Výsledky vyhľadávania - "Availability"

Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment.

Autori: Songvut P Akanimanee J Suriyo T a ďalší

Zdroj: Pharmaceutical biology [Pharm Biol] 2025 Dec; Vol. 63 (1), pp. 42-52. Date of Electronic Publication: 2025 Jan 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Plant Extracts*/pharmacokinetics , Plant Extracts*/administration & dosage , Plant Extracts*/adverse effects , Biological Availability* , Ethanol*/chemistry , Diterpenes*/pharmacokinetics , Diterpenes*/administration & dosage , COVID-19 Drug Treatment*, Humans ; Male ; Adult ; Administration, Oral ; Young Adult ; Female ; Dose-Response Relationship, Drug ; Andrographis/chemistry ; Healthy Volunteers ; Andrographis paniculata ; Middle Aged

Plasma appearance and tissue distribution of astaxanthin isomers in male Sprague-Dawley rats after oral administration of Z-isomer-enriched astaxanthin esters through thermal treatment.

Autori: Ito M Ghosh A Nishida Y a ďalší

Zdroj: Journal of the science of food and agriculture [J Sci Food Agric] 2026 Jan 15; Vol. 106 (1), pp. 698-704. Date of Electronic Publication: 2025 Sep 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Availability* , Xanthophylls*/administration & dosage , Xanthophylls*/blood , Xanthophylls*/pharmacokinetics, Animals ; Male ; Rats ; Adipose Tissue/metabolism ; Administration, Oral ; Chlorophyceae/chemistry ; Esters/metabolism ; Hot Temperature ; Isomerism ; Liver/metabolism ; Prostate/metabolism ; Rats, Sprague-Dawley ; Tissue Distribution

Untangling "dissolved" drug species from various formulations of a poorly soluble drug: Sampling methods, mechanistic insights, and IVIVC.

Autori: Lynnerup JT Lillotte T Feldmueller M a ďalší

Zdroj: Journal of pharmaceutical sciences [J Pharm Sci] 2025 Aug; Vol. 114 (8), pp. 103884. Date of Electronic Publication: 2025 Jun 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Availability* , Chemistry, Pharmaceutical*/methods, Humans ; Filtration/methods ; Micelles ; Microdialysis/methods ; Pharmaceutical Preparations/chemistry ; Solubility

Ternary Solid Dispersions as an Alternative Approach to Enhance Pharmacological Activity.

Autori: Amaliah S Aulifa DL Gazzali AM a ďalší

Zdroj: Drug design, development and therapy [Drug Des Devel Ther] 2025 Jul 03; Vol. 19, pp. 5663-5684. Date of Electronic Publication: 2025 Jul 03 (Print Publication: 2025).

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Availability* , Pharmaceutical Preparations*/chemistry , Pharmaceutical Preparations*/administration & dosage, Administration, Oral ; Drug Compounding ; Drug Liberation ; Solubility

Acidic hydrothermal processing of wheat using citrate buffer largely enhances iron and zinc bioaccessibility and bioavailability to Caco-2 cells.

Autori: Huyskens M Lemmens E Grootaert C a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Mar 01; Vol. 467, pp. 142340. Date of Electronic Publication: 2024 Dec 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Triticum*/chemistry , Triticum*/metabolism , Zinc*/metabolism , Zinc*/chemistry , Iron*/metabolism , Iron*/chemistry , Biological Availability* , Hot Temperature*, Caco-2 Cells ; Humans ; Food Handling ; Hydrogen-Ion Concentration ; Digestion ; Phytic Acid/metabolism ; Phytic Acid/chemistry ; Phytic Acid/analysis ; Citric Acid/chemistry ; Citric Acid/metabolism ; Buffers

Pickering high internal phase emulsions stabilized by soy protein isolate/κ-carrageenan complex for enhanced stability, bioavailability, and absorption mechanisms of nobiletin.

Autori: Li H Cao Y Wang L a ďalší

Zdroj: Carbohydrate polymers [Carbohydr Polym] 2025 Mar 01; Vol. 351, pp. 123117. Date of Electronic Publication: 2024 Dec 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carrageenan*/chemistry , Flavones*/chemistry , Flavones*/pharmacokinetics , Biological Availability* , Emulsions*/chemistry , Soybean Proteins*/chemistry, Humans ; Animals ; Drug Stability ; Particle Size ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/pharmacokinetics ; Caco-2 Cells ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Antioxidants/pharmacokinetics

Oxygen influences in vitro assessment for phenolic compounds: Digestive stability, α-glucosidase inhibitory activity and bioavailability.

