Výsledky vyhľadávania - "Amyloid beta-Protein Precursor"

Syringaldehyde Ameliorates Cognitive Dysfunction in APP/PS1 Mice by Stabilizing the NLRP3 Pathway.

Autori: Chen R Gao H Zhu T a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 15844-15858. Date of Electronic Publication: 2025 Jul 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Benzaldehydes*/pharmacology , Benzaldehydes*/therapeutic use , Signal Transduction*/drug effects , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Presenilin-1*/metabolism, Animals ; Mice, Transgenic ; Mice ; Hippocampus/drug effects ; Hippocampus/pathology ; Hippocampus/metabolism ; Plaque, Amyloid/pathology ; Plaque, Amyloid/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Male ; Oxidative Stress/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Maze Learning/drug effects ; Mice, Inbred C57BL

Neuronal GSK3β Protects Against Amyloid Pathology by Regulating APP Degradation.

Autori: Zhang Y Ge C Liu Y a ďalší

Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 30; Vol. 39 (22), pp. e71267.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Neurons*/metabolism , Neurons*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Amyloid beta-Peptides*/metabolism, Animals ; Mice ; Mice, Transgenic ; Mice, Knockout ; Proteolysis

Circadian rhythm of amyloid-β in the olfactory bulb and cerebellum of wild-type and APPxPS1 knock-in mice indicates a loss of rhythmicity in regions more vulnerable to amyloid pathology.

Autori: Buzinova VA Johnson CE Turton SM a ďalší

Zdroj: Biogerontology [Biogerontology] 2025 Nov 28; Vol. 27 (1), pp. 11. Date of Electronic Publication: 2025 Nov 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Circadian Rhythm*/physiology , Olfactory Bulb*/metabolism , Olfactory Bulb*/pathology , Amyloid beta-Peptides*/metabolism , Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Protein Precursor*/metabolism , Cerebellum*/metabolism , Cerebellum*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Presenilin-1*/genetics , Presenilin-1*/metabolism, Animals ; Male ; Female ; Mice, Transgenic ; Mice ; Gene Knock-In Techniques ; Disease Models, Animal ; Mice, Inbred C57BL

Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents.

Autori: Ji MJ Wu TX Tian C a ďalší

Zdroj: PLoS biology [PLoS Biol] 2025 Nov 24; Vol. 23 (11), pp. e3003513. Date of Electronic Publication: 2025 Nov 24 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Purkinje Cells*/metabolism , Purkinje Cells*/physiology , NAV1.6 Voltage-Gated Sodium Channel*/metabolism , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Motor Activity*/physiology, Animals ; Mice ; Action Potentials/physiology ; Mice, Knockout ; Synaptic Transmission/physiology ; Cerebellum/metabolism ; Mice, Inbred C57BL

Trofinetide Improves Cognitive Function in APP/PS1 Mice by Suppressing Inflammation and Apoptosis.

Autori: Chen M Ning Y Yang H a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 21; Vol. 63 (1), pp. 129. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Apoptosis*/drug effects , Inflammation*/drug therapy , Inflammation*/pathology , Cognition*/drug effects , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Presenilin-1*/metabolism, Animals ; Mice, Transgenic ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Hippocampus/pathology ; Hippocampus/drug effects ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Male ; Amyloid Precursor Protein Secretases/metabolism

Neural Stem Cell-conditioned Medium Protected Against Cognitive Dysfunction in APP/PS1 Mice.

Autori: Zheng X Xiang Q Dong X a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 11; Vol. 63 (1), pp. 27. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cognitive Dysfunction*/prevention & control , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/drug therapy , Neural Stem Cells*/metabolism , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Presenilin-1*/metabolism, Animals ; Culture Media, Conditioned/pharmacology ; Male ; Mice, Transgenic ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Alzheimer Disease ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Astrocytes/metabolism ; Astrocytes/drug effects ; Astrocytes/pathology ; Disease Models, Animal ; Plaque, Amyloid/pathology ; Plaque, Amyloid/metabolism ; Caspase 1/metabolism ; Interleukin-1beta/metabolism

Unraveling the conformational landscape of amyloid precursor protein intracellular domain.

Autori: Mandal N Skepö M

Zdroj: Biophysical journal [Biophys J] 2025 Nov 04; Vol. 124 (21), pp. 3527-3541. Date of Electronic Publication: 2025 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyloid beta-Protein Precursor*/chemistry , Amyloid beta-Protein Precursor*/metabolism , Intracellular Space*/metabolism, Molecular Dynamics Simulation ; Protein Domains ; Humans ; Scattering, Small Angle ; Protein Conformation ; Amino Acid Sequence ; Amino Acid Motifs ; Hydrogen Bonding

APP family is a regulator of endo-lysosomal membrane vulnerability.

