Search Results - "Angiotensin-Converting Enzyme 2"

Porcine angiotensin-converting enzyme 2 serves as an auxiliary receptor to enhance transmissible gastroenteritis virus invasion and replication.

Authors: Huang Y Zhang X Wu S et al.

Source: Veterinary microbiology [Vet Microbiol] 2025 Nov; Vol. 310, pp. 110691. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE

MeSH Terms: Transmissible gastroenteritis virus*/physiology , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Virus Replication* , Gastroenteritis, Transmissible, of Swine*/virology , Receptors, Virus*/metabolism , Receptors, Virus*/genetics, Animals ; Swine ; Humans

Autoimmune reactions to ACE2 triggered by SARS-CoV-2 S protein and their histopathological consequences.

Authors: Beduleva L Fomina K Khramova T et al.

Source: Scientific reports [Sci Rep] 2025 Oct 24; Vol. 15 (1), pp. 37315. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/immunology , Angiotensin-Converting Enzyme 2*/metabolism , Spike Glycoprotein, Coronavirus*/immunology , SARS-CoV-2*/immunology , COVID-19*/immunology , COVID-19*/pathology , COVID-19*/virology , Autoimmunity*, Animals ; Rats, Wistar ; Rats ; Lung/pathology ; Lung/immunology ; Humans ; Male ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/immunology ; Kidney Tubules, Proximal/pathology ; Kidney Tubules, Proximal/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; B-Lymphocytes/immunology

SARS-CoV-2 Entry Can Be Mimicked in C. elegans Expressing Human ACE2: A New Tool for Pharmacological Studies.

Authors: Romeo M Baroni S Barzago MM et al.

Source: Viruses [Viruses] 2025 Oct 18; Vol. 17 (10). Date of Electronic Publication: 2025 Oct 18.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Caenorhabditis elegans*/virology , Caenorhabditis elegans*/genetics , Caenorhabditis elegans*/metabolism , SARS-CoV-2*/physiology , SARS-CoV-2*/drug effects , Virus Internalization*/drug effects, Animals ; Humans ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; COVID-19/virology ; HEK293 Cells ; COVID-19 Drug Treatment

Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19.

Authors: Qiao Y Han Y Zhao L et al.

Source: Molecular biomedicine [Mol Biomed] 2025 Oct 15; Vol. 6 (1), pp. 74. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/genetics , Angiotensin-Converting Enzyme 2*/metabolism , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/pharmacology , Recombinant Fusion Proteins*/genetics , Cytokine Receptor gp130*/genetics , Cytokine Receptor gp130*/metabolism , SARS-CoV-2* , Receptors, Tumor Necrosis Factor, Type II*/genetics , Receptors, Tumor Necrosis Factor, Type II*/metabolism , COVID-19 Drug Treatment*, Animals ; Humans ; Mice ; COVID-19/virology ; Interleukin-6/metabolism ; Disease Models, Animal

Salidroside Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Ferroptosis Through the MAFK/lncRNA PTOV1-AS2/miR-525-5p/ACE2 Axis.

Authors: Yu X Xu B Zhang M et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71291.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Glucosides*/pharmacology , MicroRNAs*/genetics , MicroRNAs*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Phenols*/pharmacology , Ferroptosis*/drug effects , Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Reperfusion Injury*/pathology , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Lung/metabolism ; Lung/drug effects ; Lung/pathology ; Signal Transduction/drug effects ; Humans ; Cell Line

Molecular insights into species-specific ACE2 recognition of coronavirus HKU5.

Authors: Zhang Y Li Y Gao W et al.

Source: Nature communications [Nat Commun] 2025 Dec 04; Vol. 16 (1), pp. 10889. Date of Electronic Publication: 2025 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Angiotensin-Converting Enzyme 2*/chemistry , Spike Glycoprotein, Coronavirus*/metabolism , Spike Glycoprotein, Coronavirus*/chemistry , Spike Glycoprotein, Coronavirus*/genetics , Spike Glycoprotein, Coronavirus*/ultrastructure , Coronavirus*/genetics , Coronavirus*/metabolism, Animals ; Cryoelectron Microscopy ; Humans ; Species Specificity ; Protein Binding ; Chiroptera/virology ; Virus Internalization ; Models, Molecular ; Receptors, Virus/metabolism ; HEK293 Cells ; Birds/virology

The Role of ACE2 in SARS-CoV-2 Infection, Pathogenesis, and Antiviral Interventions.

