Výsledky vyhľadávania - "Benzofurans"

Anti-inflammatory cyclopropanes and benzofurans from mangrove endophytic fungus Schizophyllum sp. QYM-12.

Autori: Chen T Sun B Hu X a ďalší

Zdroj: Phytochemistry [Phytochemistry] 2025 Dec; Vol. 240, pp. 114611. Date of Electronic Publication: 2025 Jul 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzofurans*/chemistry , Benzofurans*/pharmacology , Benzofurans*/isolation & purification , Cyclopropanes*/chemistry , Cyclopropanes*/pharmacology , Cyclopropanes*/isolation & purification , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/isolation & purification , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/isolation & purification, Molecular Structure ; Animals ; Mice ; Structure-Activity Relationship ; Rhizophoraceae/microbiology

Structure-based design of benzofuran library as P. aeruginosa quorum sensing inhibitors: Synthesis, biological evaluation and molecular docking study.

Autori: Mohamed NG Qayed WS Sheha MM a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117950. Date of Electronic Publication: 2025 Jul 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quorum Sensing*/drug effects , Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/physiology , Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/chemical synthesis , Molecular Docking Simulation* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Drug Design*, Structure-Activity Relationship ; Biofilms/drug effects ; Animals ; Molecular Structure ; Microbial Sensitivity Tests ; Mice ; Dose-Response Relationship, Drug ; Humans

Ultraviolet-Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (Ficus carica L.) Leaves and Their Bioactivities.

Autori: Chen D Yuan Y Li Z a ďalší

Zdroj: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e00961. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Plant Leaves*/chemistry , Coumarins*/pharmacology , Coumarins*/chemistry , Coumarins*/isolation & purification , Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/isolation & purification , Ficus*/chemistry , Ultraviolet Rays* , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/isolation & purification , Anti-Bacterial Agents*/chemistry, Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Candida albicans/drug effects ; Molecular Structure ; Structure-Activity Relationship ; Melanins ; Dose-Response Relationship, Drug

Antidepressant-like and memory-enhancing effects of 2-phenyl-3-(phenylselanyl)benzofuran on a lipopolysaccharide-induced depression model in male mice: behavioral, biochemical, and molecular insights.

Autori: Rech TDST Paim MP Tavares NG a ďalší

Zdroj: Brain research [Brain Res] 2025 Dec 15; Vol. 1869, pp. 150011. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antidepressive Agents*/pharmacology , Depression*/drug therapy , Depression*/chemically induced , Depression*/metabolism , Benzofurans*/pharmacology , Benzofurans*/therapeutic use , Organoselenium Compounds*/pharmacology , Memory*/drug effects, Animals ; Male ; Lipopolysaccharides/pharmacology ; Mice ; Disease Models, Animal ; Behavior, Animal/drug effects ; Fluoxetine/pharmacology ; Oxidative Stress/drug effects ; Hippocampus/drug effects ; Hippocampus/metabolism ; Antioxidants/pharmacology ; Memory Disorders/drug therapy

Discovery of a novel benzofuran-7-carboxamide-based PARP1/c-Met dual inhibitor for addressing c-Met amplification-mediated PARP1i acquired-resistance.

Autori: Sun Z Hu M Xu J a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118164. Date of Electronic Publication: 2025 Sep 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proto-Oncogene Proteins c-met*/antagonists & inhibitors , Proto-Oncogene Proteins c-met*/metabolism , Benzofurans*/chemistry , Benzofurans*/pharmacology , Benzofurans*/chemical synthesis , Poly (ADP-Ribose) Polymerase-1*/antagonists & inhibitors , Poly (ADP-Ribose) Polymerase-1*/metabolism , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , Poly(ADP-ribose) Polymerase Inhibitors*/chemistry , Poly(ADP-ribose) Polymerase Inhibitors*/chemical synthesis , Drug Resistance, Neoplasm*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Drug Discovery* , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis, Humans ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Mice ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug

Usnic acid alleviates pulmonary fibrosis in vitro and in vivo by inhibiting the ZNF70-mediated Wnt/β-catenin signaling pathway.

Autori: Han ZY Cao S Tai Y a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115725. Date of Electronic Publication: 2025 Oct 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzofurans*/therapeutic use , Benzofurans*/pharmacology , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/chemically induced , Anti-Inflammatory Agents*/therapeutic use , Anti-Inflammatory Agents*/pharmacology, Animals ; Wnt Signaling Pathway/drug effects ; Mice ; Humans ; Bleomycin ; Epithelial-Mesenchymal Transition/drug effects ; Mice, Inbred C57BL ; Fibroblasts/drug effects ; Lung/pathology ; Lung/drug effects ; beta Catenin/metabolism ; Male ; Cell Line ; Disease Models, Animal

Salvianolic acid B inhibits melanoma via dual modulation of glycolysis and NK/T cell immunity.

