Suchergebnisse - "Benzopyrans"

Synthesis of 2-(3-aminopropyl)benzopyrans as potential antipsychotic agents targeting D 2 /D 3 and 5-HT 2A receptors.

Autoren: Bernabeu-Sanchis Á Varela MJ García A et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118300. Date of Electronic Publication: 2025 Jul 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Receptor, Serotonin, 5-HT2A*/metabolism , Antipsychotic Agents*/chemical synthesis , Antipsychotic Agents*/pharmacology , Antipsychotic Agents*/chemistry , Benzopyrans*/chemical synthesis , Benzopyrans*/pharmacology , Benzopyrans*/chemistry , Receptors, Dopamine D2*/metabolism , Receptors, Dopamine D3*/metabolism , Receptors, Dopamine D3*/antagonists & inhibitors, Humans ; CHO Cells ; Animals ; Cricetulus ; Molecular Docking Simulation ; Structure-Activity Relationship ; Cricetinae ; Molecular Structure ; Dose-Response Relationship, Drug ; Binding Sites

Merocyanine derivative for real-time imaging of amyloid-β and inhibition of self-aggregation and MAO-B activity.

Autoren: Liu H Li S Li X et al.

Quelle: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2025 Dec 15; Vol. 343, pp. 126582. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE

MeSH-Schlagworte: Amyloid beta-Peptides*/metabolism , Monoamine Oxidase*/metabolism , Monoamine Oxidase Inhibitors*/pharmacology , Monoamine Oxidase Inhibitors*/chemistry , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/pharmacology , Protein Aggregates*/drug effects , Indoles*/chemistry , Indoles*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/pharmacology, Animals ; Humans ; Alzheimer Disease/metabolism ; Alzheimer Disease/diagnostic imaging ; Mice ; Cell Line, Tumor ; Pyrimidinones

Synthesis, in-silico and in-vitro evaluation of quinoline-chromene hybrids as dual topoisomerase inhibitors.

Autoren: Saxena A Siddiquee NH Shahariar MH et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118422. Date of Electronic Publication: 2025 Sep 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Quinolines*/chemistry , Quinolines*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Benzopyrans*/chemical synthesis , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Topoisomerase I Inhibitors*/chemical synthesis , Topoisomerase I Inhibitors*/chemistry , Topoisomerase I Inhibitors*/pharmacology , Topoisomerase II Inhibitors*/chemical synthesis , Topoisomerase II Inhibitors*/chemistry , Topoisomerase II Inhibitors*/pharmacology, Humans ; DNA Topoisomerases, Type I/metabolism ; DNA Topoisomerases, Type I/chemistry ; Structure-Activity Relationship ; Molecular Docking Simulation ; Cell Line, Tumor ; DNA Topoisomerases, Type II/metabolism ; DNA Topoisomerases, Type II/chemistry ; Drug Screening Assays, Antitumor ; Molecular Structure ; Molecular Dynamics Simulation

Structure, biological activity, and biosynthesis of natural chromanes and chromenes.

Autoren: Liu Y Xu Y Zhang N et al.

Quelle: Archives of pharmacal research [Arch Pharm Res] 2025 Dec; Vol. 48 (11-12), pp. 1094-1130. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3786 (Electronic) Linking ISSN: 02536269 NLM ISO Abbreviation: Arch Pharm Res Subsets: MEDLINE

MeSH-Schlagworte: Biological Products*/pharmacology , Biological Products*/chemistry , Biological Products*/metabolism , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Benzopyrans*/metabolism , Chromans*/chemistry , Chromans*/pharmacology , Chromans*/metabolism, Animals ; Humans ; Molecular Structure ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Structure-Activity Relationship ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry

Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide - induced acute lung injury.

Autoren: Lu Q Zhao Y Xu X et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117420. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: PPAR gamma*/metabolism , PPAR gamma*/antagonists & inhibitors , Acute Lung Injury*/chemically induced , Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism , Lipopolysaccharides*/toxicity , Cyclooxygenase 2*/metabolism , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use , Propionates*/pharmacology , Propionates*/chemistry , Propionates*/therapeutic use , Propionates*/metabolism , Benzopyrans*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/therapeutic use , Benzopyrans*/metabolism , Cyclooxygenase 2 Inhibitors*/pharmacology , Cyclooxygenase 2 Inhibitors*/chemistry, Animals ; Molecular Docking Simulation/methods ; Mice ; Humans ; Male ; Dose-Response Relationship, Drug ; Drug Delivery Systems/methods

Tackling microbial resistance with 4H-chromen-4-one derivatives as a novel class of penicillin binding protein 2a inhibitors.

