Výsledky vyhledávání - "Amyloid beta-Protein Precursor: genetics"
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Zdroj: Nat Commun
Su, Y, Li, H, Zhang, W, Tao, S, Wang, Q, Zhang, X, Zhou, M, Huang, X, Wang, C, Tang, Y, Chen, H, Verkhratsky, A, Zha, Z, Niu, J & Yi, C 2025, 'Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis', Nature Communications, vol. 16, no. 1, pp. 5621. https://doi.org/10.1038/s41467-025-60746-wTémata: Mice, Knockout, Male, Animal, Knockout, Mice, Transgenic, Cognitive Dysfunction/metabolism, Transgenic, Neuroprotection, Presenilin-1/genetics, Article, Microglia/metabolism, Disease Models, Animal, Mice, Disease Models, Animals, Humans, Alzheimer Disease/metabolism, Female, Amyloidosis/metabolism, Plaque, Amyloid/pathology, Connexin 43/metabolism, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Peptides/metabolism, Plaque, Amyloid/pathology
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Zdroj: Brain
Brain, vol. 147, no. 8, pp. 2691-2705Témata: Male, 0301 basic medicine, Receptor, Adenosine A2A, Mice, Transgenic, Plaque, Amyloid, A(2A) receptor, Hippocampus, Animals, Memory Disorders/metabolism, Memory Disorders/genetics, Memory Disorders/pathology, Mice, Receptor, Adenosine A2A/metabolism, Receptor, Adenosine A2A/genetics, Synapses/metabolism, Synapses/pathology, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Protein Precursor/metabolism, Neurons/metabolism, Neurons/pathology, Alzheimer Disease/metabolism, Alzheimer Disease/pathology, Alzheimer Disease/genetics, Hippocampus/metabolism, Hippocampus/pathology, Presenilin-1/genetics, Disease Models, Animal, Plaque, Amyloid/pathology, Plaque, Amyloid/metabolism, Mice, Inbred C57BL, A2A receptor, Alzheimer's disease, Synapse loss, adenosine, Amyloid beta-Protein Precursor, 03 medical and health sciences, Alzheimer Disease, Presenilin-1, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurons, Memory Disorders, 0303 health sciences, 3. Good health, [SDV] Life Sciences [q-bio], Synapses, Original Article
Popis souboru: application/pdf
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38964748
https://hal.univ-lille.fr/hal-04684882v1/document
https://hal.univ-lille.fr/hal-04684882v1
https://doi.org/10.1093/brain/awae113
https://serval.unil.ch/resource/serval:BIB_58B757DC2950.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_58B757DC2950
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_58B757DC29503 -
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Zdroj: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)
Scientific reports, vol. 15, no. 1, pp. 2912Témata: Adult, Autosomal dominant Alzheimer disease (ADAD), DNA Copy Number Variations, Mosaicism, Chromosomes, Human, Pair 21, Science, Neurosciences, Complex genomic rearrangement (CGR), Middle Aged, Cerebral amyloid angiopathy (CAA), Article, Humans, Alzheimer Disease/genetics, Alzheimer Disease/pathology, Amyloid beta-Protein Precursor/genetics, Female, Chromosomes, Human, Pair 21/genetics, Pedigree, Age of Onset, Amyloid-β precursor protein gene (APP), Structural variant (SV), Amyloid beta-Protein Precursor, Alzheimer Disease, Amyloid-beta precursor protein gene (
APP ), MedicinePopis souboru: application/pdf
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39849058
https://doaj.org/article/2bc3e75a4480464bb22b59f8f0a080ff
http://hdl.handle.net/10138/592474
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_0F499632E8087
https://serval.unil.ch/notice/serval:BIB_0F499632E808
https://serval.unil.ch/resource/serval:BIB_0F499632E808.P001/REF.pdf
https://publications.scilifelab.se/publication/e91f3d289b5744af8e560cfea7c0910e -
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Zdroj: Fluids Barriers CNS
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-17 (2024)
Delvenne, A, Vandendriessche, C, Gobom, J, Burgelman, M, Dujardin, P, de Nolf, C, Tijms, B M, Teunissen, C E, Schindler, S E, Verhey, F, Ramakers, I, Martinez-Lage, P, Tainta, M, Vandenberghe, R, Schaeverbeke, J, Engelborghs, S, de Roeck, E, Popp, J, Peyratout, G, Tsolaki, M, Freund-Levi, Y, Lovestone, S, Streffer, J, Bertram, L, Blennow, K, Zetterberg, H, Visser, P J, Vandenbroucke, R E & Vos, S J B 2024, 'Involvement of the choroid plexus in Alzheimer’s disease pathophysiology : findings from mouse and human proteomic studies', FLUIDS AND BARRIERS OF THE CNS, vol. 21, no. 1, 58. https://doi.org/10.1186/s12987-024-00555-3
