Výsledky vyhľadávania - "Apoptosis - Drug Effects"

Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment: in vitro and in vivo assessment: in vitro and in vivo assessment

Autori: Prashant Pandey Dilip Kumar Arya Anit Kumar a ďalší

Zdroj: Journal of Materials Chemistry B. 13:2682-2694

Predmety: Folic Acid/chemistry, Breast Neoplasms, Antineoplastic Agents, Apoptosis, Drug Screening Assays, Ligands, Cell Proliferation/drug effects, Rats, Sprague-Dawley, Folic Acid, Breast Neoplasms/drug therapy, Cell Movement, Antineoplastic Agents/chemistry, Humans, Animals, Particle Size, Cell Proliferation, Apoptosis/drug effects, Antitumor, Hydrogen-Ion Concentration, Rats, Drug Liberation, Liposomes, Fluorouracil/pharmacology, MCF-7 Cells, Female, Sprague-Dawley, Fluorouracil, Drug Screening Assays, Antitumor, Liposomes/chemistry, Oligopeptides, Cell Survival/drug effects

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39841132
https://portal.findresearcher.sdu.dk/da/publications/10377c9f-8091-462f-9771-97b9a1cf3a66
https://doi.org/10.1039/d4tb02570a

Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors

Autori: Pellattiero, Anna Quirin, Charlotte Magrin, Federico a ďalší

Zdroj: Sci Adv

Predmety: Pyrazoles/pharmacology, Small Molecule Libraries/chemistry, Antineoplastic Agents, Pyrazoles/chemistry, OPA1 protein, human, GTP Phosphohydrolases/antagonists & inhibitors, Drug Resistance, Neoplasm/drug effects, Biochimie, biophysique & biologie moléculaire, GTP Phosphohydrolases, Small Molecule Libraries, Cytochromes c/metabolism, Enzyme Inhibitors/chemistry, Structure-Activity Relationship, Cell Line, Tumor, Mitochondria/metabolism, Antineoplastic Agents/chemistry, Small Molecule Libraries/pharmacology, Humans, Enzyme Inhibitors, Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors, Enzyme Inhibitors/pharmacology, Apoptosis/drug effects, Cytochromes c, GTP Phosphohydrolases/chemistry, Life sciences, Mitochondria/drug effects, Proto-Oncogene Proteins c-bcl-2, Sciences du vivant, Pyrazoles, Proto-Oncogene Proteins c-bcl-2/metabolism, Biomedicine and Life Sciences, GTP Phosphohydrolases/metabolism, Antineoplastic Agents/pharmacology, Biochemistry, biophysics & molecular biology

Potent combination benefit of the AKT inhibitor capivasertib and the BCL-2 inhibitor venetoclax in diffuse large B cell lymphoma

Autori: Brandon S. Willis Kevin Mongeon Hannah Dry a ďalší

Zdroj: Leukemia

Predmety: Sulfonamides, PTEN Phosphohydrolase, Apoptosis, Mice, SCID, Bridged Bicyclo Compounds, Heterocyclic, Xenograft Model Antitumor Assays, Article, Mice, Pyrimidines, Proto-Oncogene Proteins c-bcl-2, Cell Line, Tumor, Proto-Oncogene Proteins c-bcl-2/antagonists, Rituximab/pharmacology [MeSH], Cell Line, Tumor [MeSH], Bridged Bicyclo Compounds, Heterocyclic/pharmacology [MeSH], Sulfonamides/therapeutic use [MeSH], Rituximab/therapeutic use [MeSH], Bridged Bicyclo Compounds, Heterocyclic/therapeutic use [MeSH], Xenograft Model Antitumor Assays [MeSH], Pyrroles/pharmacology [MeSH], Pyrimidines/pharmacology [MeSH], Lymphoma, Large B-Cell, Diffuse/drug therapy [MeSH], Humans [MeSH], Pyrroles/therapeutic use [MeSH], Apoptosis/drug effects [MeSH], Sulfonamides/pharmacology [MeSH], 692/308/2778, Animals [MeSH], 64/60, Mice, SCID [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Lymphoma, Large B-Cell, Diffuse/pathology [MeSH], PTEN Phosphohydrolase/metabolism [MeSH], 692/699/1541/1990, Mice [MeSH], Pyrimidines/therapeutic use [MeSH], Proto-Oncogene Proteins c-bcl-2/metabolism [MeSH], Antineoplastic Combined Chemotherapy Protocols/pharmacology [MeSH], Proto-Oncogene Proteins c-akt/metabolism [MeSH], 13/95, Cell Proliferation/drug effects [MeSH], article, Antineoplastic Combined Chemotherapy Protocols, Humans, Animals, Pyrroles, Lymphoma, Large B-Cell, Diffuse, Rituximab, Proto-Oncogene Proteins c-akt, Cell Proliferation

