Výsledky vyhľadávania - "Amidines"

Camptothecin 20(S)-sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade.

Autori: Si Z Ma Y Cheng Z a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109171. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Apoptosis*/drug effects , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , DNA Topoisomerases, Type I*/metabolism , Camptothecin*/pharmacology , Camptothecin*/chemistry , Camptothecin*/analogs & derivatives , Camptothecin*/chemical synthesis , DNA Damage*/drug effects , Topoisomerase I Inhibitors*/pharmacology , Topoisomerase I Inhibitors*/chemistry , Topoisomerase I Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Amidines*/chemistry , Amidines*/pharmacology , Amidines*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Molecular Structure ; Dose-Response Relationship, Drug

Inhibition of inducible nitric oxide synthase (iNOS) alleviates thoracic aortic aneurysm by regulating mitochondrial dynamics.

Autori: Zheng ZF Zhang JJ Wu LF a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Oct 15; Vol. 1005, pp. 178071. Date of Electronic Publication: 2025 Aug 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mitochondrial Dynamics*/drug effects , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Nitric Oxide Synthase Type II*/metabolism , Aortic Aneurysm, Thoracic*/pathology , Aortic Aneurysm, Thoracic*/drug therapy , Aortic Aneurysm, Thoracic*/metabolism , Aortic Aneurysm, Thoracic*/chemically induced , Aortic Aneurysm, Thoracic*/enzymology , Amidines*/pharmacology , Amidines*/therapeutic use , Benzylamines*/pharmacology , Benzylamines*/therapeutic use , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Animals ; Humans ; Mice ; Male ; Reactive Oxygen Species/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal ; Aminopropionitrile ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism

Probing the Inhibitory Potential of Halogenated Symmetrical Formamidine Against MAO-A and MAO-B: Structural Elucidation, Molecular Dynamic Simulation and DFT Computational Studies.

Autori: Oladipo SD Luckay RC Olalekan SO a ďalší

Zdroj: Chemistry & biodiversity [Chem Biodivers] 2025 Oct; Vol. 22 (10), pp. e00886. Date of Electronic Publication: 2025 Jun 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Monoamine Oxidase*/metabolism , Monoamine Oxidase Inhibitors*/chemistry , Monoamine Oxidase Inhibitors*/pharmacology , Monoamine Oxidase Inhibitors*/chemical synthesis , Molecular Dynamics Simulation* , Density Functional Theory* , Amidines*/chemistry , Amidines*/pharmacology , Amidines*/chemical synthesis, Humans ; Molecular Structure ; Halogenation ; Structure-Activity Relationship ; Molecular Docking Simulation

Targeting inducible nitric oxide synthase with 1400W mitigates septic acute lung injury through inhibiting SLC7A11/GPX4 mediated ferroptosis.

Autori: Wang ZY Zeng T Wang X a ďalší

Zdroj: Nitric oxide : biology and chemistry [Nitric Oxide] 2025 Oct; Vol. 158, pp. 4-10. Date of Electronic Publication: 2025 May 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 9709307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8611 (Electronic) Linking ISSN: 10898603 NLM ISO Abbreviation: Nitric Oxide Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/drug effects , Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism , Acute Lung Injury*/chemically induced , Acute Lung Injury*/pathology , Nitric Oxide Synthase Type II*/antagonists & inhibitors , Nitric Oxide Synthase Type II*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/antagonists & inhibitors , Amino Acid Transport System y+*/metabolism , Amino Acid Transport System y+*/antagonists & inhibitors , Sepsis*/drug therapy , Sepsis*/metabolism , Amidines*/pharmacology , Amidines*/therapeutic use , Enzyme Inhibitors*/pharmacology, Animals ; Mice ; Lipopolysaccharides/pharmacology ; Male ; Molecular Docking Simulation ; Mice, Inbred C57BL ; Molecular Dynamics Simulation ; Imines

Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial Activity.

Autori: Klein S Moritz A Pessanha de Carvalho L a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Sep 25; Vol. 68 (18), pp. 19229-19248. Date of Electronic Publication: 2025 Sep 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antimalarials*/pharmacology , Antimalarials*/chemistry , Antimalarials*/pharmacokinetics , Antimalarials*/chemical synthesis , Plasmodium falciparum*/drug effects , Amidines*/pharmacology , Amidines*/chemistry , Amidines*/pharmacokinetics , Amidines*/chemical synthesis, Animals ; Structure-Activity Relationship ; Humans ; Mice ; Plasmodium berghei/drug effects ; Malaria/drug therapy ; Hep G2 Cells ; Parasitic Sensitivity Tests ; Rats

Ketenimine Multicomponent Strategy for Multifaceted Amidine Functionalization of Peptides on the Solid Phase.