Fluids and barriers of the CNS, vol. 21, no. 1, pp. 58
Fluids and barriers of the CNS
Fluids and barriers of the CNS, 21(1):58
FLUIDS AND BARRIERS OF THE CNSTémata: Proteomics, Male, Neurologi, Proteome, Proteome/metabolism, Choroid plexus, Amyloid-beta (A beta), Mice, Amyloid beta-Protein Precursor, VESSELS, Medicine and Health Sciences, Amyloid-β (Aβ), Choroid Plexus/metabolism, 11 Medical and Health Sciences, Amyloid beta-Protein Precursor/metabolism, Alzheimer's disease, 3. Good health, Cerebrospinal fluid, Neurology, Choroid Plexus/metabolism [MeSH], Female [MeSH], Amyloid beta-Protein Precursor/metabolism [MeSH], Mice, Inbred C57BL [MeSH], Proteomics [MeSH], Humans [MeSH], Animals [MeSH], Mice, Transgenic [MeSH], Mice [MeSH], Proteome/metabolism [MeSH], Male [MeSH], Research, Amyloid beta-Protein Precursor/genetics [MeSH], APP knock-in mice, Alzheimer Disease/metabolism [MeSH], Disease Models, Animal [MeSH], Alzheimer Disease/cerebrospinal fluid [MeSH], Alzheimer Disease/metabolism, Female, Life Sciences & Biomedicine, EXPRESSION, mice, Mice, Transgenic, Alzheimer Disease/cerebrospinal fluid, Animals, Humans, Disease Models, Animal, Amyloid beta-Protein Precursor/genetics, Mice, Inbred C57BL, proteomics, ADULT, Alzheimer Disease, RC346-429, CEREBROSPINAL-FLUID PRODUCTION, Science & Technology, Neurosciences, Biology and Life Sciences, 06 Biological Sciences, BARRIER, TRANSPORT, MODEL, 3209 Neurosciences, Choroid Plexus, Human medicine, Neurosciences & Neurology, Neurology. Diseases of the nervous system
Popis souboru: application/pdf
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39020361
https://doaj.org/article/7c5db71c472645af80c01089faaa997c
https://research.vumc.nl/en/publications/4ebbb5b9-aad9-46a1-9dd6-15f4f2ba65ce
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_AA3F1D78EAA61
https://serval.unil.ch/resource/serval:BIB_AA3F1D78EAA6.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_AA3F1D78EAA6
https://repository.uantwerpen.be/docstore/d:irua:25008
https://hdl.handle.net/10067/2077110151162165141
https://repository.publisso.de/resource/frl:6502664
https://biblio.vub.ac.be/vubir/(c5b30523-9aee-4776-ac0b-e58c8aaceabf).html
https://biblio.ugent.be/publication/01J73Q3F0X36FE71EVFSQ5Q591/file/01J73QE2PV3X1NSY0FF7P9T9GT
http://doi.org/10.1186/s12987-024-00555-3
https://biblio.ugent.be/publication/01J73Q3F0X36FE71EVFSQ5Q591
http://hdl.handle.net/1854/LU-01J73Q3F0X36FE71EVFSQ5Q591
http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-115207 -
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Zdroj: Sivasaravanaparan, M, Olesen, L Ø, Severino, M, von Linstow, M C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, 'Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699. https://doi.org/10.3233/JAD-220019
Sivasaravanaparan, M, Olesen, L Ø, Severino, M, Von Linstow, C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, 'Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APP SWE/PS1 ΔE9 Transgenic Mice', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699. https://doi.org/10.3233/JAD-220019Témata: 0301 basic medicine, Amyloid, Serotonin, Alzheimer Disease/complications, hippocampus, chronic paroxetine treatment, Mice, Transgenic, Plaque, Amyloid, Serotonin Plasma Membrane Transport Proteins/genetics, Transgenic, Amyloid beta-Protein Precursor, Mice, 03 medical and health sciences, 0302 clinical medicine, serotonin selective reuptake inhibitors, Alzheimer Disease, Presenilin-1, Animals, Humans, microgliosis, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Peptides/metabolism, Plaque, Y-maze, Serotonin Plasma Membrane Transport Proteins, Amyloid beta-Peptides, Amyloid/drug therapy, Animal, Cerebral amyloidosis, serotonin transporter occupancy, Amyloidosis, Presenilin-1/genetics, Paroxetine/pharmacology, 3. Good health, neurogenesis, Disease Models, Animal, Paroxetine, Selective Serotonin Reuptake Inhibitors/pharmacology, Disease Models, stereology, Serotonin Uptake Inhibitors/pharmacology, Plaque, Amyloid/drug therapy, Selective Serotonin Reuptake Inhibitors
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Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice