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39284898
https://repository.publisso.de/resource/frl:6495292

The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells

Autori: Larissa Nassauer Juliane W. Schott Jennifer Harre a ďalší

Zdroj: J Mol Med (Berl)
Journal of Molecular Medicine

Predmety: 0301 basic medicine, 0303 health sciences, Cell Survival, Neomycin, Apoptosis, Antineoplastic Agents, Ototoxicity, Caspase Inhibitors, Cochlea, Cell Line, Mice, 03 medical and health sciences, Hair Cells, Auditory, Animals, Original Article, Cisplatin, Caspase Inhibitors/pharmacology [MeSH], Cell Line [MeSH], Antineoplastic Agents/pharmacology [MeSH], Cochlea/drug effects [MeSH], Cisplatin/adverse effects [MeSH], Anti-apoptotic, Spiral Ganglion/drug effects [MeSH], Caspase inhibitor, Hair Cells, Auditory/drug effects [MeSH], Ototoxicity/etiology [MeSH], Neomycin/pharmacology [MeSH], Apoptosis/drug effects [MeSH], Cell Survival/drug effects [MeSH], Cisplatin/toxicity [MeSH], Animals [MeSH], Mice [MeSH], Antineoplastic Agents/toxicity [MeSH], Cisplatin/pharmacology [MeSH], Neomycin/toxicity [MeSH], Cells, Cultured [MeSH], Cochlea/cytology [MeSH], Hearing loss, Ototoxicity/prevention, Spiral Ganglion, Cells, Cultured

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39110182
https://repository.publisso.de/resource/frl:6495754

Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

Autori: Daryl Griffin Robbie Carson Debbie Moss a ďalší

Zdroj: Mol Cancer Res
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium drug BOLD-100 regulates BRAFMT colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151

Predmety: Proto-Oncogene Proteins B-raf, Ataxia Telangiectasia Mutated Proteins/metabolism, name=Oncology, name=Cancer Research, colorectal cancer, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Cancer Genes and Networks, Cell Line, ruthenium drug, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects, Cell Line, Tumor, Proto-Oncogene Proteins B-raf/genetics, Receptors, Basic Helix-Loop-Helix Transcription Factors, Humans, name=SDG 3 - Good Health and Well-being, Tumor, cell apoptosis, Apoptosis/drug effects, Colorectal Neoplasms/drug therapy, 3. Good health, Receptors, Aryl Hydrocarbon, Aryl Hydrocarbon/metabolism, BOLD-100, BRAFMT, Colorectal Neoplasms, Reactive Oxygen Species, Signal Transduction

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39083088
https://pure.qub.ac.uk/en/publications/357b4c8d-d077-4033-8c9a-433d6c961788

Dexamethasone: a double-edged sword in the treatment of osteoarthritis

Autori: Tarasova, Karyna Arteaga, Maria Belen Kidtiwong, Angkana a ďalší

Zdroj: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Predmety: Triamcinolone Acetonide Pharmacology, Chondrocytes Metabolism, Science, Anti-Inflammatory Agents, Apoptosis, Chondrocytes Drug Effects, Triamcinolone, Senescence, Triamcinolone Acetonide, Article, Dexamethasone, Cellular Senescence Drug Effects, Chondrocytes, Osteoarthritis Pathology, Osteoarthritis, Humans, Inflammation Drug Therapy, Glucocorticoids, Cells, Cultured, Cellular Senescence, Osteoarthritis Drug Therapy, Cell Proliferation, Inflammation, Glucocorticoids Pharmacology, Gene Expression Profiling, Anti-Inflammatory Agents Pharmacology, Osteoarthritis Metabolism, Cell Proliferation Drug Effects, Gene Expression Regulation Drug Effects, Chondrocytes Pathology, Dexamethasone Therapeutic Use, Dexamethasone Pharmacology, Gene Expression Regulation, Medicine, Apoptosis Drug Effects

