Search Results - "Benzo(a)pyrene"

Discovery of flavonoids as potent inhibitors of CYP1A to alleviate cellular inflammation and oxidative stress induced by benzo[a]pyrene-induced high CYP1A expression.

Authors: Li XD Ma NS He CY et al.

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2579675. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/pharmacology , Benzo(a)pyrene*/antagonists & inhibitors , Oxidative Stress*/drug effects , Cytochrome P-450 CYP1A1*/antagonists & inhibitors , Cytochrome P-450 CYP1A1*/metabolism , Cytochrome P-450 CYP1A1*/genetics , Flavonoids*/pharmacology , Flavonoids*/chemistry , Flavonoids*/chemical synthesis , Inflammation*/drug therapy , Inflammation*/metabolism , Drug Discovery*, Structure-Activity Relationship ; Humans ; Molecular Structure ; Dose-Response Relationship, Drug ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/antagonists & inhibitors

Transcriptomic profiling of Debaryomyces hansenii reveals detoxification and stress responses to benzo(a)pyrene exposure.

Authors: Padilla-Garfias F Poot-Hernández AC Araiza-Villanueva M et al.

Source: Applied and environmental microbiology [Appl Environ Microbiol] 2025 Oct 22; Vol. 91 (10), pp. e0155725. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7605801 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5336 (Electronic) Linking ISSN: 00992240 NLM ISO Abbreviation: Appl Environ Microbiol Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/metabolism , Benzo(a)pyrene*/toxicity , Transcriptome* , Debaryomyces*/genetics , Debaryomyces*/metabolism , Debaryomyces*/drug effects , Saccharomycetales*/genetics , Saccharomycetales*/metabolism , Saccharomycetales*/drug effects, Gene Expression Profiling ; Inactivation, Metabolic ; Stress, Physiological ; Biodegradation, Environmental ; Gene Expression Regulation, Fungal/drug effects ; Fungal Proteins/genetics ; Fungal Proteins/metabolism

The competitive adsorption of phenanthrene and benzo[a]pyrene by fractionated soil particles in individual and coexistence pollution.

Authors: Qi M Ning G Wang X et al.

Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 01; Vol. 304, pp. 119073. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH Terms: Phenanthrenes*/chemistry , Phenanthrenes*/analysis , Benzo(a)pyrene*/chemistry , Benzo(a)pyrene*/analysis , Soil Pollutants*/chemistry , Soil Pollutants*/analysis , Soil*/chemistry, Adsorption

Mechanisms and targeted intervention of mitochondria-dependent ferroptosis and abnormal ductular reaction caused by benzo(a)pyrene.

Authors: Du X Song S Wang J et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 543-555. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Ferroptosis*/drug effects , Mitochondria*/metabolism , Mitochondria*/drug effects , Mitochondria*/pathology , Bile Ducts*/drug effects , Bile Ducts*/pathology , Bile Ducts*/metabolism, Humans ; Animals ; Reactive Oxygen Species/metabolism ; 14-3-3 Proteins/metabolism ; 14-3-3 Proteins/genetics ; Voltage-Dependent Anion Channel 1/metabolism ; Voltage-Dependent Anion Channel 1/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Mice ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/pathology ; Calcium/metabolism

Dual antioxidant delivery based on liposome sustained release system: Molecular mechanisms for inhibiting lipid oxidation and benzo[a]pyrene formation in Chinese sausage.

Authors: Lu J Wu L Wang R et al.

Source: Food chemistry [Food Chem] 2025 Dec 01; Vol. 494, pp. 146060. Date of Electronic Publication: 2025 Aug 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Liposomes*/chemistry , Antioxidants*/chemistry , Meat Products*/analysis , Benzo(a)pyrene*/chemistry , Benzo(a)pyrene*/analysis, Oxidation-Reduction ; Animals ; Delayed-Action Preparations/chemistry ; Swine ; Resveratrol/chemistry ; Gallic Acid/chemistry ; Kinetics ; Food Preservation/methods

Comprehensive macroscopic, histopathological and molecular assessment of B[a]P and NNK-induced lung tumours in A/J mice reveals no chemopreventive efficacy of Thearubigins.

Authors: Shaikh ZM Banerji S Sunil S et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 28; Vol. 791, pp. 152951. Date of Electronic Publication: 2025 Nov 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Nitrosamines*/toxicity , Lung Neoplasms*/pathology , Lung Neoplasms*/chemically induced , Lung Neoplasms*/prevention & control , Benzo(a)pyrene*/toxicity , Anticarcinogenic Agents*, Animals ; Mice ; Carcinogens/toxicity ; Mice, Inbred A ; Male ; Butanones

Integrated transcriptomics and proteomics reveal ferroptosis induced by B[a]P and BPDE in mouse hippocampal neurons.

Authors: He H Ding S Zhou C et al.

