Výsledky vyhľadávania - "Amylin Receptor Agonists"

Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept.

Autori: Briere DA Qu H Lansu K a ďalší

Zdroj: Molecular metabolism [Mol Metab] 2025 Dec; Vol. 102, pp. 102271. Date of Electronic Publication: 2025 Oct 16.

Spôsob vydávania: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial

Informácie o časopise: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Obesity*/drug therapy , Obesity*/metabolism , Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/therapeutic use , Receptors, Islet Amyloid Polypeptide*/metabolism, Humans ; Animals ; Male ; Rats ; Female ; Adult ; Middle Aged ; Young Adult ; Islet Amyloid Polypeptide ; Rats, Sprague-Dawley ; Anti-Obesity Agents/pharmacology

Engineering of an Ultralong-Acting and Nonaggregating Dual Amylin and Calcitonin Receptor Agonist with Durable Efficacy in Obesity and Diabetes.

Autori: Zheng N Chen R Yang L a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24701-24717. Date of Electronic Publication: 2025 Nov 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Calcitonin*/agonists , Receptors, Calcitonin*/metabolism , Obesity*/drug therapy , Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/therapeutic use , Amylin Receptor Agonists*/pharmacokinetics , Amylin Receptor Agonists*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacokinetics , Receptors, Islet Amyloid Polypeptide*, Animals ; Humans ; Rats ; Male ; Rats, Zucker ; Structure-Activity Relationship

Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial.

Autori: Billings LK Hsia S Bays H a ďalší

Zdroj: Lancet (London, England) [Lancet] 2025 Dec 06; Vol. 406 (10520), pp. 2631-2643. Date of Electronic Publication: 2025 Nov 06.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

Výrazy zo slovníka MeSH: Obesity*/drug therapy , Anti-Obesity Agents*/administration & dosage , Anti-Obesity Agents*/adverse effects , Anti-Obesity Agents*/therapeutic use , Amylin Receptor Agonists*/administration & dosage, Humans ; Middle Aged ; Double-Blind Method ; Male ; Female ; Adult ; Aged ; Treatment Outcome ; Adolescent ; Young Adult ; Dose-Response Relationship, Drug ; Weight Loss/drug effects

Targeting the root cause of obesity-related comorbidities through weight independent and dependent actions on insulin sensitivity: Benefits of dual amylin and calcitonin receptor agonists.

Autori: Larsen AT Melander SA Mohamed KE a ďalší

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Sep; Vol. 190, pp. 118388. Date of Electronic Publication: 2025 Aug 05.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Insulin Resistance*/physiology , Obesity*/drug therapy , Obesity*/metabolism , Obesity*/epidemiology , Obesity*/physiopathology , Receptors, Calcitonin*/agonists , Receptors, Calcitonin*/metabolism , Amylin Receptor Agonists*/therapeutic use , Amylin Receptor Agonists*/pharmacology, Humans ; Animals ; Comorbidity ; Insulin/metabolism ; Body Weight/drug effects

Discovery of BGM1812, a Novel Dual Amylin and Calcitonin Receptor Agonist for Obesity Treatment.

Autori: Zong L Zhang Z Li X a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Jul 24; Vol. 68 (14), pp. 14907-14918. Date of Electronic Publication: 2025 Jul 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Calcitonin*/agonists , Receptors, Calcitonin*/metabolism , Obesity*/drug therapy , Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/chemistry , Amylin Receptor Agonists*/therapeutic use , Anti-Obesity Agents*/pharmacology , Anti-Obesity Agents*/chemistry , Anti-Obesity Agents*/therapeutic use , Anti-Obesity Agents*/pharmacokinetics , Drug Discovery*, Animals ; Structure-Activity Relationship ; Humans ; Molecular Dynamics Simulation ; Male ; Mice ; Rats

Amylin receptor subunit interactions are modulated by agonists and determine signaling.

