Suchergebnisse - "Azoles"

Exploration of piperazine-azole hybrids as antifungal agents against drug-resistant Candida albicans.

Autoren: Xu Z Zhang X Wei Y et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109181. Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Candida albicans*/drug effects , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis , Drug Resistance, Fungal*/drug effects , Piperazines*/chemistry , Piperazines*/pharmacology , Azoles*/chemistry , Azoles*/pharmacology , Piperazine*/pharmacology , Piperazine*/chemistry, Microbial Sensitivity Tests ; Animals ; Mice ; Molecular Structure ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Candidiasis/drug therapy ; Humans ; Mice, Inbred BALB C

Accuracy of CYP3A5 Pharmacogenomics Recommended Dosing of Tacrolimus With Concomitant Azole Antifungals Early Post-Lung Transplant.

Autoren: Pham C Le K Bay C et al.

Quelle: Clinical transplantation [Clin Transplant] 2025 Oct; Vol. 39 (10), pp. e70345.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE

MeSH-Schlagworte: Tacrolimus*/administration & dosage , Cytochrome P-450 CYP3A*/genetics , Lung Transplantation*/adverse effects , Immunosuppressive Agents*/administration & dosage , Antifungal Agents*/administration & dosage , Antifungal Agents*/therapeutic use , Azoles*/therapeutic use , Azoles*/administration & dosage , Graft Rejection*/drug therapy , Graft Rejection*/pathology , Graft Rejection*/etiology , Graft Rejection*/prevention & control , Pharmacogenetics*/methods , Postoperative Complications*/drug therapy, Humans ; Male ; Female ; Middle Aged ; Follow-Up Studies ; Prognosis ; Adult ; Graft Survival/drug effects ; Retrospective Studies ; Risk Factors ; Aged ; Dose-Response Relationship, Drug

Unravelling azole resistance in fungal pathogens: molecular mechanisms, diagnostic challenges, and therapeutic strategies.

Autoren: Eknure CS Agarwal AP Bachhav Y et al.

Quelle: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2025 Nov 27; Vol. 41 (12), pp. 476. Date of Electronic Publication: 2025 Nov 27.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Azoles*/pharmacology , Azoles*/therapeutic use , Drug Resistance, Fungal*/genetics , Antifungal Agents*/pharmacology , Antifungal Agents*/therapeutic use , Mycoses*/drug therapy , Mycoses*/diagnosis , Mycoses*/microbiology , Fungi*/drug effects , Fungi*/genetics, Humans ; Biofilms/drug effects ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Candida/drug effects ; Candida/genetics

Structure-Directed Optimization of Ebselen Derivatives as Potent NDM-1 Inhibitors Reverses Meropenem Resistance.

Autoren: Guo Y Liu C Liu W et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24272-24293. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: beta-Lactamases*/metabolism , Organoselenium Compounds*/pharmacology , Organoselenium Compounds*/chemistry , Organoselenium Compounds*/chemical synthesis , beta-Lactamase Inhibitors*/pharmacology , beta-Lactamase Inhibitors*/chemistry , beta-Lactamase Inhibitors*/chemical synthesis , Meropenem*/pharmacology , Azoles*/pharmacology , Azoles*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis, Isoindoles ; Microbial Sensitivity Tests ; Animals ; Structure-Activity Relationship ; Mice ; Humans ; Drug Resistance, Bacterial/drug effects ; Escherichia coli/drug effects

Exploring the Androgen Receptor Binding Affinity of Azole Derivatives through Multiscale Computational and Experimental Approaches.

Autoren: Pathak RK Jeong DH Jang MJ et al.

Quelle: Environmental science & technology [Environ Sci Technol] 2025 Nov 18; Vol. 59 (45), pp. 24323-24334. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Androgen*/metabolism , Azoles*, Molecular Docking Simulation ; Humans ; Molecular Dynamics Simulation

Atomistic modulation of MIF-2 structure, catalysis, and biological signaling via cysteine residues and a small molecule, Ebselen.