Autori: Lundin B Wieckiewicz N Yokomizo M a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2025 Nov; Vol. 301 (11), pp. 110774. Date of Electronic Publication: 2025 Sep 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Lysosomes*/metabolism , Intracellular Membranes*/metabolism , Intracellular Membranes*/pathology , Endosomes*/metabolism, Animals ; Mice ; Fibroblasts/metabolism ; Mice, Knockout ; Oxidative Stress ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Humans ; Alzheimer Disease/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology

Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease.

Autori: Navakkode S Kennedy BK

Zdroj: Aging cell [Aging Cell] 2025 Nov; Vol. 24 (11), pp. e70235. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/physiopathology , Alzheimer Disease*/genetics , Neuronal Plasticity*/drug effects , Ketoglutaric Acids*/pharmacology , Ketoglutaric Acids*/therapeutic use , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Presenilin-1*/metabolism , Presenilin-1*/genetics, Animals ; Disease Models, Animal ; Mice ; Male ; Female ; Mice, Transgenic ; Long-Term Potentiation/drug effects ; Synapses/drug effects ; Synapses/metabolism ; Humans

A decade progress in the phenotyping of App ^NL-G-F knock-in mouse model of Alzheimer's disease.

Autori: Manabe T Saito T

Zdroj: Neuroscience research [Neurosci Res] 2025 Nov; Vol. 220, pp. 104959. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Country of Publication: Ireland NLM ID: 8500749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8111 (Electronic) Linking ISSN: 01680102 NLM ISO Abbreviation: Neurosci Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/genetics , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Disease Models, Animal* , Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Protein Precursor*/metabolism, Animals ; Mice, Transgenic ; Mice ; Phenotype ; Gene Knock-In Techniques ; Humans ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/genetics

Altered APP trafficking drives amyloidogenic processing in primary neurons from the App ^NL-F knock-in mouse model of Alzheimer's disease.

Autori: Yu Y Zhou RZ Nilsson P a ďalší

Zdroj: Neurobiology of disease [Neurobiol Dis] 2025 Nov; Vol. 216, pp. 107129. Date of Electronic Publication: 2025 Sep 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Neurons*/metabolism , Neurons*/pathology , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Peptides*/metabolism, Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Gene Knock-In Techniques ; Protein Transport/physiology ; Peptide Fragments/metabolism ; Cells, Cultured ; Mice, Inbred C57BL

Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release.

Autori: Zhao R Sophanpanichkul P Chadarevian JP a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 28; Vol. 122 (43), pp. e2509903122. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Microglia*/metabolism , Ion Channels*/metabolism , Ion Channels*/genetics , Inflammation Mediators*/metabolism , Peptide Fragments*/metabolism, Humans ; HEK293 Cells ; Alzheimer Disease/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Induced Pluripotent Stem Cells/metabolism ; Reactive Oxygen Species/metabolism

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695).

Autori: Zielinski M Peralta Reyes FS Gremer L a ďalší

Zdroj: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Oct 03; Vol. 13 (1), pp. 209. Date of Electronic Publication: 2025 Oct 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Protein Precursor*/metabolism , Brain*/metabolism , Brain*/ultrastructure , Brain*/pathology , Amyloid beta-Peptides*/ultrastructure , Amyloid beta-Peptides*/metabolism , Amyloid beta-Peptides*/genetics , Alzheimer Disease*/genetics , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Amyloid*/ultrastructure , Amyloid*/metabolism, Animals ; Humans ; Cryoelectron Microscopy ; Mice, Transgenic ; Mutation/genetics ; Mice ; Female

RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein.

Autori: Eden J Kaufman JGG Pereira C a ďalší

Zdroj: The EMBO journal [EMBO J] 2025 Oct; Vol. 44 (19), pp. 5443-5462. Date of Electronic Publication: 2025 Aug 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , GTPase-Activating Proteins*/metabolism , GTPase-Activating Proteins*/genetics, Humans ; Animals ; Protein Transport ; Alzheimer Disease/metabolism ; Alzheimer Disease/genetics ; Mice ; Neurons/metabolism ; HEK293 Cells

Traumatic brain injury induces a sustained sensorimotor impairment associated with a dysregulated acute phase response in mice overexpressing human amyloid precursor protein.