Authors: McVoy MA Kummarapurugu AB

Source: Journal of medical virology [J Med Virol] 2025 Dec; Vol. 97 (12), pp. e70721.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , COVID-19*/virology , COVID-19*/pathology , SARS-CoV-2*/pathogenicity , SARS-CoV-2*/drug effects , Antiviral Agents*/therapeutic use , Antiviral Agents*/pharmacology, Humans ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment ; Virus Internalization/drug effects ; Animals

In Silico and In Vitro Identification of New Eugenol Derivatives as Inhibitors of the Spike SARS-CoV-2 Protein Interaction With the ACE2 Host Receptor.

Authors: Delgado-Maldonado T González-González A Moreno-Rodríguez A et al.

Source: Chemical biology & drug design [Chem Biol Drug Des] 2025 Dec; Vol. 106 (6), pp. e70212.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/chemistry , Angiotensin-Converting Enzyme 2*/antagonists & inhibitors , Eugenol*/pharmacology , Eugenol*/analogs & derivatives , Eugenol*/chemistry , Eugenol*/metabolism , Spike Glycoprotein, Coronavirus*/metabolism , Spike Glycoprotein, Coronavirus*/antagonists & inhibitors , Spike Glycoprotein, Coronavirus*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/metabolism , SARS-CoV-2*/metabolism , SARS-CoV-2*/drug effects, Humans ; Molecular Docking Simulation ; Protein Binding/drug effects ; Molecular Dynamics Simulation ; COVID-19 Drug Treatment ; Binding Sites ; COVID-19/virology

Integrative computational dissection of monobenzyl phthalate spermatotoxicity: High-affinity binding disrupts ACE2-CYP17A1 coregulation in non-obstructive azoospermia.

Authors: Zhu G Tan C Li Y

Source: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2025 Dec; Vol. 138, pp. 109063. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE

MeSH Terms: Azoospermia*/genetics , Azoospermia*/chemically induced , Azoospermia*/metabolism , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Phthalic Acids*/toxicity , Steroid 17-alpha-Hydroxylase*/metabolism , Steroid 17-alpha-Hydroxylase*/genetics , Endocrine Disruptors*/toxicity, Male ; Humans ; Mendelian Randomization Analysis ; Spermatogenesis/drug effects ; Sertoli Cells/drug effects ; Sertoli Cells/metabolism ; Molecular Docking Simulation

SCR Disease Name: Azoospermia, Nonobstructive

IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting ACE2-mediated virus binding and cell entry.

Authors: Pivniouk V Pivniouk O Uhrlaub JL et al.

Source: ImmunoHorizons [Immunohorizons] 2025 Nov 24; Vol. 9 (12).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101708159 Publication Model: Print Cited Medium: Internet ISSN: 2573-7732 (Electronic) Linking ISSN: 25737732 NLM ISO Abbreviation: Immunohorizons Subsets: MEDLINE

MeSH Terms: Interleukin-13*/pharmacology , Interleukin-13*/metabolism , Interleukin-13*/immunology , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , SARS-CoV-2*/physiology , COVID-19*/immunology , COVID-19*/virology , Virus Internalization*/drug effects , Epithelial Cells*/virology , Epithelial Cells*/immunology , Epithelial Cells*/metabolism, Humans ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Attachment/drug effects

An in vivo NanoBiT-based pseudoviral biosensor for real-time monitoring of SARS-CoV-2 spike/hACE2 interactions and therapeutic screening.

Authors: Lin CH Lin MW Yang XR et al.