Autori: Gostynska SE Karim JA Ford BE a ďalší

Zdroj: Science signaling [Sci Signal] 2025 Aug 19; Vol. 18 (900), pp. eadt8127. Date of Electronic Publication: 2025 Aug 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Signal Transduction*/drug effects , Receptors, Islet Amyloid Polypeptide*/metabolism , Receptors, Islet Amyloid Polypeptide*/genetics , Receptors, Islet Amyloid Polypeptide*/chemistry , Amylin Receptor Agonists*/pharmacology, Humans ; Animals ; Rats ; HEK293 Cells ; Cyclic AMP/metabolism ; Receptors, Calcitonin/metabolism ; Receptors, Calcitonin/genetics ; Receptor Activity-Modifying Protein 1/metabolism ; Receptor Activity-Modifying Protein 1/genetics ; Islet Amyloid Polypeptide/metabolism ; Receptor Activity-Modifying Protein 3/metabolism ; Receptor Activity-Modifying Protein 3/genetics ; Protein Subunits/metabolism ; Protein Binding ; Receptor Activity-Modifying Protein 2/metabolism ; Receptor Activity-Modifying Protein 2/genetics ; Protein Multimerization

The effect of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and rats.

Autori: Kuhre RE Ballarín-González B Brand CL a ďalší

Zdroj: EBioMedicine [EBioMedicine] 2025 Aug; Vol. 118, pp. 105862. Date of Electronic Publication: 2025 Jul 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE

Výrazy zo slovníka MeSH: Body Weight*/drug effects , Amylin Receptor Agonists* , Glucagon-Like Peptide 1*/agonists , Glucagon-Like Peptide 1*/metabolism , Metabolic Diseases*/drug therapy , Metabolic Diseases*/metabolism , Metabolic Diseases*/etiology, Animals ; Mice ; Rats ; Humans ; Male ; Energy Metabolism/drug effects ; Obesity/metabolism ; Obesity/drug therapy ; Obesity/etiology ; Insulin Resistance ; Disease Models, Animal

Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial.

Autori: Gasiorek A Heydorn A Gabery S a ďalší

Zdroj: Lancet (London, England) [Lancet] 2025 Jul 12; Vol. 406 (10499), pp. 135-148. Date of Electronic Publication: 2025 Jun 20.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucagon-Like Peptide-1 Receptor Agonists* , Amylin Receptor Agonists* , Obesity*/drug therapy , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/pharmacology , Overweight*/drug therapy, Humans ; Male ; Female ; Double-Blind Method ; Adult ; Middle Aged ; Young Adult ; Adolescent ; Dose-Response Relationship, Drug ; Diabetes Mellitus, Type 2/drug therapy

Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study.

Autori: Dahl K Toubro S Dey S a ďalší

Zdroj: Lancet (London, England) [Lancet] 2025 Jul 12; Vol. 406 (10499), pp. 149-162. Date of Electronic Publication: 2025 Jun 20.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

Výrazy zo slovníka MeSH: Obesity*/drug therapy , Amylin Receptor Agonists* , Overweight*/drug therapy , Glucagon-Like Peptide-1 Receptor Agonists* , Islet Amyloid Polypeptide*/administration & dosage , Islet Amyloid Polypeptide*/adverse effects, Humans ; Adult ; Male ; Female ; Middle Aged ; Injections, Subcutaneous ; Young Adult ; Adolescent ; Double-Blind Method ; Dose-Response Relationship, Drug

Structure, Self-Association, and Aggregation Properties of a Long-Acting Amylin Receptor Agonist.

Autori: Poulsen C Norrman M Thomsen JK a ďalší

Zdroj: Molecular pharmaceutics [Mol Pharm] 2025 Jul 07; Vol. 22 (7), pp. 3900-3909. Date of Electronic Publication: 2025 May 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amylin Receptor Agonists*/chemistry , Islet Amyloid Polypeptide*/chemistry, Amyloid/chemistry ; Circular Dichroism ; Protein Aggregates ; Scattering, Small Angle ; Fatty Acids/chemistry ; X-Ray Diffraction ; Dynamic Light Scattering ; Benzothiazoles

Synergistic-like decreases in alcohol intake following combined pharmacotherapy with GLP-1 and amylin in male rats.

