Suchergebnisse - "Binding sites"

Amber Codon Mutational Scanning and Bioorthogonal PEGylation for Epitope Mapping of Antibody Binding Sites on Human Arginase-1.

Autoren: Fernández de Santaella J Koch NG Widmer L et al.

Quelle: ACS chemical biology [ACS Chem Biol] 2025 Apr 18; Vol. 20 (4), pp. 791-801. Date of Electronic Publication: 2025 Apr 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Epitope Mapping*/methods , Arginase*/genetics , Arginase*/chemistry , Arginase*/immunology , Arginase*/metabolism , Polyethylene Glycols*/chemistry , Binding Sites, Antibody* , Codon, Terminator*/genetics, Humans ; Binding Sites ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/chemistry

Probing Antibody Binding Sites on G Protein-Coupled Receptors Using Genetically Encoded Photo-Activatable Cross-Linkers.

Autoren: Saca VR Mattheisen JM Huber T et al.

Quelle: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2937, pp. 203-215.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, G-Protein-Coupled*/chemistry , Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/genetics , Receptors, G-Protein-Coupled*/immunology , Antibodies, Monoclonal*/immunology , Antibodies, Monoclonal*/metabolism , Antibodies, Monoclonal*/chemistry , Cross-Linking Reagents*/chemistry , Binding Sites, Antibody* , Epitope Mapping*/methods, Humans ; Animals ; Epitopes/immunology ; Epitopes/chemistry ; Phenylalanine/analogs & derivatives ; Phenylalanine/chemistry ; Binding Sites ; Azides/chemistry

Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography.

Autoren: Grosjean H Aimon A Hassell-Hart S et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Apr 11; Vol. 64 (16), pp. e202424373. Date of Electronic Publication: 2025 Mar 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Binding Sites* , Crystallography, X-Ray*, Ligands

Genetic variability of respiratory syncytial virus and its impact on monoclonal antibody binding sites: a national cross-sectional study during the 2023-2024 season.

Autoren: Piralla A Romano G Acciarri C et al.

Körperschaften: Piralla A Romano G Acciarri C et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115591. Date of Electronic Publication: 2025 Sep 24.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Respiratory Syncytial Virus Infections*/virology , Respiratory Syncytial Virus Infections*/drug therapy , Respiratory Syncytial Virus Infections*/epidemiology , Respiratory Syncytial Virus Infections*/immunology , Respiratory Syncytial Virus, Human*/genetics , Respiratory Syncytial Virus, Human*/immunology , Antibodies, Monoclonal*/metabolism , Viral Fusion Proteins*/genetics, Humans ; Italy/epidemiology ; Cross-Sectional Studies ; Genetic Variation ; Phylogeny ; Female ; Male ; Binding Sites, Antibody ; Mutation ; Infant ; Antiviral Agents/therapeutic use ; Seasons ; Child, Preschool ; Palivizumab ; Drug Resistance, Viral/genetics ; Child ; Binding Sites

Extracellular domain 1 of human FcγRI (CD64) identified as the binding site for anti-FcγRI antibodies.

Autoren: Holtrop T Passchier EM O'Toole S et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2580695. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Receptors, IgG*/immunology , Receptors, IgG*/chemistry , Receptors, IgG*/genetics , Antibodies, Monoclonal*/immunology, Humans ; Animals ; Mice ; Protein Domains ; Binding Sites ; Binding Sites, Antibody ; Immunoglobulin G/immunology

ParaSurf: a surface-based deep learning approach for paratope-antigen interaction prediction.

Autoren: Papadopoulos AM Axenopoulos A Iatrou A et al.

Quelle: Bioinformatics (Oxford, England) [Bioinformatics] 2025 Feb 04; Vol. 41 (2).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

MeSH-Schlagworte: Deep Learning* , Software* , Binding Sites, Antibody* , Antigens*/chemistry , Antigens*/metabolism , Computational Biology*/methods, Protein Binding ; Models, Molecular

Off the beaten (catalytic) path: Charting the mechanistic space of enzyme reactions.

Autoren: Ribeiro, António J. M. Fernandes, Pedro A. Ramos, Maria J.

Quelle: Journal of Chemical Physics. 10/7/2025, Vol. 163 Issue 13, p1-11. 11p.

Schlagwörter: *CATALYSIS, *BINDING sites, *REACTION mechanisms (Chemistry), *INTERMEDIATES (Chemistry), *SURFACE chemistry

PreRBP: Interpretable deep learning for RNA-protein binding site prediction with attention mechanism.