Autori: Wang Y Lin R Zhang L a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Feb 28; Vol. 466, pp. 142165. Date of Electronic Publication: 2024 Nov 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Phenols*/chemistry , Phenols*/pharmacology , Phenols*/metabolism , alpha-Glucosidases*/chemistry , alpha-Glucosidases*/metabolism , Oxygen*/metabolism , Oxygen*/chemistry , Biological Availability* , Digestion*, Humans ; Kinetics ; Models, Biological ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology

Role of red beetroot in bread for reducing mycotoxin risks: Bioavailability of beetroot polyphenols and betalains with ochratoxin a, aflatoxin B1 and zearalenone in Caco-2 cells.

Autori: Paula L Ana JG Hannu P a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Feb 15; Vol. 465 (Pt 2), pp. 142036. Date of Electronic Publication: 2024 Nov 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Beta vulgaris*/chemistry , Polyphenols*/chemistry , Polyphenols*/pharmacology , Ochratoxins*/chemistry , Ochratoxins*/metabolism , Bread*/analysis , Biological Availability* , Betalains*/chemistry , Mycotoxins*/chemistry , Mycotoxins*/metabolism , Aflatoxin B1*/metabolism , Aflatoxin B1*/chemistry , Zearalenone*/chemistry , Zearalenone*/metabolism, Caco-2 Cells ; Humans ; Plant Extracts/chemistry ; Food Contamination/analysis ; Food Contamination/prevention & control

A micrometer sized porous β-cyclodextrin polymer for improving bioavailability of poorly soluble drug.

Autori: Yi S Guo T Wang Y a ďalší

Zdroj: Carbohydrate polymers [Carbohydr Polym] 2025 Feb 15; Vol. 350, pp. 123042. Date of Electronic Publication: 2024 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ibuprofen*/chemistry , Ibuprofen*/pharmacokinetics , Ibuprofen*/administration & dosage , Biological Availability* , Solubility* , Drug Carriers*/chemistry , beta-Cyclodextrins*/chemistry , Rats, Sprague-Dawley*, Animals ; Humans ; Caco-2 Cells ; Rats ; Male ; Porosity ; Drug Liberation ; Administration, Oral ; Cellulose ; Cyclodextrins

Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists.

Autori: Chen X Xu S Yang S a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 3386-3408. Date of Electronic Publication: 2025 Jan 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucagon-Like Peptide-1 Receptor*/metabolism , Biological Availability*, Animals ; Administration, Oral ; Mice ; Humans ; Structure-Activity Relationship ; Male ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/administration & dosage ; Organoselenium Compounds/pharmacology ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/pharmacokinetics ; Organoselenium Compounds/chemical synthesis ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Selenium/chemistry ; Selenium/pharmacology ; Selenium/pharmacokinetics ; Mice, Inbred C57BL ; Drug Discovery ; Cyclic AMP/metabolism

Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs.

Autori: Actis M Cresser-Brown J Caine EA a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 3591-3611. Date of Electronic Publication: 2025 Jan 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ubiquitin-Protein Ligases*/metabolism , Biological Availability*, Humans ; Administration, Oral ; Animals ; Mice ; Adaptor Proteins, Signal Transducing/metabolism ; Thalidomide/pharmacokinetics ; Thalidomide/analogs & derivatives ; Thalidomide/pharmacology ; Thalidomide/administration & dosage ; Structure-Activity Relationship ; Cell Line, Tumor ; Rats ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/administration & dosage ; Proteolysis Targeting Chimera

Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations.

Autori: Hualong M Liu J Yin T a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 2657-2679. Date of Electronic Publication: 2025 Jan 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proto-Oncogene Proteins c-ret*/antagonists & inhibitors , Proto-Oncogene Proteins c-ret*/genetics , Proto-Oncogene Proteins c-ret*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Mutation* , Cell Proliferation*/drug effects , Biological Availability*, Animals ; Humans ; Mice ; Administration, Oral ; Cell Line, Tumor ; Proteolysis/drug effects ; Drug Discovery ; Pyrazoles/pharmacology ; Pyrazoles/pharmacokinetics ; Pyrazoles/chemistry ; Pyridines/pharmacology ; Pyridines/pharmacokinetics ; Xenograft Model Antitumor Assays ; Structure-Activity Relationship ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use

Pharmacokinetics, Pharmacodynamics and Bioavailability of ACM-001.1 (S-Pindolol Benzoate) in Healthy Volunteers.

Autori: Misselwitz F Henderson D Menakuru SR a ďalší

Zdroj: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2025 Feb; Vol. 16 (1), pp. e13651. Date of Electronic Publication: 2024 Dec 12.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I

Informácie o časopise: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Availability* , Pindolol*/pharmacology , Pindolol*/pharmacokinetics , Pindolol*/therapeutic use , Healthy Volunteers*, Humans ; Male ; Adult ; Female ; Young Adult ; Middle Aged ; COVID-19 Vaccines ; Vaccines, Synthetic

Improved solubility and bioavailability of cyclolinopeptides by diacylglycerol in the β-cyclodextrin Pickering emulsions.