Source: Analytica chimica acta [Anal Chim Acta] 2025 Nov 22; Vol. 1376, pp. 344623. Date of Electronic Publication: 2025 Sep 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Spike Glycoprotein, Coronavirus*/metabolism , Spike Glycoprotein, Coronavirus*/genetics , Biosensing Techniques*/methods , SARS-CoV-2*/metabolism , SARS-CoV-2*/drug effects , COVID-19 Drug Treatment* , Antiviral Agents*/pharmacology , Antiviral Agents*/therapeutic use, Animals ; Humans ; Mice ; COVID-19/virology ; COVID-19/metabolism ; Mice, Transgenic ; Flavonoids/pharmacology ; Virus Internalization/drug effects

Targeting ACE2 with a camelid antibody inhibits SARS-CoV-2 binding and has protective effects in vivo.

Authors: Blachier S Vaney MC Conquet L et al.

Source: Nature communications [Nat Commun] 2025 Nov 21; Vol. 16 (1), pp. 10268. Date of Electronic Publication: 2025 Nov 21.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/immunology , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/chemistry , SARS-CoV-2*/immunology , SARS-CoV-2*/drug effects , COVID-19*/immunology , COVID-19*/prevention & control , COVID-19*/virology , Antibodies, Viral*/immunology, Animals ; Camelids, New World/immunology ; Humans ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Mice ; Antibodies, Neutralizing/immunology ; Female ; Protein Binding ; COVID-19 Drug Treatment ; Mice, Inbred BALB C ; Epitopes/immunology

Dynamic insights into the structural evolution of ACE2-RBD interactions through molecular dynamics simulation, Markov state modeling, and large language model mutation prediction.

Authors: Zhou Y Wang T

Source: The Journal of chemical physics [J Chem Phys] 2025 Nov 21; Vol. 163 (19).

Publication Type: Journal Article

Journal Info: Publisher: American Institute of Physics Country of Publication: United States NLM ID: 0375360 Publication Model: Print Cited Medium: Internet ISSN: 1089-7690 (Electronic) Linking ISSN: 00219606 NLM ISO Abbreviation: J Chem Phys Subsets: MEDLINE

MeSH Terms: Molecular Dynamics Simulation* , Angiotensin-Converting Enzyme 2*/chemistry , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Spike Glycoprotein, Coronavirus*/chemistry , Spike Glycoprotein, Coronavirus*/genetics , Spike Glycoprotein, Coronavirus*/metabolism , SARS-CoV-2*/chemistry , SARS-CoV-2*/metabolism, Markov Chains ; Mutation ; Thermodynamics ; Humans ; Protein Binding ; Protein Domains ; COVID-19/virology ; Binding Sites ; Large Language Models

Novel ACE2 binding in bat merbecoviruses expands potential host range.

Authors: Zhang X Ma X Chen Y et al.

Source: PLoS pathogens [PLoS Pathog] 2025 Nov 11; Vol. 21 (11), pp. e1013436. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

MeSH Terms: Chiroptera*/virology , Host Specificity* , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Receptors, Virus*/metabolism, Animals ; Humans

Development of a Novel Mucosal Vaccine Vector Derived From Human Parainfluenza Virus Type 2 and Its Efficacy as a SARS-CoV-2 Vaccine by Intratracheal Administration Using Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2.

Authors: Kawano A Asaka MN Kawano M et al.

Source: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2025 Nov; Vol. 30 (6), pp. e70058.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print Cited Medium: Internet ISSN: 1365-2443 (Electronic) Linking ISSN: 13569597 NLM ISO Abbreviation: Genes Cells Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/genetics , Angiotensin-Converting Enzyme 2*/immunology , Angiotensin-Converting Enzyme 2*/metabolism , SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , COVID-19*/prevention & control , COVID-19*/immunology , COVID-19 Vaccines*/immunology , COVID-19 Vaccines*/administration & dosage , COVID-19 Vaccines*/genetics , Parainfluenza Virus 2, Human*/immunology , Parainfluenza Virus 2, Human*/genetics, Animals ; Humans ; Mice ; Mice, Transgenic ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells ; Chlorocebus aethiops ; Genetic Vectors/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology

Analysis of binding kinetics and mass transport in SPR-based biosensor using the Generalized Integral Transform Technique and the Markov Chain Monte Carlo Method.

Authors: de Moura CHR da Silva CAM Ferreira JL et al.

