Suchergebnisse - "Benzamides"

4-substituted (1,2,5-oxadiazol-3-yl)benzamides and -benzene sulfonamides as antiplasmodial agents.

Autoren: Hermann T Hochegger P Saf R et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118150. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/chemical synthesis , Plasmodium falciparum*/drug effects , Sulfonamides*/pharmacology , Sulfonamides*/chemistry , Sulfonamides*/chemical synthesis , Benzamides*/pharmacology , Benzamides*/chemistry , Benzamides*/chemical synthesis , Oxadiazoles*/pharmacology , Oxadiazoles*/chemistry , Oxadiazoles*/chemical synthesis, Structure-Activity Relationship ; Rats ; Animals ; Molecular Structure ; Parasitic Sensitivity Tests ; Dose-Response Relationship, Drug ; Humans

Targeting fungal biofilms: design, synthesis, biological and in silico studies of novel N-(5-undecyl-1,3,4-oxadiazol-2-yl)benzamide derivatives against Candida albicans.

Autoren: Kumar AC Madalambika Bharathkumar PM et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118425. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Biofilms*/drug effects , Candida albicans*/drug effects , Candida albicans*/physiology , Antifungal Agents*/pharmacology , Antifungal Agents*/chemical synthesis , Antifungal Agents*/chemistry , Drug Design* , Benzamides*/pharmacology , Benzamides*/chemistry , Benzamides*/chemical synthesis , Oxadiazoles*/pharmacology , Oxadiazoles*/chemistry , Oxadiazoles*/chemical synthesis, Microbial Sensitivity Tests ; Structure-Activity Relationship ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug ; HEK293 Cells

2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide alleviates idiopathic pulmonary fibrosis through activation of LGALS3-mediated AGE-RAGE signaling pathway.

Autoren: Chen Y Liu Q Fu R et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115635. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/pathology , Idiopathic Pulmonary Fibrosis*/chemically induced , Galectin 3*/metabolism , Galectin 3*/genetics , Benzamides*/pharmacology , Benzamides*/therapeutic use , Receptor for Advanced Glycation End Products*/metabolism, Animals ; Humans ; Mice ; Signal Transduction/drug effects ; Male ; Female ; Bleomycin ; Mice, Inbred C57BL ; Disease Models, Animal ; Lung/pathology ; Lung/drug effects ; Aged ; Middle Aged ; Blood Proteins ; Galectins

Roflumilast mitigates idiopathic pulmonary fibrosis via inhibition of iron accumulation and ferroptosis.

Autoren: Feng L Han S Li Y et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178385. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Benzamides*/pharmacology , Benzamides*/therapeutic use , Aminopyridines*/pharmacology , Aminopyridines*/therapeutic use , Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/pathology , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/chemically induced , Iron*/metabolism, Animals ; Mice ; Bleomycin ; Male ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Cyclopropanes/pharmacology ; Cyclopropanes/therapeutic use ; Lung/drug effects ; Lung/pathology ; Lung/metabolism ; Reactive Oxygen Species/metabolism ; Mice, Inbred C57BL ; Humans ; Disease Models, Animal ; Cyclic AMP Response Element-Binding Protein/metabolism

Impact of Long-Term Structured Exercise on Body Composition in an NTRK Fusion-Positive NSCLC Patient Treated With Entrectinib.

Autoren: Avancini A Sposito M Adamoli G et al.

Quelle: Thoracic cancer [Thorac Cancer] 2025 Dec; Vol. 16 (23), pp. e70198.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Wiley Publishing Asia Pty Ltd Country of Publication: Singapore NLM ID: 101531441 Publication Model: Print Cited Medium: Internet ISSN: 1759-7714 (Electronic) Linking ISSN: 17597706 NLM ISO Abbreviation: Thorac Cancer Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Benzamides*/therapeutic use , Benzamides*/adverse effects , Benzamides*/pharmacology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Indazoles*/therapeutic use , Indazoles*/adverse effects , Indazoles*/pharmacology , Body Composition* , Exercise*, Humans ; Adult ; Male

Cerebral aspergillosis in a patient treated with acalabrutinib, a second generation Bruton's tyrosine kinase inhibitor.

