Suchergebnisse - "Beijersbergen, Roderick L."

Exploiting nanopore sequencing advances for tRNA sequencing of human cancer models

Autoren: Kochavi, Adva Velds, Arno Suzuki, Maya et al.

Quelle: Kochavi, A, Velds, A, Suzuki, M, Akichika, S, Suzuki, T, Beijersbergen, R L & Agami, R 2025, 'Exploiting nanopore sequencing advances for tRNA sequencing of human cancer models', NAR Cancer, vol. 7, no. 4, zcaf044. https://doi.org/10.1093/narcan/zcaf044

Schlagwörter: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/41190243; info:eu-repo/semantics/altIdentifier/eissn/2632-8674

Verfügbarkeit: https://pure.eur.nl/en/publications/e4790292-7f0c-4f5b-8821-450b93eb34fa
https://doi.org/10.1093/narcan/zcaf044
https://pure.eur.nl/ws/files/213919005/zcaf044.pdf
https://www.scopus.com/pages/publications/105020790273

Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer

Autoren: Severson, Tesa M. Minnee, Emma Zhu, Yanyun et al.

Weitere Verfasser: Severson, Tesa M. Minnee, Emma Zhu, Yanyun et al.

Time: 3122

Dateibeschreibung: fulltext

Relation: Cell Reports Medicine; 102215; https://trepo.tuni.fi/handle/10024/229328

Verfügbarkeit: https://trepo.tuni.fi/handle/10024/229328
https://doi.org/10.1016/j.xcrm.2025.102215

Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation

Autoren: Thus, Yvonne J. de Rooij, Martin F. M. Swier, Nathalie et al.

Quelle: Haematologica
Haematologica, Vol 108, Iss 3 (2022)

Schlagwörter: Adult, 0301 basic medicine, 0303 health sciences, Down-Regulation, Antineoplastic Agents, Lymphoma, Mantle-Cell, Bridged Bicyclo Compounds, Heterocyclic, 3. Good health, 03 medical and health sciences, Proto-Oncogene Proteins c-bcl-2, Cell Line, Tumor, Humans, Myeloid Cell Leukemia Sequence 1 Protein, Diseases of the blood and blood-forming organs, Article - Non-Hodgkin Lymphoma, RC633-647.5, Casein Kinase II

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36226498
https://doaj.org/article/44bb043e875f4dc08f5f043e88f5f9bc
https://pure.amsterdamumc.nl/en/publications/8fd4c7d4-eeb2-451a-ab7b-199be6a16086
https://doi.org/10.3324/haematol.2022.281668

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Autoren: Vergara, Xabier Manjón, Anna G. de Haas, Marcel et al.

Quelle: Vergara, X, Manjón, A G, de Haas, M, Morris, B, Schep, R, Leemans, C, Friskes, A, Beijersbergen, R L, Sanders, M A, Medema, R H & van Steensel, B 2024, 'Widespread chromatin context-dependencies of DNA double-strand break repair proteins', Nature Communications, vol. 15, no. 1, 5334. https://doi.org/10.1038/s41467-024-49232-x

Schlagwörter: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/38909016; info:eu-repo/semantics/altIdentifier/pissn/2041-1723; info:eu-repo/semantics/altIdentifier/eissn/2041-1723

Verfügbarkeit: https://pure.eur.nl/en/publications/f6382761-38cd-4785-9c81-7d7731dd7d05
https://doi.org/10.1038/s41467-024-49232-x
https://pure.eur.nl/ws/files/155445333/s41467-024-49232-x.pdf
https://www.scopus.com/pages/publications/85196649114

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

Autoren: Andronikou, Christina Burdova, Kamila Dibitetto, Diego et al.

