/genetics [MeSH], Paris [MeSH], Neoplastic Syndromes, Hereditary/diagnosis [MeSH], Mismatch Repair Endonuclease PMS2/genetics [MeSH], Germ-Line Mutation [MeSH], Neoplastic Syndromes, Hereditary/therapy [MeSH], MutS Homolog 2 Protein/genetics [MeSH], CMMRD, Brain Neoplasms/therapy [MeSH], MutL Protein Homolog 1/genetics [MeSH], Medical Biosciences - Radboud University Medical Center, 03 medical and health sciences, Oncology, Genetics, Genetics(clinical), CCMMRD, European CCMMRD consortium

File Description: application/pdf

Access URL: https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/313689
https://dspace.library.uu.nl/handle/1874/458160
https://repository.ubn.ru.nl//bitstream/handle/2066/313689/313689.pdf
https://hdl.handle.net/2066/313689
https://repository.publisso.de/resource/frl:6524068

A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases

Authors: Jeising, Sebastian Nickel, Ann-Christin Trübel, Johanna et al.

Source: J Neurooncol

Subject Terms: Female [MeSH], Brain Neoplasms/secondary [MeSH], Spheroid cultures, Brain Neoplasms/genetics [MeSH], Humans [MeSH], Antineoplastic Agents/pharmacology [MeSH], Middle Aged [MeSH], Tumor Cells, Cultured [MeSH], Personalized medicine, Drug Screening Assays, Antitumor/methods [MeSH], High-Throughput Screening Assays/methods [MeSH], Male [MeSH], High-throughput drug screening, Research, Brain metastasis, Antineoplastic Agents/therapeutic use [MeSH], Brain Neoplasms/drug therapy [MeSH], Brain Neoplasms/pathology [MeSH], High-Throughput Nucleotide Sequencing [MeSH], Male, 0301 basic medicine, Brain Neoplasms, High-Throughput Nucleotide Sequencing, Antineoplastic Agents, Middle Aged, High-Throughput Screening Assays, 03 medical and health sciences, 0302 clinical medicine, Tumor Cells, Cultured, Humans, Female, Drug Screening Assays, Antitumor

Access URL: https://pubmed.ncbi.nlm.nih.gov/38985431
https://repository.publisso.de/resource/frl:6498549

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

Authors: Kocher, Daniela Cao, Lei Guiho, Romain et al.

Contributors: Kocher, Daniela Cao, Lei Guiho, Romain et al.

Source: J Neurooncol

Subject Terms: Proto-Oncogene Proteins B-raf, 0301 basic medicine, Treatment withdrawal, MAP Kinase Signaling System, Mice, 03 medical and health sciences, Cell Line, Tumor, Humans, Animals, Child, Protein Kinase Inhibitors, MAPK inhibitor, Cell Proliferation, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Brain Neoplasms, Research, Rebound growth, Cell Line, Tumor [MeSH], Proto-Oncogene Proteins B-raf/genetics [MeSH], Microglia/drug effects [MeSH], Cytokines/metabolism [MeSH], Tumor microenvironment, Proto-Oncogene Proteins B-raf/metabolism [MeSH], Microglia/metabolism [MeSH], Glioma/drug therapy [MeSH], Glioma/pathology [MeSH], Xenograft Model Antitumor Assays [MeSH], Child [MeSH], Glioma/metabolism [MeSH], Mutation [MeSH], Brain Neoplasms/genetics [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], Humans [MeSH], MAP Kinase Signaling System/drug effects [MeSH], Animals [MeSH], Pediatric low-grade glioma, Cytokines, Mice [MeSH], Glioma/genetics [MeSH], Brain Neoplasms/drug therapy [MeSH], Cell Proliferation/drug effects [MeSH], Brain Neoplasms/metabolism [MeSH], Brain Neoplasms/pathology [MeSH], Glioma, Xenograft Model Antitumor Assays, Mutation, Microglia, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

File Description: application/pdf; pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38630384
https://hal.science/hal-04592464v1
https://hal.science/hal-04592464v1/document
https://doi.org/10.1007/s11060-024-04672-9
https://repository.publisso.de/resource/frl:6522340
https://discovery-pp.ucl.ac.uk/id/eprint/10191333/

RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma

Authors: Haidy A. Saleh Nicola Mitwasi Liliana R. Loureiro et al.

