Suchergebnisse - "Benzopyrans chemical synthesis"

Synthesis and evaluation of the tumor cell growth inhibitory potential of new putative HSP90 inhibitors

Autoren: Bizarro, A Sousa, D Lima, RT et al.

Weitere Verfasser: Bizarro, A Sousa, D Lima, RT et al.

Schlagwörter: Animals, Antineoplastic Agents / chemical synthesis, Antineoplastic Agents / pharmacology, Apoptosis / drug effects, Apoptosis / genetics, Benzopyrans / chemical synthesis, Benzopyrans / pharmacology, Carcinoma, Squamous Cell / drug therapy, Squamous Cell / genetics, Squamous Cell / metabolism, Squamous Cell / pathology, Cell Cycle / drug effects, Cell Line, Tumor, Cell Proliferation / drug effects, Cyclin-Dependent Kinase 4 / antagonists & inhibitors, Cyclin-Dependent Kinase 4 / genetics, Cyclin-Dependent Kinase 4 / metabolismo, Female, Gene Expression Regulation, Neoplastic, HSP90 Heat-Shock Proteins / antagonists & inhibitors, HSP90 Heat-Shock Proteins / genetics, HSP90 Heat-Shock Proteins / metabolism, Humans, Inhibitor of Apoptosis Proteins / antagonists & inhibitors, Inhibitor of Apoptosis Proteins / genetics, Inhibitor of Apoptosis Proteins / metabolism, Inhibitory Concentration 50

Dateibeschreibung: application/pdf

Relation: Molecules, vol.23(2):407; https://www.mdpi.com/1420-3049/23/2/407; https://hdl.handle.net/10216/127063

Verfügbarkeit: https://hdl.handle.net/10216/127063
https://doi.org/10.3390/molecules23020407

New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: Modulation of the 4-position

Autoren: Florence, Xavier Sebille, Sophie De Tullio, Pascal et al.

Quelle: Bioorganic & Medicinal Chemistry. 17:7723-7731

Schlagwörter: 0301 basic medicine, Cromakalim, Potassium Channels, Vasodilator Agents, Benzopyrans -- chemistry, Wistar, Vasodilator Agents -- chemical synthesis, Vasodilator Agents -- pharmacology, Benzopyran derivatives, Adenosine Triphosphate -- metabolism, Sciences de la santé humaine, Muscle, Smooth, Vascular, Pinacidil -- chemistry, Islets of Langerhans -- metabolism, Potassium channel openers, Islets of Langerhans, Structure-Activity Relationship, 03 medical and health sciences, Adenosine Triphosphate, Islets of Langerhans -- drug effects, Benzopyrans -- pharmacology, Animals, KATP channels, Benzopyrans, Human health sciences, Rats, Wistar, Diazoxide -- pharmacology, Pharmacy, pharmacology & toxicology, 0303 health sciences, Diazoxide -- chemistry, Pinacidil, Cromakalim analogues, Diazoxide, Vascular -- drug effects, Potassium Channels -- agonists, Pinacidil -- pharmacology, Potassium Channels -- metabolism, Stereoisomerism, Pharmacie, pharmacologie & toxicologie, Sciences bio-médicales et agricoles, Rats, Cromakalim -- chemistry, Cromakalim -- pharmacology, Vascular -- metabolism, Muscle, Benzopyrans -- chemical synthesis, Smooth, Vasodilator Agents -- chemistry

Dateibeschreibung: 1 full-text file(s): application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/19822435
https://europepmc.org/abstract/MED/19822435
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/66361/Details
https://orbi.uliege.be/handle/2268/29979
https://core.ac.uk/display/8861321
https://pubmed.ncbi.nlm.nih.gov/19822435/
https://www.ncbi.nlm.nih.gov/pubmed/19822435
https://hdl.handle.net/2268/29979
https://doi.org/10.1016/j.bmc.2009.09.041

Synthesis and activity on rat aorta rings and rat pancreatic β-cells of ring-opened analogues of benzopyran-type potassium channel activators

Autoren: Khelili, S. Florence, Xavier Bouhadja, M. et al.

Quelle: Bioorganic & Medicinal Chemistry. 16:6124-6130

Schlagwörter: Cromakalim, Potassium Channels, Muscle Relaxation, Benzopyrans -- chemistry, Wistar, In Vitro Techniques, Sciences de la santé humaine, 01 natural sciences, Cromakalim -- analogs & derivatives, Insulin Antagonists, Potassium channel opener, Insulin-Secreting Cells, Chromans -- chemical synthesis, Insulin Secretion, Benzopyrans -- pharmacology, Insulin -- secretion, Aorta -- metabolism, Animals, Insulin, Benzopyrans, Human health sciences, Chromans, Rats, Wistar, Inhibition of insulin secretion, Pharmacy, pharmacology & toxicology, Aorta, Aorta -- drug effects, Ring-opened cromakalim analogues, Potassium Channels -- metabolism, Vasorelaxant effect, Pharmacie, pharmacologie & toxicologie, Sciences bio-médicales et agricoles, Rats, 0104 chemical sciences, 3. Good health, Chromans -- chemistry, Cromakalim -- pharmacology, Insulin-Secreting Cells -- metabolism, Insulin-Secreting Cells -- drug effects, Insulin Antagonists -- pharmacology, Benzopyrans -- chemical synthesis, Chromans -- pharmacology, Insulin Antagonists -- chemical synthesis, Insulin-Secreting Cells -- secretion, Muscle Relaxation -- drug effects

Dateibeschreibung: 1 full-text file(s): application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/18479927
https://www.ncbi.nlm.nih.gov/pubmed/18479927
https://www.sciencedirect.com/science/article/pii/S0968089608003751
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/61898/Details
https://orbi.uliege.be/handle/2268/23530

Design, Synthesis, and Pharmacological Evaluation ofR/S-3,4-Dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: Toward Tissue-Selective Pancreatic β-CellKATPChannel Openers Structurally Related to (±)-Cromakalim

Autoren: Sebille, S. Gall, D. De Tullio, Pascal et al.