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40195473
https://doaj.org/article/194006edd23b4f7aaa0a959c0531241b
https://phaidra.vetmeduni.ac.at/o:4102
https://doi.org/10.1038/s41598-025-96050-2

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

Autori: Till Seiboldt Constantia Zeiser Duy Nguyen a ďalší

Prispievatelia: Till Seiboldt Constantia Zeiser Duy Nguyen a ďalší

Zdroj: Br J Cancer

Predmety: ddc:004, 0301 basic medicine, Cancer Research, bcl-X Protein, Proto-Oncogene Proteins c-myc/metabolism [MeSH], 631/67/1678, Cell Line, Tumor [MeSH], Neuroblastoma/drug therapy [MeSH], bcl-X Protein/genetics [MeSH], Neuroblastoma/genetics [MeSH], Cerebellar Neoplasms/pathology [MeSH], Drug Synergism [MeSH], Medulloblastoma/pathology [MeSH], Neuroblastoma/metabolism [MeSH], bcl-X Protein/metabolism [MeSH], Zebrafish [MeSH], Aniline Compounds/pharmacology [MeSH], N-Myc Proto-Oncogene Protein [MeSH], Xenograft Model Antitumor Assays [MeSH], Cerebellar Neoplasms/drug therapy [MeSH], Medulloblastoma/metabolism [MeSH], Proto-Oncogene Proteins c-bcl-2/genetics [MeSH], Humans [MeSH], Medulloblastoma/genetics [MeSH], Cerebellar Neoplasms/genetics [MeSH], Apoptosis/drug effects [MeSH], Neuroblastoma/pathology [MeSH], Sulfonamides/pharmacology [MeSH], Tretinoin/pharmacology [MeSH], 692/4028/67/1059/602, Animals [MeSH], Cerebellar Neoplasms/metabolism [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Mice [MeSH], Article, Proto-Oncogene Proteins c-bcl-2/metabolism [MeSH], Antineoplastic Combined Chemotherapy Protocols/pharmacology [MeSH], Medulloblastoma/drug therapy [MeSH], Proto-Oncogene Proteins c-myc/genetics [MeSH], article, Tretinoin, Apoptosis, Proto-Oncogene Proteins c-myc, Neuroblastoma, Mice, 03 medical and health sciences, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Humans, Animals, Cerebellar Neoplasms, Zebrafish, Sulfonamides, N-Myc Proto-Oncogene Protein, 0303 health sciences, Aniline Compounds, Drug Synergism, Xenograft Model Antitumor Assays, 3. Good health, Oncology, Proto-Oncogene Proteins c-bcl-2, Medulloblastoma

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38942989
https://dspace.library.uu.nl/handle/1874/455435
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/114001
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1140014
https://opus.bibliothek.uni-augsburg.de/opus4/files/114001/114001.pdf
https://doi.org/10.1038/s41416-024-02740-5
https://repository.publisso.de/resource/frl:6507758

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia

Autori: Lawson, H Holt-Martyn, JP Dembitz, V a ďalší

Prispievatelia: Lawson, H Holt-Martyn, JP Dembitz, V a ďalší

Zdroj: Nat Cancer

Predmety: Myeloid, 0301 basic medicine, Sulfonamides / therapeutic use, Proto-Oncogene Proteins / metabolism, Hypoxia-Inducible Factor 1, alpha Subunit / metabolism, Apoptosis, Acute, alpha Subunit, Apoptosis / drug effects, Article, Cell Line, Hypoxia-Inducible Factor-Proline Dioxygenases, Hypoxia-Inducible Factor-Proline Dioxygenases / metabolism, Bridged Bicyclo Compounds, Mice, 03 medical and health sciences, Proto-Oncogene Proteins, Cell Line, Tumor, Humans, Animals, Hypoxia-Inducible Factor-Proline Dioxygenases / antagonists & inhibitors, Sulfonamides / pharmacology, Membrane Proteins / genetics, Sulfonamides, 0303 health sciences, Leukemia, Tumor, Prolyl-Hydroxylase Inhibitors / therapeutic use, Protein Stability, Heterocyclic, Protein Stability / drug effects, Prolyl-Hydroxylase Inhibitors / pharmacology, Membrane Proteins, Prolyl-Hydroxylase Inhibitors, Hypoxia-Inducible Factor 1, alpha Subunit, Bridged Bicyclo Compounds, Heterocyclic, Membrane Proteins / metabolism, 3. Good health, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-bcl-2, Leukemia, Myeloid, Acute / metabolism, Disease Progression, Hypoxia-Inducible Factor 1, Leukemia, Myeloid, Acute / drug therapy, Proto-Oncogene Proteins c-bcl-2 / metabolism