Autori: McLeod RE Kale KM Weglinski C a ďalší

Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2025 Oct; Vol. 129, pp. 975-988. Date of Electronic Publication: 2025 Jul 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Brain Injuries, Traumatic*/metabolism , Brain Injuries, Traumatic*/physiopathology , Brain Injuries, Traumatic*/complications , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Acute-Phase Reaction*/metabolism, Animals ; Mice ; Mice, Transgenic ; Disease Models, Animal ; Humans ; Male ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Cytokines/metabolism ; Alzheimer Disease/metabolism ; Inflammation/metabolism ; Mice, Inbred C57BL

Alzheimer's Disease-Associated Amyloid-β Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity.

Autori: Kassir MF Lee HG Oleinik NV a ďalší

Zdroj: Cancer research [Cancer Res] 2025 Oct 01; Vol. 85 (19), pp. 3791-3811.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/metabolism , Alzheimer Disease*/immunology , Alzheimer Disease*/pathology , Mitophagy*/immunology , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Aging*/metabolism, Animals ; Mice ; Humans ; Mitochondria/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Female ; Mice, Transgenic ; Male ; Mice, Inbred C57BL ; Xenograft Model Antitumor Assays ; Cell Line, Tumor

APLP1 Interacts with SARM1 and Regulates Axonal Maintenance and Post-Injury Degeneration.

Autori: Kang M Kim H Jeon Y a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Dec 01; Vol. 63 (1), pp. 225. Date of Electronic Publication: 2025 Dec 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Armadillo Domain Proteins*/metabolism , Axons*/metabolism , Axons*/pathology , Cytoskeletal Proteins*/metabolism , Nerve Degeneration*/metabolism , Nerve Degeneration*/pathology , Amyloid beta-Protein Precursor*/metabolism, Animals ; Protein Binding ; Humans ; Mice ; Mice, Inbred C57BL ; Sciatic Nerve/pathology ; Sciatic Nerve/metabolism ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/pathology

Misclassification in memory modification in App ^NL-G-F knock-in mouse model of Alzheimer's disease.

Autori: Huang ML Suzuki Y Sasaguri H a ďalší

Zdroj: ELife [Elife] 2025 Nov 04; Vol. 14. Date of Electronic Publication: 2025 Nov 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/physiopathology , Alzheimer Disease*/genetics , Alzheimer Disease*/psychology , Memory* , Amyloid beta-Protein Precursor*/genetics, Animals ; Disease Models, Animal ; Mice ; Fear ; Mice, Transgenic ; Gene Knock-In Techniques ; Male ; Conditioning, Classical

Dihuang Yinzi Regulates cAMP/PKA/CREB-BDNF to Improve Synaptic Plasticity in APP/PS1 Mice: A Study Based on Brain Metabolomics.

Autori: Jiang HN Zhang B Zhang J a ďalší

Zdroj: Chinese journal of integrative medicine [Chin J Integr Med] 2025 Nov; Vol. 31 (11), pp. 991-1000. Date of Electronic Publication: 2025 Sep 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press Country of Publication: China NLM ID: 101181180 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1993-0402 (Electronic) Linking ISSN: 16720415 NLM ISO Abbreviation: Chin J Integr Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Brain-Derived Neurotrophic Factor*/metabolism , Cyclic AMP Response Element-Binding Protein*/metabolism , Brain*/metabolism , Brain*/drug effects , Metabolomics* , Neuronal Plasticity*/drug effects , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Cyclic AMP-Dependent Protein Kinases*/metabolism , Cyclic AMP*/metabolism , Amyloid beta-Protein Precursor*/metabolism, Animals ; Male ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Mice, Transgenic ; Mice ; Amyloid beta-Peptides/metabolism ; Signal Transduction/drug effects ; Alzheimer Disease/drug therapy ; Superoxide Dismutase/metabolism

Crocin Inhibited Aβ Generation via Modulating APP Processing, Suppressing Endoplasmic Reticulum Stress and Activating Autophagy in N2a/APP Cells.

Autori: Liang ZR Lin CJ Liu YH a ďalší

Zdroj: Chinese journal of integrative medicine [Chin J Integr Med] 2025 Nov; Vol. 31 (11), pp. 973-981. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press Country of Publication: China NLM ID: 101181180 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1993-0402 (Electronic) Linking ISSN: 16720415 NLM ISO Abbreviation: Chin J Integr Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endoplasmic Reticulum Stress*/drug effects , Autophagy*/drug effects , Amyloid beta-Peptides*/biosynthesis , Amyloid beta-Peptides*/metabolism , Amyloid beta-Protein Precursor*/metabolism , Carotenoids*/pharmacology, Animals ; Endoplasmic Reticulum Chaperone BiP ; Mice ; Humans ; Cell Line, Tumor ; Reactive Oxygen Species/metabolism ; Apoptosis/drug effects ; Calcium/metabolism