Source: Scientific reports [Sci Rep] 2025 Nov 25; Vol. 15 (1), pp. 41739. Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/genetics , Hippocampus*/drug effects , Hippocampus*/metabolism , Hippocampus*/pathology , Hippocampus*/cytology , Neurons*/drug effects , Neurons*/metabolism , Neurons*/pathology , Benzo(a)pyrene*/toxicity , Transcriptome*/drug effects, Animals ; Mice ; Proteomics/methods ; Male ; Gene Expression Profiling ; Mice, Inbred C57BL

Benzo[a]pyrene exacerbates allergen-induced airway inflammation through NLRP3-dependent dendritic cell activation and pathogenic T helper cell polarization.

Authors: Zou H Duan J Xie Y et al.

Source: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1699886. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/immunology , Dendritic Cells*/immunology , Dendritic Cells*/metabolism , Dendritic Cells*/drug effects , Benzo(a)pyrene*/toxicity , Allergens*/immunology , T-Lymphocytes, Helper-Inducer*/immunology , T-Lymphocytes, Helper-Inducer*/metabolism, Animals ; Mice ; Mice, Knockout ; Pyroglyphidae/immunology ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Cytokines/metabolism ; Mice, Inbred C57BL ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Disease Models, Animal

Prenatal benzo[a]pyrene exposure exacerbates OVA-induced asthma in offspring mice.

Authors: Li W Wu L Lu X et al.

Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 15; Vol. 307, pp. 119404. Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Asthma*/chemically induced , Asthma*/immunology , Prenatal Exposure Delayed Effects*/chemically induced, Animals ; Female ; Pregnancy ; Ovalbumin ; Mice ; Gastrointestinal Microbiome/drug effects ; Mice, Inbred C57BL ; Lung/drug effects ; Male ; Cytokines/metabolism

Novel molecular mechanisms of eosinophil-mediated chronic obstructive pulmonary disease induced by bezo[a]pyrene.

Authors: Wang X Liu L Zhang C et al.

Source: Clinical and experimental medicine [Clin Exp Med] 2025 Nov 06; Vol. 25 (1), pp. 358. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

MeSH Terms: Pulmonary Disease, Chronic Obstructive*/chemically induced , Pulmonary Disease, Chronic Obstructive*/pathology , Eosinophils*/drug effects , Eosinophils*/immunology , Benzo(a)pyrene*/toxicity, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Interaction Maps

Multigenerational and persistent toxicity of environmentally relevant concentrations of Benzo[a]pyrene in Marine Medaka (Oryzias melastigma).

Authors: Sun D Zhang X Chen S et al.

Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 01; Vol. 306, pp. 119385. Date of Electronic Publication: 2025 Nov 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH Terms: Oryzias*/physiology , Oryzias*/growth & development , Benzo(a)pyrene*/toxicity , Water Pollutants, Chemical*/toxicity, Animals ; Male ; Reproduction/drug effects ; Female

Enhanced MOA-based probabilistic dose-response assessment: Integrating alternative fitting functions and validating early-stage data extrapolation.

Authors: Ji Y Woo J Xiang M et al.

Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 01; Vol. 306, pp. 119291. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Naphthalenes*/toxicity , Toxicity Tests*/methods , Environmental Pollutants*/toxicity, Dose-Response Relationship, Drug ; No-Observed-Adverse-Effect Level ; Risk Assessment/methods ; Animals ; Humans ; Probability

Integrative insights into benzo[a]pyrene degradation mechanisms by Aspergillus fumigatus Z5: Spectroscopic, transcriptomic, and computational biological analyses.

Authors: Zhang G Yang Y Dou M et al.

Source: Journal of environmental sciences (China) [J Environ Sci (China)] 2025 Nov; Vol. 157, pp. 866-878. Date of Electronic Publication: 2025 Feb 25.

Publication Type: Journal Article

Journal Info: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/metabolism , Aspergillus fumigatus*/metabolism, Biodegradation, Environmental ; Transcriptome ; Molecular Docking Simulation ; Cytochrome P-450 Enzyme System/metabolism

Utilization of the CometChip assay for detecting PAH-induced DNA bulky adducts in a 3D primary human bronchial epithelial cell model.

Authors: Colvin VC Owiti NA Engelward BP et al.

Source: Toxicology [Toxicology] 2025 Nov; Vol. 517, pp. 154241. Date of Electronic Publication: 2025 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH Terms: DNA Adducts*/metabolism , DNA Adducts*/drug effects , Bronchi*/drug effects , Bronchi*/cytology , Bronchi*/metabolism , Bronchi*/pathology , Comet Assay*/methods , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Benzo(a)pyrene*/toxicity , Polycyclic Aromatic Hydrocarbons*/toxicity, Humans ; DNA Damage/drug effects ; Hep G2 Cells ; Cells, Cultured ; Cytochrome P-450 CYP1A1/metabolism ; Dose-Response Relationship, Drug

Role of inflammatory response in benzo[a]pyrene-induced noradrenergic axon degeneration in mouse brain.