Popis súboru: application/pdf; Print-Electronic

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38637657

Microarray-based detection and expression analysis of drug resistance in an animal model of peritoneal metastasis from colon cancer

Autori: Yagublu, Vugar Bayramov, Bayram Reissfelder, Christoph a ďalší

Zdroj: Clin Exp Metastasis

Predmety: 0301 basic medicine, Mice, Inbred BALB C, 0303 health sciences, Research, Gene Expression Profiling, Apoptosis, Gene Expression Regulation, Neoplastic, Mice, Disease Models, Animal, 03 medical and health sciences, Drug Resistance, Neoplasm, Cell Line, Tumor, Colonic Neoplasms, Animals, Humans, Fluorouracil, Cell Line, Tumor [MeSH], Mice, Inbred BALB C [MeSH], Prss11, Peritoneal Neoplasms/genetics [MeSH], Chemoresistance, Peritoneal Neoplasms/drug therapy [MeSH], Peritoneal Neoplasms/secondary [MeSH], Oligonucleotide Array Sequence Analysis [MeSH], Drug Resistance, Neoplasm/genetics [MeSH], Colonic Neoplasms/pathology [MeSH], Fluorouracil/pharmacology [MeSH], Disease Models, Animal [MeSH], BMP7, Fluorouracil/therapeutic use [MeSH], Cell survival, Humans [MeSH], Apoptosis/drug effects [MeSH], Colonic Neoplasms/genetics [MeSH], Animals [MeSH], Gene Expression Regulation, Neoplastic/drug effects [MeSH], Mice [MeSH], Colonic Neoplasms/drug therapy [MeSH], Chemotherapy, Gene Expression Profiling [MeSH], Peritoneal Neoplasms, Oligonucleotide Array Sequence Analysis

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38609535
https://repository.publisso.de/resource/frl:6521643

CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer

Autori: Ziegler, Dorian Parashar, Kanishka Leal-Esteban, Lucia a ďalší

Prispievatelia: Ziegler, Dorian Parashar, Kanishka Leal-Esteban, Lucia a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-23 (2025)
Nature communications, vol. 16, no. 1, pp. 541

Predmety: [SDV] Life Sciences [q-bio], Triple Negative Breast Neoplasms/metabolism, Triple Negative Breast Neoplasms/pathology, Triple Negative Breast Neoplasms/genetics, Humans, Apoptosis/drug effects, Mitochondria/metabolism, Female, Cyclin-Dependent Kinase 4/metabolism, Cyclin-Dependent Kinase 4/genetics, Cell Line, Tumor, Animals, Cell Proliferation/drug effects, Mitochondrial Dynamics/drug effects, Endoplasmic Reticulum/metabolism, Mice, Cyclic AMP-Dependent Protein Kinases/metabolism, Cyclic AMP-Dependent Protein Kinases/genetics, Calcium Signaling, Science, Article

Popis súboru: application/pdf

Prístupová URL adresa: https://doaj.org/article/b375f83e71b8478aa0b895a1b114bfdc
https://serval.unil.ch/notice/serval:BIB_C59FE7AA0BFC
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_C59FE7AA0BFC3
https://serval.unil.ch/resource/serval:BIB_C59FE7AA0BFC.P001/REF.pdf
https://univ-lyon1.hal.science/hal-05001542v1/document
https://univ-lyon1.hal.science/hal-05001542v1
https://doi.org/10.1038/s41467-024-55605-z

Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines

Autori: Verhees, Femke Demers, Imke Legemaate, Dion a ďalší

Zdroj: Int J Oncol

Predmety: Head and Neck Neoplasms/drug therapy virology metabolism, cell survival, Cell Line, Cell Proliferation/drug effects, Papillomavirus Infections/drug therapy virology, Signal Transduction/drug effects, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Thiazoles/pharmacology, Proto-Oncogene Proteins c-akt/metabolism, Humans, Piperazines/pharmacology, human papillomavirus, Pyridines/pharmacology, Tumor, Apoptosis/drug effects, apoptosis, Human Papillomavirus Viruses, cell line, Articles, Cyclin-Dependent Kinase 6/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism antagonists & inhibitors, Aminopyridines/pharmacology, Protein Kinase Inhibitors/pharmacology therapeutic use, Squamous Cell Carcinoma of Head and Neck/drug therapy virology metabolism pathology, cell cycle, head and neck cancer, Cyclin-Dependent Kinase 4/antagonists & inhibitors metabolism, Phosphatidylinositol 3-Kinases/metabolism, Purines/pharmacology, Cell Survival/drug effects

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP

Autori: Abbas, Ruqaia Hartmann, Oliver Asiss, Dorin Theodora a ďalší

Zdroj: Apoptosis

Predmety: ARTS, Cell Line, Tumor [MeSH], Ubiquitin-Protein Ligases/metabolism [MeSH], XIAP, Humans [MeSH], X-Linked Inhibitor of Apoptosis Protein/metabolism [MeSH], Apoptosis/drug effects [MeSH], Tumor Suppressor Protein p53/metabolism [MeSH], Apoptosis, Ubiquitin-Protein Ligases/genetics [MeSH], Animals [MeSH], Proteolysis/drug effects [MeSH], Tumor Suppressor Protein p53/genetics [MeSH], p53, Mice [MeSH], Article, Small-molecules, Ubiquitination/drug effects [MeSH], X-Linked Inhibitor of Apoptosis Protein/genetics [MeSH], Protein Binding [MeSH], Up-Regulation/drug effects [MeSH], 0301 basic medicine, 0303 health sciences, Ubiquitin-Protein Ligases, Ubiquitination, X-Linked Inhibitor of Apoptosis Protein, Up-Regulation, 3. Good health, Mice, 03 medical and health sciences, Cell Line, Tumor, Proteolysis, Humans, Animals, Tumor Suppressor Protein p53, Protein Binding

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38684550
https://repository.publisso.de/resource/frl:6524224

Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer

Autori: Finnegan, Ellen Ding, Wei Ude, Ziga a ďalší

Zdroj: Cell Oncol (Dordr)

Predmety: Sulfonamides, Research, Apoptosis, Antineoplastic Agents, Hydroxamic Acids, 3. Good health, Histone Deacetylase Inhibitors, Gene Expression Regulation, Neoplastic, Organoids, Cell Line, Tumor [MeSH], Epigenetic, Organoids/drug effects [MeSH], Microsomes, Liver/drug effects [MeSH], Antineoplastic Agents/pharmacology [MeSH], Copper/chemistry [MeSH], Histone Deacetylase Inhibitor, Copper Complex, Hydroxamic Acids/pharmacology [MeSH], Organoids/metabolism [MeSH], Colonic Neoplasms/pathology [MeSH], Colonic Neoplasms/metabolism [MeSH], Microsomes, Liver/metabolism [MeSH], Histone Deacetylase Inhibitors/pharmacology [MeSH], Humans [MeSH], Apoptosis/drug effects [MeSH], Colonic Neoplasms/genetics [MeSH], Sulfonamides/pharmacology [MeSH], Colon Cancer, Gene Expression Regulation, Neoplastic/drug effects [MeSH], Colonic Neoplasms/drug therapy [MeSH], Hydroxamic Acids/therapeutic use [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Cell Proliferation/drug effects [MeSH], Cell Line, Tumor, Colonic Neoplasms, Microsomes, Liver, Humans, Copper, Cell Proliferation

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37934338
https://repository.publisso.de/resource/frl:6524426

Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells

Autori: Su, Jinxian Zhao, Yu Li, Mengtian a ďalší

Prispievatelia: Su, Jinxian Zhao, Yu Li, Mengtian a ďalší

Zdroj: Scientific Reports

Predmety: Lactoferrin/pharmacology, Humans, Cell Cycle Checkpoints/drug effects, Carcinoma, Non-Small-Cell Lung/genetics, Cattle, Transcriptome/drug effects, Lung Neoplasms/genetics, Animals, Cell Line, Tumor, Apoptosis/drug effects, Gene Expression Regulation, Neoplastic/drug effects, A549 Cells, Cell Movement/drug effects, Gene Expression Profiling, Mitochondria/drug effects, Cell Proliferation/drug effects

Relation: https://eprints.qut.edu.au/259236/

Dostupnosť: https://doi.org/10.1038/s41598-025-13796-5
https://eprints.qut.edu.au/259236/

Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome

Autori: Catello Giordano Jonatan Kendler Maximilian Sexl a ďalší

Zdroj: issn:2213-2317 ; Redox Biology.

