Suchergebnisse - "Arthritis, Rheumatoid genetics"

Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci

Autoren: Chenfu Shi Danyun Zhao Jake Butler et al.

Quelle: Genome Biol
Genome Biology, Vol 26, Iss 1, Pp 1-29 (2025)
Shi, C, Zhao, D, Butler, J, Frantzeskos, A, Rossi, S, Ding, J, Ferrazzano, C, Wynn, C, Hum, R M, Richards, E, Gupta, M, Patel, K, Yap, C F, Plant, D, Grencis, R, Martin, P, Adamson, A, Eyre, S, Bowes, J, Barton, A, Ho, P, Rattray, M & Orozco, G 2025, 'Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci', Genome Biology, vol. 26, no. 1, 26. https://doi.org/10.1186/s13059-025-03492-y

Schlagwörter: CD8-Positive T-Lymphocytes/metabolism, CD4-Positive T-Lymphocytes, QH301-705.5, Inflammatory diseases, QH426-470, CD8-Positive T-Lymphocytes, Chromatin/metabolism, Arthritis, Rheumatoid, Arthritis, Psoriatic/genetics, Hi-C, Genetics, GWAS, Humans, Biology (General), Psoriatic/genetics, CD4-Positive T-Lymphocytes/metabolism, Arthritis, Research, Arthritis, Psoriatic, Rheumatoid/genetics, Arthritis, Rheumatoid/genetics, QTLs, Multiomics, Chromatin, Gene regulation, Gene Expression Regulation, Genetic Loci, Chromatin conformation, Genome-Wide Association Study

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39930543
https://doaj.org/article/c8cda9e5afd34a53b53b17cddf2a630f
https://research.manchester.ac.uk/en/publications/22afbe01-18aa-4252-b4f1-0696b7ab1373
https://doi.org/10.1186/s13059-025-03492-y

Identification of gene expression biomarkers to predict clinical response to methotrexate in patients with rheumatoid arthritis

Autoren: Andriko Palmowski Cindy Strehl Moritz Pfeiffenberger et al.

Quelle: Clin Rheumatol

Schlagwörter: Male, Arthritis, Rheumatoid, Methotrexate, Treatment Outcome, Antirheumatic Agents, Biomarkers, Female [MeSH], Response, Humans [MeSH], Rheumatoid arthritis, Pharmacogenomics, Treatment Outcome [MeSH], Arthritis, Rheumatoid/drug therapy [MeSH], Gene Expression [MeSH], Prediction, Arthritis, Rheumatoid/genetics [MeSH], Original Article, Male [MeSH], Antirheumatic Agents/therapeutic use [MeSH], Methotrexate/therapeutic use [MeSH], Biomarkers [MeSH], Gene signature, Humans, Gene Expression, Female, 3. Good health

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37978145
https://repository.publisso.de/resource/frl:6505751

Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers

Autoren: Christa Meisinger Simone Fischer Tracy O’Mara et al.

Quelle: J Transl Med
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-9 (2024)

Schlagwörter: Inflammation, Ovarian Neoplasms, ddc:610, Research, Arthritis, Arthritis, Psoriatic, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Arthritis, Rheumatoid, Causality, Breast cancer, Ovarian cancer, Risk Factors, Psoriatic arthritis, Autoimmune disease, Mendelian randomization, Medicine, Humans, Female, Genetic Predisposition to Disease, Genetic Predisposition to Disease [MeSH], Arthritis/genetics [MeSH], Female [MeSH], Humans [MeSH], Rheumatoid arthritis, Risk Factors [MeSH], Polymorphism, Single Nucleotide/genetics [MeSH], Arthritis, Psoriatic/genetics [MeSH], Arthritis, Rheumatoid/genetics [MeSH], Ankylosing spondylitis, Inflammation/genetics [MeSH], Ovarian Neoplasms/genetics [MeSH], Arthritis/complications [MeSH], Causality [MeSH], Computational Modelling and Epidemiology, Mendelian Randomization Analysis [MeSH], Arthritis, Rheumatoid/complications [MeSH]

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39449068
https://doaj.org/article/1fd72f1761a24a729201d9ebf46c70ce
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1165276
https://opus.bibliothek.uni-augsburg.de/opus4/files/116527/s12967-024-05765-9.pdf
https://doi.org/10.1186/s12967-024-05765-9
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/116527
https://repository.publisso.de/resource/frl:6521067

Single-cell RNA-seq analysis reveals cell subsets and gene signatures associated with Rheumatoid Arthritis Disease Activity

Autoren: Marie Binvignat Brenda Y. Miao Camilla Wibrand et al.

