Suchergebnisse - "Benchmark dose modelling"

Mono-n-hexyl phthalate: exposure estimation and assessment of health risks based on levels found in human urine samples

Autoren: Ralph Pirow Ulrike Bernauer Annegret Blume et al.

Quelle: Arch Toxicol

Schlagwörter: Adult, Male, 0301 basic medicine, Human biomonitoring data, Plasticizers/toxicity [MeSH], Female [MeSH], Phthalic Acids/urine [MeSH], Tolerable daily intake, Environmental Exposure/adverse effects [MeSH], Risk Assessment [MeSH], Adult [MeSH], Humans [MeSH], Animals [MeSH], Phthalic Acids/toxicity [MeSH], Environmental Pollutants/toxicity [MeSH], Di-n-hexyl phthalate, Male [MeSH], Germany [MeSH], Reverse dosimetry, Environmental Pollutants/urine [MeSH], Benchmark dose modelling, Child [MeSH], Mono-n-hexyl phthalate, Pregnancy [MeSH], Environmental Exposure/analysis [MeSH], Regulatory Toxicology, Phthalic Acids, Environmental Exposure, Risk Assessment, 01 natural sciences, 03 medical and health sciences, Plasticizers, Pregnancy, Germany, Humans, Animals, Female, Environmental Pollutants, Child, 0105 earth and related environmental sciences

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39153032
https://repository.publisso.de/resource/frl:6503577

Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals

Autoren: Anouck Thienpont Eunnara Cho Andrew Williams et al.

Weitere Verfasser: Anouck Thienpont Eunnara Cho Andrew Williams et al.

Quelle: Chem Res Toxicol

Schlagwörter: 0301 basic medicine, 0303 health sciences, potency ranking, Gene Expression Profiling, benchmark dose modelling, new approach methodologies (NAMs), Cell Line, 03 medical and health sciences, TempO-Seq, high-throughput toxicogenomics, Animals, Humans, HepaRG, Transcriptome, Biomarkers, DNA Damage

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38408751
https://biblio.vub.ac.be/vubir/unlocking-the-power-of-transcriptomic-biomarkers-in-qualitative-and-quantitative-genotoxicity-assessment-of-chemicals(f4d0e314-b289-4807-ba2a-80958710f662).html
https://hdl.handle.net/20.500.14017/99d1ef10-f1f3-4765-9be4-62ba997b5c48
https://biblio.vub.ac.be/vubir/unlocking-the-power-of-transcriptomic-biomarkers-in-qualitative-and-quantitative-genotoxicity-assessment-of-chemicals(99d1ef10-f1f3-4765-9be4-62ba997b5c48).html

Adipose tissue cadmium concentrations as potential determinants of serum PON1 status in an adult cohort from Southern Spain

Autoren: Maria Cruz Gomez Pellin Eduardo Linares-Ruiz Javier Esteban et al.

Quelle: Environmental Toxicology and Pharmacology. :104827

Schlagwörter: PON1Q192R phenotype, Adipose tissue, Benchmark dose modelling, PON1, Atherosclerosis, Cadmium

Zugangs-URL: https://www.sciencedirect.com/science/article/pii/S1382668925002029?via=ihub
https://doi.org/10.1016/j.etap.2025.104827

Protectiveness of NAM-based hazard assessment - which testing scope is required?

Autoren: Zobl, Walter Bitsch, Annette Blum, Jonathan et al.

Quelle: Zobl, W, Bitsch, A, Blum, J, Boei, J J W A, Capinha, L, Carta, G, Castell, J, Davoli, E, Drake, C, Fisher, C P, Heldring, M M, Islam, B, Jennings, P, Leist, M, Pellegrino-Coppola, D, Schimming, J P, Snijders, K E, Tolosa, L, van de Water, B, van Vugt-Lussenburg, B M A, Walker, P, Wehr, M M, Wijaya, L S & Escher, S E 2024, 'Protectiveness of NAM-based hazard assessment - which testing scope is required?', ALTEX, vol. 41, no. 2, pp. 302-319. https://doi.org/10.14573/altex.2309081

Schlagwörter: benchmark dose modelling, NAMs, qIVIVE, systemic toxicity, tiered hazard assessment

Verfügbarkeit: https://research.vu.nl/en/publications/4eb78287-2af8-493f-9176-4d383369b766
https://doi.org/10.14573/altex.2309081
https://hdl.handle.net/1871.1/4eb78287-2af8-493f-9176-4d383369b766
http://www.scopus.com/inward/record.url?scp=85190900186&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85190900186&partnerID=8YFLogxK

The choice of Critical Effect Size – a retrospective analysis on the risk assessment of PFAS

Autoren: Brunken, Lars Silva, Antero Vieira Öberg, Mattias

Schlagwörter: Chemical risk assessment, Benchmark dose modelling, Per- and polyfluoroalkyl substances, Critical effect size

Applying transcriptomic benchmark modelling for toxicological decision making

Autoren: Currie, R. A.