Autori: Bodake SM Marelli UK

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Sep 08; Vol. 64 (37), pp. e202509854. Date of Electronic Publication: 2025 Jul 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Peptides*/chemistry , Peptides*/chemical synthesis , Imines*/chemistry , Amidines*/chemistry, Solid-Phase Synthesis Techniques ; Copper/chemistry ; Catalysis ; Molecular Structure

Copper-Mediated Three-Component Reaction for the Synthesis of N -Sulfonylamidine on DNA.

Autori: Kwon TY Lee Y Cho KJ a ďalší

Zdroj: Organic letters [Org Lett] 2025 Apr 25; Vol. 27 (16), pp. 4316-4321. Date of Electronic Publication: 2025 Apr 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Copper*/chemistry , DNA*/chemistry , Amidines*/chemistry , Amidines*/chemical synthesis, Molecular Structure ; Alkynes/chemistry ; Azides/chemistry ; Catalysis

Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo.

Autori: Han X Alameh MG Gong N a ďalší

Zdroj: Nature chemistry [Nat Chem] 2024 Oct; Vol. 16 (10), pp. 1687-1697. Date of Electronic Publication: 2024 Jul 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lipids*/chemistry , RNA, Messenger*/genetics , Amidines*/chemistry, Animals ; Mice ; Nanoparticles/chemistry ; Humans ; Structure-Activity Relationship ; Gene Transfer Techniques ; Liposomes

Total Syntheses of Streptamidine and Klebsazolicin Using Biomimetic On-Resin Ring-Closing Amidine Formation.

Autori: Liu S Tang Y Chen S a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 16; Vol. 63 (38), pp. e202407952. Date of Electronic Publication: 2024 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amidines*/chemistry , Amidines*/chemical synthesis, Cyclization ; Biomimetics ; Structure-Activity Relationship ; Molecular Structure ; Diketopiperazines/chemistry ; Diketopiperazines/chemical synthesis ; Biomimetic Materials/chemistry ; Biomimetic Materials/chemical synthesis

Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway.

Autori: Zheng Y Ren X Qi X a ďalší

Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jun 28; Vol. 328, pp. 118058. Date of Electronic Publication: 2024 Mar 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: AMP-Activated Protein Kinases* , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Amidines*, Animals ; Zebrafish ; Oxidative Stress ; Fatigue/drug therapy ; Inflammation/drug therapy ; Antioxidants ; Signal Transduction ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use

Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability.

Autori: Kim HS Park JE Lee WH a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 16; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Checkpoint Kinase 1*/metabolism , Checkpoint Kinase 1*/antagonists & inhibitors , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/radiotherapy , Amidines*/pharmacology, Humans ; Cell Line, Tumor ; Radiation, Ionizing ; Radiation-Sensitizing Agents/pharmacology ; DNA Replication/drug effects ; Cell Proliferation/drug effects ; DNA Damage/drug effects ; Cell Cycle/drug effects

Inactivation of human glucose 6-phosphate dehydrogenase (G6PDH) by peroxyl radicals is strongly modulated by its substrate and cofactor.

Autori: Reyes JS Fuentes-Lemus E Fierro A a ďalší

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2025 Jun; Vol. 233, pp. 55-69. Date of Electronic Publication: 2025 Mar 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucosephosphate Dehydrogenase*/chemistry , Glucosephosphate Dehydrogenase*/metabolism , Glucosephosphate Dehydrogenase*/antagonists & inhibitors , NADP*/metabolism , NADP*/chemistry , Peroxides*/chemistry, Humans ; Oxidation-Reduction ; Glucose-6-Phosphate/metabolism ; Glucose-6-Phosphate/chemistry ; Amidines/chemistry ; Amidines/pharmacology ; Pentose Phosphate Pathway ; Oxidative Stress

Polyamine Inhibitor SAM486A Augments Cytarabine Cytotoxicity in Methylthioadenosine Phosphorylase-deficient Leukemia Cells.

Autori: Nishi R Fujita K Matsuda Y a ďalší

Zdroj: Anticancer research [Anticancer Res] 2024 Mar; Vol. 44 (3), pp. 981-991.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents* , Leukemia*/drug therapy , Amidines* , Indans*, Humans ; Cytarabine/pharmacology ; Purine-Nucleoside Phosphorylase/genetics ; Purine-Nucleoside Phosphorylase/metabolism ; Polyamines ; Methionine/pharmacology ; Methionine/metabolism

20-HETE mediated TRPV1 activation drives allokinesis via MrgprA3 ⁺ neurons in chronic dermatitis.