Quelle: JCI Insight
JCI Insight, vol 9, iss 16
Binvignat, M, Miao, B Y, Wibrand, C, Yang, M M, Rychkov, D, Flynn, E, Nititham, J, Tamaki, W, Khan, U, Carvidi, A, Krueger, M, Niemi, E, Sun, Y, Fragiadakis, G K, Sellam, J, Mariotti-Ferrandiz, E, Klatzmann, D, Gross, A J, Ye, C J, Butte, A J, Criswell, L A, Nakamura, M C & Sirota, M 2024, 'Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity', JCI Insight, vol. 9, no. 16. https://doi.org/10.1172/jci.insight.178499

Schlagwörter: Adult, Male, 0301 basic medicine, Leukocytes, Mononuclear/metabolism, Biomedical and clinical sciences, Immunology, Mononuclear, Rheumatoid Arthritis, Autoimmunity, Autoimmune Disease, Monocytes, Arthritis, Rheumatoid, 03 medical and health sciences, Rheumatology, Monocytes/metabolism, Clinical Research, Rheumatoid, Genetics, Leukocytes, 2.1 Biological and endogenous factors, Humans, RNA-Seq, Aged, 0303 health sciences, Biomedical and Clinical Sciences, Arthritis, Inflammatory and immune system, Human Genome, Health sciences, Arthritis, Rheumatoid/genetics, Middle Aged, Single-Cell Gene Expression Analysis, 3. Good health, Good Health and Well Being, Case-Control Studies, Leukocytes, Mononuclear, Women's Health, Female, Transcriptome, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38954480
https://escholarship.org/uc/item/4vm35904
https://escholarship.org/content/qt4vm35904/qt4vm35904.pdf

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Autoren: Saedis Saevarsdottir Lilja Stefansdottir Patrick Sulem et al.

Quelle: Ann Rheum Dis
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, Olafsdottir, T A, Olason, P I, Olsson, T, Ostrowski, S R, Hørslev-Petersen, K, Rognvaldsson, S, Sanner, H, Silberberg, G N, Stefansson, H, Sørensen, E, Sørensen, I J, Turesson, C, Bergman, T, Alfredsson, L, Kvien, T K, Brunak, S, Steinsson, K, Andersen, V, Andreassen, O A, Rantapää-Dahlqvist, S, Hetland, M L, Klareskog, L, Askling, J, Padyukov, L, Pedersen, O B, Thorsteinsdottir, U, Jonsdottir, I, Stefansson, K, Members of the DBDS Genomic Consortium & Nyegaard, M 2022, 'Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset', Annals of the Rheumatic Diseases, vol. 81, no. 8, 221754, pp. 1085-1095. https://doi.org/10.1136/annrheumdis-2021-221754
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Arlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, DBDS Genomic Consortium, The Danish RA Genetics Working Group & The Swedish Rheumatology Quality Register Biobank Study Group (SRQb) 2022, 'Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095. https://doi.org/10.1136/annrheumdis-2021-221754
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Ostrowski, S R, Sørensen, E, Sørensen, I J, Brunak, S, Andersen, V, Hetland, M L, Askling, J, Pedersen, O B & Members of the DBDS Genomic Consortium 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Annals of the Rheumatic Diseases