Source: Cancer Gene Ther

Subject Terms: 0301 basic medicine, Receptors, Chimeric Antigen, Brain Neoplasms, T-Lymphocytes, Cell Line, Tumor [MeSH], Antibodies, Bispecific/immunology [MeSH], Glioblastoma/immunology [MeSH], T-Lymphocytes/metabolism [MeSH], Receptors, Chimeric Antigen/immunology [MeSH], 13, 42, 692/699/67/580, Glioblastoma/metabolism [MeSH], TWEAK Receptor/metabolism [MeSH], Glioblastoma/pathology [MeSH], 59/5, Receptors, Chimeric Antigen/genetics [MeSH], Xenograft Model Antitumor Assays [MeSH], Killer Cells, Natural/immunology [MeSH], Glioblastoma/genetics [MeSH], 13/1, Killer Cells, Natural/metabolism [MeSH], Brain Neoplasms/genetics [MeSH], T-Lymphocytes/immunology [MeSH], Brain Neoplasms/immunology [MeSH], Humans [MeSH], 101/1, 101, Animals [MeSH], Glioblastoma/therapy [MeSH], TWEAK Receptor/genetics [MeSH], Antibodies, Bispecific/pharmacology [MeSH], Mice [MeSH], Article, 82, 82/1, 59, 692/308/153, Immunotherapy, Adoptive/methods [MeSH], Receptors, Chimeric Antigen/metabolism [MeSH], 14, Brain Neoplasms/metabolism [MeSH], article, Brain Neoplasms/pathology [MeSH], Brain Neoplasms/therapy [MeSH], Xenograft Model Antitumor Assays, Immunotherapy, Adoptive, Killer Cells, Natural, Mice, 03 medical and health sciences, 0302 clinical medicine, TWEAK Receptor, Cell Line, Tumor, Antibodies, Bispecific, Humans, Animals, Glioblastoma

Access URL: https://pubmed.ncbi.nlm.nih.gov/38582787
https://repository.publisso.de/resource/frl:6497262

Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated

Authors: McDonald, Malcolm F Gopakumar, Sricharan Juratli, Tareq A et al.

Source: Acta Neuropathol Commun
Acta Neuropathologica Communications, Vol 13, Iss 1, Pp 1-9 (2025)

Subject Terms: Male, Adult, Medical Sciences, Diseases, Neoplasms, Discontiguous, Medical Specialties, Medicine and Health Sciences, IDH WT glioma, Glioblastoma recurrence, Humans, RC346-429, Aged, Female [MeSH], Mutation [MeSH], Aged [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Glioblastoma/pathology [MeSH], Magnetic Resonance Imaging [MeSH], Multicentric, Hypermutation, Male [MeSH], Research, Neoplasm Recurrence, Local/genetics [MeSH], Glioblastoma/genetics [MeSH], Isocitrate Dehydrogenase/genetics [MeSH], Brain Neoplasms/pathology [MeSH], Mental and Social Health, Brain Neoplasms, Middle Aged, Magnetic Resonance Imaging, Isocitrate Dehydrogenase, Neoplasm Recurrence, Local, Neurology, Oncology, Mutation, Female, Neurology. Diseases of the nervous system, Neoplasm Recurrence, Local, Glioblastoma

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39815367
https://doaj.org/article/9771a7a8d58d446cbbcf0f579b63c1d4
https://repository.publisso.de/resource/frl:6498930

Clinical Management of Patients with Non-Small Cell Lung Cancer, Brain Metastases, and Actionable Genomic Alterations: A Systematic Literature Review

Authors: Khasraw, Mustafa Yalamanchili, Priyanka Santhanagopal, Anu et al.