Autori: Liu Z Lee YY Tan CP a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Feb 01; Vol. 464 (Pt 1), pp. 141553. Date of Electronic Publication: 2024 Oct 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: beta-Cyclodextrins*/chemistry , Solubility* , Emulsions*/chemistry , Biological Availability* , Peptides, Cyclic*/chemistry, Humans ; Caco-2 Cells ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Animals ; Particle Size

Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion.

Autori: Lu T Wu T Zhong H a ďalší

Zdroj: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Feb; Vol. 15 (2), pp. 700-716. Date of Electronic Publication: 2024 Jun 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ginsenosides*/chemistry , Ginsenosides*/administration & dosage , Ginsenosides*/pharmacokinetics , Solubility* , Biological Availability* , Molecular Dynamics Simulation*, Animals ; Humans ; Male ; Rats, Sprague-Dawley ; Excipients/chemistry ; Polymers/chemistry ; Rats ; Drug Compounding ; Caco-2 Cells ; Drug Liberation ; Chemistry, Pharmaceutical/methods

Deciphering the importance of nanoencapsulation to improve the availability of bioactive molecules in food sources to the human body.

Autori: Pugazhendhi A Alshehri MA Kandasamy S a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Feb 01; Vol. 464 (Pt 3), pp. 141762. Date of Electronic Publication: 2024 Oct 24.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Availability* , Nanotechnology*, Humans ; Animals ; Drug Compounding ; Fruit/chemistry ; Fruit/metabolism ; Vegetables/chemistry ; Vegetables/metabolism

Preclinical pharmacokinetics, absolute bioavailability and dose proportionality evaluation of bioactive phytochemical Withanone in rats.

Autori: Singh SK Rashid M Chaturvedi S a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Feb; Vol. 155, pp. 108128. Date of Electronic Publication: 2025 Jan 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Availability* , Dose-Response Relationship, Drug* , Withanolides*/chemistry , Withanolides*/pharmacology, Animals ; Male ; Rats ; Administration, Oral ; Molecular Structure ; Phytochemicals/chemistry ; Phytochemicals/pharmacokinetics ; Phytochemicals/pharmacology ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry

High leucine bioavailability improves beef quality by altering serum metabolism in beef cattle.

Autori: An J Zhao X Song Y a ďalší

Zdroj: Meat science [Meat Sci] 2025 Feb; Vol. 220, pp. 109693. Date of Electronic Publication: 2024 Oct 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 101160862 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4138 (Electronic) Linking ISSN: 03091740 NLM ISO Abbreviation: Meat Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Leucine*/administration & dosage , Red Meat*/analysis , Animal Feed*/analysis , Dietary Supplements* , Biological Availability* , Diet*/veterinary , Amino Acids*/metabolism, Animals ; Cattle ; Female ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/chemistry

Influence of varied processing methods on the antioxidant capacity, antibacterial activity, and bioavailability of Iranian black, oolong, and green leafy teas.

Autori: Mehrabi M Amiri M Razavi R a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Feb 01; Vol. 464 (Pt 2), pp. 141793. Date of Electronic Publication: 2024 Oct 31.

Spôsob vydávania: Journal Article; Evaluation Study

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antioxidants*/chemistry , Antioxidants*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Tea*/chemistry , Camellia sinensis*/chemistry , Camellia sinensis*/metabolism , Biological Availability* , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/metabolism, Food Handling ; Iran ; Plant Leaves/chemistry ; Bacteria/drug effects ; Bacteria/metabolism ; Fermentation ; Phenols/chemistry ; Phenols/metabolism ; Polyphenols/chemistry ; Polyphenols/metabolism ; Polyphenols/pharmacology

Water in nigella oil microemulsion for enhanced oral bioavailability of linagliptin.

Autori: Eid RK Arafa MF El Maghraby GM

Zdroj: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Feb; Vol. 15 (2), pp. 596-608. Date of Electronic Publication: 2024 May 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Linagliptin*/pharmacokinetics , Linagliptin*/administration & dosage , Linagliptin*/chemistry , Emulsions* , Biological Availability* , Water*/chemistry , Diabetes Mellitus, Experimental*/drug therapy , Rats, Wistar* , Plant Oils*/chemistry , Plant Oils*/administration & dosage , Plant Oils*/pharmacokinetics , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/chemistry, Animals ; Administration, Oral ; Male ; Rats ; Drug Liberation ; Carum ; Nigella sativa