Schlagwörter: rheumatoid arthritis, Proteomics, 0301 basic medicine, autoantibodies, Janus Kinases/genetics, polymorphism, genetic, Rheumatoid Arthritis, Biochemistry, polymorphism, Medical Genetics and Genomics, Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics, Arthritis, Rheumatoid, 03 medical and health sciences, genetic, Humans, Genetic Predisposition to Disease, Biokemi, Molecular Biology, Rheumatology and Autoimmunity, Medicinsk genetik, Janus Kinases, Non-Receptor Type 22/genetics, Reumatologi och inflammation, 0303 health sciences, Molekylärbiologi, Arthritis, Genetic Predisposition to Disease/genetics, Klinisk medicin, Rheumatoid/genetics, Interferon-alpha, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Arthritis, Rheumatoid/genetics, Medicinsk genetik och genomik, STAT Transcription Factors/genetics, 3. Good health, STAT Transcription Factors, Signal Transduction/genetics, Protein Tyrosine Phosphatase, Clinical Medicine, Medical Genetics, Genome-Wide Association Study, Signal Transduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35470158
https://vbn.aau.dk/ws/files/482474986/1085.full.pdf
https://doi.org/10.1136/annrheumdis-2021-221754
http://www.scopus.com/inward/record.url?scp=85130778612&partnerID=8YFLogxK
https://vbn.aau.dk/da/publications/239bab16-e607-4d16-aa5d-b21a089d284f
https://pure.au.dk/ws/files/335560981/Multiomics_analysis_of_rheumatoid_arthritis_yields_sequence_variants_that_have_large_effects_on_risk_of_the_seropositive_subset.pdf
https://curis.ku.dk/ws/files/314910889/1085.full.pdf
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185024
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203215
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485933
https://hdl.handle.net/11250/3026537

PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis

Autoren: Straube, Johanna Bukhari, Shoiab Lerrer, Shalom et al.

Quelle: Arthritis Res Ther
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)

Schlagwörter: KLRG1, 0301 basic medicine, ddc:610, Research, Programmed Cell Death 1 Receptor, T cells, Synovial fluid, PD-1 agonist, Diseases of the musculoskeletal system, HLA-DR Antigens, 3. Good health, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, HLA-DR Antigens [MeSH], Humans [MeSH], Programmed Cell Death 1 Receptor/genetics [MeSH], Signal Transduction [MeSH], T-Lymphocytes, Cytotoxic [MeSH], Arthritis, Rheumatoid/genetics [MeSH], Inflammatory arthritis, RC925-935, Humans, Signal Transduction, T-Lymphocytes, Cytotoxic

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38254179
https://doaj.org/article/bc6d198d04174195b30729ebf2594728
https://repository.publisso.de/resource/frl:6508745

Genetics of rheumatoid arthritis

Autoren: Seema D. Sharma Shek H. Leung Sebastien Viatte

Quelle: Sharma, S D, Leung, S H & Viatte, S 2024, 'Genetics of rheumatoid arthritis', Best practice & research: Clinical rheumatology, vol. 38, no. 4, pp. 101968. https://doi.org/10.1016/j.berh.2024.101968

Schlagwörter: Arthritis, Rheumatoid, Antirheumatic Agents, Humans, Antirheumatic Agents/therapeutic use, Genetic Predisposition to Disease, Arthritis, Rheumatoid/genetics, Mendelian Randomization Analysis, Severity of Illness Index, Genome-Wide Association Study

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38955657

The Rheumatoid Arthritis Gene Expression Signature Among Women Who Improve or Worsen During Pregnancy: A Pilot Study

Autoren: Amogh Pathi Matthew Wright Mette Kiel Smed et al.

Quelle: Pathi, A, Wright, M, Smed, M K, Nelson, J L, Olsen, J, Hetland, M L, Zoffmann, V & Jawaheer, D 2021, ' The rheumatoid arthritis gene expression signature among women who improve or worsen during pregnancy : A pilot study ', Journal of Rheumatology, vol. 48, no. 7, pp. 985-991 . https://doi.org/10.3899/jrheum.201128
Pathi, A, Wright, M, Smed, M K, Nelson, J L, Olsen, J, Hetland, M L, Zoffmann, V & Jawaheer, D 2021, 'The rheumatoid arthritis gene expression signature among women who improve or worsen during pregnancy : A pilot study', Journal of Rheumatology, vol. 48, no. 7, pp. 985-991. https://doi.org/10.3899/jrheum.201128

Schlagwörter: Pregnancy Trimester, Third, Pilot Projects, Gene expression signature, Arthritis, Rheumatoid/genetics, Statistics, Nonparametric, 3. Good health, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Humans, Female, Rheumatoid arthritis, RNA-seq, Transcriptome