Contributors: Khasraw, Mustafa Yalamanchili, Priyanka Santhanagopal, Anu et al.

Source: Adv Ther
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname

Subject Terms: Cervell - Càncer - Aspectes genètics, FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::mutación, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Lung Neoplasms, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, Brain Neoplasms, Mutation [MeSH], Brain Neoplasms/secondary [MeSH], Carcinoma, Non-Small-Cell Lung/genetics [MeSH], Brain Neoplasms/genetics [MeSH], Humans [MeSH], Lung Neoplasms/genetics [MeSH], Brain metastases, NSCLC, Genomics [MeSH], Lung Neoplasms/pathology [MeSH], Review, Systematic literature review, Carcinoma, Non-Small-Cell Lung/drug therapy [MeSH], Anaplastic Lymphoma Kinase/genetics [MeSH], Brain Neoplasms/therapy [MeSH], DISEASES::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms, DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica, Pulmons - Càncer - Aspectes genètics, Genomics, DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas, Genòmica, Anomalies cromosòmiques, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Mutation, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema nervioso::neoplasias del sistema nervioso central::neoplasias cerebrales, Carcinoma, Non-Small-Cell Lung, Mutation, Humans, Anaplastic Lymphoma Kinase, DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38509433
https://hdl.handle.net/11351/11398
https://repository.publisso.de/resource/frl:6507626

Identification of a gene expression signature associated with brain metastasis in colorectal cancer

Authors: Marlies Michl Francesco Taverna Christine Woischke et al.

Source: Clin Transl Oncol

Subject Terms: Gene Expression Regulation, Neoplastic [MeSH], Aged [MeSH], Colorectal cancer, Liver Neoplasms/metabolism [MeSH], Male [MeSH], Brain metastasis, Gene expression signature, Liver Neoplasms/genetics [MeSH], Research Article, Female [MeSH], Brain Neoplasms/secondary [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Metastatic organotropism, Biomarkers, Tumor/metabolism [MeSH], Liver Neoplasms/secondary [MeSH], ROC Curve [MeSH], Colorectal Neoplasms/pathology [MeSH], Biomarkers, Tumor/genetics [MeSH], Prognosis [MeSH], Transcriptome [MeSH], Colorectal Neoplasms/genetics [MeSH], Gene Expression Profiling [MeSH], Male, Adult, 0301 basic medicine, 0303 health sciences, Brain Neoplasms, Gene Expression Profiling, Liver Neoplasms, Middle Aged, Prognosis, 3. Good health, Gene Expression Regulation, Neoplastic, 03 medical and health sciences, ROC Curve, Biomarkers, Tumor, Humans, Female, Colorectal Neoplasms, Transcriptome, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/38558282
https://repository.publisso.de/resource/frl:6498341
https://epub.ub.uni-muenchen.de/115690/

Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET

Authors: Lena Kaiser S. Quach A. J. Zounek et al.

Source: Eur J Nucl Med Mol Imaging
European journal of nuclear medicine and molecular imaging 51(8), 2371-2381 (2024). doi:10.1007/s00259-024-06654-5
European journal of nuclear medicine, vol 51, iss 8