Autoren: Shalaby MW Abutaleb NS Dokla EME et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 01; Vol. 130, pp. 118376. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Penicillin-Binding Proteins*/antagonists & inhibitors , Penicillin-Binding Proteins*/metabolism , Methicillin-Resistant Staphylococcus aureus*/drug effects , Benzopyrans*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/chemical synthesis, Microbial Sensitivity Tests ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Gram-Positive Bacteria/drug effects

Polyketide Derivatives from the Macroalga-Associated Fungus Penicillium sclerotiorum Exhibiting Anti-Lymphangiogenic Effect.

Autoren: Ke TY Wang SW Lin ZY et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Nov 28; Vol. 88 (11), pp. 2757-2767. Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Penicillium*/chemistry , Polyketides*/pharmacology , Polyketides*/chemistry , Polyketides*/isolation & purification , Benzopyrans*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/isolation & purification , Pigments, Biological*/pharmacology , Pigments, Biological*/chemistry , Pigments, Biological*/isolation & purification, Humans ; Molecular Structure ; Endothelial Cells/drug effects ; Crystallography, X-Ray ; Nuclear Magnetic Resonance, Biomolecular

Synthesis and evaluation of a novel class of spiro[chromene-2,2'-indoline] derivatives as potent inhibitors of peptidylarginine deiminase IV to treat rheumatoid arthritis.

Autoren: Yang CW Lee YZ Hsu HY et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117985. Date of Electronic Publication: 2025 Jul 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/metabolism , Protein-Arginine Deiminase Type 4*/antagonists & inhibitors , Protein-Arginine Deiminase Type 4*/metabolism , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use , Indoles*/chemistry , Indoles*/chemical synthesis , Indoles*/pharmacology , Indoles*/therapeutic use , Spiro Compounds*/chemical synthesis , Spiro Compounds*/chemistry , Spiro Compounds*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/chemical synthesis , Benzopyrans*/pharmacology , Protein-Arginine Deiminases*/antagonists & inhibitors , Protein-Arginine Deiminases*/metabolism, Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Humans ; Dose-Response Relationship, Drug ; Male ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/chemically induced

Multi-omics analysis of the effects of fulvic acid on the growth performance of Larimichthys crocea in summer.

Autoren: Xu K Huang C Lv H et al.

Quelle: Fish physiology and biochemistry [Fish Physiol Biochem] 2025 Nov 06; Vol. 51 (6), pp. 187. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 100955049 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-5168 (Electronic) Linking ISSN: 09201742 NLM ISO Abbreviation: Fish Physiol Biochem Subsets: MEDLINE

MeSH-Schlagworte: Perciformes*/growth & development , Perciformes*/metabolism , Benzopyrans*/pharmacology , Benzopyrans*/administration & dosage, Animals ; Animal Feed/analysis ; Dietary Supplements ; Diet/veterinary ; Gastrointestinal Microbiome/drug effects ; Transcriptome ; Seasons ; Liver/metabolism ; Multiomics

Chroman, pyridine, and coumarin in a new fused scaffold as α-glucosidase inhibitor: synthesis of new derivatives, in vitro, and in silico evaluations.

Autoren: Pourmand SMH Halimi M Alaeddini A et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109139. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Coumarins*/chemistry , Coumarins*/pharmacology , Coumarins*/chemical synthesis , alpha-Glucosidases*/metabolism , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Benzopyrans*/chemical synthesis, Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Saccharomyces cerevisiae/enzymology ; Dose-Response Relationship, Drug ; Kinetics

Bioactive Isobenzofuranone and Isochromenones From a Marine-Derived Fungus Penicillium sp.: Isolation, Characterization, and Inhibitory Activity Against α-Glucosidase.

Autoren: Wang X Lin ZH Liu S et al.

Quelle: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e01466. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH-Schlagworte: Penicillium*/chemistry , Penicillium*/metabolism , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification , Glycoside Hydrolase Inhibitors*/pharmacology , alpha-Glucosidases*/metabolism , Benzofurans*/chemistry , Benzofurans*/isolation & purification , Benzofurans*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/isolation & purification , Benzopyrans*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/isolation & purification , Anti-Bacterial Agents*/chemistry, Molecular Docking Simulation ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Microbial Sensitivity Tests ; Cell Line, Tumor ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry

Discovery of New Antimicrobial Benzopyran Meroterpenoids from Acremonium sclerotigenum LW14 Using HSQC-Based DeepSAT.

Autoren: Huo R Shi D Zi G et al.

Quelle: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Oct 22; Vol. 73 (42), pp. 26793-26807. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Acremonium*/chemistry , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Benzopyrans*/isolation & purification , Terpenes*/chemistry , Terpenes*/pharmacology , Terpenes*/isolation & purification , Antifungal Agents*/chemistry , Antifungal Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology, Molecular Structure ; Microbial Sensitivity Tests ; Structure-Activity Relationship

Design, synthesis, and biological evaluation of membrane-active cannabichromene derivatives as potent antibacterial agents.