Autori: Zhang Y Li C Chen J

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115567. Date of Electronic Publication: 2025 Sep 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzofurans*/pharmacology , Benzofurans*/therapeutic use , Melanoma*/drug therapy , Melanoma*/immunology , Melanoma*/pathology , Melanoma*/metabolism , Killer Cells, Natural*/immunology , Killer Cells, Natural*/drug effects, Humans ; Animals ; Glycolysis/drug effects ; Mice ; Cell Line, Tumor ; Tumor Microenvironment/drug effects ; Xenograft Model Antitumor Assays ; Cell Proliferation/drug effects ; Female ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Depsides

DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.

Autori: Zhang H Zhang N Yang X a ďalší

Zdroj: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2025 Dec; Vol. 31 (12), pp. e70682.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neurons*/drug effects , Neurons*/metabolism , Dynamins*/metabolism , Benzofurans*/pharmacology , Benzofurans*/therapeutic use , Mitochondria*/drug effects , Mitochondria*/metabolism , Neuroprotective Agents*/pharmacology , Brain*/drug effects , Brain*/metabolism, Animals ; Mice ; Male ; Acetylation/drug effects ; Mice, Inbred C57BL

Novel 3-n-butylphthalide derivatives as potent multi-functional anti-IS agents with BBB protective function.

Autori: Shao L Lin G Chu Z a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109237. Date of Electronic Publication: 2025 Nov 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/chemical synthesis , Blood-Brain Barrier*/drug effects , Blood-Brain Barrier*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/chemical synthesis , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism, Animals ; Structure-Activity Relationship ; Molecular Structure ; Mice ; Dose-Response Relationship, Drug ; Humans ; Male ; Rats

Tetrahydrobenzofuro[3,2-b]quinoline: A dual-acting autophagy-dependent DHODH inhibitor that provokes ferroptosis in lung cancer cells.

Autori: Liu CY Gao XC Ren Y a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109203. Date of Electronic Publication: 2025 Nov 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/drug effects , Autophagy*/drug effects , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Oxidoreductases Acting on CH-CH Group Donors*/antagonists & inhibitors , Oxidoreductases Acting on CH-CH Group Donors*/metabolism , Quinolines*/pharmacology , Quinolines*/chemistry , Quinolines*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/chemical synthesis, Humans ; Animals ; Mice ; Drug Screening Assays, Antitumor ; Molecular Structure ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Dihydroorotate Dehydrogenase ; Dose-Response Relationship, Drug

Salvianolic acid B ameliorates vascular calcification in rats with chronic kidney disease combined with arteriovenous fistula by inhibiting BMP2/Smads signaling.

Autori: Ye J Li Y Yin X

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2542524. Date of Electronic Publication: 2025 Aug 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Vascular Calcification*/drug therapy , Vascular Calcification*/etiology , Vascular Calcification*/pathology , Renal Insufficiency, Chronic*/complications , Bone Morphogenetic Protein 2*/metabolism , Benzofurans*/pharmacology , Benzofurans*/therapeutic use , Smad Proteins*/metabolism, Animals ; Rats ; Signal Transduction/drug effects ; Male ; Disease Models, Animal ; Rats, Sprague-Dawley ; Arteriovenous Shunt, Surgical/adverse effects ; Kidney/pathology ; Kidney/drug effects ; Blood Urea Nitrogen ; Creatinine/blood ; Core Binding Factor Alpha 1 Subunit/metabolism ; Smad5 Protein/metabolism ; Depsides

Bioactive 2-arylbenzofuran and chalcone derivatives from Morus mesozygia Stapf.

Autori: Matundura JO Mollel JT Miah M a ďalší

Zdroj: Fitoterapia [Fitoterapia] 2025 Dec; Vol. 187, pp. 106871. Date of Electronic Publication: 2025 Sep 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

Výrazy zo slovníka MeSH: Morus*/chemistry , Benzofurans*/isolation & purification , Benzofurans*/pharmacology , Benzofurans*/chemistry , Chalcones*/isolation & purification , Chalcones*/pharmacology , Chalcones*/chemistry, Humans ; Molecular Structure ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Plant Bark/chemistry ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Cell Line, Tumor ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; NF-kappa B/metabolism ; Plant Stems/chemistry

Discovery of new aurone derivatives as submicromolar CK2 inhibitors.

Autori: Mahdysiuk MV Volynets GP Bdzhola VG a ďalší

Zdroj: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2566780. Date of Electronic Publication: 2025 Oct 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Casein Kinase II*/antagonists & inhibitors , Casein Kinase II*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Benzofurans*/chemistry , Benzofurans*/pharmacology , Benzofurans*/chemical synthesis , Drug Discovery*, Structure-Activity Relationship ; Molecular Structure ; Humans ; Molecular Docking Simulation ; Dose-Response Relationship, Drug

Aurone and its analogues as targeted drugs for the anticancer treatment.

