Search Results - "Antisickling Agents"

3D printed hydroxyurea for pediatric use: toward personalized formulations and reduced exposure risk.

Authors: Laverdière J Bendicho-Lavilla C Mahrouche L et al.

Source: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126326. Date of Electronic Publication: 2025 Oct 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/pharmacokinetics , Hydroxyurea*/administration & dosage , Hydroxyurea*/chemistry , Printing, Three-Dimensional* , Antisickling Agents*/administration & dosage , Antisickling Agents*/pharmacokinetics , Antisickling Agents*/chemistry, Animals ; Humans ; Dogs ; Tablets ; Anemia, Sickle Cell/drug therapy ; Drug Liberation ; Precision Medicine/methods ; Child ; Drug Compounding/methods ; Drug Stability

Adherence, treatment utilization, clinical and economic outcomes of patients with sickle cell disease with recurrent vaso-occlusive crises treated with recently approved chronic therapies in the US.

Authors: Udeze C Jerry M Evans K et al.

Source: Journal of comparative effectiveness research [J Comp Eff Res] 2025 Dec; Vol. 14 (12), pp. e240232. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Becaris Publishing Country of Publication: England NLM ID: 101577308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-6313 (Electronic) Linking ISSN: 20426305 NLM ISO Abbreviation: J Comp Eff Res Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/economics , Patient Acceptance of Health Care*/statistics & numerical data , Antisickling Agents*/therapeutic use , Antisickling Agents*/economics, Humans ; Female ; Male ; Retrospective Studies ; Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/economics ; United States ; Young Adult ; Adolescent ; Middle Aged ; Recurrence ; Health Care Costs/statistics & numerical data ; Medication Adherence ; Vaso-Occlusive Crises

Lower rates of maternal morbidities among pregnant women suffering from sickle cell disease who are exposed to hydroxyurea, a retrospective study from tribal area of Western India.

Authors: Desai G Balar H Dave K et al.

Source: Expert review of hematology [Expert Rev Hematol] 2025 Dec; Vol. 18 (12), pp. 1099-1105. Date of Electronic Publication: 2025 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/ethnology , Pregnancy Complications*/chemically induced , Pregnancy Complications*/epidemiology , Pregnancy Complications*/ethnology , Pregnancy Outcome*/epidemiology , Pregnancy Outcome*/ethnology , Hydroxyurea*/adverse effects , Hydroxyurea*/therapeutic use , Antisickling Agents*/adverse effects , Antisickling Agents*/therapeutic use, Retrospective Studies ; India/epidemiology ; India/ethnology ; Humans ; Female ; Pregnancy ; Young Adult ; Adult ; Case-Control Studies ; Rural Population/statistics & numerical data ; Indigenous Peoples/statistics & numerical data ; Congenital Abnormalities/epidemiology ; Congenital Abnormalities/ethnology ; Congenital Abnormalities/etiology ; Infant, Newborn

Clinical consultation: The pharmacist's role in hydroxyurea management for sickle cell disease.

Authors: Roessner C Uminski K Goodyear D et al.

Source: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2025 Nov 24; Vol. 82 (23), pp. e936-e945.

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9503023 Publication Model: Print Cited Medium: Internet ISSN: 1535-2900 (Electronic) Linking ISSN: 10792082 NLM ISO Abbreviation: Am J Health Syst Pharm Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Hydroxyurea*/therapeutic use , Hydroxyurea*/administration & dosage , Pharmacists*/organization & administration , Antisickling Agents*/therapeutic use , Antisickling Agents*/administration & dosage , Antisickling Agents*/adverse effects , Professional Role* , Referral and Consultation*, Humans ; Patient Education as Topic/methods

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential.

Authors: Omar AM El-Araby ME Ahmed TA et al.

Source: ChemMedChem [ChemMedChem] 2025 Nov 18; Vol. 20 (22), pp. e202500507. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Antisickling Agents*/chemistry , Antisickling Agents*/pharmacology , Antisickling Agents*/administration & dosage , Antisickling Agents*/therapeutic use , Antisickling Agents*/chemical synthesis , Aldehydes*/chemistry , Aldehydes*/pharmacology , Aldehydes*/therapeutic use, Humans ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Administration, Intravenous

Evaluating anti-sickling therapies for sickle cell disease: a microfluidic assay for red blood cell-mediated microvascular occlusion under hypoxia.

Authors: Sekyonda Z Du Y Oshabaheebwa S et al.

Source: Lab on a chip [Lab Chip] 2025 Nov 18; Vol. 25 (23), pp. 6256-6267. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/pathology , Erythrocytes*/drug effects , Erythrocytes*/metabolism , Erythrocytes*/pathology , Microfluidic Analytical Techniques*/instrumentation , Lab-On-A-Chip Devices* , Antisickling Agents*/pharmacology , Antisickling Agents*/therapeutic use, Humans ; Erythrocyte Deformability/drug effects ; Cell Hypoxia/drug effects

Microsensor Array for the Electrochemical Analysis of Hydroxyurea in Blood Samples of Children Affected by Sickle Cell Anemia.