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Zdroj: Rombaut, B, Schepers, M, Tiane, A, Mussen, F, Koole, L, Kessels, S, Trippaers, C, Jacobs, R, Wouters, K, Willems, E, Veggel, L V, Koulousakis, P, Deluyker, D, Bito, V, Prickaerts, J, Wens, I, Brône, B, van den Hove, D L A & Vanmierlo, T 2024, 'Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice', Cells, vol. 13, no. 12, 1000. https://doi.org/10.3390/cells13121000
Témata: Alzheimer’s disease, cognition, cyclic nucleotide phosphodiesterases type 4B, microglia, synapse, Animals, Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism, Mice, Transgenic, Alzheimer Disease/drug therapy pathology, Cognition/drug effects, Phosphodiesterase 4 Inhibitors/pharmacology therapeutic use administration & dosage, Microglia/drug effects metabolism pathology, Disease Models, Animal, Presenilin-1/genetics metabolism, Humans, Amyloid beta-Protein Precursor/genetics metabolism, Male
Relation: info:eu-repo/semantics/altIdentifier/pissn/2073-4409
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Zdroj: Nuñez-Diaz , C , Andersson , E , Schultz , N , Pocevičiūtė , D , Hansson , O , Netherlands Brain Bank , Nilsson , K P R & Wennström , M 2024 , ' The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and AppNL-F/NL-F mice ' , Alzheimer's Research & Therapy , vol. 16 , no. 1 , pp. 4 . https://doi.org/10.1186/s13195-023-01375-7
Témata: Humans, Mice, Animals, Infant, Alzheimer Disease/pathology, Amyloid beta-Peptides/metabolism, Microglia/metabolism, Ligands, Mobile Applications, Transgenic, Plaque, Amyloid/pathology, Disease Models, Animal, Amyloid beta-Protein Precursor/genetics, tau Proteins/genetics
Popis souboru: application/pdf
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Zdroj: Kourti, M & Metaxas, A 2024, 'A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease', Neurobiology of Disease, vol. 192, 106427. https://doi.org/10.1016/j.nbd.2024.106427
Témata: 5xFAD, Amyloid, APP/PS1, Interaction, Meta-analysis, Tau, tau Proteins/metabolism, Phosphorylation, Mice, Transgenic, Animals, Amyloid beta-Protein Precursor/genetics, Female, Alzheimer Disease/pathology, Amyloid beta-Peptides/metabolism, Disease Models, Animal
Popis souboru: application/pdf
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Zdroj: Alzheimers Res Ther
Res Sq
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Alzheimer’s Research & Therapy, vol 16, iss 1
Res Sq, vol 4, iss 11-09Témata: Aging, cathepsin D, Neurodegenerative, Alzheimer's Disease, Cathepsin D, Transgenic, Amyloid-β protein, Mice, Amyloid beta-Protein Precursor, 2.1 Biological and endogenous factors, Alzheimer's Disease Related Dementias (ADRD), Mice, Knockout, Biological Sciences, 3. Good health, Tauopathy, Tauopathies, Neurological, Alzheimer disease, RC321-571, Neurofibrillary tangles, Knockout, Amyloid beta-Protein Precursor/metabolism [MeSH], Aged [MeSH], Lysosomes, Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Tauopathies/metabolism [MeSH], Animals [MeSH], Mice, Knockout [MeSH], Mice, Transgenic [MeSH], Cathepsin D [MeSH], Mice [MeSH], Research, Amyloid beta-Protein Precursor/genetics [MeSH], tau Proteins/metabolism [MeSH], Disease Models, Animal [MeSH], Alzheimer Disease/pathology [MeSH], Tauopathies/genetics [MeSH], tau Proteins/genetics [MeSH], Neurosciences. Biological psychiatry. Neuropsychiatry, Mice, Transgenic, tau Proteins, Article, lysosomes, Alzheimer Disease, Acquired Cognitive Impairment, Animals, Humans, RC346-429, Aged, Amyloid beta-Peptides, Animal, tauopathy, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Disease Models, Animal, neurofibrillary tangles, Disease Models, Dementia, Biochemistry and Cell Biology, Neurology. Diseases of the nervous system, amyloid-β protein
Popis souboru: application/pdf
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37961253
https://pubmed.ncbi.nlm.nih.gov/38575959
https://doaj.org/article/c8e7a6b3cbd440008791292cdd23c305
https://repository.publisso.de/resource/frl:6516878
https://escholarship.org/uc/item/1w43m4zw
https://escholarship.org/content/qt1w43m4zw/qt1w43m4zw.pdf
https://escholarship.org/uc/item/42v7j613 -
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Zdroj: Transl Psychiatry