Autori: Shi M Yan J Zhao J a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 01; Vol. 130, pp. 118375. Date of Electronic Publication: 2025 Sep 03.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Benzofurans*/chemistry , Benzofurans*/pharmacology , Benzofurans*/chemical synthesis , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Animals

Examining the 2-aryl-5-nitrobenzofuran-based hydrazones for anti-breast (MCF-7) cancer activity, potential to induce cell cycle arrest and inhibit receptor tyrosine kinases (VEGFR-2 & EGFR).

Autori: Nkoana JK More GK Elhenawy AA a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118018. Date of Electronic Publication: 2025 Aug 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Benzofurans*/chemistry , Benzofurans*/pharmacology , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cell Cycle Checkpoints*/drug effects , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Humans ; MCF-7 Cells ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Molecular Structure ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Animals ; Chlorocebus aethiops ; Apoptosis/drug effects ; Vero Cells ; Molecular Docking Simulation ; Female

Insights into fate and mechanism of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) during sequential washing-thermal treatment of incineration fly ash.

Autori: Chen K Lin L Li J a ďalší

Zdroj: Environmental research [Environ Res] 2025 Nov 15; Vol. 285 (Pt 3), pp. 122505. Date of Electronic Publication: 2025 Aug 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Coal Ash*/chemistry , Incineration* , Benzofurans*/chemistry , Benzofurans*/analysis, Polychlorinated Dibenzodioxins/chemistry ; Polychlorinated Dibenzodioxins/analysis ; Dibenzofurans, Polychlorinated

Tissue distribution of OL9-116, a Tdp1 inhibitor based on usnic acid, is significantly altered in Lewis lung carcinoma-bearing mice compared to healthy animals.

Autori: Okhina AA Kornienko TE Rogachev AD a ďalší

Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Nov 15; Vol. 265, pp. 117054. Date of Electronic Publication: 2025 Jul 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Lewis Lung*/drug therapy , Carcinoma, Lewis Lung*/metabolism , Benzofurans*/pharmacokinetics , Benzofurans*/chemistry, Animals ; Mice ; Tissue Distribution ; Tandem Mass Spectrometry/methods ; Mice, Inbred C57BL ; Male ; Lung/metabolism ; Chromatography, Liquid/methods ; Liver/metabolism

Total Synthesis of Peniterphenyls A and E.

Autori: Xu H Li Y Fang Y a ďalší

Zdroj: Marine drugs [Mar Drugs] 2025 Nov 14; Vol. 23 (11). Date of Electronic Publication: 2025 Nov 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antiviral Agents*/chemical synthesis , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Biological Products*/chemical synthesis , Biological Products*/chemistry , Biological Products*/pharmacology , Benzofurans*/chemical synthesis , Benzofurans*/chemistry , Benzofurans*/pharmacology, Catalysis ; Palladium/chemistry ; Herpesvirus 1, Human/drug effects

Discovery of Oral Natural Benzofuranoid p -Terphenyl Derivative CHNQD-03301 as a Potent Hypoxia-Inducible Factor-1α Signaling Inhibitor for Cancer Therapy.

Autori: Wang CF Cui XN Lv LX a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 22988-23005. Date of Electronic Publication: 2025 Oct 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypoxia-Inducible Factor 1, alpha Subunit*/antagonists & inhibitors , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacokinetics , Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/administration & dosage , Benzofurans*/therapeutic use , Benzofurans*/pharmacokinetics , Drug Discovery*, Humans ; Animals ; Zebrafish ; Signal Transduction/drug effects ; Administration, Oral ; Mice ; Structure-Activity Relationship ; Cell Line, Tumor ; Xenograft Model Antitumor Assays

Senkyunolide A alleviates asthma by inhibiting TGF-β/Smad2/3 signaling pathway and NLRP3 inflammasome activation.

Autori: Zhang M Wang C Zhao R a ďalší

Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 08; Vol. 788, pp. 152809. Date of Electronic Publication: 2025 Oct 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Asthma*/drug therapy , Asthma*/metabolism , Asthma*/pathology , Asthma*/immunology , Signal Transduction*/drug effects , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/immunology , Inflammasomes*/metabolism , Inflammasomes*/immunology , Inflammasomes*/drug effects , Smad2 Protein*/metabolism , Transforming Growth Factor beta*/metabolism , Benzofurans*/pharmacology , Benzofurans*/therapeutic use, Animals ; Smad3 Protein/metabolism ; Mice ; Mice, Inbred BALB C ; Transforming Growth Factor beta1/metabolism ; Airway Remodeling/drug effects ; Cell Line ; Humans ; Ovalbumin ; Female