Predmety: Humans, Caffeic Acids Pharmacology, Caffeic Acids Chemistry, Phenylethyl Alcohol Analogs & Derivatives, Phenylethyl Alcohol Pharmacology, Phenylethyl Alcohol Chemistry, Centrosome Drug Effects, Centrosome Metabolism, Antineoplastic Agents Pharmacology, Antineoplastic Agents Chemistry, Apoptosis Drug Effects, Cell Line, Tumor, Cell Proliferation Drug Effects

Popis súboru: application/pdf

Relation: isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publikationen]; https://phaidra.vetmeduni.ac.at/o:4027

Dostupnosť: https://doi.org/10.1016/j.redox.2025.103582
https://phaidra.vetmeduni.ac.at/o:4027

Dual effect of targeting LSD1 on the invasiveness and the mechanical response of acute lymphoblastic leukemia cells

Autori: González-Novo, Raquel Armesto, Marina González-Murillo, África a ďalší

Zdroj: González-Novo, R, Armesto, M, González-Murillo, Á, Dreger, M, Hurlstone, A F L, Benito, A, Samaniego, R, Ramírez, M & Redondo-Muñoz, J 2025, 'Dual effect of targeting LSD1 on the invasiveness and the mechanical response of acute lymphoblastic leukemia cells', Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie, vol. 183, 117830. https://doi.org/10.1016/j.biopha.2025.117830

Predmety: Histone Demethylases/metabolism, Humans, Neoplasm Invasiveness, Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology, Animals, Cell Line, Tumor, Cell Movement/drug effects, Apoptosis/drug effects, Mice

Dostupnosť: https://research.manchester.ac.uk/en/publications/9514864f-6380-48aa-ba21-0d4a3337f1e8
https://doi.org/10.1016/j.biopha.2025.117830

Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth

Autori: Zhang, Liuhong Guo, Yixuan Huang, Enyuan a ďalší

Predmety: Animals, Apoptosis - drug effects, Apoptosis - genetics, Cell Proliferation - drug effects, Dihydrolipoyllysine-Residue Acetyltransferase - genetics, Dihydrolipoyllysine-Residue Acetyltransferase - metabolism, Female, Granulosa Cells - drug effects, Granulosa Cells - metabolism, Mice, Inbred C57BL, Ovarian Follicle - drug effects, Ovarian Follicle - growth & development, Ovarian Follicle - metabolism, Pyruvic Acid - metabolism

Popis súboru: pdf

Relation: ispartof: Cells (Basel, Switzerland) issue 6 vol 14; WOS:001451999600001; 991005753924407891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12174767130007891/13174767120007891; alma:61MUN_INST/bibs/991005753924407891

Dostupnosť: https://doi.org/10.3390/cells14060444
https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Pyruvate-Regulates-the-Expression-of-DLAT/991005753924407891
https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12174767130007891/13174767120007891

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

Autori: Stevenson, Leanne Cairns, Lauren Li, Xiaodun a ďalší

Prispievatelia: Stevenson, Leanne Cairns, Lauren Li, Xiaodun a ďalší

Zdroj: Sci Rep
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Stevenson, L, Cairns, L, Li, X, Jammula, S, Taylor, H, Douglas, R, McCabe, N, Gavory, G, Jacq, X, Fitzgerald, R C, Kennedy, R D, Harrison, T & Turkington, R C 2024, 'Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma', Scientific Reports, vol. 14, 32121 . https://doi.org/10.1038/s41598-024-83912-4

Predmety: 0301 basic medicine, tumor, Esophageal Neoplasms, Cell Survival, Science, Apoptosis, Antineoplastic Agents, Adenocarcinoma, inhibitor of apoptosis proteins - metabolism - antagonists & inhibitors, Article, Inhibitor of Apoptosis Proteins, apoptosis - drug effects, proto-oncogene proteins c-akt - metabolism, 03 medical and health sciences, Cell Line, Tumor, cell survival - drug effects, Humans, cell proliferation - drug effects, humans, Cell Proliferation, drug synergism, 0303 health sciences, drug resistance, neoplasm - drug effects, drug resistance, neoplasm - drug effects, Drug Synergism, cell line, adenocarcinoma - drug therapy - metabolism - pathology, cell line, tumor, signal transduction - drug effects, Drug Resistance, Neoplasm, Medicine, Proto-Oncogene Proteins c-akt, antineoplastic Agents - pharmacology, esophageal neoplasms - drug therapy - metabolism - pathology, Signal Transduction