Quelle: Spanish Journal of Environmental Mutagenesis and Genomics; Vol. 27 No. 1 (2023): 51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA) meeting; 58
Spanish Journal of Environmental Mutagenesis and Genomics; Vol. 27 Núm. 1 (2023): 51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA) meeting; 58
diffundit® Open Journal Systems Platform
Pendiente determinar

Schlagwörter: toxicogenomics, point of departure, benchmark dose modelling, crop protection

Dateibeschreibung: application/pdf

Zugangs-URL: https://ojs.diffundit.com/index.php/sema/article/view/1383

The choice of Critical Effect Size – a retrospective analysis on the risk assessment of PFAS

Autoren: Lars Brunken orcid:0000-0002-6327- Antero Vieira Silva et al.

Schlagwörter: Benchmark dose modelling, Critical effect size, Chemical risk assessment, Per- and polyfluoroalkyl substances

Relation: https://zenodo.org/communities/perforce3/; https://zenodo.org/communities/eu/; https://zenodo.org/records/8431191; oai:zenodo.org:8431191; https://doi.org/10.5281/zenodo.8431191

Verfügbarkeit: https://doi.org/10.5281/zenodo.8431191
https://zenodo.org/records/8431191

A health-based recommended occupational exposure limit for nitrous oxide using experimental animal data based on a systematic review and dose-response analysis

Autoren: Menon, Julia J.M.L. van Luijk, Judith J.A.K.R. Swinkels, Janne et al.

Quelle: Environmental research, 201

Schlagwörter: Biochimie, Environnement et pollution, Benchmark dose modelling, Nitrous oxide, Occupational exposure limit, Reproductive and developmental toxicity

Dateibeschreibung: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1016/j.envres.2021.111575; uri/info:pii/S0013935121008690; uri/info:scp/85109436704; https://dipot.ulb.ac.be/dspace/bitstream/2013/328642/1/doi_312286.pdf

Verfügbarkeit: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/328642
https://dipot.ulb.ac.be/dspace/bitstream/2013/328642/1/doi_312286.pdf

A health-based recommended occupational exposure limit for nitrous oxide using experimental animal data based on a systematic review and dose-response analysis

Autoren: Menon, Julia M.L. van Luijk, Judith A.K.R. Swinkels, Janne et al.

Quelle: Menon, J M L, van Luijk, J A K R, Swinkels, J, Lukas, E, Ritskes-Hoitinga, M, Roeleveld, N, Schlünssen, V, Mandrioli, D, Hoffmann, S, Popa, M & Scheepers, P T J 2021, 'A health-based recommended occupational exposure limit for nitrous oxide using experimental animal data based on a systematic review and dose-response analysis', Environmental Research, vol. 201, 111575. https://doi.org/10.1016/j.envres.2021.111575

Schlagwörter: Benchmark dose modelling, Nitrous oxide, Occupational exposure limit, Reproductive and developmental toxicity, SEARCH FILTER, UNCERTAINTY FACTORS, PROLONGED EXPOSURE, RISK, TOXICITY, SPONTANEOUS-ABORTION, ANESTHETIC-GASES, WORK, HALOTHANE

Dateibeschreibung: application/pdf

Verfügbarkeit: https://pure.au.dk/portal/en/publications/9092c5e4-e073-4e75-95e7-e2f7829c1399
https://doi.org/10.1016/j.envres.2021.111575
https://pure.au.dk/ws/files/274787293/1_s2.0_S0013935121008690_main.pdf
http://www.scopus.com/inward/record.url?scp=85109436704&partnerID=8YFLogxK

Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure

Autoren: Gosens Ilse Cassee et al.

Weitere Verfasser: Gosens Ilse Cassee et al.