Subject Terms: Male, Adult, genetics [Glioma], BraTS, TSPO protein, human, TSPO PET, Image Processing, (18F)fluoroethyltyrosine, genetics [Isocitrate Dehydrogenase], GABA, Computer-Assisted, Receptors, GABA, Receptors, Image Processing, Computer-Assisted, Humans, Glioma, Aged [MeSH], FET PET, Glioma/diagnostic imaging [MeSH], Original Article, Radiomics, Magnetic Resonance Imaging [MeSH], Positron-Emission Tomography/methods [MeSH], Tyrosine/analogs, Male [MeSH], Image Processing, Computer-Assisted [MeSH], Radiomics [MeSH], Receptors, GABA/genetics [MeSH], Female [MeSH], Mutation [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Glioma/genetics [MeSH], Receptors, GABA/metabolism [MeSH], Brain Neoplasms/diagnostic imaging [MeSH], Isocitrate Dehydrogenase/genetics [MeSH], ddc:610, diagnostic imaging [Glioma], Aged, analogs & derivatives [Tyrosine], Brain Neoplasms, methods [Positron-Emission Tomography], Middle Aged, Magnetic Resonance Imaging, Isocitrate Dehydrogenase, ddc, genetics [Receptors, GABA], 3. Good health, metabolism [Receptors, GABA], genetics [Brain Neoplasms], Positron-Emission Tomography, Mutation, Tyrosine, Female, diagnostic imaging [Brain Neoplasms], IDH mutation status

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38396261
https://pub.dzne.de/record/270296
https://repository.publisso.de/resource/frl:6503774
https://epub.ub.uni-muenchen.de/117673/
https://escholarship.org/uc/item/58x872x9
https://escholarship.org/content/qt58x872x9/qt58x872x9.pdf
https://mediatum.ub.tum.de/1770916

Validation of a methylation-based signature for subventricular zone involvement in glioblastoma

Authors: Felix Ehret Oliver Zühlke Leonille Schweizer et al.

Source: J Neurooncol

Subject Terms: 0301 basic medicine, 0303 health sciences, Brain Neoplasms, Research, Intracellular Signaling Peptides and Proteins, Methylation, Methylation [MeSH], Brain Neoplasms/genetics [MeSH], IDH, Humans [MeSH], Prospective Studies [MeSH], Overall survival, Glioblastoma/pathology [MeSH], Subventricular zone, Glioblastoma, Wild type, Adaptor Proteins, Signal Transducing [MeSH], Intracellular Signaling Peptides and Proteins [MeSH], Lateral Ventricles/diagnostic imaging [MeSH], Eye Proteins [MeSH], Brain Neoplasms/diagnostic imaging [MeSH], Glioblastoma/diagnostic imaging [MeSH], Glioblastoma/genetics [MeSH], Lateral Ventricles/pathology [MeSH], Brain Neoplasms/pathology [MeSH], 03 medical and health sciences, Lateral Ventricles, Humans, Prospective Studies, Eye Proteins, Adaptor Proteins, Signal Transducing

Access URL: https://pubmed.ncbi.nlm.nih.gov/38376766
https://repository.publisso.de/resource/frl:6503738

Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk–benefit analysis

Authors: Alhalabi, Obada T. Dao Trong, Philip Kaes, Manuel et al.

Source: J Neurooncol

Subject Terms: Reoperation, 03 medical and health sciences, 0302 clinical medicine, Brain Neoplasms, Research, Humans, Glioma, Recurrent glioma, Glioma/surgery [MeSH], Brain Neoplasms/genetics [MeSH], Precision oncology, Humans [MeSH], Brain Neoplasms/surgery [MeSH], Retrospective Studies [MeSH], Reoperation [MeSH], Neoplasm Recurrence, Local/surgery [MeSH], Surgical complications, Glioma/pathology [MeSH], Molecular diagnostics, Glioma/genetics [MeSH], Neoplasm Recurrence, Local/genetics [MeSH], Targeted therapy, Precision Medicine [MeSH], Brain Neoplasms/pathology [MeSH], Neoplasm Recurrence, Local, Precision Medicine, Retrospective Studies

Access URL: https://pubmed.ncbi.nlm.nih.gov/38334907
https://repository.publisso.de/resource/frl:6500703

Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas

Authors: Naureen Keric Harald Krenzlin Darius Kalasauskas et al.

Contributors: Naureen Keric Harald Krenzlin Darius Kalasauskas et al.