Autoren: Chen H Zuo Y Liu X et al.

Quelle: Analytical biochemistry [Anal Biochem] 2025 Dec; Vol. 707, pp. 115968. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

MeSH-Schlagworte: RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/chemistry , Deep Learning* , RNA*/chemistry , RNA*/metabolism, Binding Sites ; Algorithms ; Neural Networks, Computer

A new perspective on betaine: Targeting the glycine binding site of the NMDA receptor.

Autoren: Chang WT Lee MY Wang YJ et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117213. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, N-Methyl-D-Aspartate*/metabolism , Receptors, N-Methyl-D-Aspartate*/chemistry , Receptors, N-Methyl-D-Aspartate*/genetics , Glycine*/metabolism , Betaine*/pharmacology , Betaine*/metabolism, Animals ; Humans ; HEK293 Cells ; Binding Sites/physiology ; Binding Sites/drug effects ; Mice ; Molecular Docking Simulation ; Male ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Cells, Cultured ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism

Accurate prediction of protein-ATP binding sites based on a protein pretrained large language model and a fractional-order convolutional neural network.

Autoren: Guo M Tu Y Yu J et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 25; Vol. 15 (1), pp. 41886. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Neural Networks, Computer* , Adenosine Triphosphate*/metabolism , Adenosine Triphosphate*/chemistry , Proteins*/metabolism , Proteins*/chemistry, Binding Sites ; Protein Binding ; Algorithms ; Deep Learning ; Computational Biology/methods ; Convolutional Neural Networks ; Large Language Models

Optical weak measurements for protein-polyphenol interactions: A novel detection approach.

Autoren: Xu Y Guo C Yang Y et al.

Quelle: Talanta [Talanta] 2025 Nov 01; Vol. 294, pp. 128185. Date of Electronic Publication: 2025 Apr 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH-Schlagworte: Polyphenols*/chemistry , Proteins*/chemistry, Food Technology/methods ; Serum Albumin, Bovine ; Animals ; Cattle ; Optical Devices ; Humans ; Blood Proteins/chemistry ; Hemoglobins/chemistry ; Fluorescence ; Binding Sites

Genetic variability and phylogenetic analysis of the long control region in human papillomavirus types 18 and 51 from central China.

Autoren: Lin Z Li T Yang Y et al.

Quelle: Virology journal [Virol J] 2025 Oct 29; Vol. 22 (1), pp. 352. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE

MeSH-Schlagworte: Phylogeny* , Genetic Variation* , Papillomavirus Infections*/virology , Human papillomavirus 18*/genetics , Human papillomavirus 18*/classification , Human papillomavirus 18*/isolation & purification , Papillomaviridae*/genetics , Papillomaviridae*/classification , Papillomaviridae*/isolation & purification, Humans ; China/epidemiology ; Female ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA ; DNA, Viral/genetics ; DNA, Viral/chemistry ; Adult ; Computational Biology ; Binding Sites ; Human Papillomavirus Viruses

A deep learning approach based on molecular graph features and residual blocks to predict interaction sites between CircRNA and RBP.

Autoren: Liu N Zhang Y

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Oct 20; Vol. 785, pp. 152655. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: RNA, Circular*/metabolism , RNA, Circular*/chemistry , RNA, Circular*/genetics , Deep Learning* , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/chemistry , Computational Biology*/methods, Binding Sites ; Humans

Exploring the maize transcriptional regulatory landscape through large-scale profiling of transcription factor binding sites.

Autoren: Huo Q Zhang Z Zhang K et al.

Quelle: Molecular plant [Mol Plant] 2025 Oct 06; Vol. 18 (10), pp. 1777-1798. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: England NLM ID: 101465514 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-9867 (Electronic) Linking ISSN: 16742052 NLM ISO Abbreviation: Mol Plant Subsets: MEDLINE

MeSH-Schlagworte: Zea mays*/genetics , Zea mays*/metabolism , Transcription Factors*/metabolism , Transcription Factors*/genetics , Gene Regulatory Networks*, Binding Sites/genetics ; Gene Expression Regulation, Plant ; Plant Proteins/metabolism ; Plant Proteins/genetics

DNA mutagenesis driven by transcription factor competition with mismatch repair.

Autoren: Zhu W Zhang Y Sahay H et al.