Autoren: Widjaja V D'Orazio SM Das P et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Nov; Vol. 34 (11), pp. e70344.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Organoselenium Compounds*/chemistry , Organoselenium Compounds*/metabolism , Azoles*/chemistry , Azoles*/metabolism , Macrophage Migration-Inhibitory Factors*/chemistry , Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Intramolecular Oxidoreductases*/chemistry , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Cysteine*/chemistry , Cysteine*/metabolism, Isoindoles ; Signal Transduction ; Humans ; Models, Molecular ; Molecular Dynamics Simulation

Identification and Distribution of Potentially Azole-Resistant Airborne Fungi in Outdoor Environments of the Basque Country.

Autoren: Cendon-Sanchez S Pelegri-Martinez E Perez-Cuesta U et al.

Quelle: Environmental microbiology reports [Environ Microbiol Rep] 2025 Dec; Vol. 17 (6), pp. e70152.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Society for Applied Microbiology and Blackwell Pub Country of Publication: United States NLM ID: 101499207 Publication Model: Print Cited Medium: Internet ISSN: 1758-2229 (Electronic) Linking ISSN: 17582229 NLM ISO Abbreviation: Environ Microbiol Rep Subsets: MEDLINE

MeSH-Schlagworte: Fungi*/drug effects , Fungi*/isolation & purification , Fungi*/classification , Fungi*/genetics , Drug Resistance, Fungal* , Air Microbiology* , Azoles*/pharmacology , Antifungal Agents*/pharmacology, Spain

Simultaneous Quantification of Azole Antimycotics in Quantitative Dried Blood Spots: A Step Toward Home Sampling for Therapeutic Drug Monitoring.

Autoren: Li S Liu B Yuan J et al.

Quelle: Therapeutic drug monitoring [Ther Drug Monit] 2025 Dec 01; Vol. 47 (6), pp. e126-e133. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7909660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-3694 (Electronic) Linking ISSN: 01634356 NLM ISO Abbreviation: Ther Drug Monit Subsets: MEDLINE

MeSH-Schlagworte: Dried Blood Spot Testing*/methods , Drug Monitoring*/methods , Antifungal Agents*/blood , Azoles*/blood, Humans ; Reproducibility of Results ; Voriconazole/blood

Tannic acid exhibits therapeutic effects against azole-resistant invasive candidiasis and enhances the antifungal activity of fluconazole.

Autoren: Muñiz-Bernal V Ríos-López AL Treviño-Rangel RJ et al.

Quelle: Microbial pathogenesis [Microb Pathog] 2025 Dec; Vol. 209, pp. 108121. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH-Schlagworte: Antifungal Agents*/pharmacology , Antifungal Agents*/therapeutic use , Antifungal Agents*/administration & dosage , Fluconazole*/pharmacology , Fluconazole*/therapeutic use , Fluconazole*/administration & dosage , Candida albicans*/drug effects , Drug Resistance, Fungal*/drug effects , Tannins*/pharmacology , Tannins*/administration & dosage , Tannins*/therapeutic use , Candidiasis, Invasive*/drug therapy , Candidiasis, Invasive*/microbiology , Azoles*/pharmacology, Animals ; Mice, Inbred BALB C ; Mice ; Disease Models, Animal ; Cytokines/metabolism ; Cytokines/analysis ; Microbial Sensitivity Tests ; Drug Synergism ; Female ; Drug Therapy, Combination ; Polyphenols

Pharmacovigilance analysis of myopathy associated with azoles and nonstatins interactions based on US FAERS database.

Autoren: Jing S Zhang X Zhang Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 13; Vol. 15 (1), pp. 39870. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Muscular Diseases*/chemically induced , Muscular Diseases*/epidemiology , Pharmacovigilance* , Azoles*/adverse effects , Antifungal Agents*/adverse effects, Humans ; United States/epidemiology ; Drug Interactions ; Adverse Drug Reaction Reporting Systems ; Databases, Factual ; Male ; United States Food and Drug Administration ; Female ; Middle Aged ; Adult ; Aged

Synergistic effects of Cyp51 isozyme-specific azole antifungal agents on fungi with multiple cyp51 isozyme genes.