Quelle: Nanotoxicology
info:cnr-pdr/source/autori:Gosens, Ilse and Cassee, Flemming R. and Zanella, Michela and Manodori, Laura and Brunelli, Andrea and Costa, Anna Luisa and Bokkers, Bas G. H. and de Jong, Wim H. and Brown, David and Hristozov, Danail and Stone, Vicki/titolo:Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure/doi:10.3109%2F17435390.2016.1172678/rivista:Nanotoxicology (Print)/anno:2016/pagina_da:1084/pagina_a:1095/intervallo_pagine:1084–1095/volume:10

Schlagwörter: Male, 0301 basic medicine, Surface Properties, Respiratory Mucosa, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Benchmark dose modelling, Animals, Humans, Particle Size, pulmonary toxicity, Lung, Aerosols, Inhalation Exposure, 0303 health sciences, Dose-Response Relationship, Drug, Pneumonia, copper oxide, Rats, 3. Good health, organ burden, Body Burden, Nanoparticles, nanoparticles, Original Article, Copper

Dateibeschreibung: image/pdf

Zugangs-URL: https://www.tandfonline.com/doi/pdf/10.3109/17435390.2016.1172678?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/27132941
https://researchportal.hw.ac.uk/en/publications/organ-burden-and-pulmonary-toxicity-of-nano-sized-copper-ii-oxide
https://pubmed.ncbi.nlm.nih.gov/27132941/
https://dspace.library.uu.nl/handle/1874/344410
https://dspace.library.uu.nl/bitstream/1874/344410/1/Organ.pdf
https://core.ac.uk/display/53186037
https://www.tandfonline.com/doi/full/10.3109/17435390.2016.1172678
https://hdl.handle.net/20.500.14243/402516
https://doi.org/10.3109/17435390.2016.1172678
https://pubmed.ncbi.nlm.nih.gov/27132941/
https://dspace.library.uu.nl/handle/1874/344410
https://rivm.openrepository.com/handle/10029/649702

Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats

Autoren: Gosens, I Mathijssen, EAM Bokkers, BGH et al.

Weitere Verfasser: Gosens, I Mathijssen, EAM Bokkers, BGH et al.

Quelle: Nanotoxicology. 8:643-653

Schlagwörter: Male, 0301 basic medicine, Neutrophils, Biomedical Engineering, Toxicology, 01 natural sciences, 7. Clean energy, 03 medical and health sciences, Administration, Inhalation, Benchmark dose modelling, Animals, Particle Size, Nanotoxicology, Lung, 0105 earth and related environmental sciences, Inhalation Exposure, 0303 health sciences, Cerium oxide, Cerium, Pneumonia, 3. Good health, Rats, 13. Climate action, Nanoparticles, Female, Ranking, Bronchoalveolar Lavage Fluid

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/23768316
https://research-portal.uu.nl/en/publications/b937c409-2e1a-4792-ac55-cbc843e12ac6
https://doi.org/10.3109/17435390.2013.815814
https://www.tandfonline.com/doi/full/10.3109/17435390.2013.815814
http://dspace.library.uu.nl/handle/1874/305156
https://www.narcis.nl/publication/RecordID/oai%3Adspace.library.uu.nl%3A1874%2F305156
https://www.ncbi.nlm.nih.gov/pubmed/23768316
https://pubmed.ncbi.nlm.nih.gov/23768316/
https://europepmc.org/abstract/MED/23768316
https://dspace.library.uu.nl/handle/1874/305156
https://rivm.openrepository.com/handle/10029/647718

TKPlate: a web-based open source platform for Toxicokinetic and Toxicodynamic Modelling.

Autoren: Bossier Han Cortiñas Abrahantes José orcid:0000-0002-1132- et al.

Weitere Verfasser: Bossier Han Cortiñas Abrahantes José orcid:0000-0002-1132- et al.

Schlagwörter: human health, animal health, ecological risk assessment, toxicokinetic models, toxicodynamic models, physiologically-based kinetic models, forward dosimetry, reverse dosimetry, benchmark dose modelling, dynamic energy budget models, R Shiny, statistical analysis, Bayesian theory, Monte Carlo method, animal physiology, computer techniques, pharmacokinetics, toxicokinetics, toxicology, ecotoxicology

Relation: https://zenodo.org/communities/efsa-kj/; https://zenodo.org/records/7494936; oai:zenodo.org:7494936; https://doi.org/10.5281/zenodo.7494936

Verfügbarkeit: https://doi.org/10.5281/zenodo.7494936
https://zenodo.org/records/7494936

The Genetic Toxicity of Polycyclic Aromatic Hydrocarbons: A Cross-Tissue, Multi-Endpoint Study in the Transgenic MutaMouse

Autoren: Long, Alexandra

Thesis Advisors: White, Paul

Schlagwörter: Genetic toxicology, Mutation, Polycyclic aromatic hydrocarbon, Benchmark dose modelling, DNA adduct, Chromosome damage

Verfügbarkeit: http://hdl.handle.net/10393/36274

Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats

Autoren: Gosens, Ilse Mathijssen, Liesbeth E A M Bokkers, Bas G H et al.