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Translational Psychiatry 13(1), 123 (2023). doi:10.1038/s41398-023-02411-8
Kommaddi, R P 2023, ' Sex difference in evolution of cognitive decline : studies on mouse model and the Dominantly Inherited Alzheimer Network cohort ', Translational Psychiatry, vol. 13, no. 1, pp. 123 . https://doi.org/10.1038/s41398-023-02411-8Témata: Centre for Neuroscience, Male, metabolism [Amyloid beta-Peptides], Neurosciences. Biological psychiatry. Neuropsychiatry, Mice, Transgenic, Cognitive Dysfunction/genetics, Article, 12. Responsible consumption, Centre for Brain Research, Mice, Amyloid beta-Protein Precursor, Alzheimer Disease, Humans, Animals, Cognitive Dysfunction, ddc:610, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Peptides/metabolism, 10. No inequality, Sex Characteristics, Memory Disorders, Amyloid beta-Peptides, genetics [Cognitive Dysfunction], Infant, Fear, 3. Good health, Disease Models, Animal, genetics [Amyloid beta-Protein Precursor], Alzheimer Disease/metabolism, Female, metabolism [Alzheimer Disease], RC321-571
Popis souboru: application/pdf
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Zdroj: Acta Neuropathol
Témata: Male, 0301 basic medicine, Physiology, Gene, Amyloid beta-Protein Precursor, Mechanisms of Alzheimer's Disease, 0302 clinical medicine, Pathology, Disease, Age of Onset, Phosphorylation, Aged, 80 and over, PSEN1, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, Familial Amyloid Polyneuropathy, Life Sciences, Middle Aged, Alzheimer's disease, 3. Good health, Phenotype, Environmental health, Neurology, Medicine, Female, Life Sciences & Biomedicine, Adult, Heterozygote, Proteasome Endopeptidase Complex, Genotype, Hyperphosphorylation, Models, Neurological, Population, Clinical Neurology, tau Proteins, Presenilin, 03 medical and health sciences, Alzheimer Disease, Biochemistry, Genetics and Molecular Biology, Exome Sequencing, Health Sciences, Presenilin-1, Genetics, Humans, Molecular Biology, Biology, Aged, Original Paper, Science & Technology, Neurology & Neurosurgery, Neurosciences, Ubiquitination, 1103 Clinical Sciences, FOS: Biological sciences, 3209 Neurosciences, Neurosciences & Neurology, Molecular Mechanisms of Amyloidosis, 1109 Neurosciences, Female [MeSH], Proteasome Endopeptidase Complex [MeSH], Heterozygote [MeSH], Aged, 80 and over [MeSH], Phosphorylation [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Ubiquitination [MeSH], Middle Aged [MeSH], Exome Sequencing [MeSH], Models, Neurological [MeSH], Age of Onset [MeSH], Alzheimer Disease/psychology [MeSH], Male [MeSH], Amyloid beta-Protein Precursor/genetics [MeSH], Genotype [MeSH], Phenotype [MeSH], Alzheimer Disease/pathology [MeSH], Presenilin-1/genetics [MeSH], tau Proteins/genetics [MeSH]
Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00401-020-02249-0.pdf
https://pubmed.ncbi.nlm.nih.gov/33319314
https://link.springer.com/article/10.1007/s00401-020-02249-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847436
https://fis-uke.de/portal/en/publications/a-multifactorial-model-of-pathology-for-age-of-onset-heterogeneity-in-familial-alzheimers-disease(e47971dc-f1e0-4e4b-b3fb-73f7f59986e5).html
https://pubmed.ncbi.nlm.nih.gov/33319314/
https://link.springer.com/content/pdf/10.1007/s00401-020-02249-0.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33319314
https://lirias.kuleuven.be/handle/123456789/665347
https://doi.org/10.1007/s00401-020-02249-0
https://repository.publisso.de/resource/frl:6466540
https://discovery-pp.ucl.ac.uk/id/eprint/10118081/ -
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Zdroj: Communications biology 6(1), 670 (2023). doi:10.1038/s42003-023-05039-y
Témata: info:eu-repo/classification/ddc/570, Amyloid Precursor Protein Secretases: genetics, Amyloid Precursor Protein Secretases: metabolism, Catalytic Domain, Protein Conformation, beta-Strand, Amyloid beta-Protein Precursor: genetics, Amyloid beta-Protein Precursor: metabolism, Water Supply
Geografické téma: DE
Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:37355752; info:eu-repo/semantics/altIdentifier/issn/2399-3642; https://pub.dzne.de/record/258782
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Zdroj: Biological psychiatry 94(9), 721 - 731 (2023). doi:10.1016/j.biopsych.2023.04.009