Autori: Yu G Liu P Huang X a ďalší

Zdroj: Theranostics [Theranostics] 2024 Feb 04; Vol. 14 (4), pp. 1615-1630. Date of Electronic Publication: 2024 Feb 04 (Print Publication: 2024).

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proto-Oncogene Proteins B-raf* , Dermatitis* , Amidines* , Hydroxyeicosatetraenoic Acids*, Humans ; Animals ; Capsaicin/pharmacology ; Pruritus ; Pain ; Chronic Disease ; Disease Models, Animal ; TRPV Cation Channels

Free radical scavenging and anti-isolated human LDL oxidation activities of Butea superba Roxb. extract.

Autori: Sirichaiwetchakoon K Eumkeb G

Zdroj: BMC complementary medicine and therapies [BMC Complement Med Ther] 2024 Feb 03; Vol. 24 (1), pp. 75. Date of Electronic Publication: 2024 Feb 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antioxidants*/pharmacology , Antioxidants*/chemistry , Butea*/chemistry , Amidines* , Sulfonic Acids* , Benzothiazoles*, Humans ; Chromatography, Liquid ; Peroxynitrous Acid ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Tandem Mass Spectrometry ; Nitric Oxide ; Free Radicals

Three-dimensional topography of rat trigeminal ganglion neurons using a combination of retrograde labeling and tissue-clearing techniques.

Autori: Kuramoto E Fukushima M Sendo R a ďalší

Zdroj: The Journal of comparative neurology [J Comp Neurol] 2024 Feb; Vol. 532 (2), pp. e25584.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Trigeminal Ganglion*/physiology , Trigeminal Nerve* , Amidines*, Rats ; Animals ; Neurons ; Neurons, Afferent

Thioimidates provide general access to thioamide, amidine, and imidazolone peptide-bond isosteres.

Autori: Byerly-Duke J O'Brien EA Wall BJ a ďalší

Zdroj: Methods in enzymology [Methods Enzymol] 2024; Vol. 698, pp. 27-55. Date of Electronic Publication: 2024 Apr 25.

Spôsob vydávania: Journal Article; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Thioamides*/chemistry , Imidazoles*/chemistry , Peptides*/chemistry , Amidines*/chemistry

Effect of Different Carbon Sources on Antioxidant Properties of Exopolysaccharides Produced by Scleroderma areolatum (Agaricomycetes).

Autori: Xi G Lu C Wu Y a ďalší

Zdroj: International journal of medicinal mushrooms [Int J Med Mushrooms] 2024; Vol. 26 (3), pp. 67-76.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Begell House, Inc Country of Publication: United States NLM ID: 100886202 Publication Model: Print Cited Medium: Internet ISSN: 1940-4344 (Electronic) Linking ISSN: 19404344 NLM ISO Abbreviation: Int J Med Mushrooms Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antioxidants*/pharmacology , Antioxidants*/chemistry , Carbon* , Amidines* , Basidiomycota* , Sulfonic Acids* , Benzothiazoles*, DNA/chemistry ; Fructose ; Free Radical Scavengers/pharmacology

SCR Organism: Scleroderma areolatum

Protective effects of sinensetin against oxidative stress damage induced by AAPH in the brain-gut.

Autori: Jin T He M Li N a ďalší

Zdroj: Free radical research [Free Radic Res] 2025 May; Vol. 59 (5), pp. 409-425. Date of Electronic Publication: 2025 Jun 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9423872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2470 (Electronic) Linking ISSN: 10292470 NLM ISO Abbreviation: Free Radic Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/drug effects , Brain*/drug effects , Brain*/metabolism , Brain*/pathology , Flavonoids*/pharmacology , Antioxidants*/pharmacology, Animals ; Zebrafish ; Amidines

Metallofullerenol Gd@C 82 (OH) 22 preserves human erythrocyte plasma membrane integrity from AAPH-induced oxidative stress: Molecular mechanisms and antioxidant activity.

Autori: Remigante A Studzian M Spinelli S a ďalší

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2025 Mar 01; Vol. 229, pp. 499-513. Date of Electronic Publication: 2025 Jan 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/drug effects , Erythrocyte Membrane*/drug effects , Erythrocyte Membrane*/metabolism , Fullerenes*/chemistry , Fullerenes*/pharmacology , Gadolinium*/chemistry , Gadolinium*/pharmacology , Antioxidants*/pharmacology , Antioxidants*/chemistry, Humans ; Amidines/toxicity ; Amidines/pharmacology ; Lipid Peroxidation/drug effects ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Lipid Bilayers/chemistry ; Membrane Fluidity/drug effects