Source: J Neurooncol

Subject Terms: Male, 610 Medizin, Extend of resection, World Health Organization [MeSH], Prognostic factors, IDH1/2 wildtype, Male [MeSH], Astrocytoma/genetics [MeSH], Glioma/therapy [MeSH], Female [MeSH], Mutation [MeSH], Brain Neoplasms/genetics [MeSH], Humans [MeSH], Astrocytoma/pathology [MeSH], Treatment Outcome [MeSH], ErbB Receptors/genetics [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Glioblastoma, Astrocytoma/therapy [MeSH], Glioma/diagnosis [MeSH], WHO grade II or III astrocytomas, Research, Glioma/genetics [MeSH], Prognosis [MeSH], Isocitrate Dehydrogenase/genetics [MeSH], Brain Neoplasms/pathology [MeSH], Brain Neoplasms/therapy [MeSH], Astrocytoma, World Health Organization, 03 medical and health sciences, 0302 clinical medicine, 610 Medical sciences, Humans, Retrospective Studies, ddc:610, Brain Neoplasms, Glioma, Middle Aged, Prognosis, Isocitrate Dehydrogenase, ddc, 3. Good health, ErbB Receptors, Treatment Outcome, Mutation, Female

File Description: application/pdf; pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38326661
https://openscience.ub.uni-mainz.de/handle/20.500.12030/11052
https://doi.org/10.25358/openscience-11033
https://resolver.sub.uni-goettingen.de/purl?gro-2/142142
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/113580
https://doi.org/10.1007/s11060-024-04585-7
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1135805
https://opus.bibliothek.uni-augsburg.de/opus4/files/113580/113580.pdf
https://repository.publisso.de/resource/frl:6513570
https://mediatum.ub.tum.de/1770659

Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma

Authors: Lai, Thu Hang Wenzel, Barbara Dukić-Stefanović, Sladjana et al.

Contributors: Lai, Thu Hang Wenzel, Barbara Dukić-Stefanović, Sladjana et al.

Source: Eur J Nucl Med Mol Imaging

Subject Terms: 0301 basic medicine, 0303 health sciences, Brain Neoplasms, Pyridines, [18F]FET, Glycine, Glioma, Malignant brain tumors, IDH mutation, Fluorine-18, Isocitrate Dehydrogenase, Rats, Mice, 03 medical and health sciences, 0302 clinical medicine, Ivosidenib, [SDV.CAN] Life Sciences [q-bio]/Cancer, Orthotopic glioma xenograft model, Positron-Emission Tomography, CMRF, Pyridines [MeSH], Brain Neoplasms/genetics [MeSH], Humans [MeSH], Rats [MeSH], Animals [MeSH], Original Article, Mice [MeSH], Positron-Emission Tomography/methods [MeSH], Glioma/genetics [MeSH], [, Glycine/analogs, Isocitrate Dehydrogenase/genetics [MeSH], Humans, Animals

Access URL: https://pubmed.ncbi.nlm.nih.gov/37982850
https://repository.publisso.de/resource/frl:6507062

Rapid DNA methylation-based classification of pediatric brain tumors from ultrasonic aspirate specimens

Authors: Michèle Simon Luis P. Kuschel Katja von Hoff et al.

Source: J Neurooncol
Simon, M, Kuschel, L P, von Hoff, K, Yuan, D, Hernáiz Driever, P, Hain, E G, Koch, A, Capper, D, Schulz, M, Thomale, U W & Euskirchen, P 2024, 'Rapid DNA methylation-based classification of pediatric brain tumors from ultrasonic aspirate specimens', Journal of Neuro-Oncology, vol. 169, no. 1, pp. 73-83. https://doi.org/10.1007/s11060-024-04702-6