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/33323535
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203750
https://pubmed.ncbi.nlm.nih.gov/33323535/
https://www.ncbi.nlm.nih.gov/pubmed/33323535
https://www.jrheum.org/content/early/2020/12/10/jrheum.201128
https://curis.ku.dk/ws/files/313708185/nihms_1652542.pdf
https://pure.au.dk/portal/en/publications/3125b1d3-3005-40af-8683-1239469f89a6
https://doi.org/10.3899/jrheum.201128
http://www.scopus.com/inward/record.url?scp=85109249914&partnerID=8YFLogxK
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203750/pdf/nihms-1652542.pdf

Global epidemiology of rheumatoid arthritis

Autoren: Finckh, Axel Gilbert, Benoît Thomas P. Hodkinson, Bridget et al.

Quelle: Finckh, A, Gilbert, B, Hodkinson, B, Bae, S-C, Thomas, R, Deane, K D, Alpizar-Rodriguez, D & Lauper, K 2022, ' Global epidemiology of rheumatoid arthritis ', Nature Reviews Rheumatology . https://doi.org/10.1038/s41584-022-00827-y

Schlagwörter: Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Prevalence, Humans, Arthritis, Rheumatoid / epidemiology, Arthritis, Rheumatoid / genetics, 3. Good health

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36068354
https://research.manchester.ac.uk/en/publications/a6358619-cb3a-40df-aa2d-7eed505e4f61
https://doi.org/10.1038/s41584-022-00827-y
https://archive-ouverte.unige.ch/unige:169383
https://doi.org/10.1038/s41584-022-00827-y

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Autoren: Tadeja Kuret Amanda McGovern Katja Klein et al.

Weitere Verfasser: Tadeja Kuret Amanda McGovern Katja Klein et al.

Quelle: Genome Biol
Genome Biology, Vol 22, Iss 1, Pp 1-39 (2021)
Ge, X, Frank-Bertoncelj, M, Klein, K, McGovern, A, Kuret, T, Houtman, M, Burja, B, Micheroli, R, Shi, C, Marks, M, Filer, A, Buckley, C D, Orozco, G, Distler, O, Morris, A P, Martin, P, Eyre, S & Ospelt, C 2021, 'Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability', Genome Biology, vol. 22, no. 1, 247, pp. 247. https://doi.org/10.1186/s13059-021-02460-6

Schlagwörter: Male, 0301 basic medicine, Inheritance Patterns, Receptor, Interferon alpha-beta, QH426-470, Epigenesis, Genetic, 1307 Cell Biology, Arthritis, Rheumatoid, Risk Factors, Receptors, Databases, Genetic, Gene Regulatory Networks, Fibroblast-like synoviocytes, Biology (General), Receptor, Interferon alpha-beta/metabolism, 0303 health sciences, Interferon/metabolism, 10051 Rheumatology Clinic and Institute of Physical Medicine, Receptors, Interferon/metabolism, Rheumatoid/genetics, Functional genomics, Genomics, Arthritis, Rheumatoid/genetics, Middle Aged, Polymorphism, Single Nucleotide/genetics, Chromatin, 3. Good health, Enhancer Elements, Genetic, Tumor Necrosis Factor-alpha/pharmacology, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Female, Single Nucleotide/genetics, Interferon alpha-beta/metabolism, Receptor, Adult, Enhancer Elements, QH301-705.5, 610 Medicine & health, Epigenesis, Genetic/drug effects, Polymorphism, Single Nucleotide, Chromatin/metabolism, Databases, Young Adult, 03 medical and health sciences, 1311 Genetics, Genetic, Gene Regulatory Networks/drug effects, Tumor Necrosis Factor alpha-Induced Protein 3/metabolism, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Rheumatoid arthritis, Stromal cells, Genetic/genetics, Probability, Genetic/drug effects, Base Sequence, Arthritis, Research, Enhancer Elements, Genetic/genetics, Reproducibility of Results, Synovial Membrane/pathology, Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics, Fibroblasts, Inheritance Patterns/genetics, Fibroblasts/drug effects, 1105 Ecology, Evolution, Behavior and Systematics, Epigenesis