Autoren: Rezig S Talarmin JP Le Gal S et al.

Quelle: Journal de mycologie medicale [J Mycol Med] 2025 Dec; Vol. 35 (4), pp. 101586. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Masson Country of Publication: France NLM ID: 9425651 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1773-0449 (Electronic) Linking ISSN: 11565233 NLM ISO Abbreviation: J Mycol Med Subsets: MEDLINE

MeSH-Schlagworte: Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors , Pyrazines*/adverse effects , Pyrazines*/therapeutic use , Benzamides*/adverse effects , Benzamides*/therapeutic use , Protein Kinase Inhibitors*/adverse effects , Protein Kinase Inhibitors*/therapeutic use , Neuroaspergillosis*/chemically induced , Neuroaspergillosis*/diagnosis , Neuroaspergillosis*/microbiology, Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Male ; Fatal Outcome ; Aged ; Middle Aged ; Tyrosine Kinase Inhibitors

Design and development of potent roflumilast analogues targeting PDE-4B: selectivity and pharmacokinetic insights.

Autoren: Moussa AM Allam HA Al-Karmalawy AA et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109201. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Benzamides*/chemistry , Benzamides*/pharmacology , Benzamides*/chemical synthesis , Benzamides*/pharmacokinetics , Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism , Aminopyridines*/chemistry , Aminopyridines*/pharmacology , Aminopyridines*/chemical synthesis , Aminopyridines*/pharmacokinetics , Phosphodiesterase 4 Inhibitors*/pharmacology , Phosphodiesterase 4 Inhibitors*/chemistry , Phosphodiesterase 4 Inhibitors*/chemical synthesis , Phosphodiesterase 4 Inhibitors*/pharmacokinetics , Drug Design*, Cyclopropanes/chemistry ; Cyclopropanes/pharmacology ; Cyclopropanes/chemical synthesis ; Cyclopropanes/pharmacokinetics ; Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug ; Animals

Population Pharmacokinetics of Valemetostat and Exposure-Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma.

Autoren: Inoue H Wang X Garcia R et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Dec; Vol. 65 (12), pp. 1699-1711. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Lymphoma, T-Cell, Peripheral*/drug therapy , Lymphoma, T-Cell, Peripheral*/metabolism , Models, Biological* , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/administration & dosage , Benzamides*/pharmacokinetics , Benzamides*/adverse effects , Benzamides*/therapeutic use, Humans ; Male ; Middle Aged ; Female ; Adult ; Aged ; Dose-Response Relationship, Drug ; Treatment Outcome ; Young Adult

Size effects of lufenuron-loaded ZIF-8 nanoparticles on target deposition and insecticidal activity.

Autoren: Liu H Sun H Shanguan W et al.

Quelle: Pest management science [Pest Manag Sci] 2025 Dec; Vol. 81 (12), pp. 8586-8594. Date of Electronic Publication: 2025 Aug 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published for SCI by Wiley Country of Publication: England NLM ID: 100898744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4998 (Electronic) Linking ISSN: 1526498X NLM ISO Abbreviation: Pest Manag Sci Subsets: MEDLINE

MeSH-Schlagworte: Insecticides*/chemistry , Insecticides*/pharmacology , Nanoparticles*/chemistry , Benzamides*/chemistry , Benzamides*/pharmacology , Metal-Organic Frameworks*/chemistry , Zeolites*/chemistry , Moths*/drug effects , Moths*/growth & development, Animals ; Particle Size ; Larva/drug effects ; Larva/growth & development ; Fluorocarbons ; Imidazoles

Zanubrutinib versus acalabrutinib indirect treatment comparison in relapsed or refractory mantle cell lymphoma.

Autoren: Shah B Challagulla S Xu S et al.