Subject Terms: Male, Nanopore sequencing, DNA Copy Number Variations, Adolescent, Whole Genome Sequencing, Brain Neoplasms, Research, Infant, DNA Methylation, 3. Good health, Ultrasonic aspirator, Child, Preschool, Pediatric brain cancer, Humans, Female, Child, Adolescent [MeSH], Female [MeSH], Brain Neoplasms/genetics [MeSH], Humans [MeSH], Whole Genome Sequencing/methods [MeSH], DNA Copy Number Variations [MeSH], Infant [MeSH], Male [MeSH], Brain Neoplasms/classification [MeSH], DNA Methylation [MeSH], Child [MeSH], Child, Preschool [MeSH], Brain Neoplasms/pathology [MeSH]

Access URL: https://pubmed.ncbi.nlm.nih.gov/38769169
https://repository.publisso.de/resource/frl:6517544
https://pure.au.dk/portal/en/publications/5032c49e-973d-41f6-a49f-695f3039fc34
https://doi.org/10.1007/s11060-024-04702-6
http://www.scopus.com/inward/record.url?scp=85193594941&partnerID=8YFLogxK

DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma

Authors: Cakmak, Pinar Jurmeister, Philipp Divé, Iris et al.

Source: Clin Epigenetics
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)

Subject Terms: Adult, Male, 0301 basic medicine, QH426-470, DNA methylation age acceleration, Epigenesis, Genetic, 03 medical and health sciences, Genetics, Humans, Cellular Senescence, Aged, 0303 health sciences, Brain Neoplasms, Giant cell glioblastoma, DNA Methylation/genetics [MeSH], Female [MeSH], Aged [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], Humans [MeSH], Pediatric-type high-grade glioma, Middle Aged [MeSH], Glioblastoma/pathology [MeSH], Male [MeSH], Research, Epigenesis, Genetic/genetics [MeSH], Cellular Senescence/genetics [MeSH], Glioblastoma/genetics [MeSH], Epigenetic aging, Isocitrate Dehydrogenase/genetics [MeSH], Brain Neoplasms/pathology [MeSH], DNA Methylation, Middle Aged, Isocitrate Dehydrogenase, Medicine, Female, Glioblastoma

File Description: text

Access URL: https://pubmed.ncbi.nlm.nih.gov/39663543
https://doaj.org/article/8526f144477745d7a6ce35afef5ef37a
https://repository.publisso.de/resource/frl:6523204

Homozygous CDKN2A/B deletions in low- and high-grade glioma: a meta-analysis of individual patient data and predictive values of p16 immunohistochemistry testing

Authors: Noack, Darius Wach, Johannes Barrantes-Freer, Alonso et al.

Source: Acta Neuropathol Commun
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)

Subject Terms: 0301 basic medicine, 0303 health sciences, Brain Neoplasms, Research, Homozygote, Gene Deletion [MeSH], Homozygote [MeSH], Glioma, CDKN2A/B, Neoplasm Grading [MeSH], p16, Brain Neoplasms/genetics [MeSH], Humans [MeSH], Overall survival, Meta-analysis, Predictive Value of Tests [MeSH], Cyclin-Dependent Kinase Inhibitor p16/genetics [MeSH], Immunohistochemistry [MeSH], Glioma/pathology [MeSH], Glioma/diagnosis [MeSH], Glioma/genetics [MeSH], Cyclin-Dependent Kinase Inhibitor p15/genetics [MeSH], Individual patient data, Brain Neoplasms/pathology [MeSH], Immunohistochemistry, 03 medical and health sciences, Predictive Value of Tests, Humans, Neurology. Diseases of the nervous system, Neoplasm Grading, RC346-429, Cyclin-Dependent Kinase Inhibitor p16, Gene Deletion, Cyclin-Dependent Kinase Inhibitor p15

Access URL: https://pubmed.ncbi.nlm.nih.gov/39593128
https://doaj.org/article/e1dd798e74034178b2f5a383004acdcb
https://repository.publisso.de/resource/frl:6509001

Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients

Authors: Klinsing, Svenja Beck, Julia Weber, Katharina J. et al.

Contributors: Klinsing, Svenja Beck, Julia Weber, Katharina J. et al.