Quelle: Andronikou, C, Burdova, K, Dibitetto, D, Lieftink, C, Malzer, E, Kuiken, H J, Gogola, E, Ray Chaudhuri, A, Beijersbergen, R L, Hanzlikova, H, Jonkers, J & Rottenberg, S 2024, 'PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair', The EMBO journal, vol. 43, no. 6, pp. 1015-1042. https://doi.org/10.1038/s44318-024-00043-2

Schlagwörter: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/38360994; info:eu-repo/semantics/altIdentifier/pissn/0261-4189; info:eu-repo/semantics/altIdentifier/eissn/1460-2075

Verfügbarkeit: https://pure.eur.nl/en/publications/7163ae82-634d-4575-a8bd-3218c9f09754
https://doi.org/10.1038/s44318-024-00043-2
https://pure.eur.nl/ws/files/137029215/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair.pdf
https://www.scopus.com/pages/publications/85185319701

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

Autoren: Schep, Ruben Trauernicht, Max Vergara, Xabier et al.

Quelle: Schep, R, Trauernicht, M, Vergara, X, Friskes, A, Morris, B, Gregoricchio, S, Manzo, S G, Zwart, W, Beijersbergen, R L, Medema, R H & Van Steensel, B 2024, 'Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing', Nucleic Acids Research, vol. 52, no. 15, pp. 8815-8832. https://doi.org/10.1093/nar/gkae570

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/38953163; info:eu-repo/semantics/altIdentifier/pissn/0305-1048; info:eu-repo/semantics/altIdentifier/eissn/1362-4962

Verfügbarkeit: https://research.tue.nl/en/publications/0c116dd1-1334-414a-8172-21605dcd16d4
https://doi.org/10.1093/nar/gkae570
https://pure.tue.nl/ws/files/340782405/gkae570.pdf
https://www.scopus.com/pages/publications/85202475338

Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy

Autoren: Dias, Matheus Henrique Friskes, Anoek Wang, Siying et al.

Quelle: Dias , M H , Friskes , A , Wang , S , Fernandes Neto , J M , van Gemert , F , Mourragui , S , Papagianni , C , Kuiken , H J , Mainardi , S , Alvarez-Villanueva , D , Lieftink , C , Morris , B , Dekker , A , van Dijk , E , Wilms , L H S , da Silva , M S , Jansen , R A , Mulero-Sánchez , A , Malzer , E , Vidal , A , Santos , C , Salazar , R , ....

Schlagwörter: Humans, Signal Transduction, Animals, Protein Phosphatase 2/metabolism, Mice, Cell Line, Tumor, Colonic Neoplasms/drug therapy, Xenograft Model Antitumor Assays, Cell Cycle Proteins/metabolism, Protein-Tyrosine Kinases/antagonists & inhibitors, Drug Resistance, Neoplasm, Nuclear Proteins/metabolism, DNA Replication

Verfügbarkeit: https://pure.knaw.nl/portal/en/publications/27a34e16-5006-4728-a1ff-a86722948a7a
https://doi.org/10.1158/2159-8290.CD-23-0216
https://hdl.handle.net/20.500.11755/27a34e16-5006-4728-a1ff-a86722948a7a

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

Autoren: Dias, Matheus H. Friskes, Anoek Wang, Siying et al.

Quelle: Articles publicats en revistes (Ciències Clíniques)

Schlagwörter: Proteïnes quinases, Cicle cel·lular, Càncer colorectal, Resistència als medicaments, Protein kinases, Cell cycle, Colorectal cancer, Drug resistance

Dateibeschreibung: 26 p.; application/pdf

Relation: Reproducció del document publicat a: https://doi.org/10.1158/2159-8290.CD-23-0216; Cancer Discovery, 2024, vol. 14, num.7, p. 1276-1301; https://doi.org/10.1158/2159-8290.CD-23-0216; https://hdl.handle.net/2445/215109; 748248

Verfügbarkeit: https://hdl.handle.net/2445/215109

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

Autoren: de Groot, Daniel Spanjaard, Aldo Shah, Ronak et al.

Weitere Verfasser: de Groot, Daniel Spanjaard, Aldo Shah, Ronak et al.