Autoren: Ishii M Ishikawa K Mikami K et al.

Quelle: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Nov 05; Vol. 69 (11), pp. e0059825. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

MeSH-Schlagworte: Antifungal Agents*/pharmacology , Azoles*/pharmacology , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Cytochrome P450 Family 51*/genetics , Cytochrome P450 Family 51*/metabolism , Sterol 14-Demethylase*/genetics , Sterol 14-Demethylase*/metabolism, Microbial Sensitivity Tests ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Drug Synergism ; Arthrodermataceae/drug effects ; Arthrodermataceae/genetics

SCR Organism: Trichophyton rubrum

Expansion of a predominant azole-resistant Candida tropicalis genotype from 2012 to 2018: Evidence from orchard environments in Taiwan.

Autoren: Chen YZ Tseng KY Tseng MN et al.

Quelle: Medical mycology [Med Mycol] 2025 Nov 04; Vol. 63 (11).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: MEDLINE

MeSH-Schlagworte: Candida tropicalis*/genetics , Candida tropicalis*/drug effects , Candida tropicalis*/isolation & purification , Candida tropicalis*/classification , Drug Resistance, Fungal*/genetics , Genotype* , Azoles*/pharmacology , Antifungal Agents*/pharmacology, Taiwan/epidemiology ; Humans ; Multilocus Sequence Typing ; Microbial Sensitivity Tests ; Fluconazole/pharmacology

Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus.

Autoren: Toepfer S Lamping E James JE et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Nov 04; Vol. 80 (11), pp. 3065-3078.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Mucor*/drug effects , Mucor*/genetics , Mucor*/metabolism , Azoles*/pharmacology , Antifungal Agents*/pharmacology , Drug Resistance, Fungal* , Membrane Transport Proteins*/genetics , Membrane Transport Proteins*/metabolism , Drug Resistance, Multiple, Fungal*, Microbial Sensitivity Tests ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/drug effects ; Gene Expression Profiling ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Phylogeny

Mechanism of azole resistance in Candida glabrata isolates from India: clinical vs. induced perspectives.

Autoren: Pawar K Singh A

Quelle: Journal of medical microbiology [J Med Microbiol] 2025 Nov; Vol. 74 (11).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Microbiology Society Country of Publication: England NLM ID: 0224131 Publication Model: Print Cited Medium: Internet ISSN: 1473-5644 (Electronic) Linking ISSN: 00222615 NLM ISO Abbreviation: J Med Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Candida glabrata*/drug effects , Candida glabrata*/genetics , Candida glabrata*/isolation & purification , Antifungal Agents*/pharmacology , Drug Resistance, Fungal*/genetics , Azoles*/pharmacology , Candidiasis*/microbiology, Humans ; India ; Microbial Sensitivity Tests ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Fluconazole/pharmacology ; Mutation ; Biofilms/growth & development ; Biofilms/drug effects

Metabolic flux analysis of bile acid biosynthesis acidic pathway in HepG2 cells reveals CYP8B1 inhibition of azole antifungals.

Autoren: Wang Y Yu T Zhang X et al.

Quelle: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Nov; Vol. 53 (11), pp. 100168. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

MeSH-Schlagworte: Bile Acids and Salts*/biosynthesis , Bile Acids and Salts*/metabolism , Antifungal Agents*/pharmacology , Steroid 12-alpha-Hydroxylase*/metabolism , Steroid 12-alpha-Hydroxylase*/antagonists & inhibitors , Azoles*/pharmacology, Humans ; Hep G2 Cells ; Hydroxylation/drug effects

High azole MICs in Fusarium spp.: a key factor in treatment decisions for cancer patients?

Autoren: Ito RKL Melhem MSC Bonfietti LX et al.