Source: Computers in biology and medicine [Comput Biol Med] 2025 Nov; Vol. 198 (Pt A), pp. 111129. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE

MeSH Terms: Surface Plasmon Resonance*/methods , SARS-CoV-2*/metabolism , Spike Glycoprotein, Coronavirus*/metabolism , Spike Glycoprotein, Coronavirus*/chemistry , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/chemistry , Biosensing Techniques*/methods, Markov Chains ; Monte Carlo Method ; Kinetics ; Humans ; COVID-19/virology ; COVID-19/metabolism ; Protein Binding

HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor.

Authors: Liu C Park YJ Ma CB et al.

Source: Nature microbiology [Nat Microbiol] 2025 Nov; Vol. 10 (11), pp. 2860-2874. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

MeSH Terms: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Angiotensin-Converting Enzyme 2*/chemistry , Receptors, Virus*/metabolism , Receptors, Virus*/genetics , Receptors, Virus*/chemistry , Middle East Respiratory Syndrome Coronavirus*/genetics , Middle East Respiratory Syndrome Coronavirus*/metabolism , Middle East Respiratory Syndrome Coronavirus*/physiology , Middle East Respiratory Syndrome Coronavirus*/classification, Humans ; Cryoelectron Microscopy ; Animals ; Dipeptidyl Peptidase 4/metabolism ; Protein Binding ; Chiroptera/virology ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Tropism ; Phylogeny

Molecular and Functional Characterization of Sika Deer ACE2 as a Receptor for SARS-CoV-2.

Authors: Kovba A Igarashi M Mizuma K et al.

Source: Microbiology and immunology [Microbiol Immunol] 2025 Nov; Vol. 69 (11), pp. 533-543. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 7703966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-0421 (Electronic) Linking ISSN: 03855600 NLM ISO Abbreviation: Microbiol Immunol Subsets: MEDLINE

MeSH Terms: Deer*/virology , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Angiotensin-Converting Enzyme 2*/chemistry , SARS-CoV-2*/physiology , SARS-CoV-2*/metabolism , COVID-19*/transmission , COVID-19*/virology , Receptors, Virus*/metabolism , Receptors, Virus*/genetics , Receptors, Virus*/chemistry, Animals ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Humans ; Molecular Dynamics Simulation ; Amino Acid Sequence ; Protein Binding

ACE2 mitigates PEDV-induced endoplasmic reticulum stress and autophagy by inhibiting ROS production.

Authors: Li Z Chen X Ma C et al.

Source: Microbial pathogenesis [Microb Pathog] 2025 Nov; Vol. 208, pp. 108023. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Endoplasmic Reticulum Stress* , Autophagy* , Reactive Oxygen Species*/metabolism , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , Porcine epidemic diarrhea virus*/pathogenicity , Porcine epidemic diarrhea virus*/physiology , Coronavirus Infections*/virology , Coronavirus Infections*/metabolism , Peptidyl-Dipeptidase A*/metabolism , Peptidyl-Dipeptidase A*/genetics, Animals ; Humans ; Vero Cells ; Virus Replication ; Chlorocebus aethiops ; Unfolded Protein Response ; Cell Line

Ginkgolic acid as a fusion inhibitor: targeting RBD-ACE2 interaction with in silico, in vitro evidence of allosteric modulation and potent virucidal effect.

Authors: Wang J Min H Zhai Y et al.

Source: Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2025 Nov; Vol. 51 (11), pp. 1555-1572. Date of Electronic Publication: 2025 Aug 13.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE

MeSH Terms: Salicylates*/pharmacology , Salicylates*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/chemistry , SARS-CoV-2*/drug effects , Spike Glycoprotein, Coronavirus*/metabolism, Humans ; Molecular Docking Simulation ; Chlorocebus aethiops ; HEK293 Cells ; Vero Cells ; Animals ; Virus Internalization/drug effects ; Molecular Dynamics Simulation ; Allosteric Regulation/drug effects ; Ginkgo biloba/chemistry ; Dose-Response Relationship, Drug ; COVID-19 Drug Treatment ; COVID-19/virology