Authors: Shukla RP Aroosh M Cazelles R et al.

Source: Analytical chemistry [Anal Chem] 2025 Nov 11; Vol. 97 (44), pp. 24399-24414. Date of Electronic Publication: 2025 Oct 08.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/blood , Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/drug therapy , Electrochemical Techniques*/instrumentation , Electrochemical Techniques*/methods , Antisickling Agents*/blood , Antisickling Agents*/therapeutic use, Humans ; Child ; Child, Preschool ; Male

Physiologically based pharmacokinetic modeling of hydroxyurea: Implications for dose adjustment in patients with renal insufficiency.

Authors: Enzama H Cvijic S Kiptoo J et al.

Source: Journal of pharmaceutical sciences [J Pharm Sci] 2025 Nov; Vol. 114 (11), pp. 104004. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/pharmacokinetics , Hydroxyurea*/administration & dosage , Models, Biological* , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/metabolism , Renal Insufficiency*/metabolism , Antisickling Agents*/pharmacokinetics , Antisickling Agents*/administration & dosage, Humans ; Adult ; Area Under Curve ; Computer Simulation ; Male ; Female ; Middle Aged ; Dose-Response Relationship, Drug ; Young Adult

Changes in haematological indices among children with sickle cell disease on hydroxyurea treatment for at least 1 year: A cohort study.

Authors: Emuli S Tegu C Oguttu F et al.

Source: PloS one [PLoS One] 2025 Nov 03; Vol. 20 (11), pp. e0335617. Date of Electronic Publication: 2025 Nov 03 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/blood , Antisickling Agents*/therapeutic use, Humans ; Male ; Female ; Child ; Child, Preschool ; Cohort Studies ; Adolescent ; Uganda ; Hemoglobins/analysis ; Erythrocyte Indices/drug effects

Gene polymorphisms predicting response to hydroxyurea treatment in Bahraini patients with sickle cell disease.

Authors: Alshaikh FS Deifalla A Sequeira RP et al.

Source: Expert review of hematology [Expert Rev Hematol] 2025 Nov; Vol. 18 (11), pp. 999-1012. Date of Electronic Publication: 2025 Aug 13.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/genetics , Anemia, Sickle Cell*/diagnosis , Hydroxyurea*/therapeutic use , Hydroxyurea*/administration & dosage , Antisickling Agents*/therapeutic use , Polymorphism, Single Nucleotide* , Polymorphism, Genetic*, Humans ; Male ; Female ; Bahrain ; Adult ; Fetal Hemoglobin/genetics ; Adolescent ; Treatment Outcome ; Young Adult ; Gene Frequency ; Middle Aged ; Child

Effectiveness of hydroxyurea (hydroxycarbamide) in a national sickle cell disease programme in Ghana.

Authors: Dwomoh D Abankwah DNY Benneh-Akwasi Kuma AA et al.

Source: British journal of haematology [Br J Haematol] 2025 Nov; Vol. 207 (5), pp. 2099-2108. Date of Electronic Publication: 2025 Aug 07.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/epidemiology , Anemia, Sickle Cell*/blood , Antisickling Agents*/therapeutic use, Humans ; Ghana/epidemiology ; Female ; Adult ; Male ; Quality of Life ; Child ; Adolescent ; Middle Aged ; Child, Preschool ; Young Adult

Short-term risks and benefits of hydroxyurea (hydroxycarbamide)-induced transfusion independence in patients with beta-thalassaemia syndromes.

Authors: Sevanthini BR Hegde S Sridhar T et al.

Source: British journal of haematology [Br J Haematol] 2025 Nov; Vol. 207 (5), pp. 2196-2199. Date of Electronic Publication: 2025 Aug 29.

Publication Type: Letter; Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/therapeutic use , Hydroxyurea*/adverse effects , beta-Thalassemia*/therapy , beta-Thalassemia*/drug therapy , Blood Transfusion* , Antisickling Agents*/therapeutic use, Humans ; Male ; Female ; Adult ; Adolescent ; Young Adult ; Middle Aged ; Child

HABIT Efficacy Trial Intervention Improves Elements of General and Disease-Specific Quality of Life in Youth With Sickle Cell Disease.

Authors: Smaldone A Manwani D Aygun B et al.

Source: Pediatric blood & cancer [Pediatr Blood Cancer] 2025 Nov; Vol. 72 (11), pp. e31990. Date of Electronic Publication: 2025 Aug 26.

Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study

Journal Info: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/psychology , Quality of Life* , Hydroxyurea*/therapeutic use , Antisickling Agents*/therapeutic use , Medication Adherence*, Humans ; Adolescent ; Male ; Female ; Child ; Prospective Studies ; Follow-Up Studies ; Prognosis

The Protective Effect of Fetal Hemoglobin on Retinal Damage in Sickle Cell Disease Patients: A Correlation With Optical Coherence Tomography, Hematologic Parameters, and Hydroxyurea Treatment.