Dateibeschreibung: s13059-021-02460-6.pdf - application/pdf

Zugangs-URL: https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-021-02460-6
https://pubmed.ncbi.nlm.nih.gov/34433485
https://doaj.org/article/8cd52096d8e14ee7b73e6f6f9def48f2
https://research.manchester.ac.uk/en/publications/87fb8d44-1e0c-43d9-a7b8-77fd425ac076
https://doi.org/10.1186/s13059-021-02460-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385949
https://link.springer.com/content/pdf/10.1186/s13059-021-02460-6.pdf
https://www.zora.uzh.ch/id/eprint/206317/1/s13059-021-02460-6.pdf
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02460-6
https://www.zora.uzh.ch/id/eprint/206317/
https://pubmed.ncbi.nlm.nih.gov/34433485/
https://www.zora.uzh.ch/id/eprint/206317/
https://doi.org/10.5167/uzh-206317

rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?

Autoren: Susanne Schulz Pauline Zimmer Natalie Pütz et al.

Quelle: J Transl Med
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-10 (2020)

Schlagwörter: 0301 basic medicine, Genotype, Genetic Predisposition to Disease [MeSH], Immunobiology and immunotherapy, Periodontitis, Humans [MeSH], Rheumatoid arthritis, Periodontitis/genetics [MeSH], Polymorphism, Single Nucleotide/genetics [MeSH], Arthritis, Rheumatoid/genetics [MeSH], Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics [MeSH], Research, Gene Frequency/genetics [MeSH], Case-Control Studies [MeSH], Genotype [MeSH], Alleles [MeSH], SNP, Polymorphism, Single Nucleotide, Arthritis, Rheumatoid, 03 medical and health sciences, Gene Frequency, Humans, Genetic Predisposition to Disease, Alleles, CTLA4, 2. Zero hunger, ddc:610, PADI4, 0303 health sciences, Protein Tyrosine Phosphatase, Non-Receptor Type 22, PTPN22, 3. Good health, Case-Control Studies, Medicine

Dateibeschreibung: application/pdf

Zugangs-URL: https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02548-w
https://pubmed.ncbi.nlm.nih.gov/33059697
https://doaj.org/article/1da757b309d348fa8e008049c117df2e
https://link.springer.com/article/10.1186/s12967-020-02548-w/tables/2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559817
https://www.ncbi.nlm.nih.gov/pubmed/33059697
https://link.springer.com/content/pdf/10.1186/s12967-020-02548-w.pdf
https://pubmed.ncbi.nlm.nih.gov/33059697/
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02548-w
https://repository.publisso.de/resource/frl:6464823

A powerful approach for association analysis incorporating imprinting effects

Autoren: Xia, F Zhou, JY Fung, WK

Quelle: Bioinformatics. 27:2571-2577

Schlagwörter: Arthritis, Rheumatoid - genetics, Parents, 0301 basic medicine, 0303 health sciences, Polymorphism, Genetic, Models, Genetic, Rheumatoid - genetics, Arthritis, Reproducibility of Results, Nuclear Family, Arthritis, Rheumatoid, Genomic Imprinting, 03 medical and health sciences, Humans, Genetic Testing, Child, Genome-Wide Association Study

Zugangs-URL: https://academic.oup.com/bioinformatics/article-pdf/27/18/2571/16900859/btr443.pdf
https://pubmed.ncbi.nlm.nih.gov/21798962
https://academic.oup.com/bioinformatics/article/27/18/2571/181935
http://europepmc.org/articles/PMC3167056
https://doi.org/10.1093/bioinformatics/btr443
https://hub.hku.hk/handle/10722/172484
https://dblp.uni-trier.de/db/journals/bioinformatics/bioinformatics27.html#XiaZF11
https://core.ac.uk/display/38000815
http://hdl.handle.net/10722/185108
http://hdl.handle.net/10722/172484

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

Autoren: Savic, S Ouboussad, L Dickie, LJ et al.