Autori: Aranäs C Caffrey A Edvardsson CE a ďalší

Zdroj: British journal of pharmacology [Br J Pharmacol] 2025 Mar; Vol. 182 (6), pp. 1292-1305. Date of Electronic Publication: 2024 Dec 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alcohol Drinking*/drug therapy , Islet Amyloid Polypeptide*/administration & dosage , Islet Amyloid Polypeptide*/pharmacology , Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/administration & dosage , Glucagon-Like Peptides*/pharmacology , Immunoglobulin Fc Fragments*/administration & dosage , Immunoglobulin Fc Fragments*/pharmacology , Glucagon-Like Peptide 1*/administration & dosage , Glucagon-Like Peptide 1*/pharmacology , Amylin Receptor Agonists*/administration & dosage, Animals ; Male ; Female ; Rats ; Drug Synergism ; Drug Therapy, Combination ; Dose-Response Relationship, Drug ; Glucagon-Like Peptide-1 Receptor Agonists ; Calcitonin ; Recombinant Fusion Proteins

Development of the novel amylin and calcitonin receptor activators by peptide mutagenesis.

Autori: Lee S; Department of Medicinal Biotechnology, College of Health Science, Dong-A University, Busan, 49315, Republic of Korea. Electronic address: smlee1981@dau.ac.kr.

Zdroj: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2024 Dec; Vol. 762, pp. 110191. Date of Electronic Publication: 2024 Oct 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Calcitonin*/metabolism , Receptors, Calcitonin*/genetics , Receptors, Calcitonin*/agonists , Islet Amyloid Polypeptide*/metabolism , Islet Amyloid Polypeptide*/genetics , Islet Amyloid Polypeptide*/chemistry , Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/metabolism, Humans ; Animals ; Rats ; Mutagenesis ; Amino Acid Sequence ; Receptors, Islet Amyloid Polypeptide/metabolism ; Receptors, Islet Amyloid Polypeptide/genetics ; HEK293 Cells ; Peptides/pharmacology ; Peptides/chemistry

The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats.

Autori: Aranäs C Edvardsson CE Zentveld L a ďalší

Zdroj: Acta neuropsychiatrica [Acta Neuropsychiatr] 2024 Dec 06; Vol. 37, pp. e42. Date of Electronic Publication: 2024 Dec 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cambridge University Press Country of Publication: England NLM ID: 9612501 Publication Model: Electronic Cited Medium: Internet ISSN: 1601-5215 (Electronic) Linking ISSN: 09242708 NLM ISO Abbreviation: Acta Neuropsychiatr Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alcohol Drinking*/drug therapy , Amylin Receptor Agonists*/pharmacology , Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/pharmacology , Glucagon-Like Peptides*/administration & dosage , Calcitonin*/pharmacology , Calcitonin*/administration & dosage , Immunoglobulin Fc Fragments*/pharmacology , Immunoglobulin Fc Fragments*/administration & dosage , Glucagon-Like Peptide 1*/pharmacology , Glucagon-Like Peptide-1 Receptor Agonists*, Animals ; Male ; Female ; Rats ; Drug Therapy, Combination ; Ethanol/administration & dosage ; Glucagon-Like Peptide-1 Receptor ; Islet Amyloid Polypeptide ; Recombinant Fusion Proteins

The enduring metabolic improvement of combining dual amylin and calcitonin receptor agonist and semaglutide treatments in a rat model of obesity and diabetes.

Autori: Larsen AT Mohamed KE Melander SA a ďalší

Zdroj: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2024 Aug 01; Vol. 327 (2), pp. E145-E154. Date of Electronic Publication: 2024 Jun 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucagon-Like Peptides*/pharmacology , Glucagon-Like Peptides*/administration & dosage , Glucagon-Like Peptides*/therapeutic use , Receptors, Calcitonin*/agonists , Obesity*/drug therapy , Obesity*/metabolism , Rats, Zucker* , Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/therapeutic use , Rats, Sprague-Dawley* , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Drug Therapy, Combination* , Blood Glucose*/drug effects , Blood Glucose*/metabolism, Animals ; Rats ; Male ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Weight Loss/drug effects ; Disease Models, Animal ; Body Weight/drug effects ; Insulin/blood ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/therapeutic use

The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection - a novel disease-modifying osteoarthritis drug.