Authors: Reda Y Zong C Ikoma A et al.

Source: Toxicology letters [Toxicol Lett] 2025 Nov; Vol. 413, pp. 111737. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Axons*/drug effects , Axons*/pathology , Axons*/metabolism , Brain*/drug effects , Brain*/pathology , Brain*/metabolism , Neurotoxicity Syndromes*/pathology , Neurotoxicity Syndromes*/etiology , Neurotoxicity Syndromes*/prevention & control , Nerve Degeneration*/chemically induced , Nerve Degeneration*/pathology, Animals ; Male ; Mice, Inbred C57BL ; Isothiocyanates/pharmacology ; Mice ; Sulfoxides ; Microglia/drug effects ; Anti-Inflammatory Agents/pharmacology ; Neuroprotective Agents/pharmacology

Discovery of Blood-Based Proteins That Mark Benzo[a]pyrene Modulation of Autoimmunity.

Authors: Kennicott K Nie Y Liang Y

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 21; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Autoimmunity*/drug effects , Autoimmune Diseases*/blood , Autoimmune Diseases*/immunology , Autoimmune Diseases*/chemically induced , Blood Proteins*/metabolism, Animals ; Mice ; Male ; Cytokines/blood ; Biomarkers/blood ; Female ; Humans ; Mice, Inbred MRL lpr

Cerium dioxide nanoparticles coated with benzo[a]pyrene modify aryl hydrocarbon receptor activity, trophoblast differentiation and mitochondrial network phenotype in human placenta.

Authors: Degrelle SA Deval G Tête A et al.

Source: Particle and fibre toxicology [Part Fibre Toxicol] 2025 Oct 14; Vol. 22 (1), pp. 25. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101236354 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-8977 (Electronic) Linking ISSN: 17438977 NLM ISO Abbreviation: Part Fibre Toxicol Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Benzo(a)pyrene*/chemistry , Trophoblasts*/drug effects , Trophoblasts*/metabolism , Trophoblasts*/pathology , Mitochondria*/drug effects , Mitochondria*/metabolism , Mitochondria*/pathology , Cerium*/toxicity , Cerium*/chemistry , Receptors, Aryl Hydrocarbon*/metabolism , Cell Differentiation*/drug effects , Placenta*/drug effects , Placenta*/metabolism , Nanoparticles*/toxicity , Metal Nanoparticles*/toxicity , Metal Nanoparticles*/chemistry , Air Pollutants*/toxicity , Air Pollutants*/chemistry, Humans ; Female ; Pregnancy ; Phenotype ; Cells, Cultured

Immunosuppressive role of benzo[a]pyrene exposure in prostate cancer progression.

Authors: Zhang Z Zhang W Wang H et al.

Source: Journal of environmental sciences (China) [J Environ Sci (China)] 2025 Oct; Vol. 156, pp. 185-199. Date of Electronic Publication: 2024 Dec 06.

Publication Type: Journal Article

Journal Info: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Prostatic Neoplasms*/chemically induced , Prostatic Neoplasms*/immunology, Male ; Animals ; Mice ; Humans ; Disease Progression ; Cell Line, Tumor ; Apoptosis/drug effects ; Cell Proliferation/drug effects

Deciphering the carcinogenic role of benzo[a]pyrene in glioblastoma: Insights from network toxicology, single-cell transcriptomics, and Mendelian randomization.

Authors: Yi L Wang W Sun Z et al.

Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 01; Vol. 304, pp. 119155. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH Terms: Benzo(a)pyrene*/toxicity , Glioblastoma*/chemically induced , Glioblastoma*/genetics , Brain Neoplasms*/chemically induced , Brain Neoplasms*/genetics , Carcinogens*/toxicity, Humans ; Mendelian Randomization Analysis ; Transcriptome/drug effects ; Single-Cell Analysis ; Gene Expression Profiling ; Molecular Docking Simulation

Predicting the developmental toxicity of 8-methyl-benzo[a]pyrene (BaP) by physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry and read-across from BaP.

Authors: Wang D Fang J Shi M et al.

Source: Archives of toxicology [Arch Toxicol] 2025 Oct; Vol. 99 (10), pp. 4035-4050. Date of Electronic Publication: 2025 Jul 03.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

MeSH Terms: Models, Biological* , Benzo(a)pyrene*/toxicity , Benzo(a)pyrene*/pharmacokinetics , Benzopyrenes*/toxicity , Benzopyrenes*/pharmacokinetics, Animals ; Mice ; Dose-Response Relationship, Drug ; Rats ; Male ; Mouse Embryonic Stem Cells/drug effects ; Rats, Sprague-Dawley ; Female ; Toxicity Tests/methods