Quelle: Cell [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5735-5747.e15. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH-Schlagworte: DNA Mismatch Repair* , Transcription Factors*/metabolism , Mutagenesis*, Humans ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/genetics ; DNA-Binding Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; DNA Replication ; Binding Sites ; Saccharomyces cerevisiae Proteins/metabolism ; Mutation

Screening of salty peptides from enzymatic hydrolysates of Meretrix lyrata based on interaction with the TMC4 receptor.

Autoren: Song C Zhao Z Tan M et al.

Quelle: Food research international (Ottawa, Ont.) [Food Res Int] 2025 Oct; Vol. 218, pp. 116930. Date of Electronic Publication: 2025 Jun 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

MeSH-Schlagworte: Peptides*/chemistry , Peptides*/metabolism , Protein Hydrolysates*/chemistry , Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/chemistry , Sodium Chloride*/chemistry, Hydrophobic and Hydrophilic Interactions ; Hydrogen Bonding ; Amino Acid Sequence ; Protein Binding ; Binding Sites

Nanoscale binding site localization by molecular distance estimation on native cell surfaces using topological image averaging.

Autoren: Kumra Ahnlide V Kumra Ahnlide J Wrighton S et al.

Quelle: ELife [Elife] 2022 Feb 24; Vol. 11. Date of Electronic Publication: 2022 Feb 24.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH-Schlagworte: Binding Sites, Antibody*, Antibodies, Monoclonal/*metabolism , Cell Membrane/*metabolism , Epitope Mapping/*methods , Membrane Proteins/*metabolism, Binding Sites ; Cell Membrane/immunology ; Epitopes/metabolism ; Humans ; Ligands ; Membrane Proteins/immunology ; Models, Molecular

Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains.

Autoren: Nilvebrant J Ereño-Orbea J Gorelik M et al.

Quelle: Journal of molecular biology [J Mol Biol] 2021 Oct 15; Vol. 433 (21), pp. 167241. Date of Electronic Publication: 2021 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Binding Sites, Antibody* , Peptide Library*, Aspartic Acid/*chemistry , Complementarity Determining Regions/*chemistry , Immunoglobulin Heavy Chains/*chemistry, Amino Acid Sequence ; Aspartic Acid/metabolism ; Binding Sites ; Cloning, Molecular ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/metabolism ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/metabolism ; Kinetics ; Models, Molecular ; Protein Aggregates ; Protein Binding ; Protein Conformation ; Protein Folding ; Protein Interaction Domains and Motifs ; Receptor, EphA1/genetics ; Receptor, EphA1/immunology ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

Rational Engraftment of Quaternary-Interactive Acidic Loops for Anti-HIV-1 Antibody Improvement.

Autoren: Liu Q Zhang P Miao H et al.

Quelle: Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).

Publikationsart: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.

Info zur Zeitschrift: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH-Schlagworte: Binding Sites, Antibody*/immunology , Protein Engineering*, Broadly Neutralizing Antibodies/*immunology , CD4 Antigens/*metabolism , HIV Antibodies/*immunology , HIV Envelope Protein gp120/*chemistry , HIV Envelope Protein gp120/*immunology , HIV-1/*immunology, Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Binding Sites ; Broadly Neutralizing Antibodies/chemistry ; Broadly Neutralizing Antibodies/genetics ; Broadly Neutralizing Antibodies/therapeutic use ; CD4 Antigens/chemistry ; Epitopes/chemistry ; Epitopes/immunology ; HIV Antibodies/chemistry ; HIV Antibodies/genetics ; HIV Antibodies/therapeutic use ; HIV Envelope Protein gp120/metabolism ; HIV Infections/prevention & control ; HIV Infections/therapy ; Humans ; Models, Molecular ; Mutation ; Protein Binding ; Protein Multimerization ; Protein Subunits/chemistry

Hydroxyl substitution patterns affect flavonoid-HSA binding: Mechanistic insights from multispectral spectroscopy and molecular simulations.

Autoren: Zhao Z Fang X Gao Y et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 3), pp. 146803. Date of Electronic Publication: 2025 Oct 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Flavonoids*/chemistry , Flavonoids*/metabolism , Serum Albumin, Human*/chemistry , Serum Albumin*/chemistry , Serum Albumin*/metabolism, Humans ; Molecular Dynamics Simulation ; Protein Binding ; Binding Sites ; Molecular Docking Simulation ; Thermodynamics ; Circular Dichroism ; Molecular Structure ; Spectrometry, Fluorescence ; Hydrogen Bonding