Popis súboru: application/pdf; application/zip; text/xml

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39739112
https://doaj.org/article/fef048df10404b758cee606c430aea71
https://pure.qub.ac.uk/en/publications/ff636b48-4c69-4d72-ad74-2b9eb6247d3d

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade

Autori: Yu, Xin Jiang, Juan Li, Cheng a ďalší

Zdroj: Mol Med
Molecular Medicine, Vol 30, Iss 1, Pp 1-26 (2024)

Predmety: Male, 0301 basic medicine, Apoptosis, RM1-950, QD415-436, Osteolysis, Biochemistry, Mice, eIF-2 Kinase, 03 medical and health sciences, Coumarins, Osteogenesis, Animals, Humans, Aseptic loosening, 0303 health sciences, Osteoblasts, Osteoblast, Research, PERK signaling cascade, Osthole, Endoplasmic Reticulum Stress, Disease Models, Animal, Therapeutics. Pharmacology, Osteogenesis/drug effects [MeSH], eIF-2 Kinase/metabolism [MeSH], Endoplasmic Reticulum Stress/drug effects [MeSH], Osteoblasts/metabolism [MeSH], Coumarins/pharmacology [MeSH], Osteolysis/etiology [MeSH], Osteolysis/drug therapy [MeSH], Male [MeSH], Coumarins/chemistry [MeSH], Coumarins/therapeutic use [MeSH], Signal Transduction/drug effects [MeSH], Osteolysis/metabolism [MeSH], Disease Models, Animal [MeSH], Humans [MeSH], Apoptosis/drug effects [MeSH], Animals [MeSH], Evolutionary Aspects of Metabolic Diseases, ER stress, Mice [MeSH], Osteoblasts/drug effects [MeSH], Signal Transduction

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39707212
https://doaj.org/article/1db7541146d54e5b9afcf2a60182b294
https://repository.publisso.de/resource/frl:6517784

A spheroid whole mount drug testing pipeline with machine-learning based image analysis identifies cell-type specific differences in drug efficacy on a single-cell level

Autori: Vitacolonna, Mario Bruch, Roman Schneider, Richard a ďalší

Zdroj: BMC Cancer
BMC Cancer, Vol 24, Iss 1, Pp 1-23 (2024)
BMC Cancer, 24 (1), Art.-Nr.: 1542

Predmety: ddc:004, 0301 basic medicine, Antineoplastic Agents, Apoptosis, Machine Learning, 03 medical and health sciences, Imaging, Three-Dimensional, 3D drug testing, Spheroids, Cellular, Cell Line, Tumor, Image Processing, Computer-Assisted, Humans, Cell Line, Tumor [MeSH], Microscopy, Confocal/methods [MeSH], Fibroblasts/drug effects [MeSH], Humans [MeSH], Apoptosis/drug effects [MeSH], Antineoplastic Agents/pharmacology [MeSH], Tumor microenvironment, Drug resistance, Spheroids, Cellular/drug effects [MeSH], 3D co-culture, Image Processing, Computer-Assisted/methods [MeSH], Drug Screening Assays, Antitumor/methods [MeSH], Single-cell analysis, Doxorubicin/pharmacology [MeSH], Single-Cell Analysis/methods [MeSH], Research, Machine Learning [MeSH], Coculture Techniques [MeSH], Imaging, Three-Dimensional/methods [MeSH], Deep-learning image analysis, Cell Proliferation/drug effects [MeSH], Fibroblasts/metabolism [MeSH], RC254-282, Cell Proliferation, 0303 health sciences, Microscopy, Confocal, DATA processing & computer science, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Fibroblasts, Coculture Techniques, Doxorubicin, Single-Cell Analysis, Drug Screening Assays, Antitumor

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39696122
https://doaj.org/article/94688b951250495fb6faafe8830e39c4
https://repository.publisso.de/resource/frl:6497322