Quelle: Genome Biology ; volume 25, issue 1 ; ISSN 1474-760X

Verfügbarkeit: https://doi.org/10.1186/s13059-024-03451-z
https://link.springer.com/content/pdf/10.1186/s13059-024-03451-z.pdf
https://link.springer.com/article/10.1186/s13059-024-03451-z/fulltext.html

ADARp150 counteracts whole genome duplication

Autoren: van Gemert, Frank Drakaki, Alexandra Lozano, Isabel Morales et al.

Weitere Verfasser: van Gemert, Frank Drakaki, Alexandra Lozano, Isabel Morales et al.

Quelle: Nucleic Acids Research ; volume 52, issue 17, page 10370-10384 ; ISSN 0305-1048 1362-4962

Verfügbarkeit: https://doi.org/10.1093/nar/gkae700
https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae700/59209626/gkae700.pdf

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

Autoren: Chen, Mengnuo Mainardi, Sara Lieftink, Cor et al.

Quelle: Cell Reports Medicine ; volume 5, issue 3, page 101471 ; ISSN 2666-3791

Verfügbarkeit: https://doi.org/10.1016/j.xcrm.2024.101471
https://api.elsevier.com/content/article/PII:S2666379124001174?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2666379124001174?httpAccept=text/plain

Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

Autoren: Buikhuisen, Joyce Y Gomez Barila, Patricia M Cameron, Kate et al.

Weitere Verfasser: Buikhuisen, Joyce Y Gomez Barila, Patricia M Cameron, Kate et al.

Schlagwörter: Cellular attachment, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis, PAK family, Settore MED/46 - Scienze Tecniche Di Medicina Di Laboratorio, Settore MED/50 - Scienze Tecniche Mediche Applicate

Relation: info:eu-repo/semantics/altIdentifier/pmid/36869386; info:eu-repo/semantics/altIdentifier/wos/WOS:000943136200001; volume:42; issue:1; numberofpages:18; journal:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH; https://hdl.handle.net/10447/583098

Verfügbarkeit: https://hdl.handle.net/10447/583098
https://doi.org/10.1186/s13046-023-02600-9

CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma.

Autoren: Wu Yang Siying Wang Shuyi Ji et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America; 9/30/2025, Vol. 122 Issue 39, p1-9, 11p

Schlagwörter: CHOLANGIOCARCINOMA, ADENOSINE triphosphatase, DRUG target, CRISPRS, CELLULAR aging

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

Autoren: Bhin, Jinhyuk Paes Dias, Mariana Gogola, Ewa et al.

Quelle: Bhin, J, Paes Dias, M, Gogola, E, Rolfs, F, Piersma, S R, de Bruijn, R, de Ruiter, J R, van den Broek, B, Duarte, A A, Sol, W, van der Heijden, I, Andronikou, C, Kaiponen, T S, Bakker, L, Lieftink, C, Morris, B, Beijersbergen, R L, van de Ven, M, Jimenez, C R, Wessels, L F A, Rottenberg, S & Jonkers, J 2023, 'Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors', Cell Reports, vol. 42, no. 5, 112538. https://doi.org/10.1016/j.celrep.2023.112538

Relation: info:eu-repo/semantics/altIdentifier/pmid/37209095; info:eu-repo/semantics/altIdentifier/pissn/2211-1247

Verfügbarkeit: https://research.vumc.nl/en/publications/655fe927-3015-4074-8b8b-9ff2bdf09664
https://doi.org/10.1016/j.celrep.2023.112538
https://www.scopus.com/pages/publications/85159894233

Mammalian life depends on two distinct pathways of DNA damage tolerance

Autoren: Buoninfante, Olimpia Alessandra Pilzecker, Bas Spanjaard, Aldo et al.