Quelle: J Autoimmun
Savic, S, Ouboussad, L, Dickie, L J, Geiler, J, Wong, C, Doody, G M, Churchman, S M, Ponchel, F, Emery, P, Cook, G P, Buch, M H, Tooze, R M & McDermott, M F 2014, 'TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes', Journal of Autoimmunity, vol. 50, pp. 59-66. https://doi.org/10.1016/j.jaut.2013.11.002

Schlagwörter: Transcription Factors/agonists, Lipopolysaccharides, X-Box Binding Protein 1, 0301 basic medicine, DNA-Binding Proteins/agonists, Immunology, Primary Cell Culture, Toll-Like Receptor 2/agonists, Unfolded protein response (UPR), Regulatory Factor X Transcription Factors, Endoplasmic Reticulum, Article, Toll-like receptor (TLR), Arthritis, Rheumatoid, 03 medical and health sciences, Toll-Like Receptor 4/agonists, Endoplasmic Reticulum Stress/drug effects, Synovial Membrane/drug effects, Immunology and Allergy, Humans, Interleukin-6/genetics, 0303 health sciences, Interleukin-6, Tumor Necrosis Factor-alpha, Arthritis, Endoplasmic Reticulum/drug effects, Synovial Membrane, Rheumatoid/genetics, Arthritis, Rheumatoid/genetics, Fibroblasts, Lipopolysaccharides/pharmacology, Endoplasmic Reticulum Stress, Toll-Like Receptor 2, 3. Good health, Fibroblasts/drug effects, DNA-Binding Proteins, Toll-Like Receptor 4, Autocrine Communication, Gene Expression Regulation, Rheumatoid arthritis (RA), Case-Control Studies, Tumor Necrosis Factor-alpha/genetics, sXBP1, Signal Transduction, Transcription Factors

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/24387801
https://eprints.whiterose.ac.uk/86515/1/SavicJAutoimm14.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012140/
http://europepmc.org/articles/PMC4012140
https://www.research.manchester.ac.uk/portal/en/publications/tlr-dependent-xbp1-activation-induces-an-autocrine-loop-in-rheumatoid-arthritis-synoviocytes(e453d177-ca2c-4ac0-ae13-ff429cd281d0).html
https://eprints.whiterose.ac.uk/86515/
https://core.ac.uk/display/82776386
https://www.sciencedirect.com/science/article/abs/pii/S0896841113001467

Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis

Autoren: Lu, L Chen, J Xu, H et al.

Quelle: Clin Dev Immunol
Clinical and Developmental Immunology, Vol 2012 (2012)

Schlagwörter: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Lymphocyte Activation - immunology, Arthritis, Rheumatoid - genetics - immunology - metabolism, Lymphocyte Activation, Arthritis, Rheumatoid, Mice, 03 medical and health sciences, Rheumatoid - genetics - immunology - metabolism, Animals, Humans, RNA, Messenger, HMGB1 Protein, Aged, Aged, 80 and over, Arthritis, RC581-607, Middle Aged, 3. Good health, Mice, Inbred C57BL, CD4-Positive T-Lymphocytes - immunology, Th17 Cells - immunology, Cytokines, Th17 Cells, Female, Immunologic diseases. Allergy, HMGB1 Protein - genetics - metabolism, Research Article

Dateibeschreibung: text/xhtml

Zugangs-URL: http://downloads.hindawi.com/journals/jir/2012/295081.pdf
https://pubmed.ncbi.nlm.nih.gov/22110531
https://doaj.org/article/d16480dce89b4636aa1629dd9ef358ce
http://hub.hku.hk/handle/10722/148675
https://hub.hku.hk/bitstream/10722/148675/1/content.pdf
https://downloads.hindawi.com/journals/jir/2012/295081.pdf
http://europepmc.org/articles/PMC3205666
https://pubmed.ncbi.nlm.nih.gov/22110531/
https://www.hindawi.com/journals/jir/2012/295081/
http://hdl.handle.net/10722/148675

Polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOP) genotyping assay for detection of genes associated with rheumatoid arthritis and multiple sclerosis

Autoren: Nikolaou, K. Kalatzis, F. G. Giannakeas, N. et al.