Quelle: Leukemia & lymphoma [Leuk Lymphoma] 2025 Dec; Vol. 66 (12), pp. 2238-2248. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE

MeSH-Schlagworte: Lymphoma, Mantle-Cell*/drug therapy , Lymphoma, Mantle-Cell*/mortality , Lymphoma, Mantle-Cell*/pathology , Pyrazines*/therapeutic use , Pyrazines*/adverse effects , Pyrazines*/administration & dosage , Benzamides*/therapeutic use , Benzamides*/adverse effects , Benzamides*/administration & dosage , Pyrazoles*/therapeutic use , Piperidines*/therapeutic use , Pyrimidines*/therapeutic use , Neoplasm Recurrence, Local*/drug therapy , Neoplasm Recurrence, Local*/pathology, Humans ; Male ; Female ; Aged ; Middle Aged ; Drug Resistance, Neoplasm ; Treatment Outcome ; Aged, 80 and over

Development of novel benzamide class I selective lysine deacetylase inhibitors as potent anticancer agents.

Autoren: Gill JH Sellars JD Waddell PG et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2520612. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Benzamides*/pharmacology , Benzamides*/chemistry , Benzamides*/chemical synthesis , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Histone Deacetylases*/metabolism , Drug Development*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Animals ; Mice ; Cell Line, Tumor ; Female

3-Aminobenzamide-linked Multifunctional Nanoparticles: A Potent Strategy for Modulating PARP1 in Cervical Cancer Cells.

Autoren: Kaci FN Daglioglu C

Quelle: Cell biochemistry and biophysics [Cell Biochem Biophys] 2025 Dec; Vol. 83 (4), pp. 4925-4932. Date of Electronic Publication: 2025 Jun 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

MeSH-Schlagworte: Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/metabolism , Uterine Cervical Neoplasms*/drug therapy , Benzamides*/chemistry , Benzamides*/pharmacology , Poly (ADP-Ribose) Polymerase-1*/metabolism , Poly (ADP-Ribose) Polymerase-1*/antagonists & inhibitors , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Nanoparticles*/chemistry, Humans ; Female ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Silicon Dioxide/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Cisplatin/pharmacology

Discovery and structural-activity relationship of N-benzyl-2-fluorobenzamides as EGFR/HDAC3 dual-target inhibitors for the treatment of triple-negative breast cancer.

Autoren: Ge GH Guo S Li TT et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 01; Vol. 128, pp. 130362. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Histone Deacetylases*/metabolism , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/therapeutic use , Benzamides*/chemistry , Benzamides*/pharmacology , Benzamides*/chemical synthesis , Benzamides*/therapeutic use , Drug Discovery*, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Female ; Animals ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Mice ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Movement/drug effects

Oral roflumilast for psoriasis: a real-world 24-week prospective cohort study.

Autoren: Lé AM Yilmaz O Luz M et al.

Quelle: The Journal of dermatological treatment [J Dermatolog Treat] 2025 Dec; Vol. 36 (1), pp. 2464107. Date of Electronic Publication: 2025 Feb 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE

MeSH-Schlagworte: Psoriasis*/drug therapy , Psoriasis*/diagnosis , Aminopyridines*/adverse effects , Aminopyridines*/administration & dosage , Phosphodiesterase 4 Inhibitors*/adverse effects , Phosphodiesterase 4 Inhibitors*/administration & dosage , Benzamides*/adverse effects , Benzamides*/administration & dosage, Humans ; Female ; Male ; Prospective Studies ; Middle Aged ; Administration, Oral ; Adult ; Cyclopropanes/adverse effects ; Cyclopropanes/administration & dosage ; Treatment Outcome ; Severity of Illness Index ; Aged ; Weight Loss/drug effects

Benzodioxane-benzamides targeting bacterial cell division protein FtsZ potentially disrupt SlmA-mediated nucleoid occlusion and reversible biomolecular condensation.

Autoren: Sobrinos-Sanguino M Barros-Medina I Suigo L et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 2), pp. 148516. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Cytoskeletal Proteins*/metabolism , Cytoskeletal Proteins*/antagonists & inhibitors , Cytoskeletal Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/antagonists & inhibitors , Bacterial Proteins*/chemistry , Benzamides*/pharmacology , Benzamides*/chemistry , Dioxanes*/pharmacology , Dioxanes*/chemistry , Escherichia coli Proteins*/metabolism, Cell Division/drug effects ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Carrier Proteins

Oral Roflumilast Suppresses Proinflammatory Cytokine Signaling and Reduces CD4+ T-Cell and Neutrophil Infiltration in Psoriasis.