Témata: info:eu-repo/classification/ddc/610, Mice, Animals, Alzheimer Disease: genetics, Alzheimer Disease: pathology, Amyloid beta-Protein Precursor: genetics, Amyloid beta-Peptides, Individuality, Mobile Applications, Transgenic, Disease Models, Animal, Adult neurogenesis, Dementia, Hippocampus, Learning, Reserve, Variability, Amyloid beta-Protein Precursor
Geografické téma: DE
Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:37076091; info:eu-repo/semantics/altIdentifier/issn/1873-2402; info:eu-repo/semantics/altIdentifier/issn/0006-3223; https://pub.dzne.de/record/265757
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Témata: Adult, Age of Onset, Aged, Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/genetics, DNA/genetics, DNA Primers, Exons/genetics, Female, Genes, Dominant/genetics, Humans, Immunohistochemistry, Male, Membrane Proteins/genetics, Middle Aged, Pedigree, Presenilin-1, Presenilin-2, Psychiatric Status Rating Scales, Reverse Transcriptase Polymerase Chain Reaction, Switzerland
Relation: Dementia and Geriatric Cognitive Disorders; https://iris.unil.ch/handle/iris/31979; serval:BIB_13307; 000083635000001
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Přispěvatelé: a další
Témata: Age of Onset, Aged, 80 and over, Alzheimer Disease/epidemiology, Alzheimer Disease/genetics, Alzheimer Disease/pathology, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Protein Precursor/metabolism, Apolipoproteins E/genetics, Case-Control Studies, Cohort Studies, Datasets as Topic, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Heterozygote, Humans, Male, Middle Aged, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Risk Assessment/methods, Risk Factors
Popis souboru: application/pdf
Relation: Nature Communications; https://iris.unil.ch/handle/iris/161274; serval:BIB_AEF4F55D3F31; 000713875100002
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Témata: Aging/pathology, Amacrine Cells/metabolism, Amyloid beta-Protein Precursor/chemistry, Amyloid beta-Protein Precursor/deficiency, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Protein Precursor/metabolism, Animals, Newborn, Cell Differentiation, Complement System Proteins/metabolism, Dendrites/metabolism, Eye Diseases, Hereditary/genetics, Hereditary/pathology, Hereditary/physiopathology, Gene Deletion, Genetic Diseases, X-Linked/genetics, X-Linked/pathology, X-Linked/physiopathology, Mice, Inbred C57BL, Knockout, Myopia/genetics, Myopia/pathology, Myopia/physiopathology, Neurogenesis, Night Blindness/genetics, Night Blindness/pathology, Night Blindness/physiopathology
Popis souboru: application/pdf
Relation: Molecular Brain; https://iris.unil.ch/handle/iris/158437; serval:BIB_8DB27D0809EA; 000377189700001
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Témata: Aged, 80 and over, Alzheimer Disease/blood, Alzheimer Disease/immunology, Amyloid beta-Peptides/immunology, Amyloid beta-Peptides/metabolism, Amyloid beta-Protein Precursor/genetics, Animals, Newborn, Cells, Cultured, Cerebral Cortex/cytology, Disease Models, Animal, Dose-Response Relationship, Drug, Immunologic, Double-Blind Method, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation/drug effects, Gene Expression Regulation/genetics, Green Fluorescent Proteins/genetics, Hippocampus/cytology, Humans, Immunoglobulin G/metabolism, Immunoglobulin G/pharmacology, Male, Mice, Transgenic
Popis souboru: application/pdf
Relation: The Journal of Neuroscience; https://iris.unil.ch/handle/iris/136575; serval:BIB_BAEF6B47B5E9; 000306526800025
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Zdroj: Journal of Alzheimer's Disease. 2018, Vol. 63 Issue 1, p273-282. 10p.
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Zdroj: Current Alzheimer research. 13(1)
Témata: Age Factors, Aging: pathology, Alzheimer Disease: pathology, Amyloid beta-Protein Precursor: genetics, metabolism, Animals, Down Syndrome: pathology, Humans, Neurofibrillary Tangles: genetics, metabolism, microbiology, Neuropathology, tau Proteins: metabolism
Popis souboru: application/pdf
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Zdroj: Biophysical Chemistry. Oct2017, Vol. 229, p11-18. 8p.
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