Weitere Verfasser: Gosens, Ilse Mathijssen, Liesbeth E A M Bokkers, Bas G H et al.

Schlagwörter: Benchmark dose modelling, Cerium oxide, Nanoparticles, Nanotoxicology, Ranking, Biomedical Engineering, Toxicology

Dateibeschreibung: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/305156

Verfügbarkeit: https://dspace.library.uu.nl/handle/1874/305156

Selection of Appropriate Tumour Data Sets for Benchmark Dose Modelling (BMD) and Derivation of a Margin of Exposure (Moe) for Substances That Are Genotoxic and Carcinogenic: Considerations of Biological Relevance of Tumour Type, Data Quality and Uncertainty Assessment

Autoren: Edler, Lutz Hart, Andy Greaves, Peter et al.

Quelle: NYMC Faculty Publications

Schlagwörter: Benchmark Dose Modelling, Data selection, Genotoxic carcinogen, Margin of Exposure, Tumour relevance, Uncertainty assessment, Faculty, Medicine and Health Sciences

Dateibeschreibung: text/html

Relation: https://touroscholar.touro.edu/nymc_fac_pubs/5501; https://touroscholar.touro.edu/context/nymc_fac_pubs/article/6427/type/native/viewcontent/_myncbishare_nymclib.html

Verfügbarkeit: https://touroscholar.touro.edu/nymc_fac_pubs/5501
https://doi.org/10.1016/j.fct.2013.10.030
https://touroscholar.touro.edu/context/nymc_fac_pubs/article/6427/type/native/viewcontent/_myncbishare_nymclib.html

Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†.

Autoren: LeBlanc DPM Zhou G Williams A et al.

Quelle: Biology of reproduction [Biol Reprod] 2025 May 13; Vol. 112 (5), pp. 1015-1027.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE

MeSH-Schlagworte: Ethylnitrosourea*/toxicity , Mutation*/drug effects , Mutagens*/toxicity , Germ Cells*/drug effects , Spermatozoa*/drug effects, Animals ; Male ; Mice ; Mutagenicity Tests/methods ; Mutagenesis/drug effects

Protectiveness of NAM-Based Hazard Assessment – Which Testing Scope is Required?

Autoren: Zobl, W Bitsch, A Blum, J et al.

Index Begriffe: NAM, benchmark dose modelling, qIVIVE, systemic toxicity, tiered hazard assessment, info:eu-repo/semantics/article

URL: https://hdl.handle.net/10281/504079
info:eu-repo/semantics/altIdentifier/pmid/38048429
info:eu-repo/semantics/altIdentifier/wos/WOS:001207743500008
volume:41
issue:2
firstpage:302
lastpage:319
numberofpages:18
journal:ALTERNATIVES TO ANIMAL EXPERIMENTATION

N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.

Autoren: Lynch AM Howe J Hildebrand D et al.

Quelle: Mutagenesis [Mutagenesis] 2024 Mar 12; Vol. 39 (2), pp. 96-118.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8707812 Publication Model: Print Cited Medium: Internet ISSN: 1464-3804 (Electronic) Linking ISSN: 02678357 NLM ISO Abbreviation: Mutagenesis Subsets: MEDLINE

MeSH-Schlagworte: Dimethylnitrosamine*/toxicity , Mutagens*/toxicity, Mutation ; DNA Damage ; Mutagenesis

Review of evidence relating to occupational exposure limits for alpha-diketones and acetoin, and considerations for deriving an occupational exposure limit for 2,3-pentanedione.

Autoren: Card JW Scaife KM Haighton LA

Quelle: Critical reviews in toxicology [Crit Rev Toxicol] 2022 Oct; Vol. 52 (9), pp. 715-730. Date of Electronic Publication: 2023 Feb 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8914275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1547-6898 (Electronic) Linking ISSN: 10408444 NLM ISO Abbreviation: Crit Rev Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Diacetyl*/toxicity , Occupational Exposure*, Acetoin ; Ketones ; Pentanones/toxicity

A 90-day subchronic gavage toxicity study in Fischer 344 rats with 3-methylfuran.

Autoren: Gill S Kavanagh M Cherry W et al.

Quelle: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Jan; Vol. 111, pp. 341-355. Date of Electronic Publication: 2017 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Air Pollutants/*toxicity , Furans/*toxicity , Toxicity Tests, Subchronic/*methods, Administration, Oral ; Animals ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Female ; Furans/administration & dosage ; Kidney/drug effects ; Kidney/pathology ; Liver/drug effects ; Liver/pathology ; Male ; Organ Size/drug effects ; Rats ; Rats, Inbred F344 ; Spleen/drug effects ; Spleen/pathology