Autoren: Baez E Gyldenløve M Ben Abdallah H et al.

Quelle: The Journal of investigative dermatology [J Invest Dermatol] 2025 Dec; Vol. 145 (12), pp. 3079-3088.e3. Date of Electronic Publication: 2025 May 20.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Psoriasis*/drug therapy , Psoriasis*/immunology , Psoriasis*/pathology , Aminopyridines*/administration & dosage , Aminopyridines*/therapeutic use , Benzamides*/administration & dosage , Benzamides*/therapeutic use , Phosphodiesterase 4 Inhibitors*/administration & dosage , Cytokines*/metabolism , CD4-Positive T-Lymphocytes*/immunology , CD4-Positive T-Lymphocytes*/drug effects , Neutrophil Infiltration*/drug effects , Neutrophil Infiltration*/immunology, Humans ; Cyclopropanes/administration & dosage ; Male ; Female ; Administration, Oral ; Middle Aged ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Adult ; Treatment Outcome ; Skin/pathology ; Skin/immunology ; Skin/drug effects ; Double-Blind Method ; Biopsy ; Aged

Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators.

Autoren: Liang M Dou Y Zhang J et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24358-24380. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B virus*/drug effects , Hepatitis B virus*/physiology , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Benzamides*/pharmacology , Benzamides*/chemistry , Drug Design* , Piperazines*/chemistry , Piperazines*/pharmacology , Capsid*/drug effects , Capsid*/metabolism , Virus Assembly*/drug effects, Humans ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Dynamics Simulation ; Virus Replication/drug effects ; Piperazine/chemistry ; Piperazine/pharmacology

High-throughput transcriptomic screening reveals entrectinib as a repositioning opportunity in 19q12 autism spectrum disorder.

Autoren: Guin D Haditsch U Bellucci JJ et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 25; Vol. 15 (1), pp. 42001. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Autism Spectrum Disorder*/genetics , Autism Spectrum Disorder*/drug therapy , Indazoles*/pharmacology , Indazoles*/therapeutic use , Benzamides*/pharmacology , Benzamides*/therapeutic use , Transcriptome*/drug effects , Drug Repositioning*, Humans ; High-Throughput Screening Assays/methods ; Gene Expression Profiling ; Male

Synthesis, antiproliferative screening, and molecular docking of some heterocycles derived from N-(1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydrazineyl-3-oxoprop-1-en-2-yl)benzamide.

Autoren: El-Helw EAE Youssef YM Elsayed GA et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 24; Vol. 15 (1), pp. 41821. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Molecular Docking Simulation* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Benzamides*/chemistry , Benzamides*/pharmacology , Benzamides*/chemical synthesis , Heterocyclic Compounds*/chemical synthesis , Heterocyclic Compounds*/pharmacology , Heterocyclic Compounds*/chemistry, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; MCF-7 Cells ; Cyclin-Dependent Kinase 2/antagonists & inhibitors ; Cyclin-Dependent Kinase 2/chemistry ; Cyclin-Dependent Kinase 2/metabolism ; Cell Line, Tumor ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyrazoles/chemical synthesis ; HCT116 Cells ; Structure-Activity Relationship

A multifunctional probe for optical and electrochemical detection of hydrogen sulfide and real-time selective fungal imaging.

Autoren: M R Kashyap NN Sunil D et al.

Quelle: The Analyst [Analyst] 2025 Nov 17; Vol. 150 (23), pp. 5245-5261. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 0372652 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-5528 (Electronic) Linking ISSN: 00032654 NLM ISO Abbreviation: Analyst Subsets: MEDLINE

MeSH-Schlagworte: Hydrogen Sulfide*/analysis , Candida albicans*/isolation & purification , Candida albicans*/cytology , Candida albicans*/chemistry , Electrochemical Techniques*/methods , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis , Optical Imaging*/methods , Benzamides*/chemistry , Benzamides*/chemical synthesis, Aspergillus niger