Autoren: Long B Wang N Hou Z et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117888. Date of Electronic Publication: 2025 Jun 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Drug Design* , Cell Membrane*/drug effects , Benzopyrans*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/chemical synthesis, Microbial Sensitivity Tests ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Gram-Positive Bacteria/drug effects ; Gram-Negative Bacteria/drug effects ; Reactive Oxygen Species/metabolism

A facile method for the preparation of 7,8-dihydro-4H-chromene-4,5(6H)-diones as non-aromatic cycle A analogs of isoflavones and their evaluation as antiproliferative agents.

Autoren: Rubinov DB Zinovich VG Scherbakov AM et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Oct; Vol. 165, pp. 108960. Date of Electronic Publication: 2025 Sep 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Isoflavones*/pharmacology , Isoflavones*/chemistry , Isoflavones*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Benzopyrans*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism

Molecular determinants of humic and fulvic acids in enhancing micronutrient availability in calcareous soils: a comparative study on Fe, Mn, Zn, and Cu dynamics.

Autoren: Barzgar Z Towfighi H Fathi-Gerdelidani A et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 01; Vol. 15 (1), pp. 34142. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Humic Substances*/analysis , Benzopyrans*/chemistry , Benzopyrans*/analysis , Soil*/chemistry , Micronutrients*/analysis , Micronutrients*/chemistry, Copper/chemistry ; Copper/analysis ; Zinc/chemistry ; Zinc/analysis ; Manganese/chemistry ; Manganese/analysis ; Iron/chemistry ; Iron/analysis

Targeting Lung Cancer: Synthesis, Characterization, Enzyme Inhibition, and Antiproliferative Activity of 1H-Benzo[f]chromen-1-One-Thiosemicarbazones Supported by Molecular Docking.

Autoren: Raza S Islam M Çakır F et al.

Quelle: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Oct; Vol. 358 (10), pp. e70116.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry , Thiosemicarbazones*/pharmacology , Thiosemicarbazones*/chemical synthesis , Thiosemicarbazones*/chemistry , Benzopyrans*/pharmacology , Benzopyrans*/chemistry , Benzopyrans*/chemical synthesis, Humans ; Molecular Docking Simulation ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Molecular Structure ; Drug Screening Assays, Antitumor ; A549 Cells ; Dose-Response Relationship, Drug

Mechanochromic Polyurethane Shape Memory Polymer for Biomedical Applications.

Autoren: Orado T Yashkus B Chandardat R et al.

Quelle: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2025 Oct; Vol. 113 (10), pp. e37979.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE

MeSH-Schlagworte: Polyurethanes*/chemistry , Polyurethanes*/pharmacology , Indoles*/chemistry , Indoles*/pharmacology , Smart Materials*/chemistry , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Nitro Compounds*/chemistry , Nitro Compounds*/pharmacology , Biocompatible Materials*/chemistry, Animals ; Staphylococcus aureus ; Materials Testing ; Mice

Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy.

Autoren: Katiyar MK Upadhayay S Jalli DP et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Oct; Vol. 165, pp. 109008. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Microtubules*/drug effects , Microtubules*/metabolism , Thyroid Hormones*/metabolism , Benzopyrans*/chemistry , Benzopyrans*/pharmacology , Carrier Proteins*/antagonists & inhibitors , Carrier Proteins*/metabolism , Chalcone*/chemistry , Chalcone*/pharmacology , Chalcones*/chemistry , Chalcones*/pharmacology , Drug Discovery*, Humans ; Thyroid Hormone-Binding Proteins ; Female ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; MCF-7 Cells ; Dose-Response Relationship, Drug ; Pyruvate Kinase/antagonists & inhibitors ; Pyruvate Kinase/metabolism

Chemoenzymatic formal synthesis of (+)-brazilin.

Autoren: Liu J Han X Yu L et al.

Quelle: Natural product research [Nat Prod Res] 2025 Oct; Vol. 39 (19), pp. 5622-5632. Date of Electronic Publication: 2024 May 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

MeSH-Schlagworte: Lipase*/metabolism , Lipase*/chemistry , Benzopyrans*/chemical synthesis , Benzopyrans*/chemistry, Molecular Structure ; Caesalpinia/chemistry ; Fungal Proteins/metabolism ; Hydrolysis ; Candida/enzymology ; Stereoisomerism

Multi-stimuli responsive nanomaterials assembled from spiropyran-containing peptoids.

Autoren: Chakma P Harris BS Shi C et al.

Quelle: Nanoscale [Nanoscale] 2025 Dec 04; Vol. 17 (47), pp. 27350-27361. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: RSC Pub Country of Publication: England NLM ID: 101525249 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-3372 (Electronic) Linking ISSN: 20403364 NLM ISO Abbreviation: Nanoscale Subsets: MEDLINE

MeSH-Schlagworte: Benzopyrans*/chemistry , Indoles*/chemistry , Nitro Compounds*/chemistry , Nanostructures*/chemistry , Peptoids*/chemistry, Density Functional Theory