Authors: Jin J Ploysangam P Hendricks DH et al.

Source: Pediatric blood & cancer [Pediatr Blood Cancer] 2025 Oct; Vol. 72 (10), pp. e31951. Date of Electronic Publication: 2025 Aug 01.

Publication Type: Journal Article; Observational Study

Journal Info: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE

MeSH Terms: Fetal Hemoglobin*/metabolism , Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/pathology , Tomography, Optical Coherence* , Retinal Diseases*/etiology , Retinal Diseases*/blood , Retinal Diseases*/prevention & control , Retinal Diseases*/pathology , Antisickling Agents*/therapeutic use , Retina*/pathology , Retina*/drug effects, Humans ; Child ; Female ; Male ; Prospective Studies ; Adolescent ; Child, Preschool ; Follow-Up Studies ; Infant ; Prognosis

Anti-sickling efficacy and safety of Sailin-HbS, an indigenous Ayurvedic formulation.

Authors: Bhatt S Bhansali A Rajesh AS et al.

Source: Blood cells, molecules & diseases [Blood Cells Mol Dis] 2026 Feb; Vol. 116, pp. 102956. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9509932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0961 (Electronic) Linking ISSN: 10799796 NLM ISO Abbreviation: Blood Cells Mol Dis Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/blood , Medicine, Ayurvedic* , Antisickling Agents*/pharmacology , Antisickling Agents*/therapeutic use , Antisickling Agents*/adverse effects , Hemoglobin, Sickle*/metabolism , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use , Erythrocytes, Abnormal*/drug effects , Erythrocytes, Abnormal*/metabolism, Animals ; Rats ; Humans ; Male

Hydroxyurea for Children with Sickle Cell Disease: A Practical Guide for Pediatric Clinicians.

Authors: Coyne F Strouse JJ

Source: Pediatric clinics of North America [Pediatr Clin North Am] 2026 Feb; Vol. 73 (1), pp. 29-41. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0401126 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8240 (Electronic) Linking ISSN: 00313955 NLM ISO Abbreviation: Pediatr Clin North Am Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/complications , Antisickling Agents*/therapeutic use, Humans ; Child ; Practice Guidelines as Topic

A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea.

Authors: Setayesh T Chi M Oestreicher Z et al.

Source: Blood [Blood] 2025 Jul 03; Vol. 146 (1), pp. 13-28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/pharmacology , Hydroxyurea*/therapeutic use , Disease Models, Animal* , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/pathology , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/genetics , Antisickling Agents*/therapeutic use , Antisickling Agents*/pharmacology, Animals ; Mice ; Humans ; Hemoglobin, Sickle/genetics ; Hemoglobin, Sickle/metabolism ; Mice, Inbred C57BL ; Erythrocytes/metabolism ; Erythrocytes/drug effects ; Erythrocytes/pathology ; Hemoglobin C/genetics ; Hemoglobin C/metabolism ; Erythrocytes, Abnormal/pathology ; Erythrocytes, Abnormal/drug effects ; Erythrocytes, Abnormal/metabolism ; Male

Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea.

Authors: Terrigno K Flamholz ZN Mahant Mahant A et al.

Source: Frontiers in immunology [Front Immunol] 2025 Sep 26; Vol. 16, pp. 1671061. Date of Electronic Publication: 2025 Sep 26 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/therapy , Anemia, Sickle Cell*/immunology , Anemia, Sickle Cell*/blood , Hydroxyurea*/therapeutic use , Neutrophils*/immunology , Neutrophils*/metabolism , Neutrophils*/drug effects , Antisickling Agents*/therapeutic use , Cellular Senescence*, Humans ; Female ; Male ; Cytokines/blood ; Adolescent ; Child ; Inflammation/immunology ; Chemokines/blood ; Gastrointestinal Microbiome ; Child, Preschool

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-world studies.

Authors: Yassin M Minniti C Shah N et al.

Source: Blood reviews [Blood Rev] 2025 Aug; Vol. 73, pp. 101298. Date of Electronic Publication: 2025 Apr 25.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8708558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1681 (Electronic) Linking ISSN: 0268960X NLM ISO Abbreviation: Blood Rev Subsets: MEDLINE

MeSH Terms: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/complications , Antibodies, Monoclonal, Humanized*/therapeutic use , Glutamine*/therapeutic use , Antisickling Agents*/therapeutic use, Humans ; Treatment Outcome ; Clinical Trials as Topic ; Benzaldehydes ; Pyrazines ; Pyrazoles

Evaluating the long-term benefits of hydroxyurea in pediatric sickle cell anemia.

Authors: George P Kalmus G Lane PA et al.

Source: Blood advances [Blood Adv] 2025 Jul 22; Vol. 9 (14), pp. 3585-3593.

Publication Type: Journal Article

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

MeSH Terms: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Antisickling Agents*/therapeutic use, Humans ; Child ; Female ; Male ; Child, Preschool ; Adolescent ; Treatment Outcome ; Longitudinal Studies ; Emergency Service, Hospital/statistics & numerical data