Source: Acta Neuropathol Commun
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)

Subject Terms: Male, Adult, 0301 basic medicine, DNA Copy Number Variations, Cohort Studies, Cell-free DNA, Young Adult, 03 medical and health sciences, Biomarkers, Tumor, Humans, RC346-429, Aged, Aged, 80 and over, 0303 health sciences, Liquid biopsy, Whole Genome Sequencing, Brain Neoplasms, Research, Female [MeSH], Aged, 80 and over [MeSH], Whole Genome Sequencing [MeSH], Aged [MeSH], Brain Neoplasms/genetics [MeSH], Adult [MeSH], DNA Copy Number Variations/genetics [MeSH], Humans [MeSH], Cell-Free Nucleic Acids/cerebrospinal fluid [MeSH], Cerebrospinal fluid, Middle Aged [MeSH], Cohort Studies [MeSH], Male [MeSH], Brain tumor, Biomarkers, Tumor/genetics [MeSH], Young Adult [MeSH], Brain Neoplasms/diagnosis [MeSH], Next-generation sequencing, Brain Neoplasms/cerebrospinal fluid [MeSH], Biomarkers, Tumor/cerebrospinal fluid [MeSH], Cell-Free Nucleic Acids/genetics [MeSH], Middle Aged, Female, Neurology. Diseases of the nervous system, Cell-Free Nucleic Acids

Access URL: https://pubmed.ncbi.nlm.nih.gov/39568088
https://doaj.org/article/bb49ac9722b644f68630890aba9b3785
https://resolver.sub.uni-goettingen.de/purl?gro-2/146665
https://repository.publisso.de/resource/frl:6521499

Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype

Authors: Tauziède-Espariat, Arnault Friker, Lea L Nussbaumer, Gunther et al.

Contributors: Tauziède-Espariat, Arnault Friker, Lea L Nussbaumer, Gunther et al.

Source: Acta Neuropathol Commun
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)

Subject Terms: Male, 0301 basic medicine, Glioma / genetics, Adolescent, pedHGG, Glioma/diagnostic imaging [MeSH], RTK2B, Glioma/pathology [MeSH], Gliomatosis cerebri, Male [MeSH], Phenotype [MeSH], Child [MeSH], RTK2A, Adolescent [MeSH], Female [MeSH], Brain Neoplasms/genetics [MeSH], Pediatric high-grade glioma, Humans [MeSH], Neoplasms, Neuroepithelial/pathology [MeSH], Methylation, Neoplasms, Neuroepithelial/genetics [MeSH], DNA Methylation [MeSH], Neoplasms, Neuroepithelial/diagnostic imaging [MeSH], Research, Glioma/genetics [MeSH], Receptor tyrosine kinase, Brain Neoplasms/diagnostic imaging [MeSH], Child, Preschool [MeSH], Brain Neoplasms/pathology [MeSH], Neoplasms, Neuroepithelial / diagnostic imaging, Neoplasms, Neuroepithelial / pathology, 03 medical and health sciences, Brain Neoplasms / pathology, Humans, RC346-429, Child, Neoplasms, Neuroepithelial / genetics, ddc:610, 0303 health sciences, Brain Neoplasms, Glioma, Brain Neoplasms / genetics, DNA Methylation, Glioma / diagnostic imaging, Neoplasms, Neuroepithelial, Phenotype, Brain Neoplasms / diagnostic imaging, Child, Preschool, Glioma / pathology, Female, PedHGG, Neurology. Diseases of the nervous system

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39558399
https://doaj.org/article/a314c4fae9f64dd98df77f621bcc505c
https://resolver.sub.uni-goettingen.de/purl?gro-2/146730
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/118483
https://doi.org/10.1186/s40478-024-01881-1
https://opus.bibliothek.uni-augsburg.de/opus4/files/118483/40478_2024_Article_1881.pdf
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1184839
https://repository.publisso.de/resource/frl:6522216