Quelle: Buoninfante, O A, Pilzecker, B, Spanjaard, A, de Groot, D, Prekovic, S, Song, J Y, Lieftink, C, Ayidah, M, Pritchard, C E J, Vivié, J, McGrath, K E, Huijbers, I J, Philipsen, S, von Lindern, M, Zwart, W, Beijersbergen, R L, Palis, J, van den Berk, P C M & Jacobs, H 2023, 'Mammalian life depends on two distinct pathways of DNA damage tolerance', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 4, e2216055120. https://doi.org/10.1073/pnas.2216055120

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/36669105; info:eu-repo/semantics/altIdentifier/pissn/0027-8424; info:eu-repo/semantics/altIdentifier/eissn/1091-6490

Verfügbarkeit: https://pure.eur.nl/en/publications/97d9e55e-3739-4a7c-9feb-61f4e8e1c6a8
https://doi.org/10.1073/pnas.2216055120
https://pure.eur.nl/ws/files/86737266/Mammalian_life_depends_on_two_distinct_pathways_of_DNA_damage_tolerance.pdf
https://www.scopus.com/pages/publications/85146863497

PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription

Autoren: Mayayo-Peralta, Isabel Gregoricchio, Sebastian Schuurman, Karianne et al.

Quelle: Mayayo-Peralta, I, Gregoricchio, S, Schuurman, K, Yavuz, S, Zaalberg, A, Kojic, A, Abbott, N, Geverts, B, Beerthuijzen, S, Siefert, J, Severson, T M, van Baalen, M, Hoekman, L, Lieftink, C, Altelaar, M, Beijersbergen, R L, Houtsmuller, A B, Prekovic, S & Zwart, W 2023, 'PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription', Nucleic Acids Research, vol. 51, no. 18, pp. 9576-9593. https://doi.org/10.1093/nar/gkad267

Schlagwörter: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/37070193; info:eu-repo/semantics/altIdentifier/pissn/0305-1048; info:eu-repo/semantics/altIdentifier/eissn/1362-4962

Verfügbarkeit: https://pure.eur.nl/en/publications/0f40a01b-80e3-43e5-9d31-fdf7faa8ed1f
https://doi.org/10.1093/nar/gkad267
https://pure.eur.nl/ws/files/103217109/gkad267.pdf
https://www.scopus.com/pages/publications/85174932365

Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

Autoren: Buikhuisen, Joyce Y. Barila, Patricia M. Gomez Cameron, Kate et al.

Weitere Verfasser: Buikhuisen, Joyce Y. Barila, Patricia M. Gomez Cameron, Kate et al.

Schlagwörter: Cellular attachment, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis, PAK family, Oncology, Cancer Research

Dateibeschreibung: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/434534

Verfügbarkeit: https://dspace.library.uu.nl/handle/1874/434534

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma

Autoren: Mulero‐Sánchez, Antonio Ramirez, Christel F. A. du Chatinier, Aimée et al.

Weitere Verfasser: Mulero‐Sánchez, Antonio Ramirez, Christel F. A. du Chatinier, Aimée et al.

Quelle: Molecular Oncology ; volume 17, issue 6, page 964-980 ; ISSN 1574-7891 1878-0261

Verfügbarkeit: https://doi.org/10.1002/1878-0261.13377
https://onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.13377
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1878-0261.13377
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.13377

Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors

Autoren: van der Noord, Vera E. van der Stel, Wanda Louwerens, Gijs et al.

Weitere Verfasser: van der Noord, Vera E. van der Stel, Wanda Louwerens, Gijs et al.

Quelle: Breast Cancer Research ; volume 25, issue 1 ; ISSN 1465-542X

Verfügbarkeit: https://doi.org/10.1186/s13058-023-01648-x
https://link.springer.com/content/pdf/10.1186/s13058-023-01648-x.pdf
https://link.springer.com/article/10.1186/s13058-023-01648-x/fulltext.html

Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly

Autoren: van Breugel, Maria Elize van Kruijsbergen, Ila Mittal, Chitvan et al.

Quelle: Molecular Cell ; volume 83, issue 23, page 4205-4221.e9 ; ISSN 1097-2765

Verfügbarkeit: https://doi.org/10.1016/j.molcel.2023.10.037
https://api.elsevier.com/content/article/PII:S1097276523009085?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1097276523009085?httpAccept=text/plain