Quelle: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology. :6202-6205

Schlagwörter: 0301 basic medicine, Arthritis, Rheumatoid/*genetics, 0303 health sciences, Multiple Sclerosis, Base Sequence, Genotype, HLA-DR Antigens/genetics, HLA-DR Antigens, Polymorphism, Single Nucleotide/genetics, Oligonucleotide Probes/*genetics, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, 3. Good health, Arthritis, Rheumatoid, 03 medical and health sciences, Genetic Predisposition to Disease, Multiple Sclerosis/*genetics, Humans, Polymerase Chain Reaction/*methods, Oligonucleotide Probes, Alleles, HLA-DRB1 Chains

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/21097159
http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.ieee-000005627739
https://ieeexplore.ieee.org/document/5627739/
http://www.qbase.gr/sites/default/files/EMBC%202010.pdf
http://ieeexplore.ieee.org/document/5627739/
https://www.ncbi.nlm.nih.gov/pubmed/21097159
https://ikee.lib.auth.gr/record/266810
http://olympias.lib.uoi.gr/jspui/handle/123456789/19230

Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis

Autoren: Patsopoulos, N. A. Ioannidis, J. P.

Quelle: Annals of the Rheumatic Diseases. 69:561-566

Schlagwörter: Genetic Markers, 0301 basic medicine, 0303 health sciences, Polymorphism, Genetic, Arthritis, Rheumatoid/*genetics/immunology, Peptides, Cyclic/genetics, Complement C5/genetics, Rheumatoid Factor/genetics/immunology, Chromosome Mapping, Complement C5, Peptides, Cyclic, TNF Receptor-Associated Factor 1, Arthritis, Rheumatoid, 03 medical and health sciences, Chromosomes, Human, Pair 6/*genetics/immunology, Genetic Loci, Rheumatoid Factor, Humans, Chromosomes, Human, Pair 6, Genetic Predisposition to Disease, TNF Receptor-Associated Factor 1/*genetics/immunology, Epidemiologic Methods

Zugangs-URL: http://ard.bmj.com/cgi/content/short/ard.2009.109447v1
https://pubmed.ncbi.nlm.nih.gov/19401279
https://ard.bmj.com/content/69/3/561
https://www.cabdirect.org/cabdirect/abstract/20103119115
https://ard.bmj.com/content/annrheumdis/69/3/561.full.pdf
https://ard.bmj.com/content/69/3/561.full.pdf
https://www.cabdirect.org/abstracts/20103119115.html
https://europepmc.org/article/MED/19401279
http://olympias.lib.uoi.gr/jspui/handle/123456789/24781

Expression and function of the NALP3 inflammasome in rheumatoid synovium

Autoren: Kolly, Laeticia Busso, Nathalie Palmer-Lourenco, Gaby et al.

Quelle: Immunology, Vol. 129, No 2 (2010) pp. 178-185

Schlagwörter: Male, 0301 basic medicine, Ribonucleoproteins/genetics/immunology/metabolism, Interleukin-1beta, Synovial Membrane/*metabolism/pathology, Myeloid Cells/immunology/metabolism/pathology, Cell Line, Caspase 1/metabolism, Arthritis, Rheumatoid, 03 medical and health sciences, Fibroblasts/immunology/metabolism/pathology, NLR Family, Pyrin Domain-Containing 3 Protein, Osteoarthritis, Humans, Nod Signaling Adaptor Proteins/genetics/immunology/*metabolism, Myeloid Cells, ddc:610, B-Lymphocytes/immunology/metabolism/pathology, Aged, ddc:616, Aged, 80 and over, Interleukin-1beta/secretion, B-Lymphocytes, 0303 health sciences, Caspase 1, Apoptosis Regulatory Proteins/genetics/immunology/metabolism, Carrier Proteins/genetics/immunology/*metabolism, Endothelial Cells, Arthritis, Rheumatoid/genetics/*immunology/metabolism, Endothelial Cells/immunology/metabolism/pathology, Fibroblasts, Middle Aged, Osteoarthritis/genetics/*immunology/metabolism, Ribonucleoproteins, Nod Signaling Adaptor Proteins, Female, Apoptosis Regulatory Proteins, Carrier Proteins, T-Lymphocytes/immunology/metabolism/pathology

Dateibeschreibung: application/pdf

Zugangs-URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2567.2009.03174.x
https://pubmed.ncbi.nlm.nih.gov/19824913
https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2009.03174.x
https://serval.unil.ch/notice/serval:BIB_96FBFF3121D7
https://core.ac.uk/display/60830443
https://www.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2567.2009.03174.x
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814460/
https://archive-ouverte.unige.ch/unige:21049
https://archive-ouverte.unige.ch/unige:21049

Detection of parent‐of‐origin effects using general pedigree data

Autoren: Shili Lin Ji-Yuan Zhou Wing K. Fung et al.