Autori: Mohamed KE Larsen AT Melander S a ďalší

Zdroj: Arthritis research & therapy [Arthritis Res Ther] 2024 Jul 12; Vol. 26 (1), pp. 129. Date of Electronic Publication: 2024 Jul 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Calcitonin*/agonists , Receptors, Calcitonin*/metabolism , Rats, Sprague-Dawley* , Osteoarthritis*/drug therapy , Osteoarthritis*/metabolism , Amylin Receptor Agonists*/pharmacology , Weight Loss*/drug effects, Animals ; Rats ; Female ; Analgesics/pharmacology ; Male ; Diet, High-Fat/adverse effects ; Humans ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use

Dual amylin and calcitonin receptor agonist treatment reduces biomarkers associated with kidney fibrosis in diabetic rats.

Autori: Melander SA Møller AL Mohamed KE a ďalší

Zdroj: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2023 Nov 01; Vol. 325 (5), pp. E529-E539. Date of Electronic Publication: 2023 Oct 04.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/therapeutic use , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/drug therapy , Kidney*/pathology, Animals ; Rats ; Blood Glucose/metabolism ; Collagen ; Fibrosis ; Islet Amyloid Polypeptide ; Obesity ; Rats, Sprague-Dawley ; Rats, Zucker ; Receptors, Calcitonin/agonists

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.

Autori: Cao J Belousoff MJ Johnson RM a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Apr 10; Vol. 16 (1), pp. 3389. Date of Electronic Publication: 2025 Apr 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Receptors, Calcitonin*/metabolism , Receptors, Calcitonin*/chemistry , Islet Amyloid Polypeptide*/metabolism , Islet Amyloid Polypeptide*/chemistry , Receptors, Islet Amyloid Polypeptide*/metabolism , Receptors, Islet Amyloid Polypeptide*/chemistry , Calcitonin*/metabolism , Calcitonin*/chemistry , Peptides*/chemistry , Peptides*/metabolism, Humans ; Animals ; Protein Binding ; Rats ; Amylin Receptor Agonists/chemistry ; Crystallography, X-Ray

Treatment sequencing using the dual amylin and calcitonin receptor agonist KBP-336 and semaglutide results in durable weight loss.

Autori: Thorsø Larsen A Karsdal MA Henriksen K

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2023 Sep 05; Vol. 954, pp. 175837. Date of Electronic Publication: 2023 Jun 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amylin Receptor Agonists*/pharmacology , Bone Density Conservation Agents* , Diabetes Mellitus, Type 2*, Rats ; Animals ; Receptors, Calcitonin/agonists ; Islet Amyloid Polypeptide ; Rats, Sprague-Dawley ; Weight Loss ; Body Weight ; Obesity/drug therapy ; Glucagon-Like Peptide 1 ; Glucose ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents

Dual amylin and calcitonin receptor agonist treatment improves insulin sensitivity and increases muscle-specific glucose uptake independent of weight loss.

Autori: Larsen AT Melander SA Sonne N a ďalší

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Aug; Vol. 164, pp. 114969. Date of Electronic Publication: 2023 Jun 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amylin Receptor Agonists*/pharmacology , Insulin Resistance* , Diabetes Mellitus, Type 2*/drug therapy , Prediabetic State* , Diabetes Mellitus, Experimental*, Rats ; Animals ; Receptors, Calcitonin/agonists ; Islet Amyloid Polypeptide ; Rats, Sprague-Dawley ; Weight Loss ; Glucose ; Insulin ; Calcium-Regulating Hormones and Agents ; Muscles ; Blood Glucose

Improved metabolic efficacy of a dual amylin and calcitonin receptor agonist when combined with semaglutide or empagliflozin.

Autori: Melander SA Katri A Karsdal MA a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2023 Jan 05; Vol. 938, pp. 175397. Date of Electronic Publication: 2022 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amylin Receptor Agonists*/pharmacology , Amylin Receptor Agonists*/therapeutic use , Diabetes Mellitus, Type 2*/drug therapy, Rats ; Animals ; Receptors, Calcitonin/agonists ; Receptors, Calcitonin/therapeutic use ; Islet Amyloid Polypeptide ; Rats, Zucker ; Body Weight ; Obesity/drug therapy ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use