Quelle: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2025 Oct 13; Vol. 67, pp. e68. Date of Electronic Publication: 2025 Oct 13 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-9946 (Electronic) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE

MeSH-Schlagworte: Fusarium*/drug effects , Fusarium*/isolation & purification , Fusarium*/classification , Antifungal Agents*/pharmacology , Fusariosis*/drug therapy , Fusariosis*/microbiology , Azoles*/pharmacology , Neoplasms*/microbiology , Neoplasms*/complications, Humans ; Microbial Sensitivity Tests ; Male ; Female ; Middle Aged

Genomic Insights into Azole Resistance Mechanisms in Candida tropicalis Among Hematological Malignancy Patients with Candidemia.

Autoren: Ren Y Zhu Q Wu Y et al.

Quelle: Current microbiology [Curr Microbiol] 2025 Oct 13; Vol. 82 (12), pp. 552. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Candida tropicalis*/genetics , Candida tropicalis*/drug effects , Candida tropicalis*/isolation & purification , Azoles*/pharmacology , Drug Resistance, Fungal*/genetics , Antifungal Agents*/pharmacology , Hematologic Neoplasms*/complications , Hematologic Neoplasms*/microbiology , Candidemia*/microbiology , Candidemia*/complications , Candidemia*/drug therapy, Humans ; Microbial Sensitivity Tests ; Whole Genome Sequencing ; Fungal Proteins/genetics ; Genome, Fungal ; Mutation ; DNA Copy Number Variations

Proteomic and Phosphoproteomic Landscapes of Azole Resistance in Aspergillus fumigatus Biofilm Exposed to Voriconazole.

Autoren: Hong P Zheng N Wei T et al.

Quelle: Mycopathologia [Mycopathologia] 2025 Oct 09; Vol. 190 (6), pp. 100. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 7505689 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0832 (Electronic) Linking ISSN: 0301486X NLM ISO Abbreviation: Mycopathologia Subsets: MEDLINE

MeSH-Schlagworte: Aspergillus fumigatus*/drug effects , Aspergillus fumigatus*/physiology , Aspergillus fumigatus*/chemistry , Aspergillus fumigatus*/genetics , Voriconazole*/pharmacology , Antifungal Agents*/pharmacology , Biofilms*/drug effects , Biofilms*/growth & development , Drug Resistance, Fungal* , Proteome*/analysis , Azoles*/pharmacology , Fungal Proteins*/analysis , Phosphoproteins*/analysis, Proteomics ; Humans

The transcription factor RttA contributes to sterol regulation and azole resistance in Aspergillus fumigatus .

Autoren: Birštonas L Hortschansky P Bauer I et al.

Quelle: MBio [mBio] 2025 Oct 08; Vol. 16 (10), pp. e0185425. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: Aspergillus fumigatus*/drug effects , Aspergillus fumigatus*/genetics , Aspergillus fumigatus*/metabolism , Azoles*/pharmacology , Drug Resistance, Fungal*/genetics , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , Gene Expression Regulation, Fungal* , Antifungal Agents*/pharmacology , Sterols*/metabolism, Ergosterol/biosynthesis

RttA, a Zn 2 -Cys 6 transcription factor in Aspergillus fumigatus , contributes to azole resistance.

Autoren: Toyotome T Takahashi H Watanabe A et al.

Quelle: Microbiology spectrum [Microbiol Spectr] 2025 Oct 07; Vol. 13 (10), pp. e0181025. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

MeSH-Schlagworte: Aspergillus fumigatus*/genetics , Aspergillus fumigatus*/drug effects , Aspergillus fumigatus*/metabolism , Azoles*/pharmacology , Drug Resistance, Fungal*/genetics , Antifungal Agents*/pharmacology , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism, Gene Expression Regulation, Fungal/drug effects ; Microbial Sensitivity Tests ; Aspergillosis/microbiology ; Aspergillosis/drug therapy ; Humans