Quelle: Genetic Epidemiology. 34:151-158

Schlagwörter: Male, Parents, 0301 basic medicine, Genotype, Genetic Predisposition To Disease - Genetics, Inheritance Patterns, Arthritis, Rheumatoid, Genomic Imprinting, 03 medical and health sciences, Genetic, Models, Humans, Computer Simulation, Genetic Predisposition to Disease, Inheritance Patterns - Genetics, Rheumatoid - Genetics, Alleles, 0303 health sciences, Models, Genetic, Arthritis, Founder Effect, Pedigree, Haplotypes, Female, Arthritis, Rheumatoid - Genetics, Monte Carlo Method

Zugangs-URL: https://europepmc.org/articles/pmc3011930?pdf=render
https://pubmed.ncbi.nlm.nih.gov/19676055
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011930/
http://hub.hku.hk/handle/10722/172468
https://onlinelibrary.wiley.com/doi/10.1002/gepi.20445
http://europepmc.org/articles/PMC3011930
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19676055/
http://hdl.handle.net/10722/172468

Heterogeneity testing in meta‐analysis of genome searches

Autoren: Elias Zintzaras John P. A. Ioannidis

Quelle: Genetic Epidemiology. 28:123-137

Schlagwörter: 0301 basic medicine, Arthritis, Rheumatoid/*genetics, 0303 health sciences, Schizophrenia/*genetics, Genome, Human, Arthritis, Rheumatoid, 03 medical and health sciences, Meta-Analysis as Topic, Schizophrenia, Humans, Genetic Predisposition to Disease, Lod Score, Monte Carlo Method

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/15593093
https://core.ac.uk/display/132817499
https://onlinelibrary.wiley.com/doi/abs/10.1002/gepi.20048
https://www.ncbi.nlm.nih.gov/pubmed/15593093
http://olympias.lib.uoi.gr/jspui/handle/123456789/21248

Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region

Autoren: Fife, M S Fisher, S A John, S et al.

Quelle: Fife, M S, Fisher, S A, John, S, Worthington, J, Shah, C J, Ollier, W E R, Panayi, G S, Lewis, C M & Lanchbury, J S 2000, 'Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region', Arthritis Care & Research, vol. 43, no. 8, pp. 1673-1678. https://doi.org/10.1002/1529-0131(200008)43:8<1673::AID-ANR2>3.0.CO;2-Y

Schlagwörter: Adult, Male, Rheumatoid - genetics, Corticotropin-Releasing Hormone, Genetic Linkage, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Chemicals And Cas Registry Numbers, Humans, False Positive Reactions, Genetic Predisposition to Disease, Corticotropin-Releasing Hormone - genetics, Child, 10. No inequality, Alleles, Arthritis, Rheumatoid - genetics, Family Health, Arthritis, transmission, 3. Good health, Female, Lod Score, Microsatellite Repeats

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/10943856
https://research.manchester.ac.uk/en/publications/60880485-fdc2-4d44-84a5-467cf7e1fc98
https://doi.org/10.1002/1529-0131(200008)43:8<1673::AID-ANR2>3.0.CO;2-Y
https://www.research.manchester.ac.uk/portal/en/publications/multipoint-linkage-analysis-of-a-candidate-gene-locus-in-rheumatoid-arthritis-demonstrates-significant-evidence-of-linkage-and-association-with-the-corticotropinreleasing-hormone-genomic-region(60880485-fdc2-4d44-84a5-467cf7e1fc98)/export.html
http://hub.hku.hk/handle/10722/91606
https://europepmc.org/article/MED/10943856
https://www.ncbi.nlm.nih.gov/pubmed/10943856
https://research.manchester.ac.uk/en/publications/60880485-fdc2-4d44-84a5-467cf7e1fc98
http://hdl.handle.net/10722/91606