Quelle: Journal of Medicinal Chemistry. 49:4690-4697

Schlagwörter: Phenylurea Compounds -- chemistry, 0301 basic medicine, Cromakalim, Patch-Clamp Techniques, Potassium Channels, Benzopyrans -- chemistry, Thoracic -- drug effects, Wistar, Aorta, Thoracic, In Vitro Techniques, Sciences de la santé humaine, Muscle, Smooth, Vascular, Vascular -- physiology, Adenosine Triphosphate -- physiology, Structure-Activity Relationship, 03 medical and health sciences, Adenosine Triphosphate, Potassium Channels -- drug effects, Insulin-Secreting Cells, Insulin Secretion, Benzopyrans -- pharmacology, Insulin -- secretion, Animals, Insulin, Benzopyrans, Human health sciences, Rats, Wistar, Aorta, Pharmacy, pharmacology & toxicology, 0303 health sciences, Insulin-Secreting Cells -- physiology, Phenylurea Compounds -- pharmacology, Phenylurea Compounds, Vascular -- drug effects, Stereoisomerism, Pharmacie, pharmacologie & toxicologie, Sciences bio-médicales et agricoles, Thoracic -- physiology, Rats, Cromakalim -- chemistry, Insulin-Secreting Cells -- drug effects, Ion Channel Gating -- drug effects, Muscle, Benzopyrans -- chemical synthesis, Phenylurea Compounds -- chemical synthesis, Smooth, Insulin-Secreting Cells -- secretion, Ion Channel Gating, Muscle Contraction

Dateibeschreibung: No full-text files

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/16854075
https://europepmc.org/article/MED/16854075
https://www.ncbi.nlm.nih.gov/pubmed/16854075
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53286/Details
https://orbi.uliege.be/handle/2268/23359
https://pubs.acs.org/doi/10.1021/jm060161z

Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

Autoren: Khelili, Smail Florence, Xavier Bouhadja, Mourad et al.

Quelle: Bioorganic & medicinal chemistry, 16 (11

Schlagwörter: Sciences bio-médicales et agricoles, Animals, Aorta -- drug effects, Aorta -- metabolism, Benzopyrans -- chemical synthesis, Benzopyrans -- chemistry, Benzopyrans -- pharmacology, Chromans -- chemical synthesis, Chromans -- chemistry, Chromans -- pharmacology, Cromakalim -- analogs & derivatives, Cromakalim -- pharmacology, Insulin -- secretion, Insulin Antagonists -- chemical synthesis, Insulin Antagonists -- pharmacology, Insulin-Secreting Cells -- drug effects, Insulin-Secreting Cells -- metabolism, Insulin-Secreting Cells -- secretion, Muscle Relaxation -- drug effects, Potassium Channels -- metabolism, Rats, Wistar, Inhibition of insulin secretion, Potassium channel opener, Ring-opened cromakalim analogues, Vasorelaxant effect

Dateibeschreibung: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1016/j.bmc.2008.04.043; uri/info:pmid/18479927; uri/info:scp/44449092065; https://dipot.ulb.ac.be/dspace/bitstream/2013/61898/1/Elsevier_38397.pdf

Verfügbarkeit: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/61898
https://dipot.ulb.ac.be/dspace/bitstream/2013/61898/1/Elsevier_38397.pdf

Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.

Autoren: Sebille, Sophie Gall, David de Tullio, Pascal et al.

Quelle: Journal of medicinal chemistry, 49 (15

Schlagwörter: Sciences bio-médicales et agricoles, Adenosine Triphosphate -- physiology, Animals, Aorta, Thoracic -- drug effects, Thoracic -- physiology, Benzopyrans -- chemical synthesis, Benzopyrans -- chemistry, Benzopyrans -- pharmacology, Cromakalim -- chemistry, Insulin -- secretion, Insulin-Secreting Cells -- drug effects, Insulin-Secreting Cells -- physiology, Insulin-Secreting Cells -- secretion, Ion Channel Gating -- drug effects, Muscle Contraction, Muscle, Smooth, Vascular -- drug effects, Vascular -- physiology, Patch-Clamp Techniques, Phenylurea Compounds -- chemical synthesis, Phenylurea Compounds -- chemistry, Phenylurea Compounds -- pharmacology, Potassium Channels -- drug effects, Rats, Wistar, Stereoisomerism, Structure-Activity Relationship

Dateibeschreibung: No full-text files

Relation: uri/info:doi/10.1021/jm060161z; uri/info:pmid/16854075; uri/info:scp/